RU2019109011A - Композиции и способы с использованием фармакогеномного маркера - Google Patents
Композиции и способы с использованием фармакогеномного маркера Download PDFInfo
- Publication number
- RU2019109011A RU2019109011A RU2019109011A RU2019109011A RU2019109011A RU 2019109011 A RU2019109011 A RU 2019109011A RU 2019109011 A RU2019109011 A RU 2019109011A RU 2019109011 A RU2019109011 A RU 2019109011A RU 2019109011 A RU2019109011 A RU 2019109011A
- Authority
- RU
- Russia
- Prior art keywords
- sequencing
- reagent
- snps
- treatment
- snp
- Prior art date
Links
- 238000000034 method Methods 0.000 title claims 35
- 239000003550 marker Substances 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
- 230000002974 pharmacogenomic effect Effects 0.000 title 1
- 239000003153 chemical reaction reagent Substances 0.000 claims 38
- 238000012163 sequencing technique Methods 0.000 claims 38
- 108091033319 polynucleotide Proteins 0.000 claims 22
- 102000040430 polynucleotide Human genes 0.000 claims 22
- 239000002157 polynucleotide Substances 0.000 claims 22
- 230000000295 complement effect Effects 0.000 claims 21
- DQYBRTASHMYDJG-UHFFFAOYSA-N Bisindolylmaleimide Chemical compound C1=CC=C2C(C=3C(=O)NC(C=3C=3C4=CC=CC=C4NC=3)=O)=CNC2=C1 DQYBRTASHMYDJG-UHFFFAOYSA-N 0.000 claims 12
- 238000004458 analytical method Methods 0.000 claims 12
- 239000012472 biological sample Substances 0.000 claims 12
- 239000000090 biomarker Substances 0.000 claims 11
- 239000002773 nucleotide Substances 0.000 claims 10
- 125000003729 nucleotide group Chemical group 0.000 claims 10
- 229940043355 kinase inhibitor Drugs 0.000 claims 9
- 239000003909 protein kinase inhibitor Substances 0.000 claims 9
- 206010028980 Neoplasm Diseases 0.000 claims 8
- 230000003321 amplification Effects 0.000 claims 8
- 201000011510 cancer Diseases 0.000 claims 8
- 238000003199 nucleic acid amplification method Methods 0.000 claims 8
- 108020004414 DNA Proteins 0.000 claims 7
- 102000054765 polymorphisms of proteins Human genes 0.000 claims 7
- 108090000315 Protein Kinase C Proteins 0.000 claims 6
- 102000003923 Protein Kinase C Human genes 0.000 claims 6
- 238000009396 hybridization Methods 0.000 claims 6
- 150000007523 nucleic acids Chemical group 0.000 claims 6
- 238000003752 polymerase chain reaction Methods 0.000 claims 6
- 239000000758 substrate Substances 0.000 claims 5
- 206010009944 Colon cancer Diseases 0.000 claims 4
- 238000001712 DNA sequencing Methods 0.000 claims 4
- 208000031671 Large B-Cell Diffuse Lymphoma Diseases 0.000 claims 4
- 102000013530 TOR Serine-Threonine Kinases Human genes 0.000 claims 4
- 108010065917 TOR Serine-Threonine Kinases Proteins 0.000 claims 4
- 238000002405 diagnostic procedure Methods 0.000 claims 4
- 206010012818 diffuse large B-cell lymphoma Diseases 0.000 claims 4
- 208000005017 glioblastoma Diseases 0.000 claims 4
- 239000003112 inhibitor Substances 0.000 claims 4
- 238000007834 ligase chain reaction Methods 0.000 claims 4
- 238000004949 mass spectrometry Methods 0.000 claims 4
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 4
- 102000039446 nucleic acids Human genes 0.000 claims 4
- 108020004707 nucleic acids Proteins 0.000 claims 4
- 208000025638 primary cutaneous T-cell non-Hodgkin lymphoma Diseases 0.000 claims 4
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 4
