RU2019113715A - 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп) - Google Patents
9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп) Download PDFInfo
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- RU2019113715A RU2019113715A RU2019113715A RU2019113715A RU2019113715A RU 2019113715 A RU2019113715 A RU 2019113715A RU 2019113715 A RU2019113715 A RU 2019113715A RU 2019113715 A RU2019113715 A RU 2019113715A RU 2019113715 A RU2019113715 A RU 2019113715A
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- Russia
- Prior art keywords
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Links
- 201000001178 Bacterial Pneumonia Diseases 0.000 title claims 8
- 150000001875 compounds Chemical class 0.000 title 1
- 238000000034 method Methods 0.000 claims 84
- 238000001990 intravenous administration Methods 0.000 claims 29
- 150000003839 salts Chemical class 0.000 claims 9
- 125000004898 2,2-dimethylpropylamino group Chemical group CC(CN*)(C)C 0.000 claims 8
- 229960004023 minocycline Drugs 0.000 claims 8
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 7
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 7
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 6
- 241000193163 Clostridioides difficile Species 0.000 claims 4
- 230000002496 gastric effect Effects 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 208000024891 symptom Diseases 0.000 claims 4
- 206010008479 Chest Pain Diseases 0.000 claims 2
- 241001647378 Chlamydia psittaci Species 0.000 claims 2
- 206010011224 Cough Diseases 0.000 claims 2
- 241000606678 Coxiella burnetii Species 0.000 claims 2
- 206010013975 Dyspnoeas Diseases 0.000 claims 2
- 241000202934 Mycoplasma pneumoniae Species 0.000 claims 2
- 229930182555 Penicillin Natural products 0.000 claims 2
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims 2
- 206010036790 Productive cough Diseases 0.000 claims 2
- 241000191967 Staphylococcus aureus Species 0.000 claims 2
- 230000002411 adverse Effects 0.000 claims 2
- 239000003242 anti bacterial agent Substances 0.000 claims 2
- 229940088710 antibiotic agent Drugs 0.000 claims 2
- 238000011156 evaluation Methods 0.000 claims 2
- 235000013305 food Nutrition 0.000 claims 2
- 230000000474 nursing effect Effects 0.000 claims 2
- 229940049954 penicillin Drugs 0.000 claims 2
- 208000024794 sputum Diseases 0.000 claims 2
- 210000003802 sputum Anatomy 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 229930186147 Cephalosporin Natural products 0.000 claims 1
- 241001647372 Chlamydia pneumoniae Species 0.000 claims 1
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000019399 Colonic disease Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 208000000059 Dyspnea Diseases 0.000 claims 1
- 241000588724 Escherichia coli Species 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 241000606766 Haemophilus parainfluenzae Species 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 241000589242 Legionella pneumophila Species 0.000 claims 1
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 1
- 241000736262 Microbiota Species 0.000 claims 1
- 241000588621 Moraxella Species 0.000 claims 1
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 claims 1
- 206010037128 Pseudomembranous colitis Diseases 0.000 claims 1
- 230000036772 blood pressure Effects 0.000 claims 1
- 230000036760 body temperature Effects 0.000 claims 1
- 229940124587 cephalosporin Drugs 0.000 claims 1
- 150000001780 cephalosporins Chemical class 0.000 claims 1
- 238000002512 chemotherapy Methods 0.000 claims 1
- 206010009887 colitis Diseases 0.000 claims 1
- 235000013365 dairy product Nutrition 0.000 claims 1
- 238000011902 gastrointestinal surgery Methods 0.000 claims 1
- 229940047650 haemophilus influenzae Drugs 0.000 claims 1
- 210000000987 immune system Anatomy 0.000 claims 1
- 230000003834 intracellular effect Effects 0.000 claims 1
- 208000017169 kidney disease Diseases 0.000 claims 1
- 229940115932 legionella pneumophila Drugs 0.000 claims 1
- 239000003120 macrolide antibiotic agent Substances 0.000 claims 1
- 229960003085 meticillin Drugs 0.000 claims 1
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 claims 1
- 229960003702 moxifloxacin Drugs 0.000 claims 1
