RU2018122113A - Способ обнаружения бактериальной активности в биологическом образце и соответствующее детекторное устройство - Google Patents

Способ обнаружения бактериальной активности в биологическом образце и соответствующее детекторное устройство Download PDF

Info

Publication number
RU2018122113A
RU2018122113A RU2018122113A RU2018122113A RU2018122113A RU 2018122113 A RU2018122113 A RU 2018122113A RU 2018122113 A RU2018122113 A RU 2018122113A RU 2018122113 A RU2018122113 A RU 2018122113A RU 2018122113 A RU2018122113 A RU 2018122113A
Authority
RU
Russia
Prior art keywords
substances
biological sample
paragraphs
test tube
free volume
Prior art date
Application number
RU2018122113A
Other languages
English (en)
Other versions
RU2731403C2 (ru
RU2018122113A3 (ru
Inventor
Паоло ГАЛЬЯНО
Original Assignee
Алифакс С.Р.Л.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Алифакс С.Р.Л. filed Critical Алифакс С.Р.Л.
Publication of RU2018122113A publication Critical patent/RU2018122113A/ru
Publication of RU2018122113A3 publication Critical patent/RU2018122113A3/ru
Application granted granted Critical
Publication of RU2731403C2 publication Critical patent/RU2731403C2/ru

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/26—Processes using, or culture media containing, hydrocarbons
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/02—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving viable microorganisms
    • C12Q1/04—Determining presence or kind of microorganism; Use of selective media for testing antibiotics or bacteriocides; Compositions containing a chemical indicator therefor
    • C12Q1/045—Culture media therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
    • G01N33/004—CO or CO2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/0004—Gaseous mixtures, e.g. polluted air
    • G01N33/0009—General constructional details of gas analysers, e.g. portable test equipment
    • G01N33/0027—General constructional details of gas analysers, e.g. portable test equipment concerning the detector
    • G01N33/0036—General constructional details of gas analysers, e.g. portable test equipment concerning the detector specially adapted to detect a particular component
    • G01N33/005—H2
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/483—Physical analysis of biological material
    • G01N33/497—Physical analysis of biological material of gaseous biological material, e.g. breath
    • G01N33/4977—Metabolic gas from microbes, cell cultures or plant tissues
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/543—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals
    • G01N33/554—Immunoassay; Biospecific binding assay; Materials therefor with an insoluble carrier for immobilising immunochemicals the carrier being a biological cell or cell fragment, e.g. bacteria, yeast cells
    • G01N33/555—Red blood cell
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N2030/022—Column chromatography characterised by the kind of separation mechanism
    • G01N2030/025—Gas chromatography
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8813—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials
    • G01N2030/8822—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample biological materials involving blood
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N30/00—Investigating or analysing materials by separation into components using adsorption, absorption or similar phenomena or using ion-exchange, e.g. chromatography or field flow fractionation
    • G01N30/02—Column chromatography
    • G01N30/88—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86
    • G01N2030/8809—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample
    • G01N2030/8859—Integrated analysis systems specially adapted therefor, not covered by a single one of the groups G01N30/04 - G01N30/86 analysis specially adapted for the sample inorganic compounds
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/20—Air quality improvement or preservation, e.g. vehicle emission control or emission reduction by using catalytic converters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Analytical Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Medicinal Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Food Science & Technology (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Urology & Nephrology (AREA)
  • Biophysics (AREA)
  • General Engineering & Computer Science (AREA)
  • Cell Biology (AREA)
  • Combustion & Propulsion (AREA)
  • Toxicology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Claims (20)