- AXRCEOKUDYDWLF-UHFFFAOYSA-N 3-(1-methyl-3-indolyl)-4-[1-[1-(2-pyridinylmethyl)-4-piperidinyl]-3-indolyl]pyrrole-2,5-dione Chemical group C12=CC=CC=C2N(C)C=C1C(C(NC1=O)=O)=C1C(C1=CC=CC=C11)=CN1C(CC1)CCN1CC1=CC=CC=N1 AXRCEOKUDYDWLF-UHFFFAOYSA-N 0.000 claims 3
- KIWODJBCHRADND-UHFFFAOYSA-N 3-anilino-4-[1-[3-(1-imidazolyl)propyl]-3-indolyl]pyrrole-2,5-dione Chemical compound O=C1NC(=O)C(C=2C3=CC=CC=C3N(CCCN3C=NC=C3)C=2)=C1NC1=CC=CC=C1 KIWODJBCHRADND-UHFFFAOYSA-N 0.000 claims 3
- 206010008796 Chromaturia Diseases 0.000 claims 3
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 3
- 108091034117 Oligonucleotide Proteins 0.000 claims 3
- 238000003556 assay Methods 0.000 claims 3
- 238000001514 detection method Methods 0.000 claims 3
- 229950002189 enzastaurin Drugs 0.000 claims 3
- -1 4EBP1 Proteins 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 2
- 208000003174 Brain Neoplasms Diseases 0.000 claims 2
- 206010006187 Breast cancer Diseases 0.000 claims 2
- 208000026310 Breast neoplasm Diseases 0.000 claims 2
- 206010008342 Cervix carcinoma Diseases 0.000 claims 2
- AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
- 208000000461 Esophageal Neoplasms Diseases 0.000 claims 2
- 208000032612 Glial tumor Diseases 0.000 claims 2
- 206010018338 Glioma Diseases 0.000 claims 2
- 102000019058 Glycogen Synthase Kinase 3 beta Human genes 0.000 claims 2
- 108010051975 Glycogen Synthase Kinase 3 beta Proteins 0.000 claims 2
- 208000008839 Kidney Neoplasms Diseases 0.000 claims 2
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 2
- 206010025323 Lymphomas Diseases 0.000 claims 2
- 208000034578 Multiple myelomas Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 2
- 206010030155 Oesophageal carcinoma Diseases 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 206010061535 Ovarian neoplasm Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 206010035226 Plasma cell myeloma Diseases 0.000 claims 2
- 206010060862 Prostate cancer Diseases 0.000 claims 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 2
- 206010038389 Renal cancer Diseases 0.000 claims 2
- 101100273253 Rhizopus niveus RNAP gene Proteins 0.000 claims 2
- 102000003861 Ribosomal protein S6 Human genes 0.000 claims 2
- 108090000221 Ribosomal protein S6 Proteins 0.000 claims 2
- 208000000453 Skin Neoplasms Diseases 0.000 claims 2
- 208000005718 Stomach Neoplasms Diseases 0.000 claims 2
- 208000031673 T-Cell Cutaneous Lymphoma Diseases 0.000 claims 2
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims 2
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims 2
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 2
- 208000033559 Waldenström macroglobulinemia Diseases 0.000 claims 2
- 230000002491 angiogenic effect Effects 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 238000005251 capillar electrophoresis Methods 0.000 claims 2
- 201000010881 cervical cancer Diseases 0.000 claims 2
- 201000007241 cutaneous T cell lymphoma Diseases 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000006073 displacement reaction Methods 0.000 claims 2
- 239000003596 drug target Substances 0.000 claims 2
- 238000000840 electrochemical analysis Methods 0.000 claims 2
- 210000002889 endothelial cell Anatomy 0.000 claims 2
- 238000001976 enzyme digestion Methods 0.000 claims 2
