RU2019107165A - Гемостатические композиции и способы их получения - Google Patents
Гемостатические композиции и способы их получения Download PDFInfo
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- hemostatic composition
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- fibrinogen
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- A61L24/00—Surgical adhesives or cements; Adhesives for colostomy devices
- A61L24/04—Surgical adhesives or cements; Adhesives for colostomy devices containing macromolecular materials
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- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/363—Fibrinogen
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- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4833—Thrombin (3.4.21.5)
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- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
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- A61L24/106—Fibrin; Fibrinogen
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
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- C08—ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
- C08J—WORKING-UP; GENERAL PROCESSES OF COMPOUNDING; AFTER-TREATMENT NOT COVERED BY SUBCLASSES C08B, C08C, C08F, C08G or C08H
- C08J3/00—Processes of treating or compounding macromolecular substances
- C08J3/12—Powdering or granulating
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
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Claims (23)
1. Способ формирования порошкообразной гемостатической композиции, включающий этапы, на которых:
a) формируют суспензию смеси, содержащей частицы фибриногена, тромбина, волокон окисленной регенерированной целлюлозы (ОРЦ) в неводном растворителе с низкой температурой кипения;
b) распыляют суспензию через сопло на субстрат,
c) ожидают испарения неводного растворителя;
d) отделяют композицию от субстрата и просеивают композицию; и
формируют таким образом порошкообразную гемостатическую композицию.
2. Способ по п. 1, в котором указанный неводный растворитель с низкой температурой кипения представляет собой гидрофторэфир C4F9OCH3.
3. Способ по п. 1, в котором указанный неводный растворитель с низкой температурой кипения представляет собой HFE7100.
4. Способ по п. 1, в котором указанная суспензия дополнительно содержит трис.
5. Способ по п. 1, в котором указанная суспензия дополнительно содержит хлорид кальция.
6. Способ по п. 1, в котором указанная суспензия содержит порошок фибринового герметика, который содержит около 90% фибриногена, около 8% тромбина и около 2,5% (по массе) хлорида кальция.
7. Способ по п. 6, в котором указанная порошкообразная гемостатическая композиция имеет соотношение порошка фибринового герметика и ОРЦ от около 1:1 до около 10:1 по массе.
8. Способ по п. 1, в котором указанная порошкообразная гемостатическая композиция содержит порошок, имеющий размер частиц преимущественно в диапазоне от около 250 до около 850 мкм.
9. Способ по п. 8, в котором указанная порошкообразная гемостатическая композиция содержит порошок, имеющий размер частиц преимущественно в диапазоне от около 355 до около 850 мкм.
10. Способ по п. 1, в котором указанная порошкообразная гемостатическая композиция содержит по меньшей мере частично интегрированные агломерированные волокна ОРЦ, фибриноген и тромбин.
11. Гемостатическая композиция, содержащая по меньшей мере частично интегрированные агломерированные волокна ОРЦ, фибриноген и тромбин.
12. Гемостатическая композиция по п. 11, дополнительно содержащая трис.
13. Гемостатическая композиция по п. 11, дополнительно содержащая хлорид кальция.
14. Гемостатическая композиция по п. 11, содержащая порошок фибринового герметика, который содержит около 90% фибриногена, около 8% тромбина и около 2,5% (по массе) хлорида кальция.
15. Гемостатическая композиция по п. 14, имеющая соотношение порошка фибринового герметика и ОРЦ от около 1:1 до около 10:1 по массе.
16. Гемостатическая композиция по п. 11, содержащая порошок, имеющий размер частиц преимущественно в диапазоне от около 250 до около 850 мкм.
17. Гемостатическая композиция по п. 16, содержащая порошок, имеющий размер частиц преимущественно в диапазоне от около 355 до около 850 мкм.
18. Способ лечения раны путем нанесения гемостатической композиции по п. 11 на рану и/или в рану.
