RU2018126433A - Method for initiating the death of tumor cells with 5-aminolevuoleic and succinic acid and HF and microwave energy of wave radiation - Google Patents

Method for initiating the death of tumor cells with 5-aminolevuoleic and succinic acid and HF and microwave energy of wave radiation Download PDF

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RU2018126433A
RU2018126433A RU2018126433A RU2018126433A RU2018126433A RU 2018126433 A RU2018126433 A RU 2018126433A RU 2018126433 A RU2018126433 A RU 2018126433A RU 2018126433 A RU2018126433 A RU 2018126433A RU 2018126433 A RU2018126433 A RU 2018126433A
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aminolevuoleic
acid
mhz
succinic acid
alasens
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RU2018126433A
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Russian (ru)
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RU2018126433A3 (en
RU2726611C2 (en
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Николай Васильевич Цугленок
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Николай Васильевич Цугленок
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C07C55/10—Succinic acid

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Molecular Biology (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • Radiology & Medical Imaging (AREA)
  • Pathology (AREA)
  • Medical Informatics (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Radiation-Therapy Devices (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Claims (2)

1. Способ инициации гибели опухолевых клеток ВЧ и СВЧ энергией, включающий предварительное насыщение опухолевых клеток растворами 5-аминолевуолевой кислоты Аласенса 20-30 мг/кг веса человека и янтарной кислотой, принимаемых внутрь перорально 2400 мг человеком, для их максимального накопления в 10-15 раз выше, чем в опухолевых тканях, соответственно, через 3-6 и 0,5-2,5 часа после приема, отличающийся тем, что в течение 3-х дней до лечения человек переводится на белковую диету, для максимального многократного избирательного накопления в «голодных» опухолевых тканях высокоэлектропроводящих электронно-ионных растворов 5-аминолевуолевой кислоты Аласенса и янтарной кислоты, принимается человеком одноразовая мегадоза внутривенно 31 мг/кг 5-аминолевуолевой кислоты Аласенса и одноразовая мегадоза 3000 мг янтарной кислоты перорально для максимального разделения и увеличении электропроводности и диэлектрических потерь в опухолевых тканях в сравнении со здоровыми, и по истечении 24 часов после приема 5-аминолевуолевой кислоты Аласенса и приема янтарной кислоты за 2,5 часа до обработки проводится избирательная ВЧ и СВЧ электромагнитная гипертермия и фотолюминесцентная терапия опухолевых тканей энергией волнового излучения, со скоростью нагрева опухолевых тканей 0,072°С/сек, в течение 193 сек до температуры опухолевых тканей 50,5°С, при нагреве здоровых тканей не выше 40°С.1. A method for initiating the death of tumor cells by RF and microwave energy, including pre-saturation of tumor cells with solutions of 5-aminolevuoleic acid Alasens 20-30 mg / kg of human weight and succinic acid taken orally by 2400 mg by a person, for their maximum accumulation in 10-15 times higher than in tumor tissues, respectively, 3-6 and 0.5-2.5 hours after administration, characterized in that within 3 days before treatment, the person is transferred to a protein diet, for maximum multiple selective accumulation in "Hungry" opu in the tissues of highly conductive electron-ionic solutions of 5-aminolevuoleic acid Alasens and succinic acid, a person takes a single intravenous megadose of 31 mg / kg of 5-aminolevuoleic Alasens acid and a one-time megadose of 3000 mg of succinic acid orally to maximize separation and increase electrical conductivity and dielectric loss in tumor tissues in comparison with healthy ones, and after 24 hours after taking 5-aminolevuoleic acid Alasens and taking succinic acid, 2.5 hours before treatment selective RF and microwave electromagnetic hyperthermia and photoluminescent therapy of tumor tissues with wave radiation energy, with a tumor tissue heating rate of 0.072 ° C / s, for 193 seconds to a tumor tissue temperature of 50.5 ° C, when healthy tissues are heated no higher than 40 ° C . 2. Способ по п. 1, отличающийся тем, что нагрев и гипертермия опухолевых тканей, насыщенных раствором 5-аминолевуолевой кислоты Аласенса и янтарной кислоты производится ВЧ и СВЧ энергией волнового излучения, в соответствии, с глубиной проникновения электромагнитной волны в ткани человека и с глубиной расположения в них опухолевых тканей, на разрешенных частотах f=13,56 МГц - 1100 см, f=27 МГц - 545 см, f=40,68 МГц - 370 см, f=433,92 МГц - 34,5 см, f=915 МГц - 16,5 см и f=2450 МГц - 6,1 см.2. The method according to p. 1, characterized in that the heating and hyperthermia of tumor tissues saturated with a solution of 5-aminolevuoleic acid Alasens and succinic acid is produced by HF and microwave energy of wave radiation, in accordance with the depth of penetration of electromagnetic waves into human tissue and with depth the location of tumor tissues in them, at the allowed frequencies f = 13.56 MHz - 1100 cm, f = 27 MHz - 545 cm, f = 40.68 MHz - 370 cm, f = 433.92 MHz - 34.5 cm, f = 915 MHz - 16.5 cm and f = 2450 MHz - 6.1 cm.
RU2018126433A 2018-07-17 2018-07-17 Method for initiation of tumor cell death by 5-aminolevulinic and succinic acids and hf- and uhf-energy of wave radiation RU2726611C2 (en)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4106488A (en) * 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
RU2106159C1 (en) * 1996-09-27 1998-03-10 Сергей Львович Загускин Method for selectively destroying cancer tumor cells
RU2134598C1 (en) * 1997-09-29 1999-08-20 Мельников Виталий Максимович Method for treatment of tumors and virus diseases
RU2174021C1 (en) * 2000-02-14 2001-09-27 Шаталин Иван Александрович Method for treating tumors
RU2468447C1 (en) * 2011-06-27 2012-11-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "РНИОИ" Минздравсоцразвития России) Method of inducing cytological action on tumour cells

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