RU2019139434A3 - - Google Patents
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- RU2019139434A3 RU2019139434A3 RU2019139434A RU2019139434A RU2019139434A3 RU 2019139434 A3 RU2019139434 A3 RU 2019139434A3 RU 2019139434 A RU2019139434 A RU 2019139434A RU 2019139434 A RU2019139434 A RU 2019139434A RU 2019139434 A3 RU2019139434 A3 RU 2019139434A3
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/06—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations
- A61K49/08—Nuclear magnetic resonance [NMR] contrast preparations; Magnetic resonance imaging [MRI] contrast preparations characterised by the carrier
- A61K49/10—Organic compounds
- A61K49/101—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals
- A61K49/106—Organic compounds the carrier being a complex-forming compound able to form MRI-active complexes with paramagnetic metals the complex-forming compound being cyclic, e.g. DOTA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0482—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group chelates from cyclic ligands, e.g. DOTA
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/0474—Organic compounds complexes or complex-forming compounds, i.e. wherein a radioactive metal (e.g. 111In3+) is complexed or chelated by, e.g. a N2S2, N3S, NS3, N4 chelating group
- A61K51/0485—Porphyrins, texaphyrins wherein the nitrogen atoms forming the central ring system complex the radioactive metal
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1093—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies
- A61K51/1096—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody conjugates with carriers being antibodies radioimmunotoxins, i.e. conjugates being structurally as defined in A61K51/1093, and including a radioactive nucleus for use in radiotherapeutic applications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/26—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against hormones ; against hormone releasing or inhibiting factors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/286—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against neuromediator receptors, e.g. serotonin receptor, dopamine receptor
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2121/00—Preparations for use in therapy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Organic Chemistry (AREA)
- Optics & Photonics (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Genetics & Genomics (AREA)
- Biochemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Radiology & Medical Imaging (AREA)
- Endocrinology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US201762502288P | 2017-05-05 | 2017-05-05 | |
US62/502,288 | 2017-05-05 | ||
US201762545945P | 2017-08-15 | 2017-08-15 | |
US62/545,945 | 2017-08-15 | ||
PCT/US2018/031233 WO2018204872A2 (en) | 2017-05-05 | 2018-05-04 | Igf-1r monoclonal antibodies and uses thereof |
Publications (2)
Publication Number | Publication Date |
---|---|
RU2019139434A RU2019139434A (ru) | 2021-06-07 |
RU2019139434A3 true RU2019139434A3 (ru) | 2021-06-17 |
Family
ID=64016737
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
RU2019139434A RU2019139434A (ru) | 2017-05-05 | 2018-05-04 | Моноклональные антитела против igf-1r и их применение |
