RU2018126432A - Method for initiating the death of tumor cells of hydroxyaluminium with trisulfophthalocyanine and ascorbic acid and HF and microwave energy of wave radiation - Google Patents

Method for initiating the death of tumor cells of hydroxyaluminium with trisulfophthalocyanine and ascorbic acid and HF and microwave energy of wave radiation Download PDF

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RU2018126432A
RU2018126432A RU2018126432A RU2018126432A RU2018126432A RU 2018126432 A RU2018126432 A RU 2018126432A RU 2018126432 A RU2018126432 A RU 2018126432A RU 2018126432 A RU2018126432 A RU 2018126432A RU 2018126432 A RU2018126432 A RU 2018126432A
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ascorbic acid
mhz
tumor
trisulfophthalocyanine
hydroxyaluminium
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RU2018126432A
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Russian (ru)
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RU2723490C2 (en
RU2018126432A3 (en
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Николай Васильевич Цугленок
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Николай Васильевич Цугленок
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
    • A61B18/00—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body
    • A61B18/18—Surgical instruments, devices or methods for transferring non-mechanical forms of energy to or from the body by applying electromagnetic radiation, e.g. microwaves
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/365—Lactones
    • A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K41/00—Medicinal preparations obtained by treating materials with wave energy or particle radiation ; Therapies using these preparations
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61N—ELECTROTHERAPY; MAGNETOTHERAPY; RADIATION THERAPY; ULTRASOUND THERAPY
    • A61N5/00—Radiation therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/22—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains four or more hetero rings

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Organic Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biomedical Technology (AREA)
  • Epidemiology (AREA)
  • Surgery (AREA)
  • Radiology & Medical Imaging (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Physics & Mathematics (AREA)
  • Electromagnetism (AREA)
  • Otolaryngology (AREA)
  • Pathology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Medical Informatics (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)

Claims (2)

1. Способ инициации гибели опухолевых клеток ВЧ- и СВЧ-энергией, включающий предварительное насыщение опухолевых клеток раствором аскорбиновой кислоты приемом 200-300 мг и гидроксиалюминием трисульфофталоцианина 0,5-0,8 мг/кг массы тела принимаемых внутрь человеком, для его максимального накопления в опухолевых тканях, соответственно, в 50 и 1,5-1,8 раз больше, чем в здоровых через 0,5-4 и 2-8 ч после приема, отличающийся тем, что в течение 3-х дней до лечения человек переводится на белковую диету, для максимального усиления избирательного накопления в «голодных» опухолевых клетках электронно-ионных растворов аскорбиновой кислоты и гидроксиалюминия трисульфофталоцианина принимаемых перорально в одноразовой мегадозе препарата «Фотосенс» 0,81 мг/кг веса человека и препарата аскорбиновой кислоты 500 мг в виде раствора 210 мл питьевой воды, многократно увеличивающих электропроводность опухолевых тканей в сравнение со здоровыми, и по истечении 8 ч после приема препарата «Фотосенс» и дополнительного приема аскорбиновой кислоты за 4 ч, до облучения опухолей проводится избирательный нагрев опухолевых тканей электромагнитной ВЧ- и СВЧ-энергией фотоволнового излучения, со скоростью нагрева опухолевых тканей 0,073°С/с, в течение 162 с до температуры опухолевых тканей 48,5°С, при нагреве здоровых тканей не выше 40°.1. A method of initiating the death of tumor cells with RF and microwave energy, including pre-saturation of tumor cells with a solution of ascorbic acid with 200-300 mg and trisulfophthalocyanine hydroxyaluminium 0.5-0.8 mg / kg of body weight taken internally by a person, for its maximum accumulation in tumor tissues, respectively, 50 and 1.5-1.8 times more than in healthy tissue after 0.5-4 and 2-8 hours after administration, characterized in that within 3 days before treatment, the person is transferred on a protein diet, to maximize selective accumulation in hungry "tumor cells of electron-ionic solutions of ascorbic acid and hydroxyaluminium trisulfophthalocyanine taken orally in a single dose of the drug" Photosens "0.81 mg / kg of human weight and the drug ascorbic acid 500 mg in the form of a solution of 210 ml of drinking water, many times increasing the conductivity of tumor tissues in comparison with healthy ones, and after 8 hours after taking the Photosens drug and taking ascorbic acid an additional 4 hours before the tumors are irradiated, selective heating of -tumor tissues electromagnetic RF and microwave energy fotovolnovogo radiation from tumor tissue heating rate of 0,073 ° C / s during 162 s to tumor tissue temperature 48,5 ° C, during heating of healthy tissue below 40 °. 2. Способ по п. 1, отличающийся тем, что нагрев и гипертермия опухолевых тканей, насыщенных аскорбиновой кислотой и гидроксиалюминием трисульфофталоцианина проводится ВЧ- и СВЧ-энергией фотоволнового излучения, в соответствии с глубиной проникновения электромагнитной волны, в тело человека и с глубиной расположения в нем опухолевых тканей на разрешенных частотах: f=13,56 МГц - 1100 см, f=27 МГц - 545 см, f=40,68 МГц - 370 см, f=433,92 МГц - 34,5 см, f=915 МГц - 16,5 см и f=2450 МГц - 6,1 см.2. The method according to p. 1, characterized in that the heating and hyperthermia of tumor tissues saturated with ascorbic acid and trisulfophthalocyanine hydroxyaluminium is carried out by the RF and microwave energy of the photo-wave radiation, in accordance with the depth of penetration of the electromagnetic wave into the human body and with a depth of tumor tissue at the allowed frequencies: f = 13.56 MHz - 1100 cm, f = 27 MHz - 545 cm, f = 40.68 MHz - 370 cm, f = 433.92 MHz - 34.5 cm, f = 915 MHz - 16.5 cm and f = 2450 MHz - 6.1 cm.
RU2018126432A 2018-07-17 2018-07-17 Method for initiation of death of tumour cells of hydroxyaluminium trisulfophthalocyanine and ascorbic acid and hf- and microwave radiation wave energy RU2723490C2 (en)

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US4106488A (en) * 1974-08-20 1978-08-15 Robert Thomas Gordon Cancer treatment method
RU2106159C1 (en) * 1996-09-27 1998-03-10 Сергей Львович Загускин Method for selectively destroying cancer tumor cells
RU2134598C1 (en) * 1997-09-29 1999-08-20 Мельников Виталий Максимович Method for treatment of tumors and virus diseases
RU2174021C1 (en) * 2000-02-14 2001-09-27 Шаталин Иван Александрович Method for treating tumors
RU2468447C1 (en) * 2011-06-27 2012-11-27 Федеральное государственное бюджетное учреждение "Ростовский научно-исследовательский онкологический институт" Министерства здравоохранения и социального развития Российской Федерации (ФГБУ "РНИОИ" Минздравсоцразвития России) Method of inducing cytological action on tumour cells

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