JP2011527317A5 - - Google Patents
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- Publication number
- JP2011527317A5 JP2011527317A5 JP2011517170A JP2011517170A JP2011527317A5 JP 2011527317 A5 JP2011527317 A5 JP 2011527317A5 JP 2011517170 A JP2011517170 A JP 2011517170A JP 2011517170 A JP2011517170 A JP 2011517170A JP 2011527317 A5 JP2011527317 A5 JP 2011527317A5
- Authority
- JP
- Japan
- Prior art keywords
- nogo
- use according
- antagonist
- administered
- seq
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000010410 Nogo Proteins Human genes 0.000 claims 12
- 108010077641 Nogo Proteins Proteins 0.000 claims 12
- 239000005557 antagonist Substances 0.000 claims 10
- FTALBRSUTCGOEG-UHFFFAOYSA-N Riluzole Chemical group C1=C(OC(F)(F)F)C=C2SC(N)=NC2=C1 FTALBRSUTCGOEG-UHFFFAOYSA-N 0.000 claims 6
- 229960004181 riluzole Drugs 0.000 claims 6
- 206010002026 amyotrophic lateral sclerosis Diseases 0.000 claims 4
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 3
- 230000002265 prevention Effects 0.000 claims 3
- 150000001875 compounds Chemical class 0.000 claims 2
- 239000004220 glutamic acid Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US7987408P | 2008-07-11 | 2008-07-11 | |
| US61/079,874 | 2008-07-11 | ||
| PCT/EP2009/058832 WO2010004031A2 (en) | 2008-07-11 | 2009-07-10 | Novel treatment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011527317A JP2011527317A (ja) | 2011-10-27 |
| JP2011527317A5 true JP2011527317A5 (enExample) | 2012-07-26 |
Family
ID=41395512
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517170A Pending JP2011527317A (ja) | 2008-07-11 | 2009-07-10 | Ｎｏｇｏ−ａアンタゴニストによる筋萎縮性側索硬化症の治療 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20110268729A1 (enExample) |
| EP (1) | EP2323691A2 (enExample) |
| JP (1) | JP2011527317A (enExample) |
| CA (1) | CA2730473A1 (enExample) |
| WO (1) | WO2010004031A2 (enExample) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2012004773A1 (en) | 2010-07-09 | 2012-01-12 | Universite De Geneve | New uses of nogo-a inhibitors and related methods |
| EP2731611B1 (en) * | 2011-07-13 | 2019-09-18 | Cytokinetics, Inc. | Combination therapie for als |
| CN104395343A (zh) | 2012-07-05 | 2015-03-04 | 葛兰素集团有限公司 | 抗Nogo-A抗体在肌萎缩侧索硬化治疗中的最佳剂量方案 |
| WO2024041450A1 (zh) * | 2022-08-22 | 2024-02-29 | 舒泰神（北京）生物制药股份有限公司 | 特异性识别Nogo-A的抗体及其应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2753379B1 (fr) * | 1996-09-13 | 1998-10-30 | Rhone Poulenc Rorer Sa | Methode de traitement de la sclerose laterale amyotrophique |
| MXPA05001615A (es) * | 2002-08-10 | 2005-08-19 | Biogen Idec Inc | Antagonistas del nogo receptor. |
| GB0228832D0 (en) * | 2002-12-10 | 2003-01-15 | Novartis Ag | Organic compound |
| CA2549956C (en) * | 2003-12-22 | 2016-04-12 | Glaxo Group Limited | Immunoglobulins |
| US7572596B2 (en) * | 2004-12-02 | 2009-08-11 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Modulation of the neuroendoctrine system as a therapy for motor neuron disease |
| NZ564567A (en) * | 2005-07-05 | 2010-09-30 | Glaxo Group Ltd | Humanised antibodies specific for neurite outgrowth inhibitor-A and pharmaceutical uses thereof |
| WO2007046347A1 (ja) * | 2005-10-18 | 2007-04-26 | Ono Pharmaceutical Co., Ltd. | 筋萎縮性側索硬化症患者の運動神経保護用医薬 |
| GB0525662D0 (en) * | 2005-12-16 | 2006-01-25 | Glaxo Group Ltd | Immunoglobulins |
| US20080003208A1 (en) * | 2006-05-11 | 2008-01-03 | Avicena Froup, Inc. | Creatine-ligand compounds and methods of use thereof |
-
2009
- 2009-07-10 WO PCT/EP2009/058832 patent/WO2010004031A2/en not_active Ceased
- 2009-07-10 CA CA2730473A patent/CA2730473A1/en not_active Abandoned
- 2009-07-10 US US13/003,657 patent/US20110268729A1/en not_active Abandoned
- 2009-07-10 JP JP2011517170A patent/JP2011527317A/ja active Pending
- 2009-07-10 EP EP09780440A patent/EP2323691A2/en not_active Withdrawn
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