JP2019506421A - 炎症および疼痛の予防および/または治療において有用な組成物 - Google Patents
炎症および疼痛の予防および/または治療において有用な組成物 Download PDFInfo
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- A61K36/185—Magnoliopsida (dicotyledons)
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- A—HUMAN NECESSITIES
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- A61K47/543—Lipids, e.g. triglycerides; Polyamines, e.g. spermine or spermidine
- A61K47/544—Phospholipids
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- A61K47/548—Phosphates or phosphonates, e.g. bone-seeking
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Abstract
Description
a)Curcuma longa、クルクミンまたはリン脂質複合クルクミンの抽出物、
b)Zingiber officinaleの親油性抽出物、および
c)Echinacea spp.の抽出物、Zanthoxylum spp.の抽出物およびAcmella oleracea(Spilanthes oleracea)の抽出物からなる群より選択される、ポリ不飽和脂肪酸のイソブチルアミドを含む植物から得られる親油性抽出物
を含む組成物に関する。
a)Curcuma longa、クルクミンまたはリン脂質複合クルクミンの抽出物、
b)Zingiber officinaleの親油性抽出物、および
c)Echinacea spp.の抽出物、Zanthoxylum spp.の抽出物およびAcmella oleracea(Spilanthes oleracea)の抽出物からなる群より選択される、ポリ不飽和脂肪酸のイソブチルアミドを含む植物から得られる親油性抽出物
を含む組成物に関する。
a)リン脂質複合クルクミン、
b)Zingiber officinaleの親油性抽出物、および
c)Echinacea spp.、Zanthoxylum spp.またはAcmella oleracea(Spilanthes oleracea)の親油性抽出物、好ましくはZanthoxylum spp.の抽出物、より好ましくはZanthoxylum bungeanumの抽出物
を含む。
a)リン脂質複合クルクミンの50〜1000mg、
b)Zingiber officinaleの親油性抽出物の10〜80mg、および
c)Zanthoxylum spp.の親油性抽出物の1〜50mg、あるいは、Echinacea spp.またはAcmella oleracea(Spilanthes oleracea)の親油性抽出物の5〜50mg
を含む。
a)リン脂質複合クルクミンの0.1〜0.5%w/w、
b)Zingiber officinaleの親油性抽出物の0.5%w/w、および
c)Zanthoxylum spp.の親油性抽出物の0.1〜1%w/w、好ましくは0.5%w/w
を含む。
a)Curcuma longa、クルクミンまたはリン脂質複合クルクミンの抽出物、
b)Zingiber officinaleの親油性抽出物、および
c)Echinacea spp.の抽出物、Zanthoxylum spp.の抽出物およびAcmella oleracea(Spilanthes oleracea)の抽出物からなる群より選択される、ポリ不飽和脂肪酸のイソブチルアミドを含む植物から得られる親油性抽出物
を含む組成物に関する。
Zingiber officinaleの親油性抽出物(ジンゲロール25%):50.00mg
Zanthoxylum bungeanumの抽出物: 15.00mg
イソブチルアミド中25%に標準化されたCO2で抽出
アマニ油: 適量〜600mg
Zanthoxylum piperitumの抽出物: 15.00mg
イソブチルアミド中25%に標準化されたCO2で抽出
Zingiber officinaleの抽出物(ジンゲロール25%): 50.00mg
アマニ油: 適量〜700mg
リン脂質複合クルクミン、Zingiber officinale抽出物およびZanthoxylum bungeanum抽出物を含む本発明による組成物の実施例1による鎮痛活性を、ラットにおいて別々に投与された個々の成分の鎮痛活性と、および本発明の実施例1に記載の組成物中と同じ量でリン脂質複合クルクミンおよびZanthoxylum bungeanum抽出物を含むWO2015/124616による組成物の鎮痛活性と比較した。
恒常的疼痛のある膝関節疾患に罹患している40人の患者を無作為化し、実施例1に従って1日2錠、朝に1錠および夕方に1錠、またはプラセボ(担体のみからなる)で処理した。
Claims (11)
- a)Curcuma longa、クルクミンまたはリン脂質複合クルクミンの抽出物、
b)Zingiber officinaleの親油性抽出物、および
c)Echinacea spp.の抽出物、Zanthoxylum spp.の抽出物およびAcmella oleracea(Spilanthes oleracea)の抽出物からなる群より選択される、ポリ不飽和脂肪酸のイソブチルアミドを含む植物から得られる親油性抽出物
を含む組成物。 - a)リン脂質複合クルクミン、
b)Zingiber officinaleの親油性抽出物、および
c)Echinacea spp.、Zanthoxylum spp.またはAcmella oleracea(Spilanthes oleracea)の親油性抽出物、好ましくはZanthoxylum spp.の抽出物、より好ましくはZanthoxylum bungeanumの抽出物
を含む、請求項1に記載の組成物。 - 経口投与のための単位用量当たり
a)リン脂質複合クルクミンの50〜1000mg、
b)Zingiber officinaleの親油性抽出物の10〜80mg、および
c)Zanthoxylum spp.の親油性抽出物の1〜50mg、あるいは、Echinacea spp.またはAcmella oleracea(Spilanthes oleracea)の親油性抽出物の5〜50mg
を含む、請求項1または2に記載の組成物。 - 経口投与のための単位用量当たり
a)リン脂質複合クルクミン250mg、
b)Zingiber officinaleの親油性抽出物50mg、および
c)Zanthoxylum spp.の親油性抽出物の10mg
を含む、請求項3に記載の組成物。 - a)リン脂質複合クルクミンの0.1〜0.5%w/w、
