JP2006510667A5 - - Google Patents
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- JP2006510667A5 JP2006510667A5 JP2004559310A JP2004559310A JP2006510667A5 JP 2006510667 A5 JP2006510667 A5 JP 2006510667A5 JP 2004559310 A JP2004559310 A JP 2004559310A JP 2004559310 A JP2004559310 A JP 2004559310A JP 2006510667 A5 JP2006510667 A5 JP 2006510667A5
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- cell
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| EP2072617A1 (en) * | 2007-12-12 | 2009-06-24 | Trimed Biotech GmbH | Method for producing dendritic cells |
| RU2361598C1 (ru) * | 2008-02-18 | 2009-07-20 | Тихоокеанский Институт Биоорганической Химии Дальневосточного Отделения Российской Академии Наук (Тибох Дво Ран) | Средство, индуцирующее созревание дендритных клеток |
| KR101946785B1 (ko) * | 2008-03-27 | 2019-02-12 | 아스테리아스 바이오세라퓨틱스, 인크. | 영장류 다능성 줄기 세포의 조혈계 세포로의 분화 |
| CA2767300C (en) * | 2009-07-09 | 2020-01-07 | Cellerix Sa | Methods and compositions for use in cellular therapies |
| SI2534242T1 (sl) * | 2010-02-10 | 2016-08-31 | Immunicum Ab | Izboljšan sestavek za inhibicijo tumorske celične proliferacije |
| CN102933228A (zh) * | 2010-03-15 | 2013-02-13 | 宾夕法尼亚大学董事会 | 制备和储存活化的、成熟树突细胞的体系和方法 |
| RU2530523C2 (ru) * | 2012-03-29 | 2014-10-10 | Олег Борисович Егоров | Способ противоопухолевой иммунотерапии |
| US8961957B2 (en) | 2012-06-27 | 2015-02-24 | Hasumi International Research Foundation | Therapy and method for intratumorally introducing cytotoxic T lymphocyte and/or NKT cell with anti-TNF and/or anti-IL-10 |
| GB201300049D0 (en) * | 2013-01-03 | 2013-02-20 | Transimmune Ag | Method for obtaining immuno-stimulatory dendritic cells |
| KR20160093012A (ko) | 2013-11-05 | 2016-08-05 | 코그네이트 바이오서비시즈, 인코포레이티드 | 암 치료를 위한 체크포인트 억제제 및 치료제의 배합물 |
| GB201413665D0 (en) | 2014-07-03 | 2014-09-17 | Transimmune Ag And Yale University | Method for obtaining globally activated monocytes |
| CN107849537A (zh) * | 2015-06-30 | 2018-03-27 | 西北生物治疗药物公司 | 诱发改善的或增加的抗肿瘤免疫应答的经最佳活化的树突细胞 |
| JP6980650B2 (ja) | 2015-09-15 | 2021-12-15 | ノースウエスト バイオセラピューティクス，インコーポレイティド | 進行したがんを有する被験体のための活性化樹状細胞組成物および免疫療法処置に関する方法 |
| KR101749165B1 (ko) * | 2016-06-07 | 2017-06-23 | 충남대학교산학협력단 | Rv2299c 또는 Rv2299c와 ESAT-6 융합한 단백질을 포함하는 수지상 세포의 성숙화 촉진용 조성물 |
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| CN109957548B (zh) * | 2017-12-26 | 2022-03-18 | 上海尚泰生物技术有限公司 | 一种基因修饰的树突状细胞疫苗 |
| CN116637180A (zh) * | 2022-02-15 | 2023-08-25 | 沈阳药科大学 | 萜类化合物在提高其淋巴靶向作用中的应用 |
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Family Cites Families (19)
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| ATE428769T1 (de) * | 1997-10-27 | 2009-05-15 | Univ Rockefeller | Methode und zusammensetzung zur herstellung von reifen dendritischen zellen |
| US6797488B1 (en) * | 1997-12-08 | 2004-09-28 | Beth Israel Deaconess Medical Center | Methods of producing anti-angiogenic proteins |
| WO2000015264A1 (en) * | 1998-09-15 | 2000-03-23 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | In situ injection of antigen-presenting cells with genetically enhanced cytokine expression |
| KR20020013470A (ko) * | 1998-10-02 | 2002-02-20 | 미우라 아키라 | 세포성 면역의 유도방법 및 세포성 면역이 유도된 세포 |
| US6649158B1 (en) * | 1998-10-15 | 2003-11-18 | Canji, Inc. | Methods and compositions to induce antitumor response |
| US6558951B1 (en) * | 1999-02-11 | 2003-05-06 | 3M Innovative Properties Company | Maturation of dendritic cells with immune response modifying compounds |
| AU781547B2 (en) * | 1999-04-14 | 2005-05-26 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Compositions containing immunotoxins and agents that inhibit dendritic cell maturation for inducing immune tolerance to a graft |
| EP1254953A4 (en) * | 1999-12-28 | 2004-06-02 | Toyoshima Kumao | Maturity-triggering agent for immature dendritic cells |
| ES2375948T3 (es) * | 2000-05-12 | 2012-03-07 | Northwest Biotherapeutics, Inc. | Procedimiento para aumentar la presentación de clase i de ant�?genos exógenos por células dendr�?ticas humanas. |
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| DE60108661T2 (de) * | 2000-11-14 | 2006-01-05 | Université Libre de Bruxelles | Herstellung und verwendung von dendritischen zellen |
| US20020094545A1 (en) | 2000-11-30 | 2002-07-18 | Harris Paul E. | Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads |
| AU2002326463A1 (en) * | 2001-07-25 | 2003-02-17 | Northwest Biotherapeutics, Inc. | Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors |
| CN1636229B (zh) * | 2001-09-06 | 2012-12-19 | 西北生物治疗药物公司 | 引发单核树突细胞和t细胞th-1应答的组合物和方法 |
| ES2354944T3 (es) * | 2002-12-06 | 2011-03-21 | Northwest Biotherapeutics, Inc. | Administración de células dendríticas maduradas parcialmente in vitro para el tratamiento de tumores. |
| ES2321939T3 (es) * | 2003-02-27 | 2009-06-15 | Northwest Biotherapeutics, Inc. | Generacion de celulas dendriticas a partir de celulas precursoras dendriticas monociticas con gm-csf en ausencia de citoquinas adicionales. |
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