Country Status (15)
Country | Link |
---|---|
US (2) | US11433148B2 (ru) |
EP (1) | EP3638320A4 (ru) |
JP (2) | JP7191938B2 (ru) |
KR (1) | KR20200004861A (ru) |
CN (1) | CN110891614A (ru) |
AU (1) | AU2018261890A1 (ru) |
BR (1) | BR112019023249A8 (ru) |
CA (1) | CA3062538A1 (ru) |
CL (1) | CL2019003169A1 (ru) |
IL (2) | IL313115A (ru) |
MA (1) | MA49398A (ru) |
MX (1) | MX2024006675A (ru) |
RU (1) | RU2019139434A (ru) |
WO (1) | WO2018204872A2 (ru) |
ZA (1) | ZA201908072B (ru) |
Families Citing this family (11)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3720448A4 (en) | 2017-12-06 | 2021-11-03 | Avidity Biosciences, Inc. | COMPOSITIONS AND METHODS OF TREATMENT OF MUSCLE ATROPHY AND MYOTONIC DYSTROPHY |
MA54399A (fr) * | 2018-12-03 | 2021-10-13 | Fusion Pharmaceuticals Inc | Radioimmunoconjugués et polythérapie à base d'inhibiteur de point de contrôle |
IL292133A (en) * | 2019-10-18 | 2022-06-01 | Nihon Mediphysics Co Ltd | Humanized antibody labeled with a radioactive isotope |
BR112022013681A2 (pt) * | 2020-01-10 | 2022-11-16 | Fusion Pharmaceuticals Inc | Imunoterapia sustentada |
JP2023510306A (ja) * | 2020-01-10 | 2023-03-13 | フュージョン ファーマシューティカルズ インコーポレイテッド | 大環状キレートおよびその使用 |
WO2021195469A1 (en) | 2020-03-27 | 2021-09-30 | Avidity Biosciences, Inc. | Compositions and methods of treating muscle dystrophy |
WO2023049985A1 (en) * | 2021-09-29 | 2023-04-06 | National Research Council Of Canada | Egfrviii-targeted compounds and uses thereof |
WO2023070202A1 (en) * | 2021-10-25 | 2023-05-04 | Fusion Pharmaceuticals Inc. | Claudin 18.2-targeted compounds and uses thereof |
AR127556A1 (es) * | 2021-11-02 | 2024-02-07 | Fusion Pharmaceuticals Inc | Métodos para tratar el cáncer utilizando un radioinmunoconjugado |
TW202423906A (zh) * | 2022-08-22 | 2024-06-16 | 美商雅博得樂醫療公司 | Vhh抗體dota結合物 |
WO2024206858A1 (en) | 2023-03-30 | 2024-10-03 | Revolution Medicines, Inc. | Compositions for inducing ras gtp hydrolysis and uses thereof |
Family Cites Families (97)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US5175343A (en) | 1985-01-14 | 1992-12-29 | Neorx Corporation | Metal radionuclide labeled proteins for diagnosis and therapy |
US4889931A (en) | 1988-09-27 | 1989-12-26 | Salutar, Inc. | Manganese (II) chelate manufacture |
US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
DE69024826T2 (de) | 1989-02-10 | 1996-06-27 | Celltech Therapeutics Ltd | Aza-Macrozyklen und Verfahren zu deren Herstellung |
US5053503A (en) | 1989-02-17 | 1991-10-01 | Centocor | Chelating agents |
US6274713B1 (en) | 1989-04-07 | 2001-08-14 | Salutar, Inc. | Polychelants |
US5364613A (en) | 1989-04-07 | 1994-11-15 | Sieving Paul F | Polychelants containing macrocyclic chelant moieties |
US7385041B2 (en) | 1990-04-25 | 2008-06-10 | Bracco International B.V. | Dual functioning excipient for metal chelate contrast agents |
IL98534A0 (en) | 1990-06-18 | 1992-07-15 | Dow Chemical Co | The use of macrocyclic aminophosphonic acid complexes as imaging agents |
US5386011A (en) | 1990-12-27 | 1995-01-31 | Abbott Laboratories | Hexapeptide anaphylatoxin-receptor ligands |
CA2110799A1 (en) | 1991-06-14 | 1992-12-23 | Arnold H. Horwitz | Microbially-produced antibody fragments and their conjugates |
