RU2020109328A - Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака - Google Patents
Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака Download PDFInfo
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- RU2020109328A RU2020109328A RU2020109328A RU2020109328A RU2020109328A RU 2020109328 A RU2020109328 A RU 2020109328A RU 2020109328 A RU2020109328 A RU 2020109328A RU 2020109328 A RU2020109328 A RU 2020109328A RU 2020109328 A RU2020109328 A RU 2020109328A
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- lymphoma
- alkyl
- cell lymphoma
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- FCEHBMOGCRZNNI-UHFFFAOYSA-N 1-benzothiophene Chemical compound C1=CC=C2SC=CC2=C1 FCEHBMOGCRZNNI-UHFFFAOYSA-N 0.000 title claims 12
- 206010028980 Neoplasm Diseases 0.000 title claims 6
- 201000011510 cancer Diseases 0.000 title claims 5
- 239000000556 agonist Substances 0.000 title claims 2
- 239000005557 antagonist Substances 0.000 title 1
- 238000000034 method Methods 0.000 claims 14
- 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 8
- 229940124060 PD-1 antagonist Drugs 0.000 claims 7
- 229910052736 halogen Inorganic materials 0.000 claims 7
- 150000002367 halogens Chemical class 0.000 claims 7
- 206010025323 Lymphomas Diseases 0.000 claims 5
- 229910052739 hydrogen Inorganic materials 0.000 claims 5
- 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 4
- 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 4
- 229940044665 STING agonist Drugs 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 3
- -1 C 2 -C 6 haloalkynyl Chemical group 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 208000035475 disorder Diseases 0.000 claims 3
- 125000006643 (C2-C6) haloalkenyl group Chemical group 0.000 claims 2
- 206010073478 Anaplastic large-cell lymphoma Diseases 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 2
- 208000032004 Large-Cell Anaplastic Lymphoma Diseases 0.000 claims 2
- 206010042971 T-cell lymphoma Diseases 0.000 claims 2
- 208000027585 T-cell non-Hodgkin lymphoma Diseases 0.000 claims 2
- 229910052799 carbon Inorganic materials 0.000 claims 2
- 238000001802 infusion Methods 0.000 claims 2
- 238000001990 intravenous administration Methods 0.000 claims 2
- 229960003301 nivolumab Drugs 0.000 claims 2
- 229910052760 oxygen Inorganic materials 0.000 claims 2
- 229960002621 pembrolizumab Drugs 0.000 claims 2
- 230000002062 proliferating effect Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229910052717 sulfur Inorganic materials 0.000 claims 2
- 208000010839 B-cell chronic lymphocytic leukemia Diseases 0.000 claims 1
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000011691 Burkitt lymphomas Diseases 0.000 claims 1
- 208000016937 Extranodal nasal NK/T cell lymphoma Diseases 0.000 claims 1
- 206010017533 Fungal infection Diseases 0.000 claims 1
- 208000017604 Hodgkin disease Diseases 0.000 claims 1
- 208000021519 Hodgkin lymphoma Diseases 0.000 claims 1
- 208000010747 Hodgkins lymphoma Diseases 0.000 claims 1
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 1
- 208000031422 Lymphocytic Chronic B-Cell Leukemia Diseases 0.000 claims 1
- 208000025205 Mantle-Cell Lymphoma Diseases 0.000 claims 1
- 208000027190 Peripheral T-cell lymphomas Diseases 0.000 claims 1
- 206010065857 Primary Effusion Lymphoma Diseases 0.000 claims 1
- 206010036711 Primary mediastinal large B-cell lymphomas Diseases 0.000 claims 1
- 208000000102 Squamous Cell Carcinoma of Head and Neck Diseases 0.000 claims 1
- 208000010502 Subcutaneous panniculitis-like T-cell lymphoma Diseases 0.000 claims 1
