RU2018118955A - Гемосовместимый адсорбент для диализа связанных с белками уремических токсинов - Google Patents
Гемосовместимый адсорбент для диализа связанных с белками уремических токсинов Download PDFInfo
- Publication number
- RU2018118955A RU2018118955A RU2018118955A RU2018118955A RU2018118955A RU 2018118955 A RU2018118955 A RU 2018118955A RU 2018118955 A RU2018118955 A RU 2018118955A RU 2018118955 A RU2018118955 A RU 2018118955A RU 2018118955 A RU2018118955 A RU 2018118955A
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- Russia
- Prior art keywords
- hemocompatible
- adsorbent
- adsorbent according
- solid carrier
- carrier component
- Prior art date
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- 239000003463 adsorbent Substances 0.000 title claims 14
- 239000002441 uremic toxin Substances 0.000 title claims 4
- 238000000502 dialysis Methods 0.000 title 1
- 229920000642 polymer Polymers 0.000 claims 8
- 239000007787 solid Substances 0.000 claims 7
- -1 cyclic oligosaccharide Chemical class 0.000 claims 6
- 239000008280 blood Substances 0.000 claims 5
- 210000004369 blood Anatomy 0.000 claims 5
- 229930040373 Paraformaldehyde Natural products 0.000 claims 4
- 239000004696 Poly ether ether ketone Substances 0.000 claims 4
- 239000004695 Polyether sulfone Substances 0.000 claims 4
- 229920000491 Polyphenylsulfone Polymers 0.000 claims 4
- 229920002492 poly(sulfone) Polymers 0.000 claims 4
- 229920006393 polyether sulfone Polymers 0.000 claims 4
- 229920002530 polyetherether ketone Polymers 0.000 claims 4
- 229920006324 polyoxymethylene Polymers 0.000 claims 4
- 102000014914 Carrier Proteins Human genes 0.000 claims 3
- 108010078791 Carrier Proteins Proteins 0.000 claims 3
- 229920000858 Cyclodextrin Polymers 0.000 claims 3
- 238000001631 haemodialysis Methods 0.000 claims 3
- 230000000322 hemodialysis Effects 0.000 claims 3
- 229920001542 oligosaccharide Polymers 0.000 claims 3
- 239000011148 porous material Substances 0.000 claims 3
- NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims 2
- QIAFMBKCNZACKA-UHFFFAOYSA-N N-benzoylglycine Chemical compound OC(=O)CNC(=O)C1=CC=CC=C1 QIAFMBKCNZACKA-UHFFFAOYSA-N 0.000 claims 2
- 239000004677 Nylon Substances 0.000 claims 2
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
- 239000004952 Polyamide Substances 0.000 claims 2
- 239000004793 Polystyrene Substances 0.000 claims 2
- WHGYBXFWUBPSRW-FOUAGVGXSA-N beta-cyclodextrin Chemical class OC[C@H]([C@H]([C@@H]([C@H]1O)O)O[C@H]2O[C@@H]([C@@H](O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O[C@H]3O[C@H](CO)[C@H]([C@@H]([C@H]3O)O)O3)[C@H](O)[C@H]2O)CO)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O)[C@@H]3O[C@@H]1CO WHGYBXFWUBPSRW-FOUAGVGXSA-N 0.000 claims 2
- 229920001577 copolymer Polymers 0.000 claims 2
- 239000012510 hollow fiber Substances 0.000 claims 2
- BXFFHSIDQOFMLE-UHFFFAOYSA-N indoxyl sulfate Chemical compound C1=CC=C2C(OS(=O)(=O)O)=CNC2=C1 BXFFHSIDQOFMLE-UHFFFAOYSA-N 0.000 claims 2
- 239000012528 membrane Substances 0.000 claims 2
- 229920001778 nylon Polymers 0.000 claims 2
- IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 claims 2
- 229920000058 polyacrylate Polymers 0.000 claims 2
- 229920002647 polyamide Polymers 0.000 claims 2
- 229920000515 polycarbonate Polymers 0.000 claims 2
- 239000004417 polycarbonate Substances 0.000 claims 2
- 150000008442 polyphenolic compounds Chemical class 0.000 claims 2
- 235000013824 polyphenols Nutrition 0.000 claims 2
- 229920002223 polystyrene Polymers 0.000 claims 2
- WMCQWXZMVIETAO-UHFFFAOYSA-N 2-(2-carboxyethyl)-4-methyl-5-propylfuran-3-carboxylic acid Chemical compound CCCC=1OC(CCC(O)=O)=C(C(O)=O)C=1C WMCQWXZMVIETAO-UHFFFAOYSA-N 0.000 claims 1
