MX2021011598A - Uso de mir101 o mir128 en el tratamiento de trastornos convulsivos. - Google Patents
Uso de mir101 o mir128 en el tratamiento de trastornos convulsivos.Info
- Publication number
- MX2021011598A MX2021011598A MX2021011598A MX2021011598A MX2021011598A MX 2021011598 A MX2021011598 A MX 2021011598A MX 2021011598 A MX2021011598 A MX 2021011598A MX 2021011598 A MX2021011598 A MX 2021011598A MX 2021011598 A MX2021011598 A MX 2021011598A
- Authority
- MX
- Mexico
- Prior art keywords
- patient
- microrna
- mir128
- mir101
- seizure disorder
- Prior art date
Links
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7105—Natural ribonucleic acids, i.e. containing only riboses attached to adenine, guanine, cytosine or uracil and having 3'-5' phosphodiester links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/66—Microorganisms or materials therefrom
- A61K35/76—Viruses; Subviral particles; Bacteriophages
- A61K35/761—Adenovirus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
- A61K41/0047—Sonopheresis, i.e. ultrasonically-enhanced transdermal delivery, electroporation of a pharmacologically active agent
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0085—Brain, e.g. brain implants; Spinal cord
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
- A61K9/127—Liposomes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1137—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against enzymes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/14—Type of nucleic acid interfering N.A.
- C12N2310/141—MicroRNAs, miRNAs
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/32—Special delivery means, e.g. tissue-specific
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/50—Biochemical production, i.e. in a transformed host cell
- C12N2330/51—Specially adapted vectors
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2750/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssDNA viruses
- C12N2750/00011—Details
- C12N2750/14011—Parvoviridae
- C12N2750/14111—Dependovirus, e.g. adenoassociated viruses
- C12N2750/14141—Use of virus, viral particle or viral elements as a vector
- C12N2750/14143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Molecular Biology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Epidemiology (AREA)
- Microbiology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Virology (AREA)
- Physics & Mathematics (AREA)
- Plant Pathology (AREA)
- Psychology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pain & Pain Management (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Dispersion Chemistry (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Se proporcionan métodos para tratar un trastorno convulsivo en un paciente que necesita de estos, que incluyen suministrar al paciente una cantidad efectiva de una composición que aumenta el nivel de moléculas de microARN-101 en las células cerebrales del paciente. Se proporcionan métodos para tratar un trastorno convulsivo en un paciente que necesita de estos, que incluyen suministrar al paciente una cantidad efectiva de una composición que aumenta el nivel de moléculas de microARN-128 en las células cerebrales del paciente. Se proporcionan métodos para tratar un trastorno convulsivo en un paciente que necesita de estos, que incluyen administrar un vector que codifica el microARN-101, pri-miR101 o pre-miR101 al paciente. Se proporcionan métodos para tratar un trastorno convulsivo en un paciente que necesita de estos, que incluyen administrar un vector que codifica el microARN-128, pri-miR128 o pre-miR128 al paciente. En las realizaciones, los niveles aumentados de microARN-101 y/o microARN-128 causan una mejora en uno o más síntomas del trastorno convulsivo.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762595255P | 2017-12-06 | 2017-12-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2021011598A true MX2021011598A (es) | 2021-10-13 |
Family
ID=66658874
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020005952A MX2020005952A (es) | 2017-12-06 | 2018-12-06 | Uso de mir101 o mir128 en el tratamiento de trastornos convulsivos. |
MX2021011598A MX2021011598A (es) | 2017-12-06 | 2020-07-13 | Uso de mir101 o mir128 en el tratamiento de trastornos convulsivos. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2020005952A MX2020005952A (es) | 2017-12-06 | 2018-12-06 | Uso de mir101 o mir128 en el tratamiento de trastornos convulsivos. |
Country Status (10)
Country | Link |
---|---|
US (2) | US10870855B2 (es) |
EP (1) | EP3703820A4 (es) |
JP (1) | JP2021505619A (es) |
KR (1) | KR20200119782A (es) |
CN (1) | CN111417397A (es) |
AU (1) | AU2018378622A1 (es) |
CA (1) | CA3084985A1 (es) |
IL (1) | IL274838A (es) |
MX (2) | MX2020005952A (es) |
WO (1) | WO2019113266A1 (es) |
Families Citing this family (1)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CA3084985A1 (en) | 2017-12-06 | 2019-06-13 | Ovid Therapeutics Inc. | Use of mir101 or mir128 in the treatment of seizure disorders |
Family Cites Families (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US3499437A (en) | 1967-03-10 | 1970-03-10 | Ultrasonic Systems | Method and apparatus for treatment of organic structures and systems thereof with ultrasonic energy |
