RU2018103235A - Оптимально активированные дендритные клетки, индуцирующие улучшенный или повышенный противоопухолевый иммунный ответ - Google Patents
Оптимально активированные дендритные клетки, индуцирующие улучшенный или повышенный противоопухолевый иммунный ответ Download PDFInfo
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- RU2018103235A RU2018103235A RU2018103235A RU2018103235A RU2018103235A RU 2018103235 A RU2018103235 A RU 2018103235A RU 2018103235 A RU2018103235 A RU 2018103235A RU 2018103235 A RU2018103235 A RU 2018103235A RU 2018103235 A RU2018103235 A RU 2018103235A
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- dendritic cells
- tumor
- cells
- human dendritic
- bcg
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- 230000001939 inductive effect Effects 0.000 title claims 9
- 230000005975 antitumor immune response Effects 0.000 title claims 2
- 210000004443 dendritic cell Anatomy 0.000 claims 36
- 238000000034 method Methods 0.000 claims 16
- 206010028980 Neoplasm Diseases 0.000 claims 12
- 239000002243 precursor Substances 0.000 claims 11
- 210000004027 cell Anatomy 0.000 claims 10
- 230000035800 maturation Effects 0.000 claims 5
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 claims 4
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 4
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- -1 imidazoquinoline compound Chemical class 0.000 claims 4
- 239000000203 mixture Substances 0.000 claims 4
- 239000003104 tissue culture media Substances 0.000 claims 4
- 102000004127 Cytokines Human genes 0.000 claims 3
- 108090000695 Cytokines Proteins 0.000 claims 3
- 238000002955 isolation Methods 0.000 claims 3
- FQYRLEXKXQRZDH-UHFFFAOYSA-N 4-aminoquinoline Chemical compound C1=CC=C2C(N)=CC=NC2=C1 FQYRLEXKXQRZDH-UHFFFAOYSA-N 0.000 claims 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims 2
- 102000004889 Interleukin-6 Human genes 0.000 claims 2
- 108090001005 Interleukin-6 Proteins 0.000 claims 2
- 102000004890 Interleukin-8 Human genes 0.000 claims 2
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- 229940123384 Toll-like receptor (TLR) agonist Drugs 0.000 claims 2
- 238000002512 chemotherapy Methods 0.000 claims 2
- 230000004069 differentiation Effects 0.000 claims 2
- 239000002158 endotoxin Substances 0.000 claims 2
- 229940124669 imidazoquinoline Drugs 0.000 claims 2
- 229940100601 interleukin-6 Drugs 0.000 claims 2
- 229940096397 interleukin-8 Drugs 0.000 claims 2
- XKTZWUACRZHVAN-VADRZIEHSA-N interleukin-8 Chemical compound C([C@H](NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@@H](NC(C)=O)CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)NCC(=O)N[C@@H](CCSC)C(=O)N1[C@H](CCC1)C(=O)N1[C@H](CCC1)C(=O)N[C@@H](C)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CCC(O)=O)C(=O)N[C@H](CC(O)=O)C(=O)N[C@H](CC=1C=CC(O)=CC=1)C(=O)N[C@H](CO)C(=O)N1[C@H](CCC1)C(N)=O)C1=CC=CC=C1 XKTZWUACRZHVAN-VADRZIEHSA-N 0.000 claims 2
- 229920006008 lipopolysaccharide Polymers 0.000 claims 2
- 210000001165 lymph node Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
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- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 2
- 108091033319 polynucleotide Proteins 0.000 claims 2
- 102000040430 polynucleotide Human genes 0.000 claims 2
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- 239000003970 toll like receptor agonist Substances 0.000 claims 2
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- 241000193830 Bacillus <bacterium> Species 0.000 claims 1
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N EtOH Substances CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 1
- 102000008070 Interferon-gamma Human genes 0.000 claims 1
- 108010074328 Interferon-gamma Proteins 0.000 claims 1
- 102000003816 Interleukin-13 Human genes 0.000 claims 1
- 108090000176 Interleukin-13 Proteins 0.000 claims 1
- 102000003812 Interleukin-15 Human genes 0.000 claims 1
- 108090000172 Interleukin-15 Proteins 0.000 claims 1
- 102000004388 Interleukin-4 Human genes 0.000 claims 1
- 108090000978 Interleukin-4 Proteins 0.000 claims 1
- 102000000704 Interleukin-7 Human genes 0.000 claims 1
- 108010002586 Interleukin-7 Proteins 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 102000002689 Toll-like receptor Human genes 0.000 claims 1
- 108020000411 Toll-like receptor Proteins 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
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- 210000004204 blood vessel Anatomy 0.000 claims 1
- 210000001185 bone marrow Anatomy 0.000 claims 1
- 230000024245 cell differentiation Effects 0.000 claims 1
- 210000002421 cell wall Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 230000004041 dendritic cell maturation Effects 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000028709 inflammatory response Effects 0.000 claims 1
- 229960003130 interferon gamma Drugs 0.000 claims 1
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 1
