RU2018130117A - Композиции, полезные в предупреждении и/или лечении воспаления и боли - Google Patents
Композиции, полезные в предупреждении и/или лечении воспаления и боли Download PDFInfo
- Publication number
- RU2018130117A RU2018130117A RU2018130117A RU2018130117A RU2018130117A RU 2018130117 A RU2018130117 A RU 2018130117A RU 2018130117 A RU2018130117 A RU 2018130117A RU 2018130117 A RU2018130117 A RU 2018130117A RU 2018130117 A RU2018130117 A RU 2018130117A
- Authority
- RU
- Russia
- Prior art keywords
- extract
- zanthoxylum
- spp
- lipophilic
- curcumin
- Prior art date
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/12—Ketones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/28—Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/75—Rutaceae (Rue family)
- A61K36/758—Zanthoxylum, e.g. pricklyash
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9066—Curcuma, e.g. common turmeric, East Indian arrowroot or mango ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/906—Zingiberaceae (Ginger family)
- A61K36/9068—Zingiber, e.g. garden ginger
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/54—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic compound
- A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0014—Skin, i.e. galenical aspects of topical compositions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
Landscapes
- Health & Medical Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Mycology (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Alternative & Traditional Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Rheumatology (AREA)
- Molecular Biology (AREA)
- Physical Education & Sports Medicine (AREA)
- Pain & Pain Management (AREA)
- Biophysics (AREA)
- Dermatology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Immunology (AREA)
- Nutrition Science (AREA)
- Physiology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Plant Substances (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Claims (29)
1. Композиции, содержащие:
а) экстракт Curcuma longa, куркумин или комплекс куркумина с фосфолипидами;
б) липофильный экстракт Zingiber officinale; и
в) липофильный экстракт, полученный из растений, содержащих изобутиламиды полиненасыщенных жирных кислот, выбранный из группы, состоящей из экстракта Echinacea spp., экстракта Zanthoxylum spp. и экстракта Acmella oleracea (Spilanthes oleracea).
2. Композиции по п. 1, содержащие:
а) комплекс куркумина с фосфолипидами;
б) липофильный экстракт Zingiber officinale; и
в) липофильный экстракт Echinacea spp., Zanthoxylum spp. или Acmella oleracea (Spilanthes oleracea), предпочтительно экстракт Zanthoxylum spp., более предпочтительно экстракт Zanthoxylum bungeanum.
3. Композиции по п. 1 или 2, содержащие в стандартной дозе для перорального введения:
а) комплекс куркумина с фосфолипидами в количестве от 50 до 1000 мг,
б) липофильный экстракт Zingiber officinale в количестве от 10 до 80 мг,
в) липофильный экстракт Zanthoxylum spp. в количестве от 1 до 50 мг или, альтернативно, липофильный экстракт Echinacea spp. или Acmella oleracea (Spilanthes oleracea) в количестве от 5 до 50 мг.
4. Композиции по п. 3, содержащие в стандартной дозе для перорального введения:
а) 250 мг комплекса куркумина с фосфолипидами;
б) 50 мг липофильного экстракта Zingiber officinale; и
в) 10 мг липофильного экстракта Zanthoxylum spp.
5. Композиции по п. 1 или 2 для местного введения, содержащие:
а) комплекс куркумина с фосфолипидами в количестве от 0,1 до 0,5% масс/масс,
б) липофильный экстракт Zingiber officinale в количестве 0,5% масс/масс, и
в) липофильный экстракт Zanthoxylum spp. в количестве от 0,1 до 1% масс/масс, предпочтительно 0,5% масс/масс.
6. Композиции по п. 5, содержащие:
а) 0,05% масс/масс, комплекса куркумина с фосфолипидами,
б) 0,5% масс/масс, липофильного экстракта Zingiber officinale,
в) 0,5% масс/масс, липофильного экстракта Zanthoxylum spp.
7. Композиции по любому из пп. 1-3, где экстракт Echinacea spp. получен из Echinacea angustifolia или purpurea.
