RU2018125423A - Method for initiating the death of tumor cells with sodium salts of chlorin-e6, chlorin-p6 and purpurin-5 and HF and microwave energy of wave radiation - Google Patents

Method for initiating the death of tumor cells with sodium salts of chlorin-e6, chlorin-p6 and purpurin-5 and HF and microwave energy of wave radiation Download PDF

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RU2018125423A
RU2018125423A RU2018125423A RU2018125423A RU2018125423A RU 2018125423 A RU2018125423 A RU 2018125423A RU 2018125423 A RU2018125423 A RU 2018125423A RU 2018125423 A RU2018125423 A RU 2018125423A RU 2018125423 A RU2018125423 A RU 2018125423A
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chlorin
mhz
tumor
purpurin
radachlorin
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RU2018125423A
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RU2724326C2 (en
RU2018125423A3 (en
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Николай Васильевич Цугленок
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Николай Васильевич Цугленок
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/587—Unsaturated compounds containing a keto groups being part of a ring
    • C07C49/703—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups
    • C07C49/747—Unsaturated compounds containing a keto groups being part of a ring containing hydroxy groups containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
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  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Epidemiology (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (2)

1. Способ инициации гибели опухолевых клеток, включающий насыщение опухолевых клеток растворами натриевых солей хлорина-е6, хлорина-р6 и пурпурина-5 препарата "Радахлорин", вводимых внутривенно, или перорально, человеку 0,5-2,4 мг/кг веса для его максимального накопления в опухолевых тканях в 3-4 раза выше, чем в здоровых, и течение 0,5-5 ч после введения препарата, отличающийся тем, что в течение 3-х дней до лечения человек переводится на белковую диету с последующим внутривенным введением высокопроводящего электронно-ионного раствора натриевых солей хлорина-е6, хлорина-р6 и пурпурина-5 препарата "Радахлорин" в одноразовой мегадозае 2,5 мг/кг веса для максимального увеличения разницы электропроводности и диэлектрических потерь «голодных» опухолевых и здоровых тканей и через 5 ч после введения препарата "Радахлорин" проводится ВЧ и СВЧ гипертермия опухолевых тканей электромагнитной энергией фотоволнового излучения со скоростью нагрева опухолевых тканей 0,054°С/сек, за 180 сек до температуры 46,3°С, и нагреве здоровых тканей не превышающих 40°С.1. The method of initiating the death of tumor cells, including the saturation of tumor cells with solutions of sodium salts of chlorin-e 6 , chlorin-p 6 and purpurin-5 of the drug "Radachlorin", administered intravenously or orally, to a person 0.5-2.4 mg / kg the weight for its maximum accumulation in tumor tissues is 3-4 times higher than in healthy tissues, and for 0.5-5 hours after administration of the drug, characterized in that within 3 days before treatment, the person is transferred to a protein diet followed by intravenous administration of a highly conductive electron-ionic solution of sodium Olay-chlorin e 6-chlorin p 6 and purpurin 5 preparation "Radachlorin" in disposable megadozae 2.5 mg / kg to maximize the difference of electrical conductivity and the dielectric loss "hungry" tumor and healthy tissue and 5 hours after drug administration "Radachlorin" is performed by RF and microwave hyperthermia of tumor tissues with electromagnetic energy of photo-wave radiation at a rate of heating of tumor tissues of 0.054 ° C / sec, 180 seconds to a temperature of 46.3 ° C, and heating of healthy tissues not exceeding 40 ° C. 2. Способ по п. 1, отличающийся тем, что нагрев и гипертермия опухолевых тканей, насыщенных раствором натриевых солей хлорина-е6, хлорина-р6 и пурпурина-5 препарата "Радахлорин", производится ВЧ и СВЧ энергией фотоволнового излучения, в соответствии с глубиной проникновения электромагнитной волны и с глубиной расположения опухолевых тканей, на разрешенных частотах f=13,56 МГц - 1100 см; f=27 МГц - 545 см; f=40,68 МГц - 370 см; f=433,92 МГц - 34,5 см; f=915 МГц - 16,5 см и f=2450 МГц - 6,1 см.2. The method according to p. 1, characterized in that the heating and hyperthermia of the tumor tissues saturated with a solution of sodium salts of chlorin-e 6 , chlorin-p 6 and purpurin-5 of the drug "Radachlorin" is produced by the RF and microwave energy of the photo-wave radiation, in accordance with the penetration depth of the electromagnetic wave and with the depth of the location of the tumor tissue, at the allowed frequencies f = 13.56 MHz - 1100 cm; f = 27 MHz - 545 cm; f = 40.68 MHz - 370 cm; f = 433.92 MHz - 34.5 cm; f = 915 MHz - 16.5 cm and f = 2450 MHz - 6.1 cm.
RU2018125423A 2018-07-10 2018-07-10 Method for initiating the death of tumor cells with sodium salts of chlorine-e6, chlorine-p6 and purpurin-5 and hf and microwave radiation with wave radiation energy RU2724326C2 (en)

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RU2018125423A RU2724326C2 (en) 2018-07-10 2018-07-10 Method for initiating the death of tumor cells with sodium salts of chlorine-e6, chlorine-p6 and purpurin-5 and hf and microwave radiation with wave radiation energy

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RU2018125423A RU2724326C2 (en) 2018-07-10 2018-07-10 Method for initiating the death of tumor cells with sodium salts of chlorine-e6, chlorine-p6 and purpurin-5 and hf and microwave radiation with wave radiation energy

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RU2018125423A3 RU2018125423A3 (en) 2020-01-13
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US4622952A (en) * 1983-01-13 1986-11-18 Gordon Robert T Cancer treatment method
RU2106159C1 (en) * 1996-09-27 1998-03-10 Сергей Львович Загускин Method for selectively destroying cancer tumor cells
RU2174021C1 (en) * 2000-02-14 2001-09-27 Шаталин Иван Александрович Method for treating tumors
RU2006113533A (en) * 2006-04-21 2007-11-20 Валерий Иванович Чиссов (RU) METHOD FOR DESTRUCTION OF BIOTABLES AND DEVICE FOR ITS IMPLEMENTATION
CN105232148A (en) * 2007-09-14 2016-01-13 拉热尔技术有限公司 Prostate cancer ablation
RU2440158C2 (en) * 2010-02-25 2012-01-20 Юрий Александрович Белый Method of photodynamic therapy of subjects with malignant tumours

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Effective date: 20200711