RU2018125399A - Method for initiating the death of tumor cells with hydroside 3-aminophthalic acid and HF and microwave energy of wave radiation - Google Patents

Method for initiating the death of tumor cells with hydroside 3-aminophthalic acid and HF and microwave energy of wave radiation Download PDF

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RU2018125399A
RU2018125399A RU2018125399A RU2018125399A RU2018125399A RU 2018125399 A RU2018125399 A RU 2018125399A RU 2018125399 A RU2018125399 A RU 2018125399A RU 2018125399 A RU2018125399 A RU 2018125399A RU 2018125399 A RU2018125399 A RU 2018125399A
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mhz
aminophthalic acid
microwave energy
tumor
acid hydrazide
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RU2018125399A
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Russian (ru)
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RU2723488C2 (en
RU2018125399A3 (en
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Николай Васильевич Цугленок
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Николай Васильевич Цугленок
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/50—Pyridazines; Hydrogenated pyridazines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D237/00—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings
    • C07D237/26—Heterocyclic compounds containing 1,2-diazine or hydrogenated 1,2-diazine rings condensed with carbocyclic rings or ring systems
    • C07D237/30—Phthalazines
    • C07D237/32—Phthalazines with oxygen atoms directly attached to carbon atoms of the nitrogen-containing ring

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Otolaryngology (AREA)
  • Electromagnetism (AREA)
  • Physics & Mathematics (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pathology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Claims (2)

1. Способ инициации гибели опухолевых клеток ВЧ и СВЧ энергией, включающий предварительное насыщение опухолевых клеток раствором гидразида 3-аминофталевой кислоты внутривенно в дозе 20-30 мг на кг веса человека препарата "Галавит", вводимой внутривенно или в дозе 200 мг перорально для его накопления в опухолевых тканях, через 6-8 ч после введения препарата, с разницей в 3-6 раз выше, чем в здоровых, отличающийся тем, что перед введением препарата человек предварительно переводится на безуглеводную диету в течение 3-х дней, для создания глюкозного "голодания" онкоклеток и максимального насыщения онкоклеток высокоэлектропроводящим электронно-ионным раствором гидразида 3-аминофталевой кислоты для внутривенного введения в мегадозе 31 мг на кг веса человека или перорального приема 300 мг гидразида 3-аминофталевой кислоты препарата "Галавит" и по истечении 8 ч после приема 3-аминофталевой кислоты, проводится избирательная гипертермия опухолевых тканей ВЧ и СВЧ энергией фотоволнового излучения, со скоростью нагрева опухолевых тканей 0,07°С/сек, за 204 сек до температуры 51°С, и нагреве здоровых тканей до 40°С.1. A method for initiating the death of tumor cells by HF and microwave energy, including pre-saturation of tumor cells with a solution of 3-aminophthalic acid hydrazide intravenously at a dose of 20-30 mg per kg of human weight of the Galavit preparation, administered intravenously or at a dose of 200 mg orally for its accumulation in tumor tissues, 6-8 hours after administration of the drug, with a difference of 3-6 times higher than in healthy ones, characterized in that before the introduction of the drug, a person is preliminarily transferred to a carbohydrate-free diet for 3 days to create glucose cooling of cancer cells and maximum saturation of cancer cells with a highly conductive electron-ionic solution of 3-aminophthalic acid hydrazide for intravenous administration in a megadose of 31 mg per kg of human weight or oral administration of 300 mg of Galavit 3-aminophthalic acid hydrazide and after 8 hours after taking 3 -aminophthalic acid, selective hyperthermia of the tumor tissues of the HF and microwave energy of the photo-wave radiation is carried out, with the rate of heating of the tumor tissue of 0.07 ° C / s, 204 seconds to a temperature of 51 ° C, and heating is healthy x fabrics up to 40 ° С. 2. Способ по п. 1, отличающийся тем, что нагрев и гипертермия опухолевых тканей, насыщенных раствором гидразида 3-аминофталевой кислоты препарата "Галавит", производится ВЧ и СВЧ энергией волнового излучения, в соответствии с глубиной проникновения электромагнитной волны в ткани человека и с глубиной расположения в них опухолевых тканей, на разрешенных частотах f=13,56 МГц-1100 см; f=27 МГц-545 см; f=40,68 МГц-370 см; f=433,92 МГц-34,5 см; f=915 МГц-16,5 см и f=2450 МГц-6,1 см.2. The method according to p. 1, characterized in that the heating and hyperthermia of tumor tissues saturated with a solution of 3-aminophthalic acid hydrazide of the drug "Galavit" is produced by the RF and microwave energy of the wave radiation, in accordance with the depth of penetration of the electromagnetic wave into human tissue and the depth of the location of tumor tissues in them, at the allowed frequencies f = 13.56 MHz-1100 cm; f = 27 MHz-545 cm; f = 40.68 MHz-370 cm; f = 433.92 MHz-34.5 cm; f = 915 MHz-16.5 cm and f = 2450 MHz-6.1 cm.
RU2018125399A 2018-07-10 2018-07-10 Method for initiation of tumor cell death with 3-aminophthalic acid hydrobromide and hf and uhf wave radiation energy RU2723488C2 (en)

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RU2018125399A RU2723488C2 (en) 2018-07-10 2018-07-10 Method for initiation of tumor cell death with 3-aminophthalic acid hydrobromide and hf and uhf wave radiation energy

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RU2018125399A RU2723488C2 (en) 2018-07-10 2018-07-10 Method for initiation of tumor cell death with 3-aminophthalic acid hydrobromide and hf and uhf wave radiation energy

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RU2018125399A3 RU2018125399A3 (en) 2020-01-13
RU2723488C2 RU2723488C2 (en) 2020-06-11

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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4106488A (en) * 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
RU2106159C1 (en) * 1996-09-27 1998-03-10 Сергей Львович Загускин Method for selectively destroying cancer tumor cells
RU2134598C1 (en) * 1997-09-29 1999-08-20 Мельников Виталий Максимович Method for treatment of tumors and virus diseases
RU2174021C1 (en) * 2000-02-14 2001-09-27 Шаталин Иван Александрович Method for treating tumors
RU2468447C1 (en) * 2011-06-27 2012-11-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "РНИОИ" Минздравсоцразвития России) Method of inducing cytological action on tumour cells

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RU2018125399A3 (en) 2020-01-13

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Effective date: 20200711