- CUJVBAPGYBSBHJ-YWBSARSQSA-N 2-[[(1R,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21R,23R,25R,26R,28R,30R,31R,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-36,38,40,42-tetrakis(carboxymethoxy)-10,15-bis(carboxymethoxymethyl)-37,39,41,43,44,45,46,47,48,49-decahydroxy-20,25,30,35-tetrakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-5-yl]methoxy]acetic acid Chemical compound OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCC(O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCC(O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCC(O)=O)O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@H]1[C@H](OCC(O)=O)[C@H]2O)[C@H](O)[C@H]5OCC(O)=O)[C@H](O)[C@H]4OCC(O)=O)[C@H](O)[C@H]3OCC(O)=O CUJVBAPGYBSBHJ-YWBSARSQSA-N 0.000 claims 1
- BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims 1
- 239000001116 FEMA 4028 Substances 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 235000011175 beta-cyclodextrine Nutrition 0.000 claims 1
- 229960004853 betadex Drugs 0.000 claims 1
- 229940097362 cyclodextrins Drugs 0.000 claims 1
- DUGDVPXCHOVCOS-UHFFFAOYSA-N methyl prop-2-ene-1-sulfonate Chemical class COS(=O)(=O)CC=C DUGDVPXCHOVCOS-UHFFFAOYSA-N 0.000 claims 1
- ZMHLUFWWWPBTIU-UHFFFAOYSA-N p-hydroxyhippuric acid Chemical compound OC(=O)CNC(=O)C1=CC=C(O)C=C1 ZMHLUFWWWPBTIU-UHFFFAOYSA-N 0.000 claims 1
- 150000002989 phenols Chemical class 0.000 claims 1
- 229920001282 polysaccharide Polymers 0.000 claims 1
- 239000005017 polysaccharide Substances 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 238000000926 separation method Methods 0.000 claims 1
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- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Heart & Thoracic Surgery (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Engineering & Computer Science (AREA)
- Vascular Medicine (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Anesthesiology (AREA)
- Hematology (AREA)
- Animal Behavior & Ethology (AREA)
- Molecular Biology (AREA)
- Urology & Nephrology (AREA)
- Biochemistry (AREA)
- Cardiology (AREA)
- Biodiversity & Conservation Biology (AREA)
- Cell Biology (AREA)
- Emergency Medicine (AREA)
- External Artificial Organs (AREA)
- Separation Using Semi-Permeable Membranes (AREA)
- Solid-Sorbent Or Filter-Aiding Compositions (AREA)
Applications Claiming Priority (2)
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| DE102017113853.6A DE102017113853A1 (de) | 2017-06-22 | 2017-06-22 | Hämokompatibler Adsorber zur Dialyse proteingebundener Urämietoxine |
| DE102017113853.6 | 2017-06-22 |
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| RU2018118955A true RU2018118955A (ru) | 2019-11-25 |
| RU2018118955A3 RU2018118955A3 (https=) | 2021-09-15 |
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| EP (1) | EP3417937B1 (https=) |
| JP (1) | JP7048425B2 (https=) |
| CN (1) | CN109107541B (https=) |
| DE (1) | DE102017113853A1 (https=) |
| RU (1) | RU2018118955A (https=) |
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| EP3735281B1 (en) | 2018-01-05 | 2024-11-27 | Path Ex, Inc. | Device for the capture and removal of disease material from fluids |
| US11806676B2 (en) * | 2018-07-25 | 2023-11-07 | Universiteit Twente | Compositions for use in the simultaneous removal of endotoxins and uremic solutes during the treatment of patients |
| JP7526737B2 (ja) | 2019-03-06 | 2024-08-01 | ガンブロ ルンディア アクティエボラーグ | アルカリホスファターゼを含む血液処理装置 |
| US10926019B2 (en) | 2019-06-05 | 2021-02-23 | Choon Kee Lee | Gradient dialysate hemodiafiltration |
| ES3053504T3 (en) * | 2019-11-22 | 2026-01-22 | Umc Utrecht Holding Bv | Porous membranes comprising sorbent particles for improved urea capture |
| US20230405201A1 (en) * | 2020-11-13 | 2023-12-21 | Fresenius Medical Care Holdings, Inc. | Techniques for increasing red blood cell count |
| WO2024073056A1 (en) * | 2022-09-29 | 2024-04-04 | Kureha America, Inc. | Cucurbituril compositions, products, and methods of use |
