RU2019136978A - Антибактериальная композиция и способ лечения стафилококковых инфекций антибактериальной композицией - Google Patents
Антибактериальная композиция и способ лечения стафилококковых инфекций антибактериальной композицией Download PDFInfo
- Publication number
- RU2019136978A RU2019136978A RU2019136978A RU2019136978A RU2019136978A RU 2019136978 A RU2019136978 A RU 2019136978A RU 2019136978 A RU2019136978 A RU 2019136978A RU 2019136978 A RU2019136978 A RU 2019136978A RU 2019136978 A RU2019136978 A RU 2019136978A
- Authority
- RU
- Russia
- Prior art keywords
- staphylococcus
- infections
- antibacterial composition
- staphylococaphcus
- carnoscus
- Prior art date
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/162—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/08—Solutions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Immunology (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Organic Chemistry (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Biochemistry (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Materials For Medical Uses (AREA)
- Peptides Or Proteins (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (7)
1. Способ лечения стафилококковых инфекций, включающий: введение субъекту эффективного количества антибактериальной композиции, обладающей широким спектром бактерицидной активности против по меньшей мере одного или всех из следующих видов Staphylococcus: Staphylococcus arlettae, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus carnosus, Staphylococcus carprae, Staphylococcus chromogenes, Staphylococcus cohnii, Staphylococcus delphini, Staphylococcus epidermidis, Staphylococcus equorum, Staphylococcus gallinarum, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus intermedius, Staphylococcus kloosii, Staphylococcus lentus, Staphylococcus lugdunensis, Staphylococcus muscae, Staphylococcus pasteuri, Staphylococcus saprophyticus, Staphylococcus warneri и Staphylococcus xylosus, где антибактериальная композиция включает в себя антибактериальный белок, состоящий из аминокислотной последовательности, представленной в SEQ ID NO: 2.
2. Способ по п. 1, где стафилококковые инфекции представляют собой кожные инфекции, инфекции мягких тканей, синдром токсического шока, молниеносную пурпуру, эндокардит, остеомиелит, пневмонию, инфекции, связанные с протезными устройствами или инфекции мочевыводящих путей.
3. Способ по п. 2, где кожные инфекции представляют собой фолликулит, фурункулы, импетиго, раневые инфекции или синдром токсического эпидермального некролиза.
4. Способ по п. 2, где инфекции мягких тканей представляют собой пиомиозит, септический бурсит или септический артрит.
5. Способ по п. 2, где протезные устройства представляют собой протезы суставов и сердечных клапанов, сосудистые шунты, трансплантаты или катетеры.
6. Антибактериальный белок, состоящий из аминокислотной последовательности, представленной в SEQ ID NO: 2, обладающий широким спектром бактерицидной активности против по меньшей мере одного или всех из следующих видов Staphylococcus: Staphylococcus arlettae, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus carnosus, Staphylococcus carprae, Staphylococcus chromogenes, Staphylococcus cohnii, Staphylococcus delphini, Staphylococcus epidermidis, Staphylococcus equorum, Staphylococcus gallinarum, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus intermedius, Staphylococcus kloosii, Staphylococcus lentus, Staphylococcus lugdunensis, Staphylococcus muscae, Staphylococcus pasteuri, Staphylococcus saprophyticus, Staphylococcus warneri и Staphylococcus xylosus.
7. Антибактериальная композиция, содержащая антибактериальный белок, состоящий из аминокислотной последовательности, представленной в SEQ ID NO: 2, где антибактериальная композиция обладает широким спектром бактерицидной активности против по меньшей мере одного или всех из следующих видов Staphylococcus: Staphylococcus arlettae, Staphylococcus aureus, Staphylococcus auricularis, Staphylococcus carnosus, Staphylococcus carprae, Staphylococcus chromogenes, Staphylococcus cohnii, Staphylococcus delphini, Staphylococcus epidermidis, Staphylococcus equorum, Staphylococcus gallinarum, Staphylococcus haemolyticus, Staphylococcus hominis, Staphylococcus intermedius, Staphylococcus kloosii, Staphylococcus lentus, Staphylococcus lugdunensis, Staphylococcus muscae, Staphylococcus pasteuri, Staphylococcus saprophyticus, Staphylococcus warneri и Staphylococcus xylosus.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662277506P | 2016-01-12 | 2016-01-12 | |