b)Zingiber officinaleの親油性抽出物の0.5%w/w、および
c)Zanthoxylum spp.の親油性抽出物の0.1〜1%w/w、好ましくは0.5%w/w
を含む、局所投与のための請求項1または2に記載の組成物。 - a)リン脂質複合クルクミン0.05%w/w、
b)Zingiber officinaleの親油性抽出物0.5%w/w、および
c)Zanthoxylum spp.の親油性抽出物の0.5%w/w
を含む、請求項5に記載の組成物。 - Echinacea spp.の抽出物がEchinacea angustifoliaまたはpurpureaから得られる、請求項1〜3のいずれか1項に記載の組成物。
- Zanthoxylum spp.の抽出物がZanthoxylum bungeanum、Zanthoxylum piperitumまたはZanthoxylum armatumから得られる、請求項1〜6のいずれか1項に記載の組成物。
- Zingiber officinaleのジンゲオールとショウガオールの含量が20〜30%w/w、好ましくは25%w/wである、請求項1〜8のいずれか1項に記載の組成物。
- 炎症および疼痛の予防および/または治療における使用のための、請求項1〜9のいずれか1項に記載の組成物。
- 炎症および疼痛が骨関節のものである、請求項10に記載の使用のための組成物。
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
ITUB2016A001030A ITUB20161030A1 (it) | 2016-02-24 | 2016-02-24 | Composizioni utili nella prevenzione e/o nel trattamento dell’infiammazione e del dolore |
IT102016000019244 | 2016-02-24 | ||
PCT/EP2017/053787 WO2017144411A1 (en) | 2016-02-24 | 2017-02-20 | Compositions useful in the prevention and/or treatment of inflammation and pain |
Publications (2)
Publication Number | Publication Date |
---|---|
JP2019506421A true JP2019506421A (ja) | 2019-03-07 |
JP7111617B2 JP7111617B2 (ja) | 2022-08-02 |
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Application Number | Title | Priority Date | Filing Date |
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JP2018544083A Active JP7111617B2 (ja) | 2016-02-24 | 2017-02-20 | 炎症および疼痛の予防および/または治療において有用な組成物 |
Country Status (20)
Country | Link |
---|---|
US (1) | US11534472B2 (ja) |
EP (1) | EP3419641B1 (ja) |
JP (1) | JP7111617B2 (ja) |
KR (1) | KR20180113538A (ja) |
CN (1) | CN108697751B (ja) |
AU (1) | AU2017222166B2 (ja) |
BR (1) | BR112018016965B1 (ja) |
CA (1) | CA3015119A1 (ja) |
DK (1) | DK3419641T3 (ja) |
ES (1) | ES2913094T3 (ja) |
HU (1) | HUE058915T2 (ja) |
IL (1) | IL261240B (ja) |
IT (1) | ITUB20161030A1 (ja) |
MX (1) | MX2018010060A (ja) |
PL (1) | PL3419641T3 (ja) |
PT (1) | PT3419641T (ja) |
RU (1) | RU2752320C2 (ja) |
SG (1) | SG11201807032PA (ja) |
SI (1) | SI3419641T1 (ja) |
WO (1) | WO2017144411A1 (ja) |
Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101249256A (zh) * | 2008-04-11 | 2008-08-27 | 李庭华 | 一种治疗重风湿性关节炎药剂的制配方法 |
JP2013532671A (ja) * | 2010-07-26 | 2013-08-19 | インデナ エッセ ピ ア | 炎症および末梢疼痛の低減に有用なエキナセア・アングスティフォリアおよびショウガの抽出物を含む製剤 |
CN104758451A (zh) * | 2015-04-28 | 2015-07-08 | 童长虹 | 一种治疗痛风的中药组合物 |
WO2015124616A1 (en) * | 2014-02-20 | 2015-08-27 | Indena S.P.A. | Compositions containing extracts of curcuma longa and echinacea angustifolia which are useful to reduce peripheral inflammation and pain |
Family Cites Families (7)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN1031315A (zh) | 1988-09-13 | 1989-03-01 | 孙守连 | 调味汁制法 |
ATE123947T1 (de) | 1990-07-05 | 1995-07-15 | Indena Spa | Echinacea-extrakte, verfahren zur herstellung und zubereitungen, die sie enthalten. |
ITMI981542A1 (it) | 1998-07-07 | 2000-01-07 | Indena Spa | Estratti di zanthoxylum bungeanum e loro formulazioni farmaceutiche e cosmetiche |
US9088471B1 (en) * | 2014-02-19 | 2015-07-21 | Qualcomm Incorporated | Quadrature combining and adjusting |
