JP2019005569A5 - - Google Patents

Info

Publication number

JP2019005569A5

JP2019005569A5 JP2018113695A JP2018113695A JP2019005569A5 JP 2019005569 A5 JP2019005569 A5 JP 2019005569A5 JP 2018113695 A JP2018113695 A JP 2018113695A JP 2018113695 A JP2018113695 A JP 2018113695A JP 2019005569 A5 JP2019005569 A5 JP 2019005569A5

Authority

JP

Japan

Prior art keywords

blood

compatible

adsorbent according

solid carrier

carrier component

Prior art date

2018-06-14

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000003463 adsorbent Substances 0.000 claims 12
• 239000007787 solid Substances 0.000 claims 7
• 239000008280 blood Substances 0.000 claims 6
• 210000004369 blood Anatomy 0.000 claims 6
• 238000001631 haemodialysis Methods 0.000 claims 6
• 230000000322 hemodialysis Effects 0.000 claims 6
• 229920000642 polymer Polymers 0.000 claims 6
• 102000014914 Carrier Proteins Human genes 0.000 claims 3
• 108010078791 Carrier Proteins Proteins 0.000 claims 3
• 239000002253 acid Substances 0.000 claims 3
• -1 cyclic oligosaccharide Chemical class 0.000 claims 3
• 238000000502 dialysis Methods 0.000 claims 3
• 229920001542 oligosaccharide Polymers 0.000 claims 3
• 239000011148 porous material Substances 0.000 claims 3
• 229920000858 Cyclodextrin Polymers 0.000 claims 2
• 229930040373 Paraformaldehyde Natural products 0.000 claims 2
• ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims 2
• 239000004696 Poly ether ether ketone Substances 0.000 claims 2
• 239000004695 Polyether sulfone Substances 0.000 claims 2
• 229920000491 Polyphenylsulfone Polymers 0.000 claims 2
• BXFFHSIDQOFMLE-UHFFFAOYSA-N indoxyl sulfate Chemical compound C1=CC=C2C(OS(=O)(=O)O)=CNC2=C1 BXFFHSIDQOFMLE-UHFFFAOYSA-N 0.000 claims 2
• IWDCLRJOBJJRNH-UHFFFAOYSA-N p-cresol Chemical compound CC1=CC=C(O)C=C1 IWDCLRJOBJJRNH-UHFFFAOYSA-N 0.000 claims 2
• 229920002492 poly(sulfone) Polymers 0.000 claims 2
• 229920006393 polyether sulfone Polymers 0.000 claims 2
• 229920002530 polyetherether ketone Polymers 0.000 claims 2
• 229920006324 polyoxymethylene Polymers 0.000 claims 2
• 108090000623 proteins and genes Proteins 0.000 claims 2
• 102000004169 proteins and genes Human genes 0.000 claims 2
• 239000002441 uremic toxin Substances 0.000 claims 2
• CUJVBAPGYBSBHJ-YWBSARSQSA-N 2-[[(1R,3R,5R,6S,8R,10R,11S,13R,15R,16S,18R,20R,21R,23R,25R,26R,28R,30R,31R,33R,35R,36R,37R,38R,39R,40R,41R,42R,43R,44R,45R,46R,47R,48R,49R)-36,38,40,42-tetrakis(carboxymethoxy)-10,15-bis(carboxymethoxymethyl)-37,39,41,43,44,45,46,47,48,49-decahydroxy-20,25,30,35-tetrakis(hydroxymethyl)-2,4,7,9,12,14,17,19,22,24,27,29,32,34-tetradecaoxaoctacyclo[31.2.2.23,6.28,11.213,16.218,21.223,26.228,31]nonatetracontan-5-yl]methoxy]acetic acid Chemical compound OC[C@H]1O[C@@H]2O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCC(O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCC(O)=O)O[C@H]3[C@H](O)[C@@H](O)[C@H](O[C@@H]3COCC(O)=O)O[C@@H]3[C@@H](CO)O[C@H](O[C@@H]4[C@@H](CO)O[C@H](O[C@@H]5[C@@H](CO)O[C@H](O[C@H]1[C@H](OCC(O)=O)[C@H]2O)[C@H](O)[C@H]5OCC(O)=O)[C@H](O)[C@H]4OCC(O)=O)[C@H](O)[C@H]3OCC(O)=O CUJVBAPGYBSBHJ-YWBSARSQSA-N 0.000 claims 1
• NLHHRLWOUZZQLW-UHFFFAOYSA-N Acrylonitrile Chemical compound C=CC#N NLHHRLWOUZZQLW-UHFFFAOYSA-N 0.000 claims 1
• BRLQWZUYTZBJKN-UHFFFAOYSA-N Epichlorohydrin Chemical compound ClCC1CO1 BRLQWZUYTZBJKN-UHFFFAOYSA-N 0.000 claims 1
• 239000001116 FEMA 4028 Substances 0.000 claims 1
• 102000008100 Human Serum Albumin Human genes 0.000 claims 1
• 108091006905 Human Serum Albumin Proteins 0.000 claims 1
• FFFHZYDWPBMWHY-VKHMYHEASA-N L-homocysteine Chemical compound OC(=O)[C@@H](N)CCS FFFHZYDWPBMWHY-VKHMYHEASA-N 0.000 claims 1
• 239000004677 Nylon Substances 0.000 claims 1
• 239000004952 Polyamide Substances 0.000 claims 1
• 239000004793 Polystyrene Substances 0.000 claims 1
• LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims 1
• TVWHNULVHGKJHS-UHFFFAOYSA-N Uric acid Natural products N1C(=O)NC(=O)C2NC(=O)NC21 TVWHNULVHGKJHS-UHFFFAOYSA-N 0.000 claims 1
• 150000007513 acids Chemical class 0.000 claims 1
• 229960004853 betadex Drugs 0.000 claims 1
• 230000017531 blood circulation Effects 0.000 claims 1
• 239000000306 component Substances 0.000 claims 1
• 229920001577 copolymer Polymers 0.000 claims 1
• 125000004122 cyclic group Chemical group 0.000 claims 1
• 238000001914 filtration Methods 0.000 claims 1
• 239000012510 hollow fiber Substances 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• DUGDVPXCHOVCOS-UHFFFAOYSA-N methyl prop-2-ene-1-sulfonate Chemical class COS(=O)(=O)CC=C DUGDVPXCHOVCOS-UHFFFAOYSA-N 0.000 claims 1
• 229920001778 nylon Polymers 0.000 claims 1
• 150000002482 oligosaccharides Chemical class 0.000 claims 1
• 150000002989 phenols Chemical class 0.000 claims 1
• 229920002647 polyamide Polymers 0.000 claims 1
• 150000008442 polyphenolic compounds Chemical class 0.000 claims 1
• 235000013824 polyphenols Nutrition 0.000 claims 1
• 229920002223 polystyrene Polymers 0.000 claims 1
• HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 claims 1
• 239000003053 toxin Substances 0.000 claims 1
• 231100000765 toxin Toxicity 0.000 claims 1
• 108700012359 toxins Proteins 0.000 claims 1
• 238000011144 upstream manufacturing Methods 0.000 claims 1
• 229940116269 uric acid Drugs 0.000 claims 1