RU2019127523A - Продукт и способ для обработки биопротезных тканей - Google Patents
Продукт и способ для обработки биопротезных тканей Download PDFInfo
- Publication number
- RU2019127523A RU2019127523A RU2019127523A RU2019127523A RU2019127523A RU 2019127523 A RU2019127523 A RU 2019127523A RU 2019127523 A RU2019127523 A RU 2019127523A RU 2019127523 A RU2019127523 A RU 2019127523A RU 2019127523 A RU2019127523 A RU 2019127523A
- Authority
- RU
- Russia
- Prior art keywords
- cyclodextrin
- tissues
- product
- ethanol
- crosslinking process
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3683—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment
- A61L27/3687—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix subjected to a specific treatment prior to implantation, e.g. decellularising, demineralising, grinding, cellular disruption/non-collagenous protein removal, anti-calcification, crosslinking, supercritical fluid extraction, enzyme treatment characterised by the use of chemical agents in the treatment, e.g. specific enzymes, detergents, capping agents, crosslinkers, anticalcification agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2/00—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor
- A61L2/0005—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts
- A61L2/0082—Methods or apparatus for disinfecting or sterilising materials or objects other than foodstuffs or contact lenses; Accessories therefor for pharmaceuticals, biologicals or living parts using chemical substances
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
- A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
- A61L27/3604—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix characterised by the human or animal origin of the biological material, e.g. hair, fascia, fish scales, silk, shellac, pericardium, pleura, renal tissue, amniotic membrane, parenchymal tissue, fetal tissue, muscle tissue, fat tissue, enamel
- A61L27/3625—Vascular tissue, e.g. heart valves
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L31/00—Materials for other surgical articles, e.g. stents, stent-grafts, shunts, surgical drapes, guide wires, materials for adhesion prevention, occluding devices, surgical gloves, tissue fixation devices
- A61L31/04—Macromolecular materials
- A61L31/042—Polysaccharides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2400/00—Materials characterised by their function or physical properties
- A61L2400/02—Treatment of implants to prevent calcification or mineralisation in vivo
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L2430/00—Materials or treatment for tissue regeneration
- A61L2430/20—Materials or treatment for tissue regeneration for reconstruction of the heart, e.g. heart valves
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Dermatology (AREA)
- Oral & Maxillofacial Surgery (AREA)
- Transplantation (AREA)
- Heart & Thoracic Surgery (AREA)
- Vascular Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Surgery (AREA)
- Cardiology (AREA)
- Urology & Nephrology (AREA)
- Zoology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
- Steroid Compounds (AREA)
- Management, Administration, Business Operations System, And Electronic Commerce (AREA)
- Prostheses (AREA)
- Medicines Containing Plant Substances (AREA)
- Materials For Medical Uses (AREA)
Claims (19)
1. Способ обработки биопротезных тканей, в частности, биологических тканей, используемых для сердечно-сосудистых протезов, причем указанный способ включает применение циклодекстрина, способного самостоятельно удалять фосфолипиды из биопротезных тканей.
2. Способ по п. 1, в котором циклодекстрин представляет собой β-циклодекстрин.
3. Способ по п. 1 или 2 для снижения кальцификации биопротезных тканей.
4. Способ по любому из предшествующих пунктов для снижения остаточной токсичности биопротезных тканей для того, чтобы хранить биопротез в растворе, не содержащем альдегиды.
5. Способ по любому из предшествующих пунктов в сочетании с полиэтиленгликолем для достижения дегидратации ткани и этиленоксидом для стерилизации.
6. Способ по любому из предшествующих пунктов, дополнительно включающий стадию промывки, где циклодекстрин используют для удаления оставшихся молекул свободного альдегида из ткани.
7. Способ по любому из предшествующих пунктов, в котором циклодекстрин выбран в следующей группе: γ-циклодекстрин, 2-гидроксипропил-β-циклодекстрин, простой сульфобутиловый эфир β-циклодекстрина, сульфатированный β-циклодекстрин, мальтозил-β-циклодекстрин.
8. Способ по любому из предшествующих пунктов, дополнительно включающий применение этанола.
9. Способ по п. 8, в котором этанол и циклодекстрин применяют одновременно.
10. Способ по п. 8 или 9, отличающийся последовательным применением этанола, с последующим применением циклодекстрина.
11. Способ по п. 8 или 9, отличающийся последовательным применением циклодекстрина, с последующим применением этанола.
12. Способ по любому из предшествующих пунктов, включающий процесс сшивания.
13. Способ по п. 12, в котором процесс сшивания происходит после применения циклодекстрина.
14. Способ по п. 13, включающий второе применение циклодекстрина, которое происходит после процесса сшивания.
15. Способ по п. 12, в котором процесс сшивания происходит перед применением циклодекстрина.
16. Продукт для обработки биопротезных тканей, в частности, сердечно-сосудистых тканей, причем указанный продукт включает циклодекстрин.
17. Продукт по п. 16, в котором циклодекстрин представляет собой β-циклодекстрин.
18. Продукт по п. 16 или 17, дополнительно содержащий этанол.