8. Композиции по любому из пп. 1-6, где экстракт Zanthoxylum spp. получен из Zanthoxylum bungeanum, Zanthoxylum piperitum или Zanthoxylum armatum.
9. Композиции по любому из пп. 1-8, где экстракт Zingiber officinale имеет содержание гингеролов и шогаолов в диапазоне от 20 до 30% масс/масс, предпочтительно 25% масс/масс.
10. Композиции по любому из пп. 1-9 для использования в предупреждении и/или лечении воспаления и боли.
11. Композиции для использования по п. 10, где воспаление и боль являются костно-суставными.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT102016000019244 | 2016-02-24 | ||
| ITUB2016A001030A ITUB20161030A1 (it) | 2016-02-24 | 2016-02-24 | Composizioni utili nella prevenzione e/o nel trattamento dell’infiammazione e del dolore |
| PCT/EP2017/053787 WO2017144411A1 (en) | 2016-02-24 | 2017-02-20 | Compositions useful in the prevention and/or treatment of inflammation and pain |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| RU2018130117A true RU2018130117A (ru) | 2020-03-25 |
| RU2018130117A3 RU2018130117A3 (ru) | 2020-05-12 |
| RU2752320C2 RU2752320C2 (ru) | 2021-07-26 |
Family
ID=56027067
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018130117A RU2752320C2 (ru) | 2016-02-24 | 2017-02-20 | Композиции, полезные в предупреждении и/или лечении воспаления и боли |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US11534472B2 (ru) |
| EP (1) | EP3419641B1 (ru) |
| JP (1) | JP7111617B2 (ru) |
| KR (1) | KR20180113538A (ru) |
| CN (1) | CN108697751B (ru) |
| AU (1) | AU2017222166B2 (ru) |
| BR (1) | BR112018016965B1 (ru) |
| CA (1) | CA3015119A1 (ru) |
| DK (1) | DK3419641T3 (ru) |
| ES (1) | ES2913094T3 (ru) |
| HU (1) | HUE058915T2 (ru) |
| IL (1) | IL261240B (ru) |
| IT (1) | ITUB20161030A1 (ru) |
| MX (1) | MX2018010060A (ru) |
| PL (1) | PL3419641T3 (ru) |
| PT (1) | PT3419641T (ru) |
| RU (1) | RU2752320C2 (ru) |
| SG (1) | SG11201807032PA (ru) |
| SI (1) | SI3419641T1 (ru) |
| WO (1) | WO2017144411A1 (ru) |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1031315A (zh) | 1988-09-13 | 1989-03-01 | 孙守连 | 调味汁制法 |
| DK0464298T3 (da) | 1990-07-05 | 1995-11-13 | Indena Spa | Echinacea-ekstrakter, fremgangsmåde til fremstilling deraf og formuleringer, der indeholder dem |
| ITMI981542A1 (it) | 1998-07-07 | 2000-01-07 | Indena Spa | Estratti di zanthoxylum bungeanum e loro formulazioni farmaceutiche e cosmetiche |
| CN101249256A (zh) | 2008-04-11 | 2008-08-27 | 李庭华 | 一种治疗重风湿性关节炎药剂的制配方法 |
| IT1401141B1 (it) * | 2010-07-26 | 2013-07-12 | Indena Spa | Formulazioni contenenti estratti di echinacea angustifolia e di zingiber officinale utili nella riduzione dell'infiammazione e del dolore periferico |
| US9088471B1 (en) * | 2014-02-19 | 2015-07-21 | Qualcomm Incorporated | Quadrature combining and adjusting |
| SG11201606831PA (en) * | 2014-02-20 | 2016-09-29 | Indena Spa | Compositions containing extracts of curcuma longa and echinacea angustifolia which are useful to reduce peripheral inflammation and pain |
