JP2019532976A5 - - Google Patents
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- JP2019532976A5 JP2019532976A5 JP2019522669A JP2019522669A JP2019532976A5 JP 2019532976 A5 JP2019532976 A5 JP 2019532976A5 JP 2019522669 A JP2019522669 A JP 2019522669A JP 2019522669 A JP2019522669 A JP 2019522669A JP 2019532976 A5 JP2019532976 A5 JP 2019532976A5
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- 238000000034 method Methods 0.000 claims description 95
- 238000001990 intravenous administration Methods 0.000 claims description 43
- 150000003839 salts Chemical class 0.000 claims description 18
- 125000004898 2,2-dimethylpropylamino group Chemical group CC(CN*)(C)C 0.000 claims description 16
- 241001647372 Chlamydia pneumoniae Species 0.000 claims description 16
- 229960004023 minocycline Drugs 0.000 claims description 16
- 241000193998 Streptococcus pneumoniae Species 0.000 claims description 12
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims description 12
- 201000001178 Bacterial Pneumonia Diseases 0.000 claims description 10
- 208000015181 infectious disease Diseases 0.000 claims description 8
- 208000024891 symptom Diseases 0.000 claims description 8
- 241000193163 Clostridioides difficile Species 0.000 claims description 7
- 230000002496 gastric effect Effects 0.000 claims description 6
- 206010009657 Clostridium difficile colitis Diseases 0.000 claims description 5
- 206010008479 Chest Pain Diseases 0.000 claims description 4
- 206010011224 Cough Diseases 0.000 claims description 4
- 208000000059 Dyspnea Diseases 0.000 claims description 4
- 206010013975 Dyspnoeas Diseases 0.000 claims description 4
- 241000589242 Legionella pneumophila Species 0.000 claims description 4
- 241000588655 Moraxella catarrhalis Species 0.000 claims description 4
- 241000202934 Mycoplasma pneumoniae Species 0.000 claims description 4
- 229930182555 Penicillin Natural products 0.000 claims description 4
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 claims description 4
- 206010036790 Productive cough Diseases 0.000 claims description 4
- 239000003242 anti bacterial agent Substances 0.000 claims description 4
- 229940088710 antibiotic agent Drugs 0.000 claims description 4
- 238000011156 evaluation Methods 0.000 claims description 4
- 235000013305 food Nutrition 0.000 claims description 4
- 229940115932 legionella pneumophila Drugs 0.000 claims description 4
- FABPRXSRWADJSP-MEDUHNTESA-N moxifloxacin Chemical compound COC1=C(N2C[C@H]3NCCC[C@H]3C2)C(F)=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 FABPRXSRWADJSP-MEDUHNTESA-N 0.000 claims description 4
- 229960003702 moxifloxacin Drugs 0.000 claims description 4
- 229940049954 penicillin Drugs 0.000 claims description 4
- 208000024794 sputum Diseases 0.000 claims description 4
- 210000003802 sputum Anatomy 0.000 claims description 4
- 102100021486 Protein S100-G Human genes 0.000 claims description 3
- 101710122252 Protein S100-G Proteins 0.000 claims description 3
- 229930186147 Cephalosporin Natural products 0.000 claims description 2
- 241001647378 Chlamydia psittaci Species 0.000 claims description 2
- 208000019399 Colonic disease Diseases 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 241000606768 Haemophilus influenzae Species 0.000 claims description 2
- 241000606766 Haemophilus parainfluenzae Species 0.000 claims description 2
