DE102017113853A1 - Hämokompatibler Adsorber zur Dialyse proteingebundener Urämietoxine - Google Patents

Hämokompatibler Adsorber zur Dialyse proteingebundener Urämietoxine Download PDF

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Publication number
DE102017113853A1
DE102017113853A1 DE102017113853.6A DE102017113853A DE102017113853A1 DE 102017113853 A1 DE102017113853 A1 DE 102017113853A1 DE 102017113853 A DE102017113853 A DE 102017113853A DE 102017113853 A1 DE102017113853 A1 DE 102017113853A1
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Germany
Prior art keywords
blood
hemocompatible
adsorber
hemocompatible adsorber
uremic toxins
Prior art date
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Withdrawn
Application number
DE102017113853.6A
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German (de)
English (en)
Inventor
Angela Baier-Goschütz
Alexander Friebe
Roland Napierala
Juliane Gäbler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
B Braun Avitum AG
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B Braun Avitum AG
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by B Braun Avitum AG filed Critical B Braun Avitum AG
Priority to DE102017113853.6A priority Critical patent/DE102017113853A1/de
Priority to US15/969,306 priority patent/US10625241B2/en
Priority to RU2018118955A priority patent/RU2018118955A/ru
Priority to EP18176248.5A priority patent/EP3417937B1/de
Priority to JP2018113695A priority patent/JP7048425B2/ja
Priority to CN201810614783.0A priority patent/CN109107541B/zh
Publication of DE102017113853A1 publication Critical patent/DE102017113853A1/de
Withdrawn legal-status Critical Current

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    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
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    • A61M1/00—Suction or pumping devices for medical purposes; Devices for carrying-off, for treatment of, or for carrying-over, body-liquids; Drainage systems
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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Engineering & Computer Science (AREA)
  • Vascular Medicine (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Anesthesiology (AREA)
  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
DE102017113853.6A 2017-06-22 2017-06-22 Hämokompatibler Adsorber zur Dialyse proteingebundener Urämietoxine Withdrawn DE102017113853A1 (de)

Priority Applications (6)

Application Number Priority Date Filing Date Title
DE102017113853.6A DE102017113853A1 (de) 2017-06-22 2017-06-22 Hämokompatibler Adsorber zur Dialyse proteingebundener Urämietoxine
US15/969,306 US10625241B2 (en) 2017-06-22 2018-05-02 Hemocompatible adsorber for the dialysis of protein-bound uremic toxins
RU2018118955A RU2018118955A (ru) 2017-06-22 2018-05-23 Гемосовместимый адсорбент для диализа связанных с белками уремических токсинов
EP18176248.5A EP3417937B1 (de) 2017-06-22 2018-06-06 Hämokompatibler adsorber zur dialyse proteingebundener urämietoxine
JP2018113695A JP7048425B2 (ja) 2017-06-22 2018-06-14 タンパク質結合尿毒症性毒素の透析のための血液適合性吸着体
CN201810614783.0A CN109107541B (zh) 2017-06-22 2018-06-14 用于蛋白质结合的尿毒症毒素的透析的血液相容性吸附剂

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE102017113853.6A DE102017113853A1 (de) 2017-06-22 2017-06-22 Hämokompatibler Adsorber zur Dialyse proteingebundener Urämietoxine

Publications (1)

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DE102017113853A1 true DE102017113853A1 (de) 2018-12-27

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DE102017113853.6A Withdrawn DE102017113853A1 (de) 2017-06-22 2017-06-22 Hämokompatibler Adsorber zur Dialyse proteingebundener Urämietoxine

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US (1) US10625241B2 (https=)
EP (1) EP3417937B1 (https=)
JP (1) JP7048425B2 (https=)
CN (1) CN109107541B (https=)
DE (1) DE102017113853A1 (https=)
RU (1) RU2018118955A (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3735281B1 (en) 2018-01-05 2024-11-27 Path Ex, Inc. Device for the capture and removal of disease material from fluids
US11806676B2 (en) * 2018-07-25 2023-11-07 Universiteit Twente Compositions for use in the simultaneous removal of endotoxins and uremic solutes during the treatment of patients
JP7526737B2 (ja) 2019-03-06 2024-08-01 ガンブロ ルンディア アクティエボラーグ アルカリホスファターゼを含む血液処理装置
US10926019B2 (en) 2019-06-05 2021-02-23 Choon Kee Lee Gradient dialysate hemodiafiltration
ES3053504T3 (en) * 2019-11-22 2026-01-22 Umc Utrecht Holding Bv Porous membranes comprising sorbent particles for improved urea capture
US20230405201A1 (en) * 2020-11-13 2023-12-21 Fresenius Medical Care Holdings, Inc. Techniques for increasing red blood cell count
WO2024073056A1 (en) * 2022-09-29 2024-04-04 Kureha America, Inc. Cucurbituril compositions, products, and methods of use
CN120923796B (zh) * 2025-08-06 2026-02-06 上海安德松申医疗科技股份有限公司 一种用于清除蛋白结合毒素及中大分子毒素吸附剂及其制备方法

Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD109363A5 (https=) 1973-02-09 1974-11-05
US4140652A (en) 1977-01-12 1979-02-20 Korshak Vasily V Method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons
EP0129905A2 (de) 1983-06-23 1985-01-02 Ceskoslovenska akademie ved Poröse synthetische Sorbentien mit biokompatibler Oberfläche und ihre Herstellung
US4889634A (en) 1988-10-04 1989-12-26 Gynex, Inc. Dialysate solution containing hydroxypropyl-beta-cyclodextrin and method of using same
WO2009157877A1 (en) 2008-06-23 2009-12-30 Temasek Polytechnic A sorbent for a dialysis device
WO2010045474A2 (en) 2008-10-16 2010-04-22 Fresenius Medical Care Holdings, Inc. Method of removing protein-bound deleterious substances during extracorporeal renal replacement treatment
WO2015091842A2 (de) 2013-12-20 2015-06-25 Fresenius Medical Care Deutschland Gmbh Verfahren zur entfernung proteingebundener urämietoxine durch adsorption an dialysierbare hilfsstoffe
WO2015136107A1 (de) 2014-03-14 2015-09-17 Fresenius Medical Care Deutschland Gmbh Adsorbergranulat zur entfernung urämischer toxine

Family Cites Families (16)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE109363C (https=) 1898-11-23 1900-02-14
JPS54482A (en) * 1977-06-01 1979-01-05 Toshimitsu Niwa Device for clamping albumin
JPS5774048U (https=) * 1980-10-20 1982-05-07
US6878269B2 (en) * 1996-01-31 2005-04-12 Kaneka Corporation Device for body fluid purification and system for body fluid purification
JPH09266948A (ja) * 1996-01-31 1997-10-14 Kanegafuchi Chem Ind Co Ltd 血液浄化器および血液浄化装置
DE19705366C2 (de) 1997-02-12 2002-08-01 Fresenius Ag Trägermaterial zur Reinigung proteinhaltiger Lösungen, Verfahren zur Herstellung des Trägermaterials und Verwendung des Trägermaterials
JP2004075741A (ja) * 2002-08-12 2004-03-11 Asahi Kasei Corp 血液適合性に優れた分岐ポリエチレンオキシド−ポリスルホンブロック共重合体
CN1317068C (zh) 2003-04-30 2007-05-23 中国科学院大连化学物理研究所 吸附胆红素的环糊精交联聚合物微球及其制备和应用
EP1752171A1 (en) 2005-07-28 2007-02-14 Istituto Clinico Humanitas Haemofilters for blood detoxification
JP5370712B2 (ja) * 2008-02-21 2013-12-18 日東電工株式会社 酸性水溶性標的物質吸着ポリマー及びその製造方法
CN101322932B (zh) * 2008-07-23 2011-03-16 大连理工大学 偶联环糊精的水溶性多聚物吸附材料及其应用
WO2010021973A2 (en) * 2008-08-17 2010-02-25 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
DE102010012282A1 (de) 2010-03-22 2011-09-22 Fresenius Medical Care Deutschland Gmbh Pharmazeutische Zusammensetzung enthaltend Cyclodextrin-Copolymer
US20120027837A1 (en) * 2010-07-27 2012-02-02 Massachusetts Institute Of Technology Multilayer coating compositions, coated substrates and methods thereof
EP2446908B1 (en) * 2010-11-02 2015-07-15 ICinnovation BV Electrosorption and decomposition device for the purification of blood and other fluids
US10463776B2 (en) * 2015-12-31 2019-11-05 Baxter International Inc. Methods and apparatuses using urea permselective diffusion through charged membranes

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DD109363A5 (https=) 1973-02-09 1974-11-05
GB1466702A (en) 1973-02-09 1977-03-09 Sandoz Ltd Polymer encapsulated-activated carbon
US4140652A (en) 1977-01-12 1979-02-20 Korshak Vasily V Method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons
EP0129905A2 (de) 1983-06-23 1985-01-02 Ceskoslovenska akademie ved Poröse synthetische Sorbentien mit biokompatibler Oberfläche und ihre Herstellung
US4889634A (en) 1988-10-04 1989-12-26 Gynex, Inc. Dialysate solution containing hydroxypropyl-beta-cyclodextrin and method of using same
WO2009157877A1 (en) 2008-06-23 2009-12-30 Temasek Polytechnic A sorbent for a dialysis device
WO2010045474A2 (en) 2008-10-16 2010-04-22 Fresenius Medical Care Holdings, Inc. Method of removing protein-bound deleterious substances during extracorporeal renal replacement treatment
WO2015091842A2 (de) 2013-12-20 2015-06-25 Fresenius Medical Care Deutschland Gmbh Verfahren zur entfernung proteingebundener urämietoxine durch adsorption an dialysierbare hilfsstoffe
WO2015136107A1 (de) 2014-03-14 2015-09-17 Fresenius Medical Care Deutschland Gmbh Adsorbergranulat zur entfernung urämischer toxine

Non-Patent Citations (24)

