CA2990640A1 - Optimally activated dendritic cells that induce an improved or increased anti-tumor immune response - Google Patents

Optimally activated dendritic cells that induce an improved or increased anti-tumor immune response Download PDF

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Publication number
CA2990640A1
CA2990640A1 CA2990640A CA2990640A CA2990640A1 CA 2990640 A1 CA2990640 A1 CA 2990640A1 CA 2990640 A CA2990640 A CA 2990640A CA 2990640 A CA2990640 A CA 2990640A CA 2990640 A1 CA2990640 A1 CA 2990640A1
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tumor
cells
dendritic cells
human
dendritic cell
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CA2990640A
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French (fr)
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Marnix L. Bosch
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Northwest Biotherapeutics LLC
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Northwest Biotherapeutics LLC
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • C12N5/064—Immunosuppressive dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/15—Cells of the myeloid line, e.g. granulocytes, basophils, eosinophils, neutrophils, leucocytes, monocytes, macrophages or mast cells; Myeloid precursor cells; Antigen-presenting cells, e.g. dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/19—Dendritic cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/20—Cellular immunotherapy characterised by the effect or the function of the cells
    • A61K40/24—Antigen-presenting cells [APC]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/35—Cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0639—Dendritic cells, e.g. Langherhans cells in the epidermis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/515—Animal cells
    • A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2501/20—Cytokines; Chemokines
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    • C12N2506/00—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells
    • C12N2506/11—Differentiation of animal cells from one lineage to another; Differentiation of pluripotent cells from blood or immune system cells

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  • Biomedical Technology (AREA)
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  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Mycology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Oncology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
CA2990640A 2015-06-30 2016-06-29 Optimally activated dendritic cells that induce an improved or increased anti-tumor immune response Pending CA2990640A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201562187086P 2015-06-30 2015-06-30
US62/187,086 2015-06-30
PCT/US2016/040134 WO2017004230A1 (en) 2015-06-30 2016-06-29 Optimally activated dendritic cells that induce an improved or increased anti-tumor immune response

Publications (1)

Publication Number Publication Date
CA2990640A1 true CA2990640A1 (en) 2017-01-05

Family

ID=57609106

Family Applications (1)

Application Number Title Priority Date Filing Date
CA2990640A Pending CA2990640A1 (en) 2015-06-30 2016-06-29 Optimally activated dendritic cells that induce an improved or increased anti-tumor immune response

Country Status (14)

Country Link
US (2) US11124768B2 (https=)
EP (2) EP3317403B1 (https=)
JP (3) JP6985939B2 (https=)
KR (1) KR102763373B1 (https=)
CN (2) CN107849537A (https=)
AR (1) AR106496A1 (https=)
AU (2) AU2016286112B2 (https=)
CA (1) CA2990640A1 (https=)
ES (1) ES3032055T3 (https=)
IL (2) IL312668A (https=)
MX (2) MX2018000056A (https=)
PL (1) PL424035A1 (https=)
RU (1) RU2018103235A (https=)
WO (1) WO2017004230A1 (https=)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018160666A1 (en) * 2017-02-28 2018-09-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Short-term activated dc1s and methods for their production and use
SG11202011806WA (en) 2018-06-21 2021-01-28 Univ Gent Method for the in vitro differentiation and maturation of dendritic cells for therapeutic use
AU2020363707A1 (en) * 2019-10-07 2022-04-28 Northwest Biotherapeutics, Inc. In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response
CN117417886B (zh) * 2023-10-20 2024-05-14 广东壹加再生医学研究院有限公司 一种负载肿瘤抗原的树突状细胞激活的t淋巴细胞的培养方法
CN119286782B (zh) * 2024-12-11 2025-04-04 上海赛笠百傲生物医药有限公司 一种高效诱导外周血来源单核细胞至不成熟树突状细胞的方法

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PT633929E (pt) 1992-04-01 2004-07-30 Merix Bioscience Inc Metodo para proliferacao (in vitro) de precursores de celulas dentifricas e sua utilizacao para produzir imunogenios
US6080409A (en) * 1995-12-28 2000-06-27 Dendreon Corporation Immunostimulatory method
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
US6558951B1 (en) 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
US20020094545A1 (en) 2000-11-30 2002-07-18 Harris Paul E. Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads
AU2002326463A1 (en) 2001-07-25 2003-02-17 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
CN1636229B (zh) * 2001-09-06 2012-12-19 西北生物治疗药物公司 引发单核树突细胞和t细胞th-1应答的组合物和方法
WO2004000444A1 (en) 2002-06-19 2003-12-31 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
ES2354944T3 (es) * 2002-12-06 2011-03-21 Northwest Biotherapeutics, Inc. Administración de células dendríticas maduradas parcialmente in vitro para el tratamiento de tumores.
ES2321939T3 (es) * 2003-02-27 2009-06-15 Northwest Biotherapeutics, Inc. Generacion de celulas dendriticas a partir de celulas precursoras dendriticas monociticas con gm-csf en ausencia de citoquinas adicionales.
KR100887560B1 (ko) 2007-04-24 2009-03-09 크레아젠 주식회사 준성숙 수지상 세포를 포함하는 류마티스 관절염 치료용약제학적 조성물
EP3375868A1 (en) 2007-11-08 2018-09-19 Dana Farber Cancer Institute, Inc. Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28
EP2072617A1 (en) 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
AU2009237577B2 (en) 2008-04-18 2014-06-05 Baxter Healthcare Sa Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
EP2968406A4 (en) * 2013-03-14 2016-10-26 Icahn School Med Mount Sinai WITH AUTOLOGOUS TUMORLYSAT-LOADED DENDRITIC CELL VACCINE FOR THE TREATMENT OF LIVER CANCER

Also Published As

Publication number Publication date
JP2022023248A (ja) 2022-02-07
CN114774356A (zh) 2022-07-22
MX2018000056A (es) 2018-05-28
BR112017028602A2 (pt) 2018-09-04
JP6985939B2 (ja) 2021-12-22
EP3317403A1 (en) 2018-05-09
RU2018103235A (ru) 2019-07-31
CN107849537A (zh) 2018-03-27
US20180187145A1 (en) 2018-07-05
IL256522A (en) 2018-02-28
US11124768B2 (en) 2021-09-21
EP3317403A4 (en) 2019-07-03
JP2024101059A (ja) 2024-07-26
HK1255084A1 (en) 2019-08-02
AU2023202977A1 (en) 2023-06-01
US20220145246A1 (en) 2022-05-12
JP2018523996A (ja) 2018-08-30
AU2023202977B2 (en) 2026-03-05
WO2017004230A1 (en) 2017-01-05
AU2016286112A1 (en) 2018-02-15
KR102763373B1 (ko) 2025-02-07
KR20180022949A (ko) 2018-03-06
IL312668A (en) 2024-07-01
AU2016286112B2 (en) 2023-02-16
AR106496A1 (es) 2018-01-24
EP4574159A3 (en) 2025-09-17
IL256522B2 (en) 2024-10-01
EP3317403B1 (en) 2025-03-05
IL256522B1 (en) 2024-06-01
PL424035A1 (pl) 2019-01-02
ES3032055T3 (en) 2025-07-15
MX2023001622A (es) 2023-03-09
EP4574159A2 (en) 2025-06-25
RU2018103235A3 (https=) 2019-12-23

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