- 241000588747 Klebsiella pneumoniae Species 0.000 claims description 2
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims description 2
- 208000003100 Pseudomembranous Enterocolitis Diseases 0.000 claims description 2
- 206010037128 Pseudomembranous colitis Diseases 0.000 claims description 2
- 241000191967 Staphylococcus aureus Species 0.000 claims description 2
- 235000013361 beverage Nutrition 0.000 claims description 2
- 230000036772 blood pressure Effects 0.000 claims description 2
- 230000036760 body temperature Effects 0.000 claims description 2
- 229940124587 cephalosporin Drugs 0.000 claims description 2
- 150000001780 cephalosporins Chemical class 0.000 claims description 2
- 238000002512 chemotherapy Methods 0.000 claims description 2
- 230000000112 colonic effect Effects 0.000 claims description 2
- 235000013365 dairy product Nutrition 0.000 claims description 2
- 238000011902 gastrointestinal surgery Methods 0.000 claims description 2
- 229940047650 haemophilus influenzae Drugs 0.000 claims description 2
- 210000000987 immune system Anatomy 0.000 claims description 2
- 230000000968 intestinal effect Effects 0.000 claims description 2
- 230000003834 intracellular effect Effects 0.000 claims description 2
- 208000017169 kidney disease Diseases 0.000 claims description 2
- 239000003120 macrolide antibiotic agent Substances 0.000 claims description 2
- 229960003085 meticillin Drugs 0.000 claims description 2
- 244000005700 microbiome Species 0.000 claims description 2
- 230000000474 nursing effect Effects 0.000 claims description 2
- 244000052769 pathogen Species 0.000 claims description 2
- 230000036387 respiratory rate Effects 0.000 claims description 2
- 238000002560 therapeutic procedure Methods 0.000 claims description 2
- 125000005490 tosylate group Chemical group 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 208000015634 Rectal Neoplasms Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 201000010099 disease Diseases 0.000 claims 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- 206010038038 rectal cancer Diseases 0.000 claims 1
- 201000001275 rectum cancer Diseases 0.000 claims 1
- JEECQCWWSTZDCK-IQZGDKDPSA-N omadacycline Chemical compound C([C@H]1C2)C3=C(N(C)C)C=C(CNCC(C)(C)C)C(O)=C3C(=O)C1=C(O)[C@@]1(O)[C@@H]2[C@H](N(C)C)C(O)=C(C(N)=O)C1=O JEECQCWWSTZDCK-IQZGDKDPSA-N 0.000 description 10
- 229950004150 omadacycline Drugs 0.000 description 10
- 208000022559 Inflammatory bowel disease Diseases 0.000 description 1
- 206010028980 Neoplasm Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000005713 exacerbation Effects 0.000 description 1
- 229940068196 placebo Drugs 0.000 description 1
- 239000000902 placebo Substances 0.000 description 1
- 230000036470 plasma concentration Effects 0.000 description 1
- 229940126409 proton pump inhibitor Drugs 0.000 description 1
- 239000000612 proton pump inhibitor Substances 0.000 description 1
- 230000036325 urinary excretion Effects 0.000 description 1
- 210000002700 urine Anatomy 0.000 description 1
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2023006239A JP2023058513A (ja) | 2016-11-01 | 2023-01-19 | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
| JP2024223840A JP2025041746A (ja) | 2016-11-01 | 2024-12-19 | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