1. Способ обнаружения бактериальной активности в биологическом образце (14), в частности, но не только, в образцах крови, включающий следующие стадии
помещение биологического образца (14) в запечатанную и стерилизованную пробирку (12),
определение свободного объема (18) для накопления газа внутри упомянутой пробирки (12) над биологическим образцом (14),
отбор образца летучих веществ из упомянутого свободного объема,
анализ содержания неорганических газообразных веществ, в частности, СO2, Н2 и/или O2, присутствующих в упомянутом образце летучих веществ, с помощью газового микрохроматографа (22) с потоком, подходящим для обнаружения присутствия неорганических веществ, образованных в ходе бактериального метаболизма в упомянутом биологическом образце (14) в интервале от 1 м.д. до 10 м.д., при этом упомянутое обнаружение неорганических веществ проводят в постоянном потоке с различными интервалами отбора проб для построения кривой роста, относящейся к измеренным неорганическим веществам, как с повышением СO2, так и с понижением O2.
2. Способ по п. 1, отличающийся тем, что образец летучих веществ отбирают из свободного объема (18) и одновременно с помощью сенсора измеряют общее изменение давления в пробирке (12).
3. Способ по любому из пп. 1, 2, отличающийся тем, что включает
отбор образца летучих веществ из упомянутой свободного объема (18) путем помещения иглы (24) в пробирку (12) сквозь пробку (16),
возврат образца летучих веществ, отобранных из пробирки (12) в ту же пробирку (12) с помощью второй иглы (24), соединенной с устройством для ввода (33) с целью рециркуляции газообразной среды в свободном объеме (18).
4. Способ по любому из пп. 1-3, отличающийся тем, что с помощью упомянутого газового микрохроматографа (22), проводят динамическое измерение газообразных веществ, присутствующих в упомянутом свободном объеме (18), с одним или несколькими определенными интервалами времени, с целью определения динамики роста количеств индивидуальных неорганических газообразных веществ, присутствующих в упомянутом свободном объеме (18).
5. Способ по п. 3 или 4, отличающийся тем, что, после каждого отбора образца летучих веществ проводят возврат этого образца летучих веществ в упомянутый свободный объем и проводят новое последовательное измерение с целью определения того, остается ли количество органического компонента внутри него постоянным или увеличивается.
6. Способ по любому из пп. 1-5, отличающийся тем, что культивационную или питательную среду вводят вместе с биологическим образцом (14) в пробирку (12).
7. Способ по любому из пп. 1-5, отличающийся тем, что производят эксклюзивное введение чистого биологического образца (14) в пробирку (12).
8. Способ по любому из пп. 1-7, отличающийся тем, что в пробирку (12) производят введение вспомогательных веществ, подходящих для ускорения репликации бактерий.
9. Способ по п. 8, отличающийся тем, что упомянутые вспомогательные вещества являются углеводородами, такими как метан, этан, пропан или похожими или сопоставимыми веществами.
10. Способ по п. 8, отличающийся тем, что в нем используют лизирующие вещества, способные увеличить присутствие и/или повысить возможность обнаружения бактерий в упомянутом биологическом образце (14), и способные повысить определяемость бактерий внутри эритроцитов.
11. Способ по любому из пп. 1-10, отличающийся тем, что в нем используют магнитный элемент для перемешивания биологического образца (14).
12. Способ по любому из пп. 1-11, отличающийся тем, что упомянутый биологический образец (14) вводят в пробирку (12) при пониженном давлении для отбора биологического образца (14) непосредственно у пациента.
13. Способ по любому из пп. 1-12, отличающийся тем, что в биологический образец (14) или в бактериальную культуру (26) вводят связывающие комплексообразующие вещества к возможным антибиотическим веществам.
14. Способ по любому из пп. 1-13, отличающийся тем, проводят измерение давления в пробирке (12).
RU2018122113A 2015-11-27 2016-11-28 Способ обнаружения бактериальной активности в биологическом образце и соответствующее детекторное устройство RU2731403C2 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
ITUB2015A005975A ITUB20155975A1 (it) 2015-11-27 2015-11-27 Procedimento per la rilevazione di attivita' batterica in un campione biologico e relativa unita' di rilevazione
IT102015000077866 2015-11-27
PCT/IB2016/057162 WO2017090015A1 (en) 2015-11-27 2016-11-28 Method to detect bacterial activity in a biological sample and corresponding detection unit

Publications (3)

Publication Number Publication Date
RU2018122113A true RU2018122113A (ru) 2019-12-27
RU2018122113A3 RU2018122113A3 (ru) 2020-03-13
RU2731403C2 RU2731403C2 (ru) 2020-09-02

Family

ID=55538434

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2018122113A RU2731403C2 (ru) 2015-11-27 2016-11-28 Способ обнаружения бактериальной активности в биологическом образце и соответствующее детекторное устройство

Country Status (11)

Country Link
US (1) US20180348181A1 (ru)
EP (1) EP3380842B1 (ru)
JP (1) JP6961592B2 (ru)
KR (1) KR20180085755A (ru)
CN (1) CN108603881A (ru)
BR (1) BR112018010764A2 (ru)
CA (1) CA3006414A1 (ru)
ES (1) ES2769006T3 (ru)
IT (1) ITUB20155975A1 (ru)
RU (1) RU2731403C2 (ru)
WO (1) WO2017090015A1 (ru)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN107084907A (zh) * 2017-06-07 2017-08-22 浙江师范大学 血液细菌培养检测方法及其应用
KR101991200B1 (ko) * 2018-05-17 2019-06-19 주종일 세포 배양 시스템에서 기체성분 농도 측정을 위한 시료 채취 장치
KR102159084B1 (ko) * 2019-01-28 2020-09-23 한국기계연구원 항균특성 평가 장치 및 이를 이용한 항균특성 평가방법
KR102553667B1 (ko) * 2020-07-02 2023-07-11 주식회사 엘지화학 가스 포집 장치
CN113447589B (zh) * 2021-06-30 2023-08-01 界首市好味来食品有限公司 一种多功能食品质量检测平台
CN114242558B (zh) * 2021-12-14 2023-11-14 中国科学院大连化学物理研究所 一种离子迁移谱脉冲吹扫负压热解吸进样器及进样方法

