RU2018126429A - Method for initiating the death of tumor cells with the hematoporpherin sodium salt, ascorbic acid and HF and microwave wave radiation energy - Google Patents

Method for initiating the death of tumor cells with the hematoporpherin sodium salt, ascorbic acid and HF and microwave wave radiation energy Download PDF

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Publication number
RU2018126429A
RU2018126429A RU2018126429A RU2018126429A RU2018126429A RU 2018126429 A RU2018126429 A RU 2018126429A RU 2018126429 A RU2018126429 A RU 2018126429A RU 2018126429 A RU2018126429 A RU 2018126429A RU 2018126429 A RU2018126429 A RU 2018126429A
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Prior art keywords
tumor
mhz
hematoporpherin
ascorbic acid
sodium salt
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RU2018126429A
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Russian (ru)
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RU2726610C2 (en
RU2018126429A3 (en
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Николай Васильевич Цугленок
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Николай Васильевич Цугленок
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

Claims (2)

1. Способ инициации гибели опухолевых клеток ВЧ и СВЧ энергией, включающий предварительное насыщение опухолевых клеток растворами натриевой соли гематопорферина 2-3 мг/кг и аскорбиновой кислотой 200-300 мг/кг массы тела, принимаемых внутрь человеком, для его максимального накопления в опухолевых тканях, соответственно, через 48-72 и 0,5-4 часа после приема, в 8-10 раз и до 50 раз выше, чем в здоровых, отличающийся тем, что в течение 3-х дней до лечения человек переводится на белковую диету, для максимального увеличения избирательного накопления в «голодных» опухолевых тканях высокоэлектропроводящих растворов натриевой соли гематопорферина и аскорбиновой кислотой принимается внутривенно одноразовая мегадоза 3,2 мг натриевой соли гематопорферина препарата «Фотогем» и перорально мегадоза 500 мг аскорбиновой кислоты, для многократного увеличения электропроводности и диэлектрических потерь опухолевых и здоровых тканей, и по истечении 72 часов после приема препарата «Фотогем» и приема АК за 4 часа до обработки проводится избирательная ВЧ и СВЧ электромагнитная гипертермия опухолевых тканей энергией фотоволновым излучением, со скоростью нагрева опухолевых тканей 0,010°С/сек, в течение 216 сек до температуры опухолевых тканей 58°С, при нагреве здоровых тканей не выше 40°С.1. A method for initiating the death of tumor cells by HF and microwave energy, including pre-saturation of tumor cells with hematoporpherin sodium salt solutions of 2-3 mg / kg and ascorbic acid 200-300 mg / kg of body weight taken internally by a person for its maximum accumulation in tumor tissues , respectively, after 48-72 and 0.5-4 hours after administration, 8-10 times and up to 50 times higher than in healthy ones, characterized in that within 3 days before treatment the person is transferred to a protein diet, to maximize selective accumulation in “hunger” In the tumor tissues of highly electroconductive solutions of hematoporpherin sodium salt and ascorbic acid, a single-dose megadose of 3.2 mg Photogem sodium hematoporpherin sodium and 500 mg of ascorbic acid oral megadose is taken to increase the electrical conductivity and dielectric loss of tumor and healthy tissues, and 72 hours after taking Photogem and taking AK 4 hours before treatment, selective HF and microwave electromagnetic hyperthermia of tumor tissue is performed s fotovolnovym energy radiation from tumor tissue heating rate of 0.010 ° C / sec for 216 sec to tumor tissue temperature 58 ° C, during heating of healthy tissue below 40 ° C. 2. Способ по п. 1, отличающийся тем, что нагрев и гипертермия опухолевых тканей, насыщенных растворами натриевой соли гематопорферина препарата "Фотогем" и АК производится ВЧ и СВЧ энергией волнового излучения, в соответствии с частотой, с глубиной проникновения электромагнитной волны в тело человека и с глубиной расположения в нем опухолевых тканей, на разрешенных частотах f=13,56 МГц - 1100 см, f=27 МГц - 545 см, f=40,68 МГц - 370 см, f=433,92 МГц - 34,5 см, f=915 МГц - 16,5 см и f=2450 МГц - 6,1 см.2. The method according to p. 1, characterized in that the heating and hyperthermia of the tumor tissues saturated with solutions of the hematoporphyrin sodium salt of the drug Photogem and AK is produced by the RF and microwave energy of the wave radiation, in accordance with the frequency, with the depth of penetration of the electromagnetic wave into the human body and with the depth of the location of tumor tissues in it, at the allowed frequencies f = 13.56 MHz - 1100 cm, f = 27 MHz - 545 cm, f = 40.68 MHz - 370 cm, f = 433.92 MHz - 34.5 cm, f = 915 MHz - 16.5 cm and f = 2450 MHz - 6.1 cm.
RU2018126429A 2018-07-17 2018-07-17 Method for initiation of tumour cell death by sodium salt of hematoporphyrin, ascorbic acid and hf and microwave energy wave radiation RU2726610C2 (en)

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RU2018126429A RU2726610C2 (en) 2018-07-17 2018-07-17 Method for initiation of tumour cell death by sodium salt of hematoporphyrin, ascorbic acid and hf and microwave energy wave radiation

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RU2018126429A RU2726610C2 (en) 2018-07-17 2018-07-17 Method for initiation of tumour cell death by sodium salt of hematoporphyrin, ascorbic acid and hf and microwave energy wave radiation

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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4106488A (en) * 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
RU2106159C1 (en) * 1996-09-27 1998-03-10 Сергей Львович Загускин Method for selectively destroying cancer tumor cells
RU2134598C1 (en) * 1997-09-29 1999-08-20 Мельников Виталий Максимович Method for treatment of tumors and virus diseases
RU2174021C1 (en) * 2000-02-14 2001-09-27 Шаталин Иван Александрович Method for treating tumors
RU2468447C1 (en) * 2011-06-27 2012-11-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "РНИОИ" Минздравсоцразвития России) Method of inducing cytological action on tumour cells

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Effective date: 20200718