Applications Claiming Priority (11)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662416010P | 2016-11-01 | 2016-11-01 | |
| US62/416,010 | 2016-11-01 | ||
| US201662422843P | 2016-11-16 | 2016-11-16 | |
| US62/422,843 | 2016-11-16 | ||
| US201762480516P | 2017-04-02 | 2017-04-02 | |
| US62/480,516 | 2017-04-02 | ||
| US201762500611P | 2017-05-03 | 2017-05-03 | |
| US62/500,611 | 2017-05-03 | ||
| US201762514415P | 2017-06-02 | 2017-06-02 | |
| US62/514,415 | 2017-06-02 | ||
| PCT/US2017/059165 WO2018085216A1 (en) | 2016-11-01 | 2017-10-31 | 9-aminomethyl minocycline compounds and use thereof in treating community-acquire bacterial pneumonia (cabp) |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023006239A Division JP2023058513A (ja) | 2016-11-01 | 2023-01-19 | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2019532976A JP2019532976A (ja) | 2019-11-14 |
| JP2019532976A5 true JP2019532976A5 (enExample) | 2020-12-10 |
| JP7545803B2 JP7545803B2 (ja) | 2024-09-05 |
Family
ID=62076212
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2019522669A Active JP7545803B2 (ja) | 2016-11-01 | 2017-10-31 | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
| JP2023006239A Pending JP2023058513A (ja) | 2016-11-01 | 2023-01-19 | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
| JP2024223840A Pending JP2025041746A (ja) | 2016-11-01 | 2024-12-19 | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2023006239A Pending JP2023058513A (ja) | 2016-11-01 | 2023-01-19 | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
| JP2024223840A Pending JP2025041746A (ja) | 2016-11-01 | 2024-12-19 | ９－アミノメチルミノサイクリン化合物及び市中感染型細菌性肺炎（ｃａｂｐ）の治療におけるその使用 |
Country Status (14)
| Country | Link |
|---|---|
| US (4) | US10383884B2 (enExample) |
| EP (1) | EP3534908B1 (enExample) |
| JP (3) | JP7545803B2 (enExample) |
| CN (1) | CN110087655A (enExample) |
| AU (1) | AU2017353588B2 (enExample) |
| BR (1) | BR112019008897A2 (enExample) |
| CA (1) | CA3042514A1 (enExample) |
| MX (2) | MX2019005070A (enExample) |
| MY (1) | MY200446A (enExample) |
| PH (1) | PH12019500960A1 (enExample) |
| RU (1) | RU2019113715A (enExample) |
| SG (2) | SG11201903846TA (enExample) |
| TW (4) | TW201821082A (enExample) |
| WO (1) | WO2018085216A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| RU2019113715A (ru) * | 2016-11-01 | 2020-12-03 | Паратек Фармасьютикалс, Инк. | 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп) |
| US20200126094A1 (en) * | 2018-10-19 | 2020-04-23 | BioIDC, Inc. | Medical research fraud detection system and software |
| PT117254B (pt) | 2021-05-26 | 2024-04-18 | Hovione Farm S A | Método de síntese de compostos 9-aminometil tetraciclinas |
Family Cites Families (76)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US2990331A (en) | 1956-11-23 | 1961-06-27 | Pfizer & Co C | Stable solutions of salts of tetracyclines for parenteral administration |
| US2980584A (en) | 1957-10-29 | 1961-04-18 | Pfizer & Co C | Parenteral magnesium oxytetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3062717A (en) | 1958-12-11 | 1962-11-06 | Pfizer & Co C | Intramuscular calcium tetracycline acetic or lactic acid carboxamide vehicle preparation |
| US3165531A (en) | 1962-03-08 | 1965-01-12 | Pfizer & Co C | 13-substituted-6-deoxytetracyclines and process utilizing the same |