CN105012901A (zh) * | 2014-12-02 | 2015-11-04 | 陈方标 | 颈腰透骨消痛液搽剂 |
CN104921053A (zh) * | 2015-07-06 | 2015-09-23 | 天宁香料(江苏)有限公司 | 一种鸡肉味调味香精的制备方法 |
ITUA20164757A1 (it) * | 2016-06-29 | 2017-12-29 | Indena Spa | Composizioni utili nella prevenzione e/o nel trattamento dell’infiammazione e del dolore osteoarticolare e del danno cartilagineo |
-
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- 2017-02-20 ES ES17708993T patent/ES2913094T3/es active Active
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- 2017-02-20 CN CN201780012244.3A patent/CN108697751B/zh active Active
- 2017-02-20 US US15/999,727 patent/US11534472B2/en active Active
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- 2017-02-20 MX MX2018010060A patent/MX2018010060A/es unknown
- 2017-02-20 SG SG11201807032PA patent/SG11201807032PA/en unknown
- 2017-02-20 HU HUE17708993A patent/HUE058915T2/hu unknown
- 2017-02-20 KR KR1020187023946A patent/KR20180113538A/ko active Search and Examination
- 2017-02-20 WO PCT/EP2017/053787 patent/WO2017144411A1/en active Application Filing
- 2017-02-20 SI SI201731144T patent/SI3419641T1/sl unknown
- 2017-02-20 BR BR112018016965-0A patent/BR112018016965B1/pt active IP Right Grant
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- 2017-02-20 RU RU2018130117A patent/RU2752320C2/ru active
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Patent Citations (4)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
CN101249256A (zh) * | 2008-04-11 | 2008-08-27 | 李庭华 | 一种治疗重风湿性关节炎药剂的制配方法 |
JP2013532671A (ja) * | 2010-07-26 | 2013-08-19 | インデナ エッセ ピ ア | 炎症および末梢疼痛の低減に有用なエキナセア・アングスティフォリアおよびショウガの抽出物を含む製剤 |
WO2015124616A1 (en) * | 2014-02-20 | 2015-08-27 | Indena S.P.A. | Compositions containing extracts of curcuma longa and echinacea angustifolia which are useful to reduce peripheral inflammation and pain |
CN104758451A (zh) * | 2015-04-28 | 2015-07-08 | 童长虹 | 一种治疗痛风的中药组合物 |
Non-Patent Citations (1)
Title |
---|
ARTHRITIS RHEUM, vol. 44, no. 11, JPN6020048032, 2001, pages 2531 - 2538, ISSN: 0004561933 * |
Also Published As
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AU2017222166A1 (en) | 2018-09-06 |
US20210205388A1 (en) | 2021-07-08 |
AU2017222166B2 (en) | 2023-11-09 |
CN108697751B (zh) | 2022-01-21 |
JP7111617B2 (ja) | 2022-08-02 |
BR112018016965B1 (pt) | 2022-10-25 |
SI3419641T1 (sl) | 2022-06-30 |
EP3419641A1 (en) | 2019-01-02 |
ITUB20161030A1 (it) | 2017-08-24 |
IL261240B (en) | 2022-05-01 |
RU2018130117A3 (ja) | 2020-05-12 |
PT3419641T (pt) | 2022-05-13 |
BR112018016965A2 (pt) | 2019-01-08 |
EP3419641B1 (en) | 2022-04-06 |
RU2018130117A (ru) | 2020-03-25 |
ES2913094T3 (es) | 2022-05-31 |
IL261240A (en) | 2018-10-31 |
PL3419641T3 (pl) | 2022-06-27 |
DK3419641T3 (da) | 2022-04-19 |
SG11201807032PA (en) | 2018-09-27 |
CN108697751A (zh) | 2018-10-23 |
CA3015119A1 (en) | 2017-08-31 |
KR20180113538A (ko) | 2018-10-16 |
US11534472B2 (en) | 2022-12-27 |
WO2017144411A1 (en) | 2017-08-31 |
RU2752320C2 (ru) | 2021-07-26 |
HUE058915T2 (hu) | 2022-09-28 |
MX2018010060A (es) | 2019-01-21 |
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