RU2018122113A - Способ обнаружения бактериальной активности в биологическом образце и соответствующее детекторное устройство - Google Patents

Способ обнаружения бактериальной активности в биологическом образце и соответствующее детекторное устройство Download PDF

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RU2018122113A
RU2018122113A RU2018122113A RU2018122113A RU2018122113A RU 2018122113 A RU2018122113 A RU 2018122113A RU 2018122113 A RU2018122113 A RU 2018122113A RU 2018122113 A RU2018122113 A RU 2018122113A RU 2018122113 A RU2018122113 A RU 2018122113A
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Паоло ГАЛЬЯНО
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Claims (20)

1. Способ обнаружения бактериальной активности в биологическом образце (14), в частности, но не только, в образцах крови, включающий следующие стадии
помещение биологического образца (14) в запечатанную и стерилизованную пробирку (12),
определение свободного объема (18) для накопления газа внутри упомянутой пробирки (12) над биологическим образцом (14),
отбор образца летучих веществ из упомянутого свободного объема,
анализ содержания неорганических газообразных веществ, в частности, СO2, Н2 и/или O2, присутствующих в упомянутом образце летучих веществ, с помощью газового микрохроматографа (22) с потоком, подходящим для обнаружения присутствия неорганических веществ, образованных в ходе бактериального метаболизма в упомянутом биологическом образце (14) в интервале от 1 м.д. до 10 м.д., при этом упомянутое обнаружение неорганических веществ проводят в постоянном потоке с различными интервалами отбора проб для построения кривой роста, относящейся к измеренным неорганическим веществам, как с повышением СO2, так и с понижением O2.
2. Способ по п. 1, отличающийся тем, что образец летучих веществ отбирают из свободного объема (18) и одновременно с помощью сенсора измеряют общее изменение давления в пробирке (12).
3. Способ по любому из пп. 1, 2, отличающийся тем, что включает
отбор образца летучих веществ из упомянутой свободного объема (18) путем помещения иглы (24) в пробирку (12) сквозь пробку (16),
возврат образца летучих веществ, отобранных из пробирки (12) в ту же пробирку (12) с помощью второй иглы (24), соединенной с устройством для ввода (33) с целью рециркуляции газообразной среды в свободном объеме (18).
4. Способ по любому из пп. 1-3, отличающийся тем, что с помощью упомянутого газового микрохроматографа (22), проводят динамическое измерение газообразных веществ, присутствующих в упомянутом свободном объеме (18), с одним или несколькими определенными интервалами времени, с целью определения динамики роста количеств индивидуальных неорганических газообразных веществ, присутствующих в упомянутом свободном объеме (18).
5. Способ по п. 3 или 4, отличающийся тем, что, после каждого отбора образца летучих веществ проводят возврат этого образца летучих веществ в упомянутый свободный объем и проводят новое последовательное измерение с целью определения того, остается ли количество органического компонента внутри него постоянным или увеличивается.
6. Способ по любому из пп. 1-5, отличающийся тем, что культивационную или питательную среду вводят вместе с биологическим образцом (14) в пробирку (12).
7. Способ по любому из пп. 1-5, отличающийся тем, что производят эксклюзивное введение чистого биологического образца (14) в пробирку (12).
8. Способ по любому из пп. 1-7, отличающийся тем, что в пробирку (12) производят введение вспомогательных веществ, подходящих для ускорения репликации бактерий.
9. Способ по п. 8, отличающийся тем, что упомянутые вспомогательные вещества являются углеводородами, такими как метан, этан, пропан или похожими или сопоставимыми веществами.
10. Способ по п. 8, отличающийся тем, что в нем используют лизирующие вещества, способные увеличить присутствие и/или повысить возможность обнаружения бактерий в упомянутом биологическом образце (14), и способные повысить определяемость бактерий внутри эритроцитов.
11. Способ по любому из пп. 1-10, отличающийся тем, что в нем используют магнитный элемент для перемешивания биологического образца (14).
12. Способ по любому из пп. 1-11, отличающийся тем, что упомянутый биологический образец (14) вводят в пробирку (12) при пониженном давлении для отбора биологического образца (14) непосредственно у пациента.
13. Способ по любому из пп. 1-12, отличающийся тем, что в биологический образец (14) или в бактериальную культуру (26) вводят связывающие комплексообразующие вещества к возможным антибиотическим веществам.
14. Способ по любому из пп. 1-13, отличающийся тем, проводят измерение давления в пробирке (12).
RU2018122113A 2015-11-27 2016-11-28 Способ обнаружения бактериальной активности в биологическом образце и соответствующее детекторное устройство RU2731403C2 (ru)

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ITUB2015A005975A ITUB20155975A1 (it) 2015-11-27 2015-11-27 Procedimento per la rilevazione di attivita' batterica in un campione biologico e relativa unita' di rilevazione
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PCT/IB2016/057162 WO2017090015A1 (en) 2015-11-27 2016-11-28 Method to detect bacterial activity in a biological sample and corresponding detection unit

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CN108603881A (zh) 2018-09-28
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EP3380842B1 (en) 2019-11-13
ITUB20155975A1 (it) 2017-05-27
RU2018122113A3 (ru) 2020-03-13
JP2018536413A (ja) 2018-12-13
ES2769006T3 (es) 2020-06-24
RU2731403C2 (ru) 2020-09-02
US20180348181A1 (en) 2018-12-06
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WO2017090015A1 (en) 2017-06-01
EP3380842A1 (en) 2018-10-03

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