ATE210464T1 (de) | 1992-06-09 | 2001-12-15 | Neorx Corp | BIOTIN-DOTA KONJUGATE UND DEREN VERWENDUNG IN ßPRETARGETINGß VERFAHREN |
US5358704A (en) | 1993-09-30 | 1994-10-25 | Bristol-Myers Squibb | Hepatobiliary tetraazamacrocyclic magnetic resonance contrast agents |
GB9504922D0 (en) | 1995-03-10 | 1995-04-26 | Nycomed As | Process |
CZ294425B6 (cs) | 1997-04-14 | 2005-01-12 | Micromet Ag | Způsob výroby anti-humánního antigenového receptoru, anti-humánní antigenový receptor, řetězec VH a VL, souprava pro selekci anti-humánních antigenových receptorů a farmaceutická kompozice, obsahující uvedený receptor |
IT1291624B1 (it) | 1997-04-18 | 1999-01-11 | Bracco Spa | Chelati complessi di metalli paramagnetici a bassa tossicita' |
IT1304501B1 (it) | 1998-12-23 | 2001-03-19 | Bracco Spa | Uso di derivati di acidi biliari coniugati con complessi metallicicome "blood pool agents" per l'indagine diagnostica tramite risonanza |
AU5871000A (en) | 1999-06-11 | 2001-01-02 | Paul G. Abrams | High dose radionuclide complexes for bone marrow suppression |
DE10002939C1 (de) | 2000-01-13 | 2001-09-20 | Schering Ag | Paramagnetische DOTA-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung für die Herstellung von pharmazeutischen Mitteln |
US20020052354A1 (en) | 2000-01-27 | 2002-05-02 | Schering Ag | Paramagnetic DOTA derivatives, pharmaceutical agents that contain the latter, process for their production, and their use for MR imaging of necrosis and infarction |
US6264966B1 (en) | 2000-02-22 | 2001-07-24 | Concat, Ltd. | Compounds with chelation affinity and selectivity for first transition elements and their use in cosmetics and personal care products, inhibition of metalloenzymes, and inhibition of reperfusion injury |
US20060233704A1 (en) | 2000-05-12 | 2006-10-19 | Maecke Helmut R | Prochelator for the preparation of radiometal labeled molecules having improved biological properties |
AU2002249935A1 (en) | 2001-01-08 | 2002-08-19 | Neorx Corporation | Radioactively labelled conjugates of phosphonates |
DE10135355C1 (de) | 2001-07-20 | 2003-04-17 | Schering Ag | Konjugate makrocyclischer Metallkomplexe mit Biomolekülen und deren Verwendung zur Herstellung von Mitteln für die NMR- und Radiodiagnostik sowie die Radiotherapie |
DE10135356C1 (de) | 2001-07-20 | 2003-04-17 | Schering Ag | Makrocyclische Metallkomplexe und deren Verwendung zur Herstellung von Konjugaten mit Biomolekülen |
TWI284539B (en) | 2001-07-30 | 2007-08-01 | Epix Pharm Inc | A method for making a magnetic resonance (MR) imaging agent, a MR imaging contrast agent, a method for altering stability of a peptide and a modified peptide |
US20040204561A1 (en) | 2002-08-06 | 2004-10-14 | Ellison Jeffrey J. | Peptide aggregates |
DE10250870A1 (de) | 2002-10-31 | 2004-05-13 | Switch Biotech Ag | Zusammensetzung enthaltend Aktivatoren von IK-Kaliumkanälen und Calcineurin-Antagonisten und deren Verwendung |
US20060235296A1 (en) | 2003-02-13 | 2006-10-19 | Bracco Imaging S.P.A. | Contrast enhanced x-ray phase imaging |
WO2004082722A2 (en) | 2003-03-19 | 2004-09-30 | Universitätsspital Basel | Radiolabeled conjugates based on substance p and the uses thereof |