19. Набор для обработки биопротезных тканей, содержащий два отдельных продукта, а именно: первый продукт, содержащий циклодекстрин, и второй продукт, содержащий этанол.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP17157490.8 | 2017-02-22 | ||
| EP17157490.8A EP3366324A1 (en) | 2017-02-22 | 2017-02-22 | Product and method for the treatment of bioprosthetic tissues |
| PCT/EP2017/080977 WO2018153525A1 (en) | 2017-02-22 | 2017-11-30 | Product and method for the treatment of bioprosthetic tissues |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019127523A true RU2019127523A (ru) | 2021-03-23 |
| RU2019127523A3 RU2019127523A3 (ru) | 2021-03-23 |
Family
ID=58108558
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019127523A RU2019127523A (ru) | 2017-02-22 | 2017-11-30 | Продукт и способ для обработки биопротезных тканей |
Country Status (13)
| Country | Link |
|---|---|
| US (1) | US11660375B2 (ru) |
| EP (2) | EP3366324A1 (ru) |
| JP (1) | JP2020508193A (ru) |
| KR (1) | KR20190121326A (ru) |
| CN (1) | CN110494171A (ru) |
| AU (1) | AU2017400910B2 (ru) |
| BR (1) | BR112019017295A2 (ru) |
| CA (1) | CA3054091A1 (ru) |
| ES (1) | ES2936112T3 (ru) |
| IL (1) | IL268865A (ru) |
| RU (1) | RU2019127523A (ru) |
| SG (1) | SG11201907695WA (ru) |
| WO (1) | WO2018153525A1 (ru) |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS55159760A (en) * | 1979-06-01 | 1980-12-12 | Sugiyama Sangyo Kagaku Kenkyusho | Healthy food |
| JPS57186463A (en) * | 1981-05-08 | 1982-11-16 | Nisshin Oil Mills Ltd:The | Production of mayonnaise-like acidic emulsion food product |
| JP3495082B2 (ja) * | 1994-04-13 | 2004-02-09 | 財団法人糧食研究会 | コレステロールの回収方法 |
| US5931969A (en) | 1994-07-29 | 1999-08-03 | Baxter International Inc. | Methods and apparatuses for treating biological tissue to mitigate calcification |
| JPH08173060A (ja) * | 1994-12-28 | 1996-07-09 | Q P Corp | コレステロール含有液状食品中のコレステロール除去方法 |
| BR0115106A (pt) * | 2000-11-01 | 2006-02-21 | Edwards Lifesciences Corp | métodos para a preparação de tecido bioprotético e dispositivos implantáveis compreendendo tal tecido bioprotético |
| US7989157B2 (en) * | 2005-01-11 | 2011-08-02 | Medtronic, Inc. | Solution for storing bioprosthetic tissue used in a biological prosthesis |
| US7579381B2 (en) * | 2005-03-25 | 2009-08-25 | Edwards Lifesciences Corporation | Treatment of bioprosthetic tissues to mitigate post implantation calcification |
| CN101161293A (zh) * | 2006-10-12 | 2008-04-16 | 胡盛寿 | 异种生物组织材料的抗钙化改性方法 |
| US8357387B2 (en) * | 2007-12-21 | 2013-01-22 | Edwards Lifesciences Corporation | Capping bioprosthetic tissue to reduce calcification |
| WO2013090145A1 (en) * | 2011-12-13 | 2013-06-20 | Boston Scientific Scimed, Inc. | Decalcifying heart valve |
| EP2712633B1 (de) * | 2012-10-02 | 2015-04-29 | Biotronik AG | Bioprosthetische Komponenten für ein Implantat, insbesondere teilvernetzte biologische Herzklappen |
| CN106190949B (zh) * | 2015-05-08 | 2020-04-10 | 上海微创心通医疗科技有限公司 | 一种干态动物源性胶原纤维组织材料及其制备方法和生物假体 |
-
2017
- 2017-02-22 EP EP17157490.8A patent/EP3366324A1/en not_active Withdrawn
- 2017-11-30 ES ES17829940T patent/ES2936112T3/es active Active
- 2017-11-30 EP EP17829940.0A patent/EP3585451B1/en active Active
- 2017-11-30 WO PCT/EP2017/080977 patent/WO2018153525A1/en unknown
- 2017-11-30 RU RU2019127523A patent/RU2019127523A/ru not_active Application Discontinuation
- 2017-11-30 US US16/487,117 patent/US11660375B2/en active Active
- 2017-11-30 AU AU2017400910A patent/AU2017400910B2/en active Active
- 2017-11-30 SG SG11201907695WA patent/SG11201907695WA/en unknown
- 2017-11-30 CA CA3054091A patent/CA3054091A1/en active Pending
- 2017-11-30 BR BR112019017295-5A patent/BR112019017295A2/pt not_active Application Discontinuation
- 2017-11-30 CN CN201780089366.2A patent/CN110494171A/zh active Pending
- 2017-11-30 JP JP2019565610A patent/JP2020508193A/ja active Pending
- 2017-11-30 KR KR1020197027202A patent/KR20190121326A/ko not_active Application Discontinuation
-
2019
- 2019-08-22 IL IL26886519A patent/IL268865A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| BR112019017295A2 (pt) | 2020-03-31 |
| ES2936112T3 (es) | 2023-03-14 |
| SG11201907695WA (en) | 2019-09-27 |
| EP3585451B1 (en) | 2022-10-19 |
| CN110494171A (zh) | 2019-11-22 |
| RU2019127523A3 (ru) | 2021-03-23 |
| WO2018153525A1 (en) | 2018-08-30 |
| CA3054091A1 (en) | 2018-08-30 |
| AU2017400910B2 (en) | 2023-10-12 |
| AU2017400910A1 (en) | 2019-09-12 |
| JP2020508193A (ja) | 2020-03-19 |
| US20210213169A1 (en) | 2021-07-15 |
| EP3366324A1 (en) | 2018-08-29 |
| EP3585451A1 (en) | 2020-01-01 |
| US11660375B2 (en) | 2023-05-30 |
| KR20190121326A (ko) | 2019-10-25 |
| IL268865A (en) | 2019-10-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20210602 |