Applications Claiming Priority (5)
Application Number | Priority Date | Filing Date | Title |
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CN201610666290.2 | 2016-08-15 | ||
CN201610666290.2A CN107754005B (zh) | 2016-08-15 | 2016-08-15 | 止血组合物及其制造方法 |
US15/258,549 | 2016-09-07 | ||
US15/258,549 US11229720B2 (en) | 2016-08-15 | 2016-09-07 | Hemostatic compositions and methods of making thereof |
PCT/IB2017/054884 WO2018033835A1 (en) | 2016-08-15 | 2017-08-10 | Hemostatic compositions and methods of making thereof |
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RU2019107165A true RU2019107165A (ru) | 2020-09-15 |
RU2019107165A3 RU2019107165A3 (ru) | 2020-12-14 |
RU2756891C2 RU2756891C2 (ru) | 2021-10-06 |
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RU2019107165A RU2756891C2 (ru) | 2016-08-15 | 2017-08-10 | Гемостатические композиции и способы их получения |
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US (2) | US11229720B2 (ru) |
EP (2) | EP3496769B1 (ru) |
JP (1) | JP6968870B2 (ru) |
CN (1) | CN107754005B (ru) |
AU (1) | AU2017311658B2 (ru) |
BR (1) | BR112019003015B1 (ru) |
CA (1) | CA3033932A1 (ru) |
ES (1) | ES2831854T3 (ru) |
IL (1) | IL264613B (ru) |
MA (1) | MA53939A (ru) |
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CN108348633B (zh) | 2015-11-06 | 2022-07-08 | 伊西康公司 | 压实止血纤维素聚集体 |
US11413335B2 (en) * | 2018-02-13 | 2022-08-16 | Guangzhou Bioseal Biotech Co. Ltd | Hemostatic compositions and methods of making thereof |
CN107754005B (zh) | 2016-08-15 | 2021-06-15 | 广州倍绣生物技术有限公司 | 止血组合物及其制造方法 |
AU2018396037A1 (en) | 2017-12-29 | 2020-06-18 | Baxter Healthcare Sa | Spray-dried thrombin and methods of using and making spray-dried thrombin |
CN110732037B (zh) | 2018-07-20 | 2023-05-26 | 广州倍绣生物技术有限公司 | 止血糊剂及其制备方法 |
CN108926736A (zh) * | 2018-08-20 | 2018-12-04 | 北京化工大学 | 多糖基组织粘合医用胶及其应用 |
WO2021109979A1 (en) * | 2019-12-06 | 2021-06-10 | Guangzhou Bioseal Biotech Co., Ltd. | Flowable fibrinogen thrombin paste |
CN112972755B (zh) * | 2021-03-25 | 2022-07-05 | 哈尔滨瀚邦医疗科技有限公司 | 一种基于猪源纤维蛋白原和凝血酶的生物止血材料的制备方法 |
WO2023196787A2 (en) * | 2022-04-04 | 2023-10-12 | Vascudyne, Inc. | Improved constructed tissue |
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US2517772A (en) * | 1945-05-11 | 1950-08-08 | Parke Davis & Co | Neutralized oxidized cellulose products |
US3364200A (en) | 1960-03-28 | 1968-01-16 | Johnson & Johnson | Oxidized cellulose product and method for preparing the same |
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- 2016-09-07 US US15/258,549 patent/US11229720B2/en active Active
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2017
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- 2017-08-10 CA CA3033932A patent/CA3033932A1/en active Pending
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- 2017-08-10 RU RU2019107165A patent/RU2756891C2/ru active
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WO2018033835A1 (en) | 2018-02-22 |
BR112019003015B1 (pt) | 2022-10-11 |
ES2831854T3 (es) | 2021-06-09 |
MA53939A (fr) | 2021-09-15 |
RU2019107165A3 (ru) | 2020-12-14 |
IL264613B (en) | 2022-03-01 |
JP2019524348A (ja) | 2019-09-05 |
CN107754005B (zh) | 2021-06-15 |
AU2017311658B2 (en) | 2021-09-23 |
US20180043054A1 (en) | 2018-02-15 |
AU2017311658A1 (en) | 2019-02-07 |
BR112019003015A2 (pt) | 2019-05-14 |
CN107754005A (zh) | 2018-03-06 |
CA3033932A1 (en) | 2018-02-22 |
EP3766526A1 (en) | 2021-01-20 |
EP3496769B1 (en) | 2020-09-23 |
US11229720B2 (en) | 2022-01-25 |
EP3496769A1 (en) | 2019-06-19 |
JP6968870B2 (ja) | 2021-11-17 |
IL264613A (en) | 2019-02-28 |
RU2756891C2 (ru) | 2021-10-06 |
US20220096708A1 (en) | 2022-03-31 |
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