| CN105012901A (zh) * | 2014-12-02 | 2015-11-04 | 陈方标 | 颈腰透骨消痛液搽剂 |
| CN104758451A (zh) * | 2015-04-28 | 2015-07-08 | 童长虹 | 一种治疗痛风的中药组合物 |
| CN104921053A (zh) * | 2015-07-06 | 2015-09-23 | 天宁香料（江苏）有限公司 | 一种鸡肉味调味香精的制备方法 |
| ITUA20164757A1 (it) * | 2016-06-29 | 2017-12-29 | Indena Spa | Composizioni utili nella prevenzione e/o nel trattamento dell’infiammazione e del dolore osteoarticolare e del danno cartilagineo |
-
2016
- 2016-02-24 IT ITUB2016A001030A patent/ITUB20161030A1/it unknown
-
2017
- 2017-02-20 MX MX2018010060A patent/MX2018010060A/es unknown
- 2017-02-20 US US15/999,727 patent/US11534472B2/en active Active
- 2017-02-20 AU AU2017222166A patent/AU2017222166B2/en active Active
- 2017-02-20 JP JP2018544083A patent/JP7111617B2/ja active Active
- 2017-02-20 SG SG11201807032PA patent/SG11201807032PA/en unknown
- 2017-02-20 WO PCT/EP2017/053787 patent/WO2017144411A1/en active Application Filing
- 2017-02-20 ES ES17708993T patent/ES2913094T3/es active Active
- 2017-02-20 PL PL17708993T patent/PL3419641T3/pl unknown
- 2017-02-20 CA CA3015119A patent/CA3015119A1/en active Pending
- 2017-02-20 SI SI201731144T patent/SI3419641T1/sl unknown
- 2017-02-20 KR KR1020187023946A patent/KR20180113538A/ko not_active Application Discontinuation
- 2017-02-20 BR BR112018016965-0A patent/BR112018016965B1/pt active IP Right Grant
- 2017-02-20 HU HUE17708993A patent/HUE058915T2/hu unknown
- 2017-02-20 EP EP17708993.5A patent/EP3419641B1/en active Active
- 2017-02-20 CN CN201780012244.3A patent/CN108697751B/zh active Active
- 2017-02-20 DK DK17708993.5T patent/DK3419641T3/da active
- 2017-02-20 RU RU2018130117A patent/RU2752320C2/ru active
- 2017-02-20 PT PT177089935T patent/PT3419641T/pt unknown
-
2018
- 2018-08-20 IL IL261240A patent/IL261240B/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US11534472B2 (en) | 2022-12-27 |
| AU2017222166B2 (en) | 2023-11-09 |
| BR112018016965B1 (pt) | 2022-10-25 |
| KR20180113538A (ko) | 2018-10-16 |
| RU2018130117A3 (ru) | 2020-05-12 |
| BR112018016965A2 (pt) | 2019-01-08 |
| CN108697751B (zh) | 2022-01-21 |
| EP3419641A1 (en) | 2019-01-02 |
| ITUB20161030A1 (it) | 2017-08-24 |
| EP3419641B1 (en) | 2022-04-06 |
| JP2019506421A (ja) | 2019-03-07 |
| PT3419641T (pt) | 2022-05-13 |
| WO2017144411A1 (en) | 2017-08-31 |
| CA3015119A1 (en) | 2017-08-31 |
| AU2017222166A1 (en) | 2018-09-06 |
| JP7111617B2 (ja) | 2022-08-02 |
| HUE058915T2 (hu) | 2022-09-28 |
| IL261240B (en) | 2022-05-01 |
| RU2752320C2 (ru) | 2021-07-26 |
| DK3419641T3 (da) | 2022-04-19 |
| CN108697751A (zh) | 2018-10-23 |
| PL3419641T3 (pl) | 2022-06-27 |
| SI3419641T1 (sl) | 2022-06-30 |
| SG11201807032PA (en) | 2018-09-27 |
| US20210205388A1 (en) | 2021-07-08 |
| IL261240A (en) | 2018-10-31 |
| MX2018010060A (es) | 2019-01-21 |
| ES2913094T3 (es) | 2022-05-31 |
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