JP7048425B2 - タンパク質結合尿毒症性毒素の透析のための血液適合性吸着体 - Google Patents

タンパク質結合尿毒症性毒素の透析のための血液適合性吸着体 Download PDF

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JP7048425B2
JP7048425B2 JP2018113695A JP2018113695A JP7048425B2 JP 7048425 B2 JP7048425 B2 JP 7048425B2 JP 2018113695 A JP2018113695 A JP 2018113695A JP 2018113695 A JP2018113695 A JP 2018113695A JP 7048425 B2 JP7048425 B2 JP 7048425B2
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blood
compatible
dialysis
protein
cyclodextrin
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JP2019005569A (ja
JP2019005569A5 (https=
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アンゲラ・バイアー‐ゴシュッツ
アレクサンダー・フリーベ
ローラント・ナピーララ
ユリアネ・ゲープラー
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B Braun Avitum AG
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    • B01J20/22—Solid sorbent compositions or filter aid compositions; Sorbents for chromatography; Processes for preparing, regenerating or reactivating thereof comprising organic material
    • B01J20/24—Naturally occurring macromolecular compounds, e.g. humic acids or their derivatives
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    • A61M1/14—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis
    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
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    • A61M1/16—Dialysis systems; Artificial kidneys; Blood oxygenators ; Reciprocating systems for treatment of body fluids, e.g. single needle systems for hemofiltration or pheresis with membranes
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    • A—HUMAN NECESSITIES
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  • Chemical & Material Sciences (AREA)
  • Analytical Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
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  • Hematology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Urology & Nephrology (AREA)
  • Biochemistry (AREA)
  • Cardiology (AREA)
  • Biodiversity & Conservation Biology (AREA)
  • Cell Biology (AREA)
  • Emergency Medicine (AREA)
  • External Artificial Organs (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Solid-Sorbent Or Filter-Aiding Compositions (AREA)
JP2018113695A 2017-06-22 2018-06-14 タンパク質結合尿毒症性毒素の透析のための血液適合性吸着体 Active JP7048425B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE102017113853.6A DE102017113853A1 (de) 2017-06-22 2017-06-22 Hämokompatibler Adsorber zur Dialyse proteingebundener Urämietoxine
DE102017113853.6 2017-06-22

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JP2019005569A JP2019005569A (ja) 2019-01-17
JP2019005569A5 JP2019005569A5 (https=) 2021-07-26
JP7048425B2 true JP7048425B2 (ja) 2022-04-05

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US (1) US10625241B2 (https=)
EP (1) EP3417937B1 (https=)
JP (1) JP7048425B2 (https=)
CN (1) CN109107541B (https=)
DE (1) DE102017113853A1 (https=)
RU (1) RU2018118955A (https=)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3735281B1 (en) 2018-01-05 2024-11-27 Path Ex, Inc. Device for the capture and removal of disease material from fluids
US11806676B2 (en) * 2018-07-25 2023-11-07 Universiteit Twente Compositions for use in the simultaneous removal of endotoxins and uremic solutes during the treatment of patients
JP7526737B2 (ja) 2019-03-06 2024-08-01 ガンブロ ルンディア アクティエボラーグ アルカリホスファターゼを含む血液処理装置
US10926019B2 (en) 2019-06-05 2021-02-23 Choon Kee Lee Gradient dialysate hemodiafiltration
ES3053504T3 (en) * 2019-11-22 2026-01-22 Umc Utrecht Holding Bv Porous membranes comprising sorbent particles for improved urea capture
US20230405201A1 (en) * 2020-11-13 2023-12-21 Fresenius Medical Care Holdings, Inc. Techniques for increasing red blood cell count
WO2024073056A1 (en) * 2022-09-29 2024-04-04 Kureha America, Inc. Cucurbituril compositions, products, and methods of use
CN120923796B (zh) * 2025-08-06 2026-02-06 上海安德松申医疗科技股份有限公司 一种用于清除蛋白结合毒素及中大分子毒素吸附剂及其制备方法

Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090292A (en) 1997-02-12 2000-07-18 Fresenius Ag Device for purifying solutions containing proteins and use of the device
CN1317068C (zh) 2003-04-30 2007-05-23 中国科学院大连化学物理研究所 吸附胆红素的环糊精交联聚合物微球及其制备和应用
CN101322932A (zh) 2008-07-23 2008-12-17 大连理工大学 偶联环糊精的水溶性多聚物吸附材料及其应用
JP2009502905A (ja) 2005-07-28 2009-01-29 ヒューマニタス・ミラソーレ・エス．ピー．エー． 血液を解毒するための血液濾過材
US20100040674A1 (en) 2008-08-17 2010-02-18 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
JP2013522330A (ja) 2010-03-22 2013-06-13 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロデキストリン共重合体を含有する医薬組成物