- 208000031672 T-Cell Peripheral Lymphoma Diseases 0.000 claims 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 1
- 208000037844 advanced solid tumor Diseases 0.000 claims 1
- 206010002449 angioimmunoblastic T-cell lymphoma Diseases 0.000 claims 1
- 201000008274 breast adenocarcinoma Diseases 0.000 claims 1
- 201000009613 breast lymphoma Diseases 0.000 claims 1
- 230000004663 cell proliferation Effects 0.000 claims 1
- 238000002648 combination therapy Methods 0.000 claims 1
- 150000001875 compounds Chemical class 0.000 claims 1
- 208000035250 cutaneous malignant susceptibility to 1 melanoma Diseases 0.000 claims 1
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 1
- 208000037902 enteropathy Diseases 0.000 claims 1
- 201000003444 follicular lymphoma Diseases 0.000 claims 1
- 208000024386 fungal infectious disease Diseases 0.000 claims 1
- 229940084434 fungoid Drugs 0.000 claims 1
- 201000000459 head and neck squamous cell carcinoma Diseases 0.000 claims 1
- 238000002347 injection Methods 0.000 claims 1
- 239000007924 injection Substances 0.000 claims 1
- 208000028774 intestinal disease Diseases 0.000 claims 1
- 230000002601 intratumoral effect Effects 0.000 claims 1
- 210000003563 lymphoid tissue Anatomy 0.000 claims 1
- 201000007919 lymphoplasmacytic lymphoma Diseases 0.000 claims 1
- 208000020968 mature T-cell and NK-cell non-Hodgkin lymphoma Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 208000037819 metastatic cancer Diseases 0.000 claims 1
- 208000011575 metastatic malignant neoplasm Diseases 0.000 claims 1
- 208000037843 metastatic solid tumor Diseases 0.000 claims 1
- 210000004400 mucous membrane Anatomy 0.000 claims 1
- 229950010773 pidilizumab Drugs 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 238000010254 subcutaneous injection Methods 0.000 claims 1
- 239000007929 subcutaneous injection Substances 0.000 claims 1
- 230000009885 systemic effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/38—Heterocyclic compounds having sulfur as a ring hetero atom
- A61K31/381—Heterocyclic compounds having sulfur as a ring hetero atom having five-membered rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
- A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
- A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
- C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Organic Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Genetics & Genomics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201762541180P | 2017-08-04 | 2017-08-04 | |
| US62/541,180 | 2017-08-04 | ||
| PCT/US2018/044275 WO2019027857A1 (en) | 2017-08-04 | 2018-07-30 | COMBINATIONS OF PD-1 ANTAGONISTS AND STING BENZO [B] THIOPHENIC AGONISTS FOR THE TREATMENT OF CANCER |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2020109328A true RU2020109328A (ru) | 2021-09-06 |
| RU2020109328A3 RU2020109328A3 (enExample) | 2021-11-09 |
Family
ID=65234179
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2020109328A RU2020109328A (ru) | 2017-08-04 | 2018-07-30 | Комбинации антагонистов pd-1 и бензо[b]тиофеновых агонистов sting для лечения рака |
Country Status (8)
| Country | Link |
|---|---|
| US (1) | US11312772B2 (enExample) |
| EP (1) | EP3661499A4 (enExample) |
| JP (1) | JP2020529421A (enExample) |
| AU (1) | AU2018311965A1 (enExample) |
| CA (1) | CA3071537A1 (enExample) |
| MA (1) | MA49773A (enExample) |
| RU (1) | RU2020109328A (enExample) |
| WO (1) | WO2019027857A1 (enExample) |
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|---|---|---|---|---|
| TN2020000158A1 (en) * | 2016-10-04 | 2022-04-04 | Merck Sharp & Dohme | BENZO[b]THIOPHENE COMPOUNDS AS STING AGONISTS |