- 229940006361 moxifloxacin 400 mg Drugs 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 229940126409 proton pump inhibitor Drugs 0.000 claims 1
- 239000000612 proton pump inhibitor Substances 0.000 claims 1
- 230000036387 respiratory rate Effects 0.000 claims 1
- 208000013220 shortness of breath Diseases 0.000 claims 1
- 125000005490 tosylate group Chemical group 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/65—Tetracyclines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pulmonology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416010P | 2016-11-01 | 2016-11-01 | |
| US62/416,010 | 2016-11-01 | ||
| US201662422843P | 2016-11-16 | 2016-11-16 | |
| US62/422,843 | 2016-11-16 | ||
| US201762480516P | 2017-04-02 | 2017-04-02 | |
| US62/480,516 | 2017-04-02 | ||
| US201762500611P | 2017-05-03 | 2017-05-03 | |
| US62/500,611 | 2017-05-03 | ||
| US201762514415P | 2017-06-02 | 2017-06-02 | |
| US62/514,415 | 2017-06-02 | ||
| PCT/US2017/059165 WO2018085216A1 (en) | 2016-11-01 | 2017-10-31 | 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp) |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019113715A true RU2019113715A (ru) | 2020-12-03 |
| RU2019113715A3 RU2019113715A3 (enExample) | 2020-12-07 |
Family
ID=62076212
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019113715A RU2019113715A (ru) | 2016-11-01 | 2017-10-31 | 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп) |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10383884B2 (enExample) |
| EP (1) | EP3534908B1 (enExample) |
| JP (3) | JP7545803B2 (enExample) |
| CN (1) | CN110087655A (enExample) |
| AU (1) | AU2017353588B2 (enExample) |
| BR (1) | BR112019008897A2 (enExample) |
| CA (1) | CA3042514A1 (enExample) |
| MX (2) | MX2019005070A (enExample) |
| MY (1) | MY200446A (enExample) |
| PH (1) | PH12019500960A1 (enExample) |
| RU (1) | RU2019113715A (enExample) |
| SG (2) | SG11201903846TA (enExample) |
| TW (4) | TW202423450A (enExample) |
| WO (1) | WO2018085216A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018085216A1 (en) * | 2016-11-01 | 2018-05-11 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp) |
| US20200126094A1 (en) * | 2018-10-19 | 2020-04-23 | BioIDC, Inc. | Medical research fraud detection system and software |
| PT117254B (pt) | 2021-05-26 | 2024-04-18 | Hovione Farm S A | Método de síntese de compostos 9-aminometil tetraciclinas |
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| US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
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| US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| NL6607516A (enExample) | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| CA999855A (en) | 1972-09-18 | 1976-11-16 | Societa' Farmaceutici Italia S.P.A. | Process for the preparation of tetracyclines derivatives in the 7 position |
| US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
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| TWI746610B (zh) | 2016-08-03 | 2021-11-21 | 美商派瑞泰Ｓｐｖ２有限公司 | 9-胺甲基米諾四環素化合物及其用途 |
| WO2018085216A1 (en) * | 2016-11-01 | 2018-05-11 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp) |
-
2017
- 2017-10-31 WO PCT/US2017/059165 patent/WO2018085216A1/en not_active Ceased
- 2017-10-31 RU RU2019113715A patent/RU2019113715A/ru unknown
- 2017-10-31 MX MX2019005070A patent/MX2019005070A/es unknown
- 2017-10-31 MY MYPI2019002176A patent/MY200446A/en unknown
- 2017-10-31 EP EP17867238.2A patent/EP3534908B1/en active Active
- 2017-10-31 SG SG11201903846TA patent/SG11201903846TA/en unknown
- 2017-10-31 CN CN201780079110.3A patent/CN110087655A/zh active Pending
- 2017-10-31 JP JP2019522669A patent/JP7545803B2/ja active Active
- 2017-10-31 BR BR112019008897A patent/BR112019008897A2/pt not_active Application Discontinuation
- 2017-10-31 SG SG10201913599RA patent/SG10201913599RA/en unknown
- 2017-10-31 AU AU2017353588A patent/AU2017353588B2/en active Active
- 2017-10-31 US US15/798,573 patent/US10383884B2/en active Active
- 2017-10-31 CA CA3042514A patent/CA3042514A1/en active Pending
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2019
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2020
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2023
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2024
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