RU2018126428A - Method for initiating the death of tumor cells with ascorbic and folic acids and HF and microwave energy of wave radiation - Google Patents

Method for initiating the death of tumor cells with ascorbic and folic acids and HF and microwave energy of wave radiation Download PDF

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RU2018126428A
RU2018126428A RU2018126428A RU2018126428A RU2018126428A RU 2018126428 A RU2018126428 A RU 2018126428A RU 2018126428 A RU2018126428 A RU 2018126428A RU 2018126428 A RU2018126428 A RU 2018126428A RU 2018126428 A RU2018126428 A RU 2018126428A
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ascorbic
mhz
folic acid
tumor cells
tumor
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RU2018126428A
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Russian (ru)
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RU2018126428A3 (en
RU2723489C2 (en
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Николай Васильевич Цугленок
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Николай Васильевич Цугленок
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D475/00—Heterocyclic compounds containing pteridine ring systems
    • C07D475/02—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4
    • C07D475/04—Heterocyclic compounds containing pteridine ring systems with an oxygen atom directly attached in position 4 with a nitrogen atom directly attached in position 2

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Surgery (AREA)
  • Epidemiology (AREA)
  • Pathology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Radiology & Medical Imaging (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Claims (2)

1. Способ инициации гибели опухолевых клеток ВЧ и СВЧ энергией, включающий предварительное насыщение опухолевых клеток раствором аскорбиновой в дозе 400 мг и фолиевой кислоты в дозе 20-30 мг препаратом «Аскофол», принимаемых внутрь человеком, для его максимального накопления в опухолевых тканях через 3,5-4,5 и 2-4 часа после приема, отличающийся тем, что в течение 3-х дней до лечения человек переводится на белковую диету, для максимального усиления избирательного накопления в «голодных» опухолевых клетках высокоэлектропроводящих электронно-ионных растворов аскорбиновой и фолиевой кислоты, в несколько раз увеличивающих электропроводность и диэлектрические потери в опухолевых клетках в сравнение со здоровыми при одноразовых мегадозах аскорбиновой и фолиевой кислоты, принимаемых перорально 500 мг аскорбиновой кислоты и 31 мг фолиевой кислоты, и по истечении 4 часов после приема аскорбиновой и фолиевой кислоты проводится избирательная фотоэлектромагнитная ВЧ и СВЧ обработка опухолевых тканей энергией фотоволнового излучения, со скоростью нагрева опухолевых тканей 0,037°С/сек, в течение 280 сек до температуры опухолевых тканей 47°С, при нагреве здоровых тканей не выше 40°С.1. A method for initiating the death of tumor cells by HF and microwave energy, which includes pre-saturation of tumor cells with a solution of ascorbic acid in a dose of 400 mg and folic acid in a dose of 20-30 mg with Ascofol taken internally by a person to maximize its accumulation in tumor tissues after 3 , 5-4.5 and 2-4 hours after administration, characterized in that within 3 days before treatment, the person is transferred to a protein diet to maximize selective accumulation of highly electrically conductive electron-ionic ions in "hungry" tumor cells solutions of ascorbic and folic acid, several times increasing the conductivity and dielectric loss in tumor cells in comparison with healthy ones with a single megadose of ascorbic and folic acid, taken orally 500 mg of ascorbic acid and 31 mg of folic acid, and after 4 hours after taking ascorbic and folic acid, selective photoelectromagnetic RF and microwave treatment of tumor tissues with photovoltaic energy is carried out with a tumor tissue heating rate of 0.037 ° C / s, in 280 seconds to a temperature of tumor tissue 47 ° C, when heating healthy tissues not higher than 40 ° C. 2. Способ по п. 1, отличающийся тем, что нагрев и гипертермия опухолевых тканей, насыщенных раствором аскорбиновой и фолиевой кислотами препарата "Аскофол" производится ВЧ и СВЧ энергией волнового излучения, в соответствии с глубиной проникновения электромагнитной волны в тело человека и с глубиной расположения в нем опухолевых тканей, на разрешенных частотах: f=13,56 МГц - 1100 см, f=27 МГц - 545 см, f=40,68 МГц - 370 см, f=433,92 МГц - 34,5 см, f=915 МГц - 16,5 см и f=2450 МГц - 6,1 см.2. The method according to p. 1, characterized in that the heating and hyperthermia of the tumor tissues saturated with the ascofol and folic acid solution of the drug "Askofol" is produced by the RF and microwave energy of the wave radiation, in accordance with the depth of penetration of the electromagnetic wave into the human body and with a depth of location tumor tissue in it, at the allowed frequencies: f = 13.56 MHz - 1100 cm, f = 27 MHz - 545 cm, f = 40.68 MHz - 370 cm, f = 433.92 MHz - 34.5 cm, f = 915 MHz - 16.5 cm and f = 2450 MHz - 6.1 cm.
RU2018126428A 2018-07-17 2018-07-17 Method for initiation of tumor cell death with ascorbic and folic acid and hf and uhf wave radiation energy RU2723489C2 (en)

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RU2018126428A RU2723489C2 (en) 2018-07-17 2018-07-17 Method for initiation of tumor cell death with ascorbic and folic acid and hf and uhf wave radiation energy

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RU2018126428A RU2723489C2 (en) 2018-07-17 2018-07-17 Method for initiation of tumor cell death with ascorbic and folic acid and hf and uhf wave radiation energy

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RU2018126428A3 RU2018126428A3 (en) 2020-01-20
RU2018126428A true RU2018126428A (en) 2020-01-20
RU2723489C2 RU2723489C2 (en) 2020-06-11

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Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4106488A (en) * 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
RU2106159C1 (en) * 1996-09-27 1998-03-10 Сергей Львович Загускин Method for selectively destroying cancer tumor cells
RU2134598C1 (en) * 1997-09-29 1999-08-20 Мельников Виталий Максимович Method for treatment of tumors and virus diseases
RU2174021C1 (en) * 2000-02-14 2001-09-27 Шаталин Иван Александрович Method for treating tumors
RU2468447C1 (en) * 2011-06-27 2012-11-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "РНИОИ" Минздравсоцразвития России) Method of inducing cytological action on tumour cells

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