| US3454697A (en) | 1965-06-08 | 1969-07-08 | American Cyanamid Co | Tetracycline antibiotic compositions for oral use |
| NL6607516A (enExample) | 1966-05-31 | 1967-12-01 | ||
| DE1767891C3 (de) | 1968-06-28 | 1980-10-30 | Pfizer | Verfahren zur Herstellung von wäßrigen arzneilichen Lösungen für die parenterale, perorale und lokale Anwendung mit einem Gehalt an einem Tetracyclinderivat |
| NL158172B (nl) | 1972-09-18 | 1978-10-16 | Farmaceutici Italia | Werkwijze voor het bereiden van tetracyclinederivaten met een substituent op de 7-plaats. |
| US3957980A (en) | 1972-10-26 | 1976-05-18 | Pfizer Inc. | Doxycycline parenteral compositions |
| DE2442829A1 (de) | 1974-09-06 | 1976-03-18 | Merck Patent Gmbh | Tetracyclische verbindungen und verfahren zu ihrer herstellung |
| US4018889A (en) | 1976-01-02 | 1977-04-19 | Pfizer Inc. | Oxytetracycline compositions |
| US4126680A (en) | 1977-04-27 | 1978-11-21 | Pfizer Inc. | Tetracycline antibiotic compositions |
| US5589470A (en) | 1990-02-26 | 1996-12-31 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| US4806529A (en) | 1982-11-18 | 1989-02-21 | Trustees Of Tufts College, Tufts University | Tetracycline activity enhancement |
| US5064821A (en) | 1982-11-18 | 1991-11-12 | Trustees Of Tufts College | Method and compositions for overcoming tetracycline resistance within living cells |
| US4806372A (en) | 1985-02-15 | 1989-02-21 | Georgia Oil & Gas Co., Inc. | Nitrite-free-curing of bacon and product thereof |
| US6756365B2 (en) | 1991-11-06 | 2004-06-29 | Trustees Of Tufts College | Reducing tetracycline resistance in living cells |
| WO1999037306A1 (en) | 1998-01-23 | 1999-07-29 | Trustees Of Tufts College | Pharmaceutically active compounds and methods of use thereof |
| US6256365B1 (en) | 1999-08-16 | 2001-07-03 | Analogic Corporation | Apparatus and method for reconstruction of images in a computed tomography system using oblique slices |
| US6849615B2 (en) | 1999-09-14 | 2005-02-01 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| US6500812B2 (en) | 1999-09-14 | 2002-12-31 | Paratek Pharmaceuticals, Inc. | 13-substituted methacycline compounds |
| EP1666454B1 (en) | 1999-09-14 | 2011-09-07 | Trustees Of Tufts College | Methods of preparing substituted tetracyclines with transition metal-based chemistries |
| EP1263442A1 (en) | 2000-01-24 | 2002-12-11 | Trustees Of Tufts College | TETRACYCLINE COMPOUNDS FOR TREATMENT OF i CRYPTOSPORIDIUM PARVUM /i RELATED DISORDERS |
| DE60129116T2 (de) | 2000-03-31 | 2008-03-13 | Trustees Of Tufts College, Medford | 7- und 9-carbamat, harnstoff, thioharnstoff, thiocarbamat und heteroaryl-amino substituierte tetracyclinverbindungen |
| ATE264295T1 (de) | 2000-05-15 | 2004-04-15 | Paratek Pharm Innc | 7-substituierte kondensierte ring-tetrazyclin- verbindungen |
| US20040224927A1 (en) | 2000-06-16 | 2004-11-11 | Trustees Of Tufts College | 7-N-substituted phenyl tetracycline compounds |
| US20020132798A1 (en) | 2000-06-16 | 2002-09-19 | Nelson Mark L. | 7-phenyl-substituted tetracycline compounds |
| AU2001268475A1 (en) | 2000-06-16 | 2002-01-02 | Trustees Of Tufts College | 7-phenyl-substituted tetracycline compounds |
| CZ2003343A3 (cs) | 2000-07-07 | 2003-05-14 | Trustees Of Tufts College | 7-Substituované tetracyklinové sloučeniny |