| US62/277,506 | 2016-01-12 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018124798A Division RU2707738C1 (ru) | 2016-01-12 | 2017-01-09 | Антибактериальная композиция и способ лечения стафилококковых инфекций антибактериальной композицией |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2019136978A true RU2019136978A (ru) | 2019-12-19 |
| RU2019136978A3 RU2019136978A3 (ru) | 2020-04-02 |
| RU2729934C2 RU2729934C2 (ru) | 2020-08-13 |
Family
ID=59310874
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018124798A RU2707738C1 (ru) | 2016-01-12 | 2017-01-09 | Антибактериальная композиция и способ лечения стафилококковых инфекций антибактериальной композицией |
| RU2019136978A RU2729934C2 (ru) | 2016-01-12 | 2017-01-09 | Антибактериальная композиция и способ лечения стафилококковых инфекций антибактериальной композицией |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018124798A RU2707738C1 (ru) | 2016-01-12 | 2017-01-09 | Антибактериальная композиция и способ лечения стафилококковых инфекций антибактериальной композицией |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11229677B2 (ru) |
| EP (1) | EP3402506A4 (ru) |
| JP (1) | JP7085483B2 (ru) |
| CN (1) | CN109414478B (ru) |
| AU (1) | AU2017208114B2 (ru) |
| BR (1) | BR112018014175A2 (ru) |
| CA (1) | CA3010564C (ru) |
| MX (1) | MX2018008545A (ru) |
| RU (2) | RU2707738C1 (ru) |
| SG (1) | SG11201811479RA (ru) |
| UA (1) | UA126022C2 (ru) |
| WO (1) | WO2017122111A1 (ru) |
| ZA (1) | ZA201804013B (ru) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN110734474B (zh) * | 2019-11-29 | 2021-10-19 | 中山大学 | 一种抗菌肽的筛选方法及其应用 |
| CN111235119B (zh) * | 2020-03-05 | 2021-11-23 | 苏州十一方生物科技有限公司 | 一种融合抗菌蛋白的制备及应用 |
| CN112402591B (zh) * | 2020-11-23 | 2022-12-16 | 中国农业科学院饲料研究所 | 防御素dlp4在治疗仔猪渗出性皮炎中的应用 |
| KR20240015753A (ko) * | 2022-07-26 | 2024-02-06 | 주식회사 인트론바이오테크놀로지 | 황색포도알균을 포함한 포도알균에 대하여 강력한 용균 활성을 갖는 항균단백질 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1151842C (zh) | 1995-07-27 | 2004-06-02 | 基因技术股份有限公司 | 稳定等渗的冻干蛋白制剂 |
| IE20060488A1 (en) | 2006-06-29 | 2008-01-09 | Teagasc Agric Food Dev Authori | Recombinant staphylococcal phage lysin as an antibacterial agent |
| KR100759988B1 (ko) * | 2006-08-04 | 2007-09-19 | 주식회사 인트론바이오테크놀로지 | 황색포도상구균에 특이적인 항균 단백질 |
| KR100910961B1 (ko) | 2007-09-13 | 2009-08-05 | 주식회사 인트론바이오테크놀로지 | 황색포도상구균의 균막 처치에 효과적인 박테리오파지 또는그것 유래의 용균단백질 |
| KR101016918B1 (ko) | 2009-01-08 | 2011-02-25 | 주식회사 인트론바이오테크놀로지 | 박테리아 특이적 넓은 항균 활성을 갖는 신규한 리신 단백질 |
| US8043613B2 (en) * | 2009-02-12 | 2011-10-25 | Intron Biotechnology, Inc. | Podoviriedae bacteriophage having killing activity specific to Staphylococcus aureus |
| US9603909B2 (en) * | 2012-05-29 | 2017-03-28 | Intron Biotechnology, Inc. | Composition capable of improving stability of bacteriophage lysin proteins |
| JP7085482B2 (ja) * | 2016-01-12 | 2022-06-16 | イントロン バイオテクノロジー，インコーポレイテッド | スタフィロコッカス感染症のための凍結乾燥製剤を製造する方法 |
-
2017
- 2017-01-09 BR BR112018014175A patent/BR112018014175A2/pt unknown
- 2017-01-09 AU AU2017208114A patent/AU2017208114B2/en active Active
- 2017-01-09 JP JP2018536456A patent/JP7085483B2/ja active Active
- 2017-01-09 RU RU2018124798A patent/RU2707738C1/ru active
- 2017-01-09 EP EP17738258.7A patent/EP3402506A4/en active Pending
- 2017-01-09 US US16/300,566 patent/US11229677B2/en active Active
- 2017-01-09 WO PCT/IB2017/050087 patent/WO2017122111A1/en active Application Filing
- 2017-01-09 CA CA3010564A patent/CA3010564C/en active Active
- 2017-01-09 SG SG11201811479RA patent/SG11201811479RA/en unknown
- 2017-01-09 UA UAA201813040A patent/UA126022C2/uk unknown
- 2017-01-09 CN CN201780006444.8A patent/CN109414478B/zh active Active
- 2017-01-09 MX MX2018008545A patent/MX2018008545A/es unknown
- 2017-01-09 RU RU2019136978A patent/RU2729934C2/ru active
-
2018
- 2018-06-15 ZA ZA2018/04013A patent/ZA201804013B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA3010564A1 (en) | 2017-07-20 |
| US11229677B2 (en) | 2022-01-25 |
| UA126022C2 (uk) | 2022-08-03 |
| AU2017208114B2 (en) | 2023-04-13 |
| CN109414478A (zh) | 2019-03-01 |
| CA3010564C (en) | 2024-01-30 |
| WO2017122111A1 (en) | 2017-07-20 |
| US20190282657A1 (en) | 2019-09-19 |
| MX2018008545A (es) | 2018-12-19 |
| RU2729934C2 (ru) | 2020-08-13 |
| AU2017208114A1 (en) | 2018-07-26 |
| JP7085483B2 (ja) | 2022-06-16 |
| CN109414478B (zh) | 2022-08-23 |
| EP3402506A1 (en) | 2018-11-21 |
| KR20180114010A (ko) | 2018-10-17 |
| RU2019136978A3 (ru) | 2020-04-02 |
| SG11201811479RA (en) | 2019-01-30 |
| ZA201804013B (en) | 2019-07-31 |
| EP3402506A4 (en) | 2019-09-04 |
| RU2707738C1 (ru) | 2019-11-29 |
| BR112018014175A2 (pt) | 2018-12-26 |
| JP2019503379A (ja) | 2019-02-07 |
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