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3740320A (en) * 1971-01-25 1973-06-19 R Arthur Apparatus and method for measuring the amount of gas absorbed or released by a substance
US4152213A (en) * 1977-03-10 1979-05-01 Johnston Laboratories, Inc. Vacuum detection of bacteria
GB9700012D0 (en) * 1997-01-02 1997-02-19 Aromascan Plc Improvements in the detection of bacteria
US7057168B2 (en) * 1999-07-21 2006-06-06 Sionex Corporation Systems for differential ion mobility analysis
US6395229B1 (en) * 2000-05-22 2002-05-28 Michael Markelov Headspace sampling apparatus and method
CN1217188C (zh) * 2002-12-05 2005-08-31 清华大学 微型气相色谱柱、气相色谱系统以及在样品中分析组分的方法
GB2438139A (en) * 2005-01-31 2007-11-14 Graf Internat Ltd A method of detecting and identifying bacteria
US20060223052A1 (en) * 2005-03-30 2006-10-05 Kimberly-Clark Worldwide, Inc. Technique for detecting microorganisms
EP1978087A1 (en) * 2007-04-02 2008-10-08 Consultatie Implementatie Technisch Beheer B.V. System and method for detecting micro-organisms
AT505306B1 (de) * 2007-07-09 2008-12-15 Mbonline Gmbh Vorrichtung zur überwachung von wasser auf mikrobielle keime
ITFI20070275A1 (it) * 2007-12-07 2009-06-08 Diesse Diagnostica Senese Spa "dispositivo e metodo di analisi microbiologica di campioni biologici"
IT1395560B1 (it) * 2008-08-22 2012-09-28 Alifax Holding S P A Procedimento per l'indagine batteriologica su plasma
US8518663B2 (en) * 2009-04-27 2013-08-27 The Charles Stark Draper Laboratory, Inc. Rapid detection of volatile organic compounds for identification of Mycobacterium tuberculosis in a sample
JP5610513B2 (ja) * 2009-05-12 2014-10-22 一般財団法人電力中央研究所 乾式アンモニア分解処理方法及び乾式アンモニア分解処理装置及び発電設備
ITUD20130021A1 (it) * 2013-02-20 2014-08-21 Alifax Holding S P A Procedimento per l'identificazione di classi batteriche tramite gas cromatografia/spettrometria di massa in campioni biologici
JP5892614B2 (ja) * 2013-03-11 2016-03-23 地方独立行政法人北海道立総合研究機構 光触媒担持体、その製法及び光触媒担持体を用いた有機物分解方法

Also Published As

Publication number Publication date
ES2769006T3 (es) 2020-06-24
CN108603881A (zh) 2018-09-28
ITUB20155975A1 (it) 2017-05-27
WO2017090015A1 (en) 2017-06-01
RU2731403C2 (ru) 2020-09-02
EP3380842A1 (en) 2018-10-03
RU2018122113A3 (ru) 2020-03-13
JP6961592B2 (ja) 2021-11-05
KR20180085755A (ko) 2018-07-27
EP3380842B1 (en) 2019-11-13
BR112018010764A2 (pt) 2018-11-27
CA3006414A1 (en) 2017-06-01
JP2018536413A (ja) 2018-12-13
US20180348181A1 (en) 2018-12-06

Similar Documents

Publication Publication Date Title
RU2018122113A (ru) Способ обнаружения бактериальной активности в биологическом образце и соответствующее детекторное устройство
WO2009154377A3 (ko) 실시간 연속 검출장치
EA201190244A1 (ru) Одноразовая микрофлюидная тест-кассета для количественного биоанализа аналитов
MX2012012661A (es) Detector del crecimiento microbiano.
NZ597217A (en) Quantitative and self-calibrating chemical analysis using paper-based microfluidic systems
EP2309256A3 (en) Chromatographic measurement apparatus
López et al. Analysis of methane
ATE426658T1 (de) Vorrichtung zur entnahme, zum sammeln und zum transport biologischer proben
SE0702489L (sv) Anordning för biokemisk bearbetning och analys av provvätska
US10114007B2 (en) Apparatus and method for analyzing breath gas mixture for halitosis detection
WO2012166954A3 (en) Systems and methods for estimating photosynthetic carbon assimilation
Apostolou et al. Extraction-less, rapid assay for the direct detection of 2, 4, 6-trichloroanisole (TCA) in cork samples
Trepiccione et al. Measurement of total CO 2 in microliter samples of urine and other biological fluids using infrared detection of CO 2
CN105002300B (zh) 一种鱼类神经坏死病毒现场快速高灵敏检测方法及试剂盒
KR102130159B1 (ko) 신선도 지시계
CN105806968A (zh) 同时检测正庚烷、异辛烷、乙酸乙酯、异丙醇的气相色谱分析方法及其应用
CN104316616B (zh) 一种测定酒醅及白酒中氯化苦残留量的方法
Li et al. A novel test method for evaluating the methane gas permeability of biogas storage membrane
MX2012008427A (es) Desecantes mejoradores de la exactitud.
CN104673664A (zh) 一种血液样本培养装置
CN107727764A (zh) 一种测定盐酸金霉素中氯乙烷与氯仿残留的自动顶空进样气相色谱法
CN1615431A (zh) 测定气态物质经过薄膜的渗透的方法和装置
CN104407068A (zh) 一种气相色谱仪
BR112016020786A2 (pt) dispositivo e método para testar a eficácia de conservante
CN104569183B (zh) 一种利用离子排阻色谱柱检测食用菌培养液中草酸的方法