US4303636A (en) | 1974-08-20 | 1981-12-01 | Gordon Robert T | Cancer treatment |
US4315514A (en) | 1980-05-08 | 1982-02-16 | William Drewes | Method and apparatus for selective cell destruction |
US4923437A (en) | 1986-07-18 | 1990-05-08 | Gordon Robert T | Process for applying a localized magnetic or electric field |
US5059415A (en) | 1989-02-21 | 1991-10-22 | The State Of Oregon Acting By And Through The Oregon State Board Of Higher Education On Behalf Of Oregon Health | Method for diagnostically imaging lesions in the brain inside a blood-brain barrier |
US5112596A (en) | 1990-04-23 | 1992-05-12 | Alkermes, Inc. | Method for increasing blood-brain barrier permeability by administering a bradykinin agonist of blood-brain barrier permeability |
US5438989A (en) | 1990-08-10 | 1995-08-08 | Hochman; Darryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
US5465718A (en) | 1990-08-10 | 1995-11-14 | Hochman; Daryl | Solid tumor, cortical function, and nerve tissue imaging methods and device |
US5307816A (en) | 1991-08-21 | 1994-05-03 | Kabushiki Kaisha Toshiba | Thrombus resolving treatment apparatus |
US5291890A (en) | 1991-08-29 | 1994-03-08 | General Electric Company | Magnetic resonance surgery using heat waves produced with focussed ultrasound |
US5524620A (en) | 1991-11-12 | 1996-06-11 | November Technologies Ltd. | Ablation of blood thrombi by means of acoustic energy |
JP3325300B2 (ja) | 1992-02-28 | 2002-09-17 | 株式会社東芝 | 超音波治療装置 |
US5526814A (en) | 1993-11-09 | 1996-06-18 | General Electric Company | Automatically positioned focussed energy system guided by medical imaging |
US5368032A (en) | 1993-11-09 | 1994-11-29 | General Electric Company | Manually positioned focussed energy system guided by medical imaging |
US5443068A (en) | 1994-09-26 | 1995-08-22 | General Electric Company | Mechanical positioner for magnetic resonance guided ultrasound therapy |
US5752515A (en) | 1996-08-21 | 1998-05-19 | Brigham & Women's Hospital | Methods and apparatus for image-guided ultrasound delivery of compounds through the blood-brain barrier |
WO2007035721A2 (en) | 2005-09-19 | 2007-03-29 | The Trustees Of Columbia University In The City Of New York | Ultrasound method to open blood brain barrier |
WO2008137915A2 (en) * | 2007-05-07 | 2008-11-13 | Medimmune, Llc | Anti-icos antibodies and their use in treatment of oncology, transplantation and autoimmune disease |
WO2011101869A1 (en) * | 2010-02-22 | 2011-08-25 | Transgene Biotek Ltd. | Adeno-associated virus 2/8 - micro rna-101 therapy for liver cancer |
GB201103062D0 (en) * | 2011-02-22 | 2011-04-06 | Isis Innovation | Method |
GB201223244D0 (en) * | 2012-12-21 | 2013-02-06 | Ucb Pharma Gmbh | Micrornas as therapeutics and biomarkers for epilepsy |
CN107207597A (zh) | 2014-11-06 | 2017-09-26 | 儿研所儿童医学中心 | 用于癌症和自身免疫疾病的免疫疗法 |
MX2017010369A (es) * | 2015-02-10 | 2017-12-14 | Genzyme Corp | Arni variante. |
US20180201937A1 (en) * | 2015-08-04 | 2018-07-19 | The University Of Chicago | Inhibitors of cacna1a/alpha1a subunit internal ribosomal entry site (ires) and methods of treating spinocerebellar ataxia type 6 |
US11072804B2 (en) * | 2016-02-12 | 2021-07-27 | Combigene Ab | Vector |
US20190060400A1 (en) * | 2017-03-15 | 2019-02-28 | Ovid Therapeutics Inc. | Use of designer receptors exclusively activated by designer drugs and ultrasound in the treatment of seizure disorders |
CA3084985A1 (en) | 2017-12-06 | 2019-06-13 | Ovid Therapeutics Inc. | Use of mir101 or mir128 in the treatment of seizure disorders |
-
2018
- 2018-12-06 CA CA3084985A patent/CA3084985A1/en active Pending
- 2018-12-06 US US16/211,309 patent/US10870855B2/en active Active
- 2018-12-06 KR KR1020207019430A patent/KR20200119782A/ko not_active Application Discontinuation
- 2018-12-06 AU AU2018378622A patent/AU2018378622A1/en active Pending
- 2018-12-06 WO PCT/US2018/064158 patent/WO2019113266A1/en unknown
- 2018-12-06 MX MX2020005952A patent/MX2020005952A/es unknown
- 2018-12-06 CN CN201880076488.2A patent/CN111417397A/zh active Pending
- 2018-12-06 EP EP18886725.3A patent/EP3703820A4/en not_active Withdrawn
- 2018-12-06 JP JP2020531161A patent/JP2021505619A/ja active Pending
-
2020
- 2020-05-21 IL IL274838A patent/IL274838A/en unknown
- 2020-07-13 MX MX2021011598A patent/MX2021011598A/es unknown
- 2020-11-17 US US16/950,395 patent/US11761006B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP3703820A4 (en) | 2020-12-09 |
US10870855B2 (en) | 2020-12-22 |
WO2019113266A1 (en) | 2019-06-13 |
AU2018378622A1 (en) | 2020-05-28 |
MX2020005952A (es) | 2022-01-03 |
US11761006B2 (en) | 2023-09-19 |
EP3703820A1 (en) | 2020-09-09 |
JP2021505619A (ja) | 2021-02-18 |
US20190169619A1 (en) | 2019-06-06 |
IL274838A (en) | 2020-07-30 |
CN111417397A (zh) | 2020-07-14 |
US20210095292A1 (en) | 2021-04-01 |
CA3084985A1 (en) | 2019-06-13 |
KR20200119782A (ko) | 2020-10-20 |
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MX2021011598A (es) | Uso de mir101 o mir128 en el tratamiento de trastornos convulsivos. |