WO2005001415A2 (en) | 2003-05-23 | 2005-01-06 | Epix Pharmaceuticals, Inc. | Optically pure and enriched isomers of chelating ligands and contrast agents |
JP4262545B2 (ja) | 2003-07-09 | 2009-05-13 | 三菱電機株式会社 | カスコード接続回路及びその集積回路 |
SG144160A1 (en) * | 2003-07-24 | 2008-07-29 | Bracco Imaging Spa | Stable radiopharmaceutical compositions and methods for their preparation |
EP1671128B1 (en) | 2003-09-12 | 2010-02-17 | Life Technologies Corporation | Applications of the resonance energy transfer between terbium and GFP |
KR20060111581A (ko) | 2003-12-19 | 2006-10-27 | 쉐링 코포레이션 | 약제학적 조성물 |
WO2005079803A1 (en) | 2004-02-13 | 2005-09-01 | Pfizer Products, Inc. | Compounds for treatment of cardiovascular diseases |
WO2006015318A2 (en) | 2004-07-30 | 2006-02-09 | Biogen Idec Inc. | Antibody conjugated to a drug moiety via a poptidic linker |
CA2580141C (en) | 2004-09-23 | 2013-12-10 | Genentech, Inc. | Cysteine engineered antibodies and conjugates |
US20060222595A1 (en) | 2005-03-31 | 2006-10-05 | Priyabrata Mukherjee | Nanoparticles for therapeutic and diagnostic applications |
US7618957B2 (en) | 2005-07-15 | 2009-11-17 | Bayer Schering Pharma Aktiengesellschaft | Perfluoroalkyl-containing complexes, process for their production as well as their use |
EP1904462A2 (de) | 2005-07-15 | 2008-04-02 | Bayer Schering Pharma Aktiengesellschaft | Perfluoralkylhaltige komplexe, verfahren zu deren herstellung, sowie deren verwendung |
US20100226884A1 (en) | 2009-01-20 | 2010-09-09 | Immunomedics, Inc. | Novel Class of Monospecific and Bispecific Humanized Antibodies that Target the Insulin-like Growth Factor Type I Receptor (IGF-1R) |
US8034898B2 (en) | 2005-12-29 | 2011-10-11 | Collagen Medical, LLC | Methods of collagen imaging |
KR20080103562A (ko) | 2006-03-15 | 2008-11-27 | 말린크로트, 인코포레이티드 | 치환된 방향족 잔기 및 그의 유도체를 갖는 킬레이팅 컨쥬게이트 |
US7777029B2 (en) | 2006-05-02 | 2010-08-17 | San Diego State University (Sdsu) Foundation | Bifunctional chelators for sequestering lanthanides |
WO2008112008A2 (en) | 2006-08-11 | 2008-09-18 | Invitrogen Corporation | Sensor proteins and assay methods |
US8691761B2 (en) | 2006-10-16 | 2014-04-08 | Jean E. F. Rivier | Somatostatin receptor 2 antagonists |
GB0624587D0 (en) | 2006-12-08 | 2007-01-17 | Univ Muenchen Tech | Chelating agent |
CA2676413A1 (en) | 2007-01-19 | 2008-07-31 | Mallinckrodt Inc. | Diagnostic and therapeutic cyclooxygenase-2 binding ligands |
WO2008134289A2 (en) | 2007-04-26 | 2008-11-06 | Mallinckrodt Inc. | High relaxivity coordinatively unsaturated lanthanide complexes |
ES2676598T3 (es) | 2007-08-27 | 2018-07-23 | Liebel-Flarsheim Company Llc | Eliminación de sílice a partir de compuestos hidrosolubles mediante nanofiltración y cromatografía en fase inversa |
CA2697612A1 (en) | 2007-08-28 | 2009-03-12 | Biogen Idec Ma Inc. | Anti-igf-1r antibodies and uses thereof |
US20090208421A1 (en) | 2008-02-19 | 2009-08-20 | Dominique Meyer | Process for preparing a pharmaceutical formulation of contrast agents |
DE102008045937B4 (de) | 2008-04-11 | 2017-01-26 | Johannes-Gutenberg-Universität Mainz | Radiopharmakon aus einem Metallion und einem Markierungsvorläufer und Verwendung des Radiopharmakons |