- 201000004101 esophageal cancer Diseases 0.000 claims 2
- 206010017758 gastric cancer Diseases 0.000 claims 2
- 201000010536 head and neck cancer Diseases 0.000 claims 2
- 208000014829 head and neck neoplasm Diseases 0.000 claims 2
- 238000004128 high performance liquid chromatography Methods 0.000 claims 2
- 238000012165 high-throughput sequencing Methods 0.000 claims 2
- 238000000338 in vitro Methods 0.000 claims 2
- 238000011901 isothermal amplification Methods 0.000 claims 2
- 201000010982 kidney cancer Diseases 0.000 claims 2
- 208000032839 leukemia Diseases 0.000 claims 2
- 201000007270 liver cancer Diseases 0.000 claims 2
- 208000014018 liver neoplasm Diseases 0.000 claims 2
- 201000005202 lung cancer Diseases 0.000 claims 2
- 208000020816 lung neoplasm Diseases 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 230000001404 mediated effect Effects 0.000 claims 2
- 238000000386 microscopy Methods 0.000 claims 2
- 201000005962 mycosis fungoides Diseases 0.000 claims 2
- 239000002077 nanosphere Substances 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 230000026731 phosphorylation Effects 0.000 claims 2
- 238000006366 phosphorylation reaction Methods 0.000 claims 2
- 229920001184 polypeptide Polymers 0.000 claims 2
- 102000004196 processed proteins & peptides Human genes 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 238000012175 pyrosequencing Methods 0.000 claims 2
- 230000010076 replication Effects 0.000 claims 2
- 230000004044 response Effects 0.000 claims 2
- 108091008146 restriction endonucleases Proteins 0.000 claims 2
- 238000007894 restriction fragment length polymorphism technique Methods 0.000 claims 2
- 238000005096 rolling process Methods 0.000 claims 2
- 238000007480 sanger sequencing Methods 0.000 claims 2
- 239000004065 semiconductor Substances 0.000 claims 2
- 238000007841 sequencing by ligation Methods 0.000 claims 2
- 201000000849 skin cancer Diseases 0.000 claims 2
- 239000007787 solid Substances 0.000 claims 2
- 201000011549 stomach cancer Diseases 0.000 claims 2
- 238000003786 synthesis reaction Methods 0.000 claims 2
- 238000002560 therapeutic procedure Methods 0.000 claims 2
- 238000013518 transcription Methods 0.000 claims 2
- 230000035897 transcription Effects 0.000 claims 2
- 230000005641 tunneling Effects 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 101710105094 Cyclic AMP-responsive element-binding protein Proteins 0.000 claims 1
- 201000003741 Gastrointestinal carcinoma Diseases 0.000 claims 1
- 102000001253 Protein Kinase Human genes 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 208000016025 Waldenstroem macroglobulinemia Diseases 0.000 claims 1
- 230000002411 adverse Effects 0.000 claims 1
- 230000008236 biological pathway Effects 0.000 claims 1
- 102000036109 cAMP binding proteins Human genes 0.000 claims 1
- 108091010966 cAMP binding proteins Proteins 0.000 claims 1
- 208000029742 colonic neoplasm Diseases 0.000 claims 1
- 229960004397 cyclophosphamide Drugs 0.000 claims 1
- 229960004679 doxorubicin Drugs 0.000 claims 1
- 238000001962 electrophoresis Methods 0.000 claims 1
- 238000001502 gel electrophoresis Methods 0.000 claims 1
- 238000003205 genotyping method Methods 0.000 claims 1
- 201000002313 intestinal cancer Diseases 0.000 claims 1
- 238000002493 microarray Methods 0.000 claims 1
