|
US4816567A
(en)
|
1983-04-08 |
1989-03-28 |
Genentech, Inc. |
Recombinant immunoglobin preparations
|
|
JPS6147500A
(ja)
|
1984-08-15 |
1986-03-07 |
Res Dev Corp Of Japan |
キメラモノクロ−ナル抗体及びその製造法
|
|
EP0173494A3
(en)
|
1984-08-27 |
1987-11-25 |
The Board Of Trustees Of The Leland Stanford Junior University |
Chimeric receptors by dna splicing and expression
|
|
GB8422238D0
(en)
|
1984-09-03 |
1984-10-10 |
Neuberger M S |
Chimeric proteins
|
|
JPS61134325A
(ja)
|
1984-12-04 |
1986-06-21 |
Teijin Ltd |
ハイブリツド抗体遺伝子の発現方法
|
|
US5225539A
(en)
|
1986-03-27 |
1993-07-06 |
Medical Research Council |
Recombinant altered antibodies and methods of making altered antibodies
|
|
GB8607679D0
(en)
|
1986-03-27 |
1986-04-30 |
Winter G P |
Recombinant dna product
|
|
JP3101690B2
(ja)
|
1987-03-18 |
2000-10-23 |
エス・ビィ・２・インコーポレイテッド |
変性抗体の、または変性抗体に関する改良
|
|
EP0436597B1
(en)
|
1988-09-02 |
1997-04-02 |
Protein Engineering Corporation |
Generation and selection of recombinant varied binding proteins
|
|
US5223409A
(en)
|
1988-09-02 |
1993-06-29 |
Protein Engineering Corp. |
Directed evolution of novel binding proteins
|
|
US5530101A
(en)
|
1988-12-28 |
1996-06-25 |
Protein Design Labs, Inc. |
Humanized immunoglobulins
|
|
GB8905669D0
(en)
|
1989-03-13 |
1989-04-26 |
Celltech Ltd |
Modified antibodies
|
|
WO1991000906A1
(en)
|
1989-07-12 |
1991-01-24 |
Genetics Institute, Inc. |
Chimeric and transgenic animals capable of producing human antibodies
|
|
DE69120146T2
(de)
|
1990-01-12 |
1996-12-12 |
Cell Genesys Inc |
Erzeugung xenogener antikörper
|
|
US5427908A
(en)
|
1990-05-01 |
1995-06-27 |
Affymax Technologies N.V. |
Recombinant library screening methods
|
|
GB9015198D0
(en)
|
1990-07-10 |
1990-08-29 |
Brien Caroline J O |
Binding substance
|
|
DK0585287T3
(da)
|
1990-07-10 |
2000-04-17 |
Cambridge Antibody Tech |
Fremgangsmåde til fremstilling af specifikke bindingsparelementer
|
|
ATE158021T1
(de)
|
1990-08-29 |
1997-09-15 |
Genpharm Int |
Produktion und nützung nicht-menschliche transgentiere zur produktion heterologe antikörper
|
|
DE69133557D1
(de)
|
1990-08-29 |
2007-03-15 |
Pharming Intellectual Pty Bv |
Homologe rekombination in säugetier-zellen
|
|
CA2095633C
(en)
|
1990-12-03 |
2003-02-04 |
Lisa J. Garrard |
Enrichment method for variant proteins with altered binding properties
|
|
EP1820858B1
(en)
|
1991-03-01 |
2009-08-12 |
Dyax Corporation |
Chimeric protein comprising micro-protein having two or more disulfide bonds and embodiments thereof
|
|
ATE414768T1
(de)
|
1991-04-10 |
2008-12-15 |
Scripps Research Inst |
Bibliotheken heterodimerer rezeptoren mittels phagemiden
|
|
EP0519596B1
(en)
|
1991-05-17 |
2005-02-23 |
Merck & Co. Inc. |
A method for reducing the immunogenicity of antibody variable domains
|
|
DE4122599C2
(de)
|
1991-07-08 |
1993-11-11 |
Deutsches Krebsforsch |
Phagemid zum Screenen von Antikörpern
|
|
DK1621554T4
(da)
|
1992-08-21 |
2012-12-17 |
Univ Bruxelles |
Immunoglobuliner blottet for lette kæder
|
|
US5851804A
(en)
|
1996-05-06 |
1998-12-22 |
Apollon, Inc. |
Chimeric kanamycin resistance gene
|