| WO2019046511A1 (en) | 2017-08-31 | 2019-03-07 | Sperovie Biosciences, Inc. | COMPOUNDS, COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISEASE |
| MA52754A (fr) | 2018-05-25 | 2021-04-14 | Incyte Corp | Composés hétérocycliques tricycliques en tant qu'activateurs de sting |
| US10875872B2 (en) | 2018-07-31 | 2020-12-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| WO2020028565A1 (en) | 2018-07-31 | 2020-02-06 | Incyte Corporation | Tricyclic heteraryl compounds as sting activators |
| TW202446772A (zh) | 2018-10-11 | 2024-12-01 | 日商小野藥品工業股份有限公司 | Ｓｔｉｎｇ促效化合物 |
| US11596692B1 (en) | 2018-11-21 | 2023-03-07 | Incyte Corporation | PD-L1/STING conjugates and methods of use |
| US12129267B2 (en) | 2019-01-07 | 2024-10-29 | Incyte Corporation | Heteroaryl amide compounds as sting activators |
| WO2020194160A1 (en) | 2019-03-28 | 2020-10-01 | Lupin Limited | Macrocyclic compounds as sting agonists |
| US12269816B2 (en) | 2019-04-30 | 2025-04-08 | Sichuan Kelun-Biotech Biopharmaceutical Co., Ltd. | Benzothiophene compound, preparation method therefor and use thereof |
| EP3962493A2 (en) | 2019-05-03 | 2022-03-09 | Flagship Pioneering Innovations V, Inc. | Methods of modulating immune activity/level of irf or sting or of treating cancer, comprising the administration of a sting modulator and/or purinergic receptor modulator or postcellular signaling factor |
| TW202116330A (zh) | 2019-07-09 | 2021-05-01 | 日商武田藥品工業股份有限公司 | Sting 促效劑及檢查點抑制劑之投與 |
| MX420195B (es) | 2019-07-22 | 2025-02-10 | Lupin Ltd | Compuestos macrocíclicos como agonistas de sting y métodos y usos de los mismos |
| US11155567B2 (en) | 2019-08-02 | 2021-10-26 | Mersana Therapeutics, Inc. | Sting agonist compounds and methods of use |
| BR112022019919A2 (pt) | 2020-04-02 | 2023-02-14 | Mersana Therapeutics Inc | Conjugado de anticorpo-fármaco compreendendo agonistas de sting |
| EP4134098A4 (en) * | 2020-04-10 | 2024-05-15 | ONO Pharmaceutical Co., Ltd. | Method of cancer therapy |
| CN116490244A (zh) * | 2020-11-18 | 2023-07-25 | 武田药品工业株式会社 | Sting激动剂、检查点抑制剂和辐射的施用 |
| KR20230110254A (ko) * | 2020-11-18 | 2023-07-21 | 다케다 야쿠힌 고교 가부시키가이샤 | Sting 작용제, 관문 저해제, 및 방사선의 투여 |
| CN113429384B (zh) * | 2021-05-12 | 2022-04-08 | 中山大学附属第五医院 | 一类干扰素基因刺激因子靶向的放射性pet显像剂 |
| CN113521303B (zh) * | 2021-07-07 | 2024-01-02 | 中山大学附属第一医院 | 一种共同负载pd-l1抗体和sting激动剂的纳米囊泡及其制备方法与应用 |
| CN115772154B (zh) * | 2021-09-08 | 2024-04-30 | 上海交通大学 | 一类含有氘取代的苯并噻吩类衍生物及其制备与用途 |
| EP4490195A2 (en) * | 2022-03-07 | 2025-01-15 | Arima Genomics, Inc. | Methods of selecting and treating cancer subjects that are candidates for treatment using inhibitors of a pd-1 pathway |
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-
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- 2018-07-30 MA MA049773A patent/MA49773A/fr unknown
- 2018-07-30 WO PCT/US2018/044275 patent/WO2019027857A1/en not_active Ceased
- 2018-07-30 AU AU2018311965A patent/AU2018311965A1/en not_active Abandoned
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- 2018-07-30 EP EP18841987.3A patent/EP3661499A4/en not_active Withdrawn
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| US20210130466A1 (en) | 2021-05-06 |
| MA49773A (fr) | 2021-04-21 |
| JP2020529421A (ja) | 2020-10-08 |
| EP3661499A1 (en) | 2020-06-10 |
| RU2020109328A3 (enExample) | 2021-11-09 |
| WO2019027857A1 (en) | 2019-02-07 |
| CA3071537A1 (en) | 2019-02-07 |
| AU2018311965A1 (en) | 2020-02-13 |
| US11312772B2 (en) | 2022-04-26 |
| EP3661499A4 (en) | 2021-04-21 |
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