- 238000012544 monitoring process Methods 0.000 claims 1
- 239000000101 novel biomarker Substances 0.000 claims 1
- 238000003499 nucleic acid array Methods 0.000 claims 1
- XOFYZVNMUHMLCC-ZPOLXVRWSA-N prednisone Chemical compound O=C1C=C[C@]2(C)[C@H]3C(=O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 XOFYZVNMUHMLCC-ZPOLXVRWSA-N 0.000 claims 1
- 229960004618 prednisone Drugs 0.000 claims 1
- 108060006633 protein kinase Proteins 0.000 claims 1
- 230000004043 responsiveness Effects 0.000 claims 1
- 239000000523 sample Substances 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 claims 1
- 210000002700 urine Anatomy 0.000 claims 1
- OGWKCGZFUXNPDA-XQKSVPLYSA-N vincristine Chemical compound C([N@]1C[C@@H](C[C@]2(C(=O)OC)C=3C(=CC4=C([C@]56[C@H]([C@@]([C@H](OC(C)=O)[C@]7(CC)C=CCN([C@H]67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)C[C@@](C1)(O)CC)CC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-XQKSVPLYSA-N 0.000 claims 1
- 229960004528 vincristine Drugs 0.000 claims 1
- OGWKCGZFUXNPDA-UHFFFAOYSA-N vincristine Natural products C1C(CC)(O)CC(CC2(C(=O)OC)C=3C(=CC4=C(C56C(C(C(OC(C)=O)C7(CC)C=CCN(C67)CC5)(O)C(=O)OC)N4C=O)C=3)OC)CN1CCC1=C2NC2=CC=CC=C12 OGWKCGZFUXNPDA-UHFFFAOYSA-N 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/106—Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/156—Polymorphic or mutational markers
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Pathology (AREA)
- Analytical Chemistry (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Biochemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Apparatus Associated With Microorganisms And Enzymes (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medical Treatment And Welfare Office Work (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201662382734P | 2016-09-01 | 2016-09-01 | |
| US62/382,734 | 2016-09-01 | ||
| US201662414601P | 2016-10-28 | 2016-10-28 | |
| US62/414,601 | 2016-10-28 | ||
| PCT/US2017/049747 WO2018045240A1 (en) | 2016-09-01 | 2017-08-31 | Methods and composition for the prediction of the activity of enzastaurin |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2019109011A true RU2019109011A (ru) | 2020-10-05 |
| RU2019109011A3 RU2019109011A3 (enExample) | 2021-01-22 |
Family
ID=59923555
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2019109011A RU2019109011A (ru) | 2016-09-01 | 2017-08-31 | Композиции и способы с использованием фармакогеномного маркера |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US11421280B2 (enExample) |
| EP (1) | EP3507384B1 (enExample) |
| JP (3) | JP7197915B2 (enExample) |
| KR (1) | KR20190046935A (enExample) |
| CN (1) | CN109952383B (enExample) |
| AU (1) | AU2017318669B2 (enExample) |
| BR (1) | BR112019003951A2 (enExample) |
| CA (1) | CA3035386A1 (enExample) |
| JO (1) | JOP20190025A1 (enExample) |
| MX (1) | MX2019002377A (enExample) |
| PH (1) | PH12019500422A1 (enExample) |
| RU (1) | RU2019109011A (enExample) |
| SG (2) | SG11201901762WA (enExample) |
| TW (2) | TW202313973A (enExample) |
| WO (1) | WO2018045240A1 (enExample) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20190025A1 (ar) | 2016-09-01 | 2019-02-19 | Denovo Biopharma Llc | طرق وتركيبة لتوقع نشاط إنزاستورين |
| CN110496223B (zh) * | 2018-05-17 | 2021-09-10 | 复旦大学附属肿瘤医院 | 一种治疗非霍奇金氏淋巴瘤的药物组合物 |