Family Cites Families (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE109363C (https=) 1898-11-23 1900-02-14
GB1466702A (en) 1973-02-09 1977-03-09 Sandoz Ltd Polymer encapsulated-activated carbon
US4140652A (en) 1977-01-12 1979-02-20 Korshak Vasily V Method of preparing blood-compatible sorbents for recovering exo- and endogenic poisons
JPS54482A (en) * 1977-06-01 1979-01-05 Toshimitsu Niwa Device for clamping albumin
JPS5774048U (https=) * 1980-10-20 1982-05-07
CS248505B1 (en) 1983-06-23 1987-02-12 Marie Tlustakova Method of biocompatible layer production on surface of porous synthetic sorbents' particles
US4889634A (en) 1988-10-04 1989-12-26 Gynex, Inc. Dialysate solution containing hydroxypropyl-beta-cyclodextrin and method of using same
US6878269B2 (en) * 1996-01-31 2005-04-12 Kaneka Corporation Device for body fluid purification and system for body fluid purification
JPH09266948A (ja) * 1996-01-31 1997-10-14 Kanegafuchi Chem Ind Co Ltd 血液浄化器および血液浄化装置
JP2004075741A (ja) * 2002-08-12 2004-03-11 Asahi Kasei Corp 血液適合性に優れた分岐ポリエチレンオキシド−ポリスルホンブロック共重合体
JP5370712B2 (ja) * 2008-02-21 2013-12-18 日東電工株式会社 酸性水溶性標的物質吸着ポリマー及びその製造方法
US9067017B2 (en) 2008-06-23 2015-06-30 Temasek Polytechnic Flow system of a dialysis device and a portable dialysis device
WO2010045474A2 (en) 2008-10-16 2010-04-22 Fresenius Medical Care Holdings, Inc. Method of removing protein-bound deleterious substances during extracorporeal renal replacement treatment
US20120027837A1 (en) * 2010-07-27 2012-02-02 Massachusetts Institute Of Technology Multilayer coating compositions, coated substrates and methods thereof
EP2446908B1 (en) * 2010-11-02 2015-07-15 ICinnovation BV Electrosorption and decomposition device for the purification of blood and other fluids
DE102013021957A1 (de) 2013-12-20 2015-06-25 Fresenius Medical Care Deutschland Gmbh Verfahren zur Entfernung proteingebundener Urämietoxine durch Adsorption an dialysierbare Hilfsstoffe
EP2918337A1 (de) 2014-03-14 2015-09-16 Fresenius Medical Care Deutschland GmbH Adsorbergranulat zur Entfernung urämischer Toxine
US10463776B2 (en) * 2015-12-31 2019-11-05 Baxter International Inc. Methods and apparatuses using urea permselective diffusion through charged membranes

Patent Citations (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6090292A (en) 1997-02-12 2000-07-18 Fresenius Ag Device for purifying solutions containing proteins and use of the device
CN1317068C (zh) 2003-04-30 2007-05-23 中国科学院大连化学物理研究所 吸附胆红素的环糊精交联聚合物微球及其制备和应用
JP2009502905A (ja) 2005-07-28 2009-01-29 ヒューマニタス・ミラソーレ・エス．ピー．エー． 血液を解毒するための血液濾過材
CN101322932A (zh) 2008-07-23 2008-12-17 大连理工大学 偶联环糊精的水溶性多聚物吸附材料及其应用
US20100040674A1 (en) 2008-08-17 2010-02-18 Massachusetts Institute Of Technology Controlled delivery of bioactive agents from decomposable films
JP2013522330A (ja) 2010-03-22 2013-06-13 フレゼニウス メディカル ケア ドイッチェランド ゲゼルシャフト ミット ベシュレンクテル ハフツング シクロデキストリン共重合体を含有する医薬組成物

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
Jatupol Junthip, et al.，Layer-by-layer coating of textile with two oppositely charged cyclodextrin polyelectrolytes for extended drug delivery，JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A，Vol. 104 No. 6，2016年，pp. 1408-1414

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