US8546531B2 (en) | 2008-07-16 | 2013-10-01 | The General Hospital Corporation | Methods and reagents for preparing multifunctional probes |
EP2147684A1 (en) | 2008-07-22 | 2010-01-27 | Bracco Imaging S.p.A | Diagnostic Agents Selective Against Metalloproteases |
JP2012507573A (ja) | 2008-11-06 | 2012-03-29 | ルイーザ ブラッチ、 | ニューロテンシン誘導分岐ペプチドおよびその使用 |
WO2010088527A2 (en) | 2009-01-30 | 2010-08-05 | Mayo Foundation For Medical Education And Research | Peptides and nanoparticles for therapeutic and diagnostic applications |
CN102356087A (zh) | 2009-03-19 | 2012-02-15 | 惠氏有限责任公司 | [2-(8,9-二氧代-2,6-二氮杂双环[5.2.0]壬-1(7)-烯-2-基)乙基]膦酸及其前体的制备方法 |
WO2011005609A2 (en) | 2009-07-08 | 2011-01-13 | Mayo Foundation For Medical Education And Research | Imaging gastrointestinal volumes and motility |
US8765920B2 (en) | 2009-12-23 | 2014-07-01 | The Scripps Research Institute | Tyrosine bioconjugation through aqueous Ene-like reactions |
WO2011090492A1 (en) | 2010-01-19 | 2011-07-28 | Immunomedics, Inc. | Novel class of monospecific and bispecific humanized antibodies that target the insulin-like growth factor type i receptor (igf-1r) |
EP2397466B1 (en) | 2010-06-15 | 2012-11-28 | Centre National De La Recherche Scientifique CNRS | X-ray and gamma-photon activatable organic compounds, their preparation and their uses |
US9573978B2 (en) | 2010-08-12 | 2017-02-21 | S&T Global, Inc. | Cyclosporin derivatives for the treatment and prevention of a viral infection |
US12097269B2 (en) | 2010-10-27 | 2024-09-24 | Vikas Kundra | Dual mode gadolinium nanoparticle contrast agents |
FR2968999B1 (fr) | 2010-12-20 | 2013-01-04 | Guerbet Sa | Nanoemulsion de chelate pour irm |
CA2827170A1 (en) * | 2011-02-11 | 2012-08-16 | David M. Hilbert | Monovalent and multivalent multispecific complexes and uses thereof |
US8685916B2 (en) | 2011-03-09 | 2014-04-01 | Signature Therapeutics, Inc. | Opioid prodrugs with heterocyclic linkers |
DK2721045T3 (en) | 2011-06-20 | 2017-07-24 | Radiomedix Inc | COMPOSITIONS, METHODS OF SYNTHESIS AND USE OF CARBOHYDRATE TARGETED AGENTS |
FR2976825B1 (fr) | 2011-06-22 | 2014-02-21 | Total Sa | Nanotraceurs pour le marquage d'eaux d'injection de champs petroliers |
EP2604281B1 (en) | 2011-12-14 | 2014-07-30 | Centre National de la Recherche Scientifique (CNRS) | Clicked somatostatin conjugated analogs for biological applications |
KR20130083592A (ko) | 2012-01-13 | 2013-07-23 | 현대약품 주식회사 | 치환된 피페리딘 유도체 및 이의 제조방법 |
EP2852685A1 (en) * | 2012-03-30 | 2015-04-01 | Merck Sharp & Dohme Corp. | Igf1 biomarker for igf1r inhibitor therapy |
MX2014015419A (es) | 2012-06-14 | 2015-07-14 | Janssen Biotech Inc | Tratamiento de celulas pluripotentes. |
CN102743770B (zh) | 2012-06-18 | 2017-07-21 | 申宝忠 | 一种靶向性分子成像探针及活体分子成像方法 |
US10039843B2 (en) * | 2012-09-07 | 2018-08-07 | Bracco Imaging S.P.A. | Paramagnetic solid lipid nanoparticles (pSLNs) containing metal amphiphilic complexes for MRI |
WO2014124307A2 (en) | 2013-02-08 | 2014-08-14 | The Regents Of The University Of Michigan | Targeted theranostics |
CN105164136B (zh) | 2013-05-06 | 2017-12-22 | 默克专利股份公司 | 作为激酶抑制剂的大环化合物 |
US10786497B2 (en) | 2013-08-16 | 2020-09-29 | Equip, Llc | Discrete PEG constructs |