| US20220193062A1 (en) * | 2018-09-12 | 2022-06-23 | Denovo Biopharma Llc | Combination of enzastaurin and inhibitors of btk and uses thereof |
| CN111549033B (zh) * | 2020-06-11 | 2021-02-12 | 南京市江宁医院 | 慢病毒感染人表皮角质细胞株及其构建方法和应用 |
| US11227690B1 (en) * | 2020-09-14 | 2022-01-18 | Opendna Ltd. | Machine learning prediction of therapy response |
| TWI808838B (zh) * | 2021-07-23 | 2023-07-11 | 高雄醫學大學 | 二代荷爾蒙藥物於治療攝護腺癌療效評估之臨床治療藥物預測暨推薦系統及方法 |
| US20230131677A1 (en) * | 2021-10-21 | 2023-04-27 | Toyota Research Institute, Inc. | Systems and methods for predicting the effect of an intervention via machine learning |
| CN118339312A (zh) * | 2021-11-23 | 2024-07-12 | 索元生物医药(美国)有限公司 | 用于评估多核苷酸递送和癌疗法之功效的组合物和方法 |
| US12474842B2 (en) * | 2021-12-13 | 2025-11-18 | Google Llc | Optimizing data placement based on data temperature and lifetime prediction |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE456367T1 (de) | 1993-12-23 | 2010-02-15 | Lilly Co Eli | Proteinkinase c inhibitoren |
| EP1309679A2 (en) * | 2000-08-16 | 2003-05-14 | Chiron Corporation | Human genes and gene expression products |
| US20040072217A1 (en) | 2002-06-17 | 2004-04-15 | Affymetrix, Inc. | Methods of analysis of linkage disequilibrium |
| CA2393720C (en) | 2002-07-12 | 2010-09-14 | Eli Lilly And Company | Crystalline 2,5-dione-3-(1-methyl-1h-indol-3-yl)-4-[1-(pyridin-2-ylmethyl)piperidin-4-yl]-1h-indol-3-yl]-1h-pyrrole mono-hydrochloride |
| WO2007145992A2 (en) | 2006-06-05 | 2007-12-21 | Perlegen Sciences, Inc. | Genetic basis of treatment response in depression patients |
| KR102006417B1 (ko) * | 2011-01-31 | 2019-08-01 | 드노보 바이오마커스 인코포레이티드 | 게놈약학적 바이오마커 동정 방법 |
| EP2718486A4 (en) * | 2011-06-08 | 2014-12-31 | Denovo Biopharma Hangzhou Ltd Co | METHODS AND COMPOSITIONS FOR PREDICTING THE ACTIVITY OF A RETINOID RECEPTOR X MODULATOR |
| JOP20190025A1 (ar) | 2016-09-01 | 2019-02-19 | Denovo Biopharma Llc | طرق وتركيبة لتوقع نشاط إنزاستورين |
-
2017
- 2017-06-16 JO JOP/2019/0025A patent/JOP20190025A1/ar unknown
- 2017-08-31 SG SG11201901762WA patent/SG11201901762WA/en unknown
- 2017-08-31 AU AU2017318669A patent/AU2017318669B2/en not_active Ceased
- 2017-08-31 RU RU2019109011A patent/RU2019109011A/ru unknown
- 2017-08-31 KR KR1020197009407A patent/KR20190046935A/ko not_active Ceased
- 2017-08-31 WO PCT/US2017/049747 patent/WO2018045240A1/en not_active Ceased
- 2017-08-31 US US16/327,788 patent/US11421280B2/en active Active
- 2017-08-31 MX MX2019002377A patent/MX2019002377A/es unknown
- 2017-08-31 SG SG10201912134TA patent/SG10201912134TA/en unknown
- 2017-08-31 CN CN201780066737.5A patent/CN109952383B/zh active Active
- 2017-08-31 TW TW111122709A patent/TW202313973A/zh unknown
- 2017-08-31 CA CA3035386A patent/CA3035386A1/en active Pending
- 2017-08-31 BR BR112019003951A patent/BR112019003951A2/pt not_active IP Right Cessation
- 2017-08-31 TW TW106129838A patent/TWI771317B/zh not_active IP Right Cessation
- 2017-08-31 EP EP17771623.0A patent/EP3507384B1/en active Active
- 2017-08-31 JP JP2019512609A patent/JP7197915B2/ja active Active
-
2019
- 2019-02-27 PH PH12019500422A patent/PH12019500422A1/en unknown
-
2020
- 2020-08-26 JP JP2020142358A patent/JP2020188816A/ja active Pending
-
2022
- 2022-08-18 US US17/820,772 patent/US20230074781A1/en not_active Abandoned
