RU2018125428A - Method for initiating the death of tumor cells with sodium salts of Chlorin-e6 and HF and microwave energy of wave radiation - Google Patents

Method for initiating the death of tumor cells with sodium salts of Chlorin-e6 and HF and microwave energy of wave radiation Download PDF

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RU2018125428A
RU2018125428A RU2018125428A RU2018125428A RU2018125428A RU 2018125428 A RU2018125428 A RU 2018125428A RU 2018125428 A RU2018125428 A RU 2018125428A RU 2018125428 A RU2018125428 A RU 2018125428A RU 2018125428 A RU2018125428 A RU 2018125428A
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mhz
tumor
chlorin
sodium salts
administration
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RU2018125428A
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RU2724327C2 (en
RU2018125428A3 (en
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Николай Васильевич Цугленок
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Николай Васильевич Цугленок
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
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  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Radiology & Medical Imaging (AREA)
  • Otolaryngology (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Molecular Biology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Radiation-Therapy Devices (AREA)
  • Medical Informatics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (2)

1. Способ инициации гибели опухолевых клеток, включающий насыщение опухолевых клеток раствором натриевых солей Хлорина-е6, вводимых внутривенно человеку 50-115 мг/кг веса для его максимального накопления в опухолевых тканях, после приема в 8-10 раз выше, чем в здоровых тканях через 3-5 ч после введения препарата, отличающийся тем, что в течение 3-х дней до лечения человек переводится на белковую диету с последующим внутривенным введением высокопроводящего электронно-ионного раствора натриевых солей Хлорина-е6 в мегадозе 120 мг/кг веса для максимального усиления разницы электропроводности и диэлектрических потерь для голодных опухолевых и здоровых тканей и через 5 ч после введения препарата "Хлорин-е6" проводится ВЧ и СВЧ гипертермия опухолевых тканей фотоэлектромагнитной энергией фотоволнового излучения со скоростью нагрева опухолевых тканей 0,037°С/сек, за 240 сек до температуры 45,5°С, и нагреве здоровых тканей не превышающих 40°С.1. The method of initiating the death of tumor cells, including saturation of tumor cells with a solution of sodium salts of Chlorin-e 6 , administered intravenously to humans 50-115 mg / kg of body weight for its maximum accumulation in tumor tissues, after administration is 8-10 times higher than in healthy 3-5 hours after administration of the drug, characterized in that within 3 days before treatment, the person is transferred to a protein diet followed by intravenous administration of a highly conductive electron-ionic solution of sodium salts of Chlorin-e 6 in a megadose of 120 mg / kg weight for Maksim ceiling elements gain difference of electrical conductivity and dielectric loss for starving the tumor and healthy tissues and 5 hours after drug administration "Chlorine-e 6" is held RF and microwave hyperthermia tumor tissues photoelectromagnetic energy fotovolnovogo radiation from tumor tissue heating rate of 0,037 ° C / sec, 240 sec to a temperature of 45.5 ° C, and heating of healthy tissues not exceeding 40 ° C. 2. Способ по п. 1, отличающийся тем, что нагрев и гипертермия опухолевых тканей, насыщенных раствором натриевых солей Хлорина-е6, производится ВЧ и СВЧ энергией волнового излучения, в соответствии с глубиной проникновения электромагнитной волны и с глубиной расположения опухолевых тканей, на разрешенных частотах: f=13,56 МГц - 1100 см; f=27 МГц - 545 см; f=40,68 МГц - 370 см; f=433,92 МГц - 34,5 см; f=915 МГц - 16,5 см и f=2450 МГц - 6,1 см.2. The method according to p. 1, characterized in that the heating and hyperthermia of the tumor tissues saturated with a solution of sodium salts of Chlorin-e 6 is produced by the HF and microwave energy of the wave radiation, in accordance with the depth of penetration of the electromagnetic wave and with the depth of the location of the tumor tissue, allowed frequencies: f = 13.56 MHz - 1100 cm; f = 27 MHz - 545 cm; f = 40.68 MHz - 370 cm; f = 433.92 MHz - 34.5 cm; f = 915 MHz - 16.5 cm and f = 2450 MHz - 6.1 cm.
RU2018125428A 2018-07-10 2018-07-10 Method for initiating death of tumour cells with sodium salts of chlorine-e 6 and hf and microwave radiation with wave radiation energy RU2724327C2 (en)

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Publication number Priority date Publication date Assignee Title
US5236410A (en) * 1990-08-02 1993-08-17 Ferrotherm International, Inc. Tumor treatment method
RU2106159C1 (en) * 1996-09-27 1998-03-10 Сергей Львович Загускин Method for selectively destroying cancer tumor cells
RU2174021C1 (en) * 2000-02-14 2001-09-27 Шаталин Иван Александрович Method for treating tumors
RU2006113533A (en) * 2006-04-21 2007-11-20 Валерий Иванович Чиссов (RU) METHOD FOR DESTRUCTION OF BIOTABLES AND DEVICE FOR ITS IMPLEMENTATION
EP2197533B1 (en) * 2007-09-14 2015-04-01 Lazure Technologies, LLC Prostate cancer ablation
RU2382659C1 (en) * 2008-10-28 2010-02-27 Государственное образовательное учреждение высшего профессионального образования "Саратовский государственный университет им. Н.Г. Чернышевского" Method of local tumor destruction by means of shf heating of magnetic nanoparticles

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RU2018125428A3 (en) 2020-01-13

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Effective date: 20200711