| CN120923796B (zh) * | 2025-08-06 | 2026-02-06 | 上海安德松申医疗科技股份有限公司 | 一种用于清除蛋白结合毒素及中大分子毒素吸附剂及其制备方法 |
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| DE109363C (https=) | 1898-11-23 | 1900-02-14 | ||
| GB1466702A (en) | 1973-02-09 | 1977-03-09 | Sandoz Ltd | Polymer encapsulated-activated carbon |
| US4140652A (en) | 1977-01-12 | 1979-02-20 | Korshak Vasily V | Method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons |
| JPS54482A (en) * | 1977-06-01 | 1979-01-05 | Toshimitsu Niwa | Device for clamping albumin |
| JPS5774048U (https=) * | 1980-10-20 | 1982-05-07 | ||
| CS248505B1 (en) | 1983-06-23 | 1987-02-12 | Marie Tlustakova | Method of biocompatible layer production on surface of porous synthetic sorbents' particles |
| US4889634A (en) | 1988-10-04 | 1989-12-26 | Gynex, Inc. | Dialysate solution containing hydroxypropyl-beta-cyclodextrin and method of using same |
| US6878269B2 (en) * | 1996-01-31 | 2005-04-12 | Kaneka Corporation | Device for body fluid purification and system for body fluid purification |
| JPH09266948A (ja) * | 1996-01-31 | 1997-10-14 | Kanegafuchi Chem Ind Co Ltd | 血液浄化器および血液浄化装置 |
| DE19705366C2 (de) | 1997-02-12 | 2002-08-01 | Fresenius Ag | Trägermaterial zur Reinigung proteinhaltiger Lösungen, Verfahren zur Herstellung des Trägermaterials und Verwendung des Trägermaterials |
| JP2004075741A (ja) * | 2002-08-12 | 2004-03-11 | Asahi Kasei Corp | 血液適合性に優れた分岐ポリエチレンオキシド−ポリスルホンブロック共重合体 |
| CN1317068C (zh) | 2003-04-30 | 2007-05-23 | 中国科学院大连化学物理研究所 | 吸附胆红素的环糊精交联聚合物微球及其制备和应用 |
| EP1752171A1 (en) | 2005-07-28 | 2007-02-14 | Istituto Clinico Humanitas | Haemofilters for blood detoxification |
| JP5370712B2 (ja) * | 2008-02-21 | 2013-12-18 | 日東電工株式会社 | 酸性水溶性標的物質吸着ポリマー及びその製造方法 |
| US9067017B2 (en) | 2008-06-23 | 2015-06-30 | Temasek Polytechnic | Flow system of a dialysis device and a portable dialysis device |
| CN101322932B (zh) * | 2008-07-23 | 2011-03-16 | 大连理工大学 | 偶联环糊精的水溶性多聚物吸附材料及其应用 |
| WO2010021973A2 (en) * | 2008-08-17 | 2010-02-25 | Massachusetts Institute Of Technology | Controlled delivery of bioactive agents from decomposable films |
| WO2010045474A2 (en) | 2008-10-16 | 2010-04-22 | Fresenius Medical Care Holdings, Inc. | Method of removing protein-bound deleterious substances during extracorporeal renal replacement treatment |
| DE102010012282A1 (de) | 2010-03-22 | 2011-09-22 | Fresenius Medical Care Deutschland Gmbh | Pharmazeutische Zusammensetzung enthaltend Cyclodextrin-Copolymer |
| US20120027837A1 (en) * | 2010-07-27 | 2012-02-02 | Massachusetts Institute Of Technology | Multilayer coating compositions, coated substrates and methods thereof |
| EP2446908B1 (en) * | 2010-11-02 | 2015-07-15 | ICinnovation BV | Electrosorption and decomposition device for the purification of blood and other fluids |
| DE102013021957A1 (de) | 2013-12-20 | 2015-06-25 | Fresenius Medical Care Deutschland Gmbh | Verfahren zur Entfernung proteingebundener Urämietoxine durch Adsorption an dialysierbare Hilfsstoffe |
| EP2918337A1 (de) | 2014-03-14 | 2015-09-16 | Fresenius Medical Care Deutschland GmbH | Adsorbergranulat zur Entfernung urämischer Toxine |
| US10463776B2 (en) * | 2015-12-31 | 2019-11-05 | Baxter International Inc. | Methods and apparatuses using urea permselective diffusion through charged membranes |
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- 2018-06-14 CN CN201810614783.0A patent/CN109107541B/zh active Active
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| JP2019005569A (ja) | 2019-01-17 |
| EP3417937B1 (de) | 2021-04-14 |
| CN109107541B (zh) | 2023-05-02 |
| RU2018118955A3 (https=) | 2021-09-15 |
| DE102017113853A1 (de) | 2018-12-27 |
| CN109107541A (zh) | 2019-01-01 |
| US20180369783A1 (en) | 2018-12-27 |
| JP7048425B2 (ja) | 2022-04-05 |
| EP3417937A1 (de) | 2018-12-26 |
| US10625241B2 (en) | 2020-04-21 |
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