WO2015038968A1 (en) | 2013-09-13 | 2015-03-19 | The General Hospital Corporation | Activatable fibrin-binding probes |
EA037778B1 (ru) | 2013-10-18 | 2021-05-20 | Дойчес Кребсфоршунгсцентрум | Меченые ингибиторы простатического специфического мембранного антигена (псма), их применение в качестве агентов для визуализации и фармацевтических агентов для лечения рака предстательной железы |
US10758636B2 (en) * | 2013-11-12 | 2020-09-01 | Centre For Probe Development And Commercialization | Residualizing linkers and uses thereof |
CN105939732A (zh) | 2013-12-03 | 2016-09-14 | 通用医疗公司 | 分子成像探针 |
FR3015547B1 (fr) | 2013-12-20 | 2016-01-01 | Total Sa | Methode pour ajuster le taux d'inhibiteurs dans un puits de petrole ou de gaz |
GB201403875D0 (en) | 2014-03-05 | 2014-04-16 | Cantargia Ab | Novel antibodies and uses thereof |
AU2015243380B2 (en) | 2014-04-11 | 2020-05-14 | Medimmune, Llc | Conjugated compounds comprising cysteine-engineered antibodies |
KR20160145790A (ko) | 2014-04-25 | 2016-12-20 | 리나트 뉴로사이언스 코프. | 약물이 고도로 로딩된 항체-약물 접합체 |
EP3142710A4 (en) | 2014-05-16 | 2018-04-25 | Memorial Sloan Kettering Cancer Center | One-step labeling of antibodies to high specific activity with actinium-225 |
EP3180037A1 (en) | 2014-07-29 | 2017-06-21 | Vrije Universiteit Brussel | Radio-labelled antibody fragments for use in the prognosis, diagnosis of cancer as well as for the prediction of cancer therapy response |
BE1021191B1 (fr) | 2014-08-29 | 2015-10-27 | Anmi S.A. | Kit pour radiomarquage. |
GB201417067D0 (en) | 2014-09-26 | 2014-11-12 | South African Nuclear Energy | Radiopharmaceutical conjugate |
DE102014115154A1 (de) | 2014-10-17 | 2016-04-21 | SCV-SpezialChemikalien-Vertrieb GmbH | Konjugierte Bisphosphonate für die Diagnostik und Therapie von Knochenerkrankungen |
CN107406494B (zh) | 2014-11-25 | 2022-03-25 | 百时美施贵宝公司 | 用于成像的新型pd-l1结合多肽 |
US20190015518A1 (en) | 2016-01-04 | 2019-01-17 | University Of Kansas | Drug delivery compositions and methods |
US10758634B2 (en) | 2016-03-18 | 2020-09-01 | Wake Forest University | Compounds, compositions and associated methods using zirconium-89 in immuno-positron emission tomography |
EP3619191A4 (en) | 2017-05-05 | 2020-12-16 | Fusion Pharmaceuticals Inc. | PHARMACOKINETIC IMPROVEMENTS OF BIFUNCTIONAL CHELATES AND THEIR USES |
US10093741B1 (en) * | 2017-05-05 | 2018-10-09 | Fusion Pharmaceuticals Inc. | IGF-1R monoclonal antibodies and uses thereof |
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US20230052140A1 (en) | 2023-02-16 |
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MA49398A (fr) | 2020-04-22 |
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JP2020518674A (ja) | 2020-06-25 |
IL270457B1 (en) | 2024-07-01 |
MX2024006675A (es) | 2024-06-24 |
US11433148B2 (en) | 2022-09-06 |
EP3638320A2 (en) | 2020-04-22 |
IL270457A (ru) | 2020-01-30 |
AU2018261890A1 (en) | 2019-11-28 |
US20190083662A1 (en) | 2019-03-21 |
RU2019139434A (ru) | 2021-06-07 |
JP7191938B2 (ja) | 2022-12-19 |
CA3062538A1 (en) | 2018-11-08 |
KR20200004861A (ko) | 2020-01-14 |
WO2018204872A2 (en) | 2018-11-08 |
CN110891614A (zh) | 2020-03-17 |
BR112019023249A2 (pt) | 2020-06-02 |
IL313115A (en) | 2024-07-01 |
ZA201908072B (en) | 2023-04-26 |