| EA201000496A1 (ru) | 2000-07-07 | 2010-10-29 | Трастис Оф Тафтс Коллидж | Замещенное соединение миноциклина, способ получения замещенных соединений миноциклина (варианты) |
| EP1303479B1 (en) | 2000-07-07 | 2011-04-06 | Trustees Of Tufts College | 7-, 8- and 9-substituted tetracycline compounds |
| US7094806B2 (en) | 2000-07-07 | 2006-08-22 | Trustees Of Tufts College | 7, 8 and 9-substituted tetracycline compounds |
| US20050143353A1 (en) | 2000-07-07 | 2005-06-30 | Paratek Pharmaceuticals, Inc. | 13-Substituted methacycline compounds |
| US7553828B2 (en) | 2001-03-13 | 2009-06-30 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| HRP20030743A2 (en) | 2001-03-13 | 2005-06-30 | Paratek Pharmaceuticals | 7,9-substituted tetracycline compounds |
| AU2002250331A1 (en) | 2001-03-13 | 2002-09-24 | Paratek Pharmaceuticals, Inc. | 7-pyrollyl tetracycline compounds and methods of use thereof |
| EP1241160A1 (en) | 2001-03-13 | 2002-09-18 | Glaxo Group Limited | Tetracycline derivatives and their use as antibiotic agents |
| US7045507B2 (en) | 2001-03-14 | 2006-05-16 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds as synergistic antifungal agents |
| JP2004530661A (ja) | 2001-03-14 | 2004-10-07 | パラテック ファーマシューティカルズ インコーポレイテッド | 抗真菌剤としての置換テトラサイクリン化合物 |
| US8088820B2 (en) | 2001-04-24 | 2012-01-03 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for the treatment of malaria |
| US20060194773A1 (en) | 2001-07-13 | 2006-08-31 | Paratek Pharmaceuticals, Inc. | Tetracyline compounds having target therapeutic activities |
| EP2332549A1 (en) | 2001-07-13 | 2011-06-15 | Paratek Pharmaceuticals, Inc. | Novel tetracyclines and their use in medicine |
| AU2002365120A1 (en) | 2001-08-02 | 2003-07-15 | Paratek Pharmaceuticals, Inc. | Medicaments |
| AU2002323688A1 (en) | 2001-09-10 | 2003-03-24 | Paratek Pharmaceuticals, Inc. | Computational method for determining oral bioavailability |
| US7056902B2 (en) | 2002-01-08 | 2006-06-06 | Paratek Pharmaceuticals, Inc. | 4-dedimethylamino tetracycline compounds |
| EP2316450A1 (en) | 2002-03-08 | 2011-05-04 | Paratek Pharmaceuticals, Inc. | Amino-methyl substituted tetracycline compounds |
| KR101083498B1 (ko) | 2002-03-21 | 2011-11-16 | 파라테크 파마슈티컬스, 인크. | 치환된 테트라시클린 화합물 |
| CN1700922A (zh) | 2002-07-12 | 2005-11-23 | 帕拉特克药品公司 | 3、10或12a位取代的四环素化合物 |
| US8173624B2 (en) | 2002-10-24 | 2012-05-08 | Paratek Pharmaceuticals, Inc. | Methods of using substituted tetracycline compounds to modulate RNA |
| WO2004091513A2 (en) | 2003-04-10 | 2004-10-28 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl substituted minocycline compounds |
| US20060287283A1 (en) | 2003-07-09 | 2006-12-21 | Paratek Pharmaceuticals, Inc. | Prodrugs of 9-aminomethyl tetracycline compounds |
| CN1845897A (zh) | 2003-07-09 | 2006-10-11 | 帕拉特克药品公司 | 取代的四环素化合物 |
| EP2332904A3 (en) | 2004-01-15 | 2012-04-11 | Paratek Pharmaceuticals, Inc. | Derivatives of tetracycline compounds |
| EP2284151A3 (en) | 2004-10-25 | 2011-09-21 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds |
| EP2301916A3 (en) | 2004-10-25 | 2011-09-28 | Paratek Pharmaceuticals, Inc. | 4-aminotetracyclines and methods of use thereof |
| EP1848685A1 (en) | 2005-02-04 | 2007-10-31 | Paratek Pharmaceuticals, Inc. | 11a, 12-derivatives of tetracycline compounds |
| CA2616224A1 (en) | 2005-07-21 | 2007-02-01 | Paratek Pharmaceuticals, Inc. | 10-substituted tetracyclines and methods of use thereof |