* Cited by examiner, † Cited by third party
Title
Alsbaiee A, Smith BJ, Xiao L, Ling Y, Helbling DE, Dichtel WR. Rapid removal of organic micropollutants from water by a porus β-cyclodextrin polymer. Nature 2016; 529: 790-794 / 206
Bergström J. Uraemic toxicity. In: Kopple JD, Massry SG (eds). Nutritional Management and Renal Disease. Williams et. Wilkins, Baltimore, 1997; 97-190
Biros et. al.. (Chem. Soc. Rev., 2007,36, 93-104
Cravotto et al. und Hapiot et al. offenbaren zudem eine neue Möglichkeit für die Modifizierung von Cyclodextrinen als Festphasenreaktion ohne Wasser mit Hilfe einer Kugelmühle [24, 25]
Glorieux et al., Uremic toxins and new methods to control their accumulation: game changers for the concept of dialysis adequacy, Clinicla Kidney Jornal 2015; 8: 353-362
Hammond et al. publizierten 2009 weiterhin das erste Beispiel für einen Adsorber auf Basis von Poly(carboxymethyl-β-cyclodextrin)
Hoenich NA, Woffindin C, Matthews JNS, Goldfinch ME. Turnbull J. Clinical comparison of high-flux cellulose acetate and synthetic membranes. Nephrol Dial Transplant 1994; 9: 60-66
Jicsinszky L, Caporaso M, Tuza K, Martina K, Gaudino EC, Cravotto G. Nucleophilic Substitutions of 6 0-Monotosyl-β-cyclodextrin in a Planetary Ball Mill. Sustainable Chem Eng 2016; 4:919-929
Jindal KK, McDougall J, Woods B, Nowakowski L, Goldstein MB. A study of the basic principles determining the performance of several high flux dialyzers. Am J Kidney Dis 1989; 14: 507-511
Krieter et al., Pilot trial on ionic strength hemodiafiltration, a novel dialysis technique for increased protein bound toxin removal, Poster EDTA 2014
Menuel S, Doumert B, Saitzek S, Ponchel A. Delevoye L, Monlier E, Hapiot F. Selective Secondary Face Modification of Cyclodextrins by Mechanosynthesis. J Org Chem 2015; 80:6259-6266
Morin et al. vorgeschlagenen Poly(trimethylammonium-β-cyclodextrin), bestehen [20]
Niwa T. Organic acids and the uremic syndrome: protein metabolite hypothesis in the progression of chronic renal failure. Semin Nephrol 1996; 16:167-182
Pavlenko D, van Gereffen, van Steenbergen MJ, Glorieux G, Vanholder R, Gerritesen KGF, Stamatialis DF. New low-flux mixed matrix membranes that offer superior removal of protein-bound toxines from human plasma. Nature, Scientific Reports 2016; DOI: 10.1038/srep34429: 1-9
Paylenko, Geffen, van, Steenbergen, Glorieux, Vanholder, Gerritsen, Stamatialis: New low-flux mixed matrix membranes that offer superior removal of protein-bound toxins from human plasma. In: Scientific Reports, 6, 05.10.2016, Artikelnummer 34429. *
Pedehontaa-Hiaa G, Guerrouache M, Carbonnier B, Le Derf F, Morin CJ. Layer-by-Layer Assemblies Based on a Cationic β-Cyclodextrin Polymer: Chiral Stationary Phases for Open-Tubular Electrochromatography. Chromatographia 2015; 78: 533-541
Shaw PE, Buslig BS. Selective Removal of Bitter Compounds from Grapefruit Juice and from Aqueous Solution with Cyclodextrin Polymers and with Amberlite XAD-4. J Agric Food Chem 1986; 34: 837-840
Smith RC, Riollano M, Leung A, Hammond PT. Layer-by-Layer Platform Technology for Small-Molecule Delivery. Angew. Chem. Int. Ed. 2009; 48: 8974-8977
Smith, Riollano, Leung, Hammond: Layer-by:layer Platform Technology for small-Molecule Delivery. In: Angew. Chem. Int. Ed., 48, 2009, 8974-8977. *
Tetta C, Cavaillon JM, Schulze M, Ronco C, Ghezzi PM, Camussi G, Serra AM, Lonnemann FC et G. Removal of cytokines and activated complement components in an experimental model of continuous plasma filtration coupled with sorbent adsorption. Nephrol Dial Transplant 1998; 13: 1458-1464
Tijink MSL, Wester M, Sun J, Saris A, Bolhuis-Versteeg LAM, Saiful S, Joles JA, Borneman Z, Wessling M, Stamatialis DF. A novel approach for blood purification: Mixed-matrix membranes combining diffusion and adsorption in one step. Acta Biomaterialia 2012; 8: 2279-2287
Vanholder et al., Kidney International,63(2003) 1934 - 1943
Vanholder R, De Smet R, Ringoir S. Assessment of urea and other uremic markers for quantification of dialysis efficacy. Clin Chem 1992; 38: 1429-1436
Zheng Y, Wyman IW. Supramolecular Nanostructures Based on Cyclodextrin an Poly(ethylene oxide): Synthesis, Structural Characterizations and Applications for Drug Delivery. Polymers 2016; 8: 198 (18 pages)

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