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- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/06—Animal cells or tissues; Human cells or tissues
- C12N5/0602—Vertebrate cells
- C12N5/0634—Cells from the blood or the immune system
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- Health & Medical Sciences (AREA)
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- General Health & Medical Sciences (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
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- Organic Chemistry (AREA)
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- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Developmental Biology & Embryology (AREA)
- Virology (AREA)
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- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187086P | 2015-06-30 | 2015-06-30 | |
| US62/187,086 | 2015-06-30 | ||
| PCT/US2016/040134 WO2017004230A1 (en) | 2015-06-30 | 2016-06-29 | Optimally activated dendritic cells that induce an improved or increased anti-tumor immune response |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2018103235A true RU2018103235A (ru) | 2019-07-31 |
| RU2018103235A3 RU2018103235A3 (https=) | 2019-12-23 |
Family
ID=57609106
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018103235A RU2018103235A (ru) | 2015-06-30 | 2016-06-29 | Оптимально активированные дендритные клетки, индуцирующие улучшенный или повышенный противоопухолевый иммунный ответ |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US11124768B2 (https=) |
| EP (2) | EP3317403B1 (https=) |
| JP (3) | JP6985939B2 (https=) |
| KR (1) | KR102763373B1 (https=) |
| CN (2) | CN107849537A (https=) |
| AR (1) | AR106496A1 (https=) |
| AU (2) | AU2016286112B2 (https=) |
| CA (1) | CA2990640A1 (https=) |
| ES (1) | ES3032055T3 (https=) |
| IL (2) | IL312668A (https=) |
| MX (2) | MX2018000056A (https=) |
| PL (1) | PL424035A1 (https=) |
| RU (1) | RU2018103235A (https=) |
| WO (1) | WO2017004230A1 (https=) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2018160666A1 (en) * | 2017-02-28 | 2018-09-07 | University Of Pittsburgh-Of The Commonwealth System Of Higher Education | Short-term activated dc1s and methods for their production and use |
| SG11202011806WA (en) | 2018-06-21 | 2021-01-28 | Univ Gent | Method for the in vitro differentiation and maturation of dendritic cells for therapeutic use |
| AU2020363707A1 (en) * | 2019-10-07 | 2022-04-28 | Northwest Biotherapeutics, Inc. | In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response |
| CN117417886B (zh) * | 2023-10-20 | 2024-05-14 | 广东壹加再生医学研究院有限公司 | 一种负载肿瘤抗原的树突状细胞激活的t淋巴细胞的培养方法 |
| CN119286782B (zh) * | 2024-12-11 | 2025-04-04 | 上海赛笠百傲生物医药有限公司 | 一种高效诱导外周血来源单核细胞至不成熟树突状细胞的方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PT633929E (pt) | 1992-04-01 | 2004-07-30 | Merix Bioscience Inc | Metodo para proliferacao (in vitro) de precursores de celulas dentifricas e sua utilizacao para produzir imunogenios |
| US6080409A (en) * | 1995-12-28 | 2000-06-27 | Dendreon Corporation | Immunostimulatory method |
| US7659119B2 (en) | 1996-02-12 | 2010-02-09 | Argos Therapeutics, Inc. | Method and compositions for obtaining mature dendritic cells |
| US6558951B1 (en) | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
| US20020094545A1 (en) | 2000-11-30 | 2002-07-18 | Harris Paul E. | Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads |
| AU2002326463A1 (en) | 2001-07-25 | 2003-02-17 | Northwest Biotherapeutics, Inc. | Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors |
| CN1636229B (zh) * | 2001-09-06 | 2012-12-19 | 西北生物治疗药物公司 | 引发单核树突细胞和t细胞th-1应答的组合物和方法 |
| WO2004000444A1 (en) | 2002-06-19 | 2003-12-31 | Northwest Biotherapeutics, Inc. | Tangential flow filtration devices and methods for leukocyte enrichment |
| ES2354944T3 (es) * | 2002-12-06 | 2011-03-21 | Northwest Biotherapeutics, Inc. | Administración de células dendríticas maduradas parcialmente in vitro para el tratamiento de tumores. |
| ES2321939T3 (es) * | 2003-02-27 | 2009-06-15 | Northwest Biotherapeutics, Inc. | Generacion de celulas dendriticas a partir de celulas precursoras dendriticas monociticas con gm-csf en ausencia de citoquinas adicionales. |
| KR100887560B1 (ko) | 2007-04-24 | 2009-03-09 | 크레아젠 주식회사 | 준성숙 수지상 세포를 포함하는 류마티스 관절염 치료용약제학적 조성물 |
| EP3375868A1 (en) | 2007-11-08 | 2018-09-19 | Dana Farber Cancer Institute, Inc. | Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28 |
| EP2072617A1 (en) | 2007-12-12 | 2009-06-24 | Trimed Biotech GmbH | Method for producing dendritic cells |
| AU2009237577B2 (en) | 2008-04-18 | 2014-06-05 | Baxter Healthcare Sa | Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes |
| EP2968406A4 (en) * | 2013-03-14 | 2016-10-26 | Icahn School Med Mount Sinai | WITH AUTOLOGOUS TUMORLYSAT-LOADED DENDRITIC CELL VACCINE FOR THE TREATMENT OF LIVER CANCER |
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2016
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