|
CA2258570A1
(en)
|
1996-06-17 |
1997-12-24 |
Biodynamics Associates |
Method and kits for preparing multicomponent nucleic acid constructs
|
|
US20020086330A1
(en)
|
2000-01-31 |
2002-07-04 |
Rosen Craig A. |
Nucleic acids, proteins, and antibodies
|
|
EP1259601A2
(en)
|
2000-02-22 |
2002-11-27 |
Ahuva Nissim |
Chimeric and tcr phage display libraries, chimeric and tcr reagents and methods of use thereof
|
|
HRP20080197T8
(hr)
*
|
2003-09-18 |
2008-07-31 |
Symphogen A/S |
Postupak za povezivanje sekvenci od interesa
|
|
TWI333977B
(en)
|
2003-09-18 |
2010-12-01 |
Symphogen As |
Method for linking sequences of interest
|
|
US20060199191A1
(en)
|
2004-12-13 |
2006-09-07 |
Demian Obregon |
Methods and compositions for the synthesis of RNA and DNA
|
|
CN101370832B
(zh)
|
2005-12-02 |
2014-07-02 |
健泰科生物技术公司 |
结合多肽及其用途
|
|
BRPI0808551B1
(pt)
*
|
2007-03-01 |
2022-04-05 |
Symphogen A/S |
Composições de anticorpo para o receptor do fator de crescimento antiepidérmico recombinante, molécula de ligação bi-específica e composição farmacêutica que os compreende
|
|
DK2121920T3
(da)
|
2007-03-01 |
2011-11-21 |
Symphogen As |
Fremgangsmåde til kloning af sammenhørende antistoffer
|
|
US8877688B2
(en)
|
2007-09-14 |
2014-11-04 |
Adimab, Llc |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
EP3124497B1
(en)
|
2007-09-14 |
2020-04-15 |
Adimab, LLC |
Rationally designed, synthetic antibody libraries and uses therefor
|
|
EP2604279A1
(en)
|
2008-03-27 |
2013-06-19 |
ZymoGenetics, Inc. |
Compositions and methods for inhibiting PDGFRBETA and VEGF-A
|
|
WO2010005593A1
(en)
*
|
2008-07-11 |
2010-01-14 |
President And Fellows Of Harvard College |
Systems and methods of droplet-based selection
|
|
CN102137928A
(zh)
|
2008-08-29 |
2011-07-27 |
西福根有限公司 |
克隆禽源抗体的方法
|
|
US8497071B2
(en)
|
2009-06-29 |
2013-07-30 |
California Institute Of Technology |
Isolation of unknown rearranged T-cell receptors from single cells
|
|
IT1395574B1
(it)
|
2009-09-14 |
2012-10-16 |
Guala Dispensing Spa |
Dispositivo di erogazione
|
|
WO2011071943A1
(en)
*
|
2009-12-07 |
2011-06-16 |
Prognosys Biosciences, Inc. |
Peptide display arrays
|
|
CA2799746C
(en)
|
2010-05-17 |
2020-11-24 |
Sai Reddy |
Rapid isolation of monoclonal antibodies from animals
|
|
EP2640745B1
(en)
*
|
2010-09-10 |
2018-11-07 |
MedImmune Limited |
Bivalent and bispecific anti-il6/anti-il23 antibodies
|
|
WO2012083225A2
(en)
|
2010-12-16 |
2012-06-21 |
Gigagen, Inc. |
System and methods for massively parallel analysis of nycleic acids in single cells
|
|
CN103732738A
(zh)
|
2011-04-28 |
2014-04-16 |
小利兰斯坦福大学托管委员会 |
与样品相关的多核苷酸的鉴定
|
|
US20140243234A1
(en)
|
2011-08-03 |
2014-08-28 |
Texas Biomedical Research Institute |
Nucleic acid compositions, methods and kits for rapid pairing of affinity agents
|
|
EP2783214A2
(en)
|
2011-11-23 |
2014-10-01 |
The Board of Regents of The University of Texas System |
Proteomic identification of antibodies
|
|
EP2794652B1
(en)
*
|
2011-12-21 |
2017-11-15 |
F. Hoffmann-La Roche AG |
Rapid method for cloning and expression of cognate antibody variable region gene segments