- 2022-09-16 JP JP2022148064A patent/JP2022173308A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| PH12019500422A1 (en) | 2019-05-27 |
| RU2019109011A3 (enExample) | 2021-01-22 |
| AU2017318669A1 (en) | 2019-03-07 |
| MX2019002377A (es) | 2019-09-05 |
| CN109952383B (zh) | 2024-01-05 |
| CN109952383A (zh) | 2019-06-28 |
| JP7197915B2 (ja) | 2022-12-28 |
| BR112019003951A2 (pt) | 2019-06-25 |
| US11421280B2 (en) | 2022-08-23 |
| TW202313973A (zh) | 2023-04-01 |
| SG11201901762WA (en) | 2019-03-28 |
| US20230074781A1 (en) | 2023-03-09 |
| TWI771317B (zh) | 2022-07-21 |
| US20190233902A1 (en) | 2019-08-01 |
| TW201812125A (zh) | 2018-04-01 |
| JP2022173308A (ja) | 2022-11-18 |
| EP3507384B1 (en) | 2023-08-30 |
| JP2019528705A (ja) | 2019-10-17 |
| SG10201912134TA (en) | 2020-02-27 |
| KR20190046935A (ko) | 2019-05-07 |
| AU2017318669B2 (en) | 2023-04-20 |
| CA3035386A1 (en) | 2018-03-08 |
| WO2018045240A1 (en) | 2018-03-08 |
| EP3507384A1 (en) | 2019-07-10 |
| JP2020188816A (ja) | 2020-11-26 |
| JOP20190025A1 (ar) | 2019-02-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| RU2019109011A (ru) | Композиции и способы с использованием фармакогеномного маркера | |
| Wang et al. | Single cell sequencing: a distinct new field | |
| Reeser et al. | Validation of a targeted RNA sequencing assay for kinase fusion detection in solid tumors | |
| JP2019528705A5 (enExample) | ||
| US9862995B2 (en) | Measurement of nucleic acid variants using highly-multiplexed error-suppressed deep sequencing | |
| JP2021503943A5 (enExample) | ||
| US10100351B2 (en) | High-throughput sequencing detection method for methylated CpG islands | |
| US20140045706A1 (en) | Methods and systems for haplotype determination | |
| US20140017683A1 (en) | Method for single cell genome analysis and kit therefor | |
| JP2019520037A5 (enExample) | ||
| CN105274190A (zh) | 一种检测cyp3a4*1g和mdr1c1236t的基因多态性的hrm方法 | |
| US20160208240A1 (en) | Ngs workflow | |
| EP3105324B1 (en) | Ngs systems control and methods involving the same | |
| US20170137807A1 (en) | Improved ngs workflow | |
| Latini et al. | An overview of the use of SNaPshot for predicting blood group antigens | |
| RU2609641C1 (ru) | Способ анализа соматических мутаций в химерном гене BCR/ABL с использованием ОТ-ПЦР и последующей гибридизацией с олигонуклеотидным биологическим микрочипом (биочипом) | |
| Sa'adah et al. | A rapid, accurate and simple screening method for spinal muscular atrophy: high-resolution melting analysis using dried blood spots on filter paper | |
| Nguyen-Dumont et al. | Hi-Plex targeted sequencing is effective using DNA derived from archival dried blood spots | |
| KR101136008B1 (ko) | 옥사닌 염기를 포함한 라이게이션 단편서열을 이용한 리가제 기반 단일염기다형성 분석방법 및 그 단편서열을 포함하는 단일염기다형성 분석용 시스템 | |
| JP2005323565A (ja) | 標的ｄｎａ配列において一塩基変異多型の存在を検出する方法及びキット | |
| KR101700622B1 (ko) | 개의 품종 식별을 위한 dna 마커 및 이를 이용한 개 품종 식별방법 | |
| RU2695783C1 (ru) | Способ определения полиморфных маркеров в генах SLCO1B1, APOE и ABCB1 для определения индивидуальной чувствительности к статинам | |
| Diaz-Ortiz et al. | Testing for Allele-specific Expression from Human Brain Samples | |
| RU2509153C1 (ru) | Способ анализа транслокаций eml4-alk, ассоциированных с чувствительностью рака легкого к противоопухолевой таргетной терапии | |
| KR20140000734A (ko) | 비결합성 변형염기가 포함된 ｄｎａ 라이게이션 단편을 사용한 고효율의 리가아제 기반 ｓｎｐ분석 |