| WO2007087416A2 (en) | 2006-01-24 | 2007-08-02 | Paratek Pharaceuticals, Inc. | Methods of increasing oral bioavailability of tetracyclines |
| CA2652346A1 (en) | 2006-05-15 | 2007-11-22 | Paratek Pharmaceuticals, Inc. | Methods of regulating expression of genes or of gene products using substituted tetracycline compounds |
| WO2008045507A2 (en) | 2006-10-11 | 2008-04-17 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of bacillus anthracis infections |
| US8513223B2 (en) | 2006-12-21 | 2013-08-20 | Paratek Pharmaceuticals, Inc. | Substituted tetracycline compounds for treatment of inflammatory skin disorders |
| ES2463457T3 (es) | 2006-12-21 | 2014-05-28 | Paratek Pharmaceuticals, Inc. | Derivados de la tetraciclina para el tratamiento de infecciones bacterianas, virales y parasitarias |
| US20080261913A1 (en) | 2006-12-28 | 2008-10-23 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of liver disorders |
| JP2010523684A (ja) | 2007-04-12 | 2010-07-15 | パラテック ファーマシューティカルズ インコーポレイテッド | テトラサイクリン化合物を用いる、脊髄筋委縮症を治療するための方法 |
| JP2010525069A (ja) | 2007-04-27 | 2010-07-22 | パラテック ファーマシューティカルズ インコーポレイテッド | アミノアルキルテトラサイクリン化合物の合成方法および精製方法 |
| US9522872B2 (en) | 2007-07-06 | 2016-12-20 | Paratek Pharmaceuticals, Inc. | Methods for synthesizing substituted tetracycline compounds |
| CA2717703A1 (en) | 2008-03-05 | 2009-09-11 | Paratek Pharmaceuticals, Inc. | Minocycline compounds and methods of use thereof |
| PT2271348T (pt) | 2008-03-28 | 2018-04-16 | Paratek Pharm Innc | Formulação de comprimido oral de composto de tetraciclina |
| US20100022483A1 (en) | 2008-04-14 | 2010-01-28 | Paratek Pharmaceuticals, Inc. | Substituted Tetracycline Compounds |
| TW202216656A (zh) | 2008-05-19 | 2022-05-01 | 美商Ｐｒｔｋ Ｓｐｖ２公司 | 四環素化合物之甲苯磺酸鹽及同素異形體 |
| HRP20130928T1 (hr) | 2008-08-08 | 2013-11-22 | Tetraphase Pharmaceuticals, Inc. | C7-fluor supstituirani spojevi tetraciklina |
| AU2016235151A1 (en) * | 2015-03-24 | 2017-10-12 | Paratek Pharmaceuticals, Inc. | Minocycline compounds for biodefense |
| CN119454720A (zh) * | 2016-03-24 | 2025-02-18 | 帕拉特克Spv2有限责任公司 | 用于治疗和预防艰难梭菌感染的方法 |
| US10238670B2 (en) | 2016-05-02 | 2019-03-26 | Paratek Pharmaceuticals, Inc. | 9-aminomethyl minocycline compounds and methods of use thereof in urinary tract infection (UTI) treatment |
| TW202206081A (zh) | 2016-08-03 | 2022-02-16 | 美商派瑞泰Ｓｐｖ２有限公司 | ９—胺甲基米諾四環素化合物及其用途 |
| RU2019113715A (ru) * | 2016-11-01 | 2020-12-03 | Паратек Фармасьютикалс, Инк. | 9-аминометилминоциклиновые соединения и их применение для лечениия внебольничной бактериальной пневмонии(вбп) |
-
2017
- 2017-10-31 RU RU2019113715A patent/RU2019113715A/ru unknown
- 2017-10-31 EP EP17867238.2A patent/EP3534908B1/en active Active
- 2017-10-31 JP JP2019522669A patent/JP7545803B2/ja active Active
- 2017-10-31 MY MYPI2019002176A patent/MY200446A/en unknown
- 2017-10-31 SG SG11201903846TA patent/SG11201903846TA/en unknown
- 2017-10-31 US US15/798,573 patent/US10383884B2/en active Active
- 2017-10-31 WO PCT/US2017/059165 patent/WO2018085216A1/en not_active Ceased
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- 2017-10-31 CN CN201780079110.3A patent/CN110087655A/zh active Pending
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2020
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2023
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