RU2018125401A - Method for initiating the death of tumor cells with succinic acid and HF and microwave energy of wave radiation - Google Patents

Method for initiating the death of tumor cells with succinic acid and HF and microwave energy of wave radiation Download PDF

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RU2018125401A
RU2018125401A RU2018125401A RU2018125401A RU2018125401A RU 2018125401 A RU2018125401 A RU 2018125401A RU 2018125401 A RU2018125401 A RU 2018125401A RU 2018125401 A RU2018125401 A RU 2018125401A RU 2018125401 A RU2018125401 A RU 2018125401A
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succinic acid
mhz
tumor
person
microwave energy
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RU2018125401A
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Russian (ru)
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RU2018125401A3 (en
RU2739196C2 (en
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Николай Васильевич Цугленок
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Николай Васильевич Цугленок
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A61N5/02—Radiation therapy using microwaves

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Pathology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Radiology & Medical Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Radiation-Therapy Devices (AREA)

Claims (2)

1. Способ инициации гибели опухолевых клеток ВЧ и СВЧ энергией, включающий прием раствора янтарной кислоты человеком перорально до 2400 мг растворенной в 50-200 мл воды, для максимального накопления янтарной кислоты в опухолевых тканях в 3-4 раза выше чем в здоровых в течение 0,5-2,5 часов после приема, отличающийся тем, что в течение 3-х дней до лечения человек переводится на безуглеводную диету, для создания глюкозного "голодания" онкоклеток и для максимального многократного разделения электрофизических свойств увеличения электропроводности и диэлектрических потерь в опухолевых тканях в сравнении со здоровыми, человеком принимается перорально одноразовая мегадоза 3000 мг янтарной кислоты, и после 2,5 часов после приема проводится ВЧ и СВЧ избирательная гипертермия опухолевых тканей энергией фотоволнового излучения, насыщенных высоэлектропроводящими электронно-ионными растворами янтарной кислоты, со скоростью нагрева опухолевых тканей 0,03°С/сек, в течение 300 сек до температуры опухолевых тканей 45°С и здоровых тканей не выше 40°С.1. A method for initiating the death of tumor cells by HF and microwave energy, including taking a solution of succinic acid by a person orally up to 2400 mg of water dissolved in 50-200 ml, to maximize the accumulation of succinic acid in tumor tissues 3-4 times higher than in healthy tissue during 0 , 5-2.5 hours after administration, characterized in that within 3 days before treatment the person is transferred to a carbohydrate-free diet to create glucose “starvation” of cancer cells and to maximize multiple separation of the electrophysical properties of increasing electrical conductivity and electrical losses in tumor tissues in comparison with healthy ones, a person is taken orally a one-time megadose of 3000 mg of succinic acid, and after 2.5 hours after administration, RF and microwave selective hyperthermia of the tumor tissue with photovoltaic energy saturated with high-conductive electron-ionic solutions of succinic acid is performed the heating rate of the tumor tissue is 0.03 ° C / s, for 300 seconds to a temperature of the tumor tissue of 45 ° C and healthy tissue is not higher than 40 ° C. 2. Способ по п. 1, отличающийся тем, что нагрев и гипертермия опухолевых тканей, насыщенных раствором янтарной кислоты, одновременно производится ВЧ и СВЧ энергией волнового излучения, в соответствии с глубиной проникновения электромагнитной волны в биологические ткани и с глубиной расположения опухолевых тканей в теле человека, на разрешенных частотах f=13,56 МГц - 1100 см, f=27 МГц - 545 см, f=40,68 МГц - 370 см, f=433,92 МГц - 34,5 см, f=915 МГц - 16,5 см и f=2450 МГц - 6,1 см.2. The method according to p. 1, characterized in that the heating and hyperthermia of the tumor tissues saturated with succinic acid solution is simultaneously produced by the HF and microwave energy of the wave radiation, in accordance with the depth of penetration of the electromagnetic wave into biological tissues and with the depth of the location of the tumor tissue in the body person, at the allowed frequencies f = 13.56 MHz - 1100 cm, f = 27 MHz - 545 cm, f = 40.68 MHz - 370 cm, f = 433.92 MHz - 34.5 cm, f = 915 MHz - 16.5 cm and f = 2450 MHz - 6.1 cm.
RU2018125401A 2018-07-10 2018-07-10 Method for initiating death of tumor cells with succinic acid and hf- and uhf energy of wave radiation RU2739196C2 (en)

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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023197901A1 (en) * 2022-04-11 2023-10-19 华中科技大学 Tumor cell-derived microparticle loaded with succinic acid, preparation method therefor, and use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2414936C1 (en) * 2009-08-06 2011-03-27 Учреждение Российской академии медицинских наук Российский онкологический научный центр имени Н.Н. Блохина РАМН Method of treating rectal cancer
RU2477641C1 (en) * 2011-09-30 2013-03-20 Учреждение Российской академии медицинских наук Российский онкологический научный центр имени Н.Н. Блохина РАМН Method of treating rectal cancer
WO2016196719A2 (en) * 2015-06-02 2016-12-08 The Secant Group, Llc Hyperthermia targeting compositions, devices, and methods for cancer therapy
WO2016209936A1 (en) * 2015-06-22 2016-12-29 Duke University Synergistic nanotherapy systems and methods of use thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2023197901A1 (en) * 2022-04-11 2023-10-19 华中科技大学 Tumor cell-derived microparticle loaded with succinic acid, preparation method therefor, and use thereof

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RU2739196C2 (en) 2020-12-21

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Effective date: 20201228