|
|
US9701959B2
(en)
|
2012-02-02 |
2017-07-11 |
Invenra Inc. |
High throughput screen for biologically active polypeptides
|
|
EP2626433B1
(en)
|
2012-02-09 |
2017-04-12 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
Method for linking nucleic acids in a microsome from endoplasmatic reticuli
|
|
SG11201408128WA
(en)
|
2012-06-15 |
2015-01-29 |
Adaptive Biotechnologies Corp |
Uniquely tagged rearranged adaptive immune receptor genes in a complex gene set
|
|
EP2861760B1
(en)
*
|
2012-06-15 |
2020-01-01 |
The Board of Regents of The University of Texas System |
High throughput sequencing of multiple transcripts of a single cell
|
|
WO2014043813A1
(en)
|
2012-09-19 |
2014-03-27 |
British Columbia Cancer Agency Branch |
Immune repertoire profiling
|
|
GB2525568B
(en)
|
2013-03-15 |
2020-10-14 |
Abvitro Llc |
Single cell barcoding for antibody discovery
|
|
KR20150132479A
(ko)
|
2013-03-15 |
2015-11-25 |
어댑티브 바이오테크놀로지스 코포레이션 |
복합 유전자 세트에서의 독특하게 태그되고 재배열된 적응 면역 수용체 유전자
|
|
RU2578009C2
(ru)
|
2013-05-08 |
2016-03-20 |
Закрытое акционерное общество "ЕВРОГЕН" |
Способ идентификации нативных пар фрагментов днк или рнк, присутствующих в одних и тех же живых клетках
|
|
EP3041934A1
(en)
*
|
2013-09-03 |
2016-07-13 |
Moderna Therapeutics, Inc. |
Chimeric polynucleotides
|
|
GB201402591D0
(en)
|
2014-02-14 |
2014-04-02 |
Memo Therapeutics Ag |
Method for recovering two or more genes, or gene products, encoding an immunoreceptor
|
|
US10066265B2
(en)
|
2014-04-01 |
2018-09-04 |
Adaptive Biotechnologies Corp. |
Determining antigen-specific t-cells
|
|
GB201407852D0
(en)
*
|
2014-05-02 |
2014-06-18 |
Iontas Ltd |
Preparation of libraries od protein variants expressed in eukaryotic cells and use for selecting binding molecules
|
|
US10202640B2
(en)
|
2014-05-07 |
2019-02-12 |
The Board Of Trustees Of The Leland Stanford Junior University |
Single cell analysis of T cells using high-throughput multiplex amplification and deep sequencing
|
|
EP3517625B1
(en)
|
2014-05-22 |
2021-01-20 |
The University of British Columbia |
Methods for determining lymphocyte receptor chain pairs
|
|
EP3950944A1
(en)
|
2014-09-15 |
2022-02-09 |
AbVitro LLC |
High-throughput nucleotide library sequencing
|
|
CA2966201A1
(en)
|
2014-10-29 |
2016-05-06 |
Adaptive Biotechnologies Corp. |
Highly-multiplexed simultaneous detection of nucleic acids encoding paired adaptive immune receptor heterodimers from many samples
|
|
US10513733B2
(en)
|
2015-03-23 |
2019-12-24 |
Board Of Regents, The University Of Texas System |
High throughout sequencing of paired VH and VL transcripts from B cells secreting antigen-specific antibodies
|
|
AU2016253964B2
(en)
|
2015-04-27 |
2022-07-07 |
Abvitro Llc |
Methods of sequencing, determining, pairing, and validating therapeutic agents and disease specific antigens
|
|
US9422547B1
(en)
|
2015-06-09 |
2016-08-23 |
Gigagen, Inc. |
Recombinant fusion proteins and libraries from immune cell repertoires
|
|
EP3443087B1
(en)
*
|
2016-04-12 |
2024-09-18 |
Medimmune, LLC |
Immune repertoire mining
|