KR102763373B1 - 향상되거나 증가된 항-종양 면역 반응을 유도하는 최적으로 활성화된 수지상 세포 - Google Patents

향상되거나 증가된 항-종양 면역 반응을 유도하는 최적으로 활성화된 수지상 세포 Download PDF

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KR102763373B1
KR102763373B1 KR1020187002974A KR20187002974A KR102763373B1 KR 102763373 B1 KR102763373 B1 KR 102763373B1 KR 1020187002974 A KR1020187002974 A KR 1020187002974A KR 20187002974 A KR20187002974 A KR 20187002974A KR 102763373 B1 KR102763373 B1 KR 102763373B1
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dendritic cells
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KR20180022949A (ko
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마르닉스 엘. 보쉬
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노쓰웨스트 바이오써라퓨틱스, 인크.
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KR1020187002974A 2015-06-30 2016-06-29 향상되거나 증가된 항-종양 면역 반응을 유도하는 최적으로 활성화된 수지상 세포 Active KR102763373B1 (ko)

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Application Number Priority Date Filing Date Title
US201562187086P 2015-06-30 2015-06-30
US62/187,086 2015-06-30
PCT/US2016/040134 WO2017004230A1 (en) 2015-06-30 2016-06-29 Optimally activated dendritic cells that induce an improved or increased anti-tumor immune response

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KR20180022949A KR20180022949A (ko) 2018-03-06
KR102763373B1 true KR102763373B1 (ko) 2025-02-07

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US (2) US11124768B2 (https=)
EP (2) EP3317403B1 (https=)
JP (3) JP6985939B2 (https=)
KR (1) KR102763373B1 (https=)
CN (2) CN107849537A (https=)
AR (1) AR106496A1 (https=)
AU (2) AU2016286112B2 (https=)
CA (1) CA2990640A1 (https=)
ES (1) ES3032055T3 (https=)
IL (2) IL312668A (https=)
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PL (1) PL424035A1 (https=)
RU (1) RU2018103235A (https=)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102919756B1 (ko) 2018-06-21 2026-01-28 유니버시테이트 젠트 치료용 수지상 세포의 시험관내 분화 및 성숙 방법

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2018160666A1 (en) * 2017-02-28 2018-09-07 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Short-term activated dc1s and methods for their production and use
AU2020363707A1 (en) * 2019-10-07 2022-04-28 Northwest Biotherapeutics, Inc. In vitro methods and compositions for enhancing the activation of dendritic cells and t cells, and for inducing a th-1 immune response
CN117417886B (zh) * 2023-10-20 2024-05-14 广东壹加再生医学研究院有限公司 一种负载肿瘤抗原的树突状细胞激活的t淋巴细胞的培养方法
CN119286782B (zh) * 2024-12-11 2025-04-04 上海赛笠百傲生物医药有限公司 一种高效诱导外周血来源单核细胞至不成熟树突状细胞的方法

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130273654A1 (en) * 2003-02-27 2013-10-17 Northwest Biotherapeutics, Inc. Generation of Dendritic Cells from Monocytic Dendritic Precursor Cells with GM-CSF in the Absence of Additional Cytokines

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PT633929E (pt) 1992-04-01 2004-07-30 Merix Bioscience Inc Metodo para proliferacao (in vitro) de precursores de celulas dentifricas e sua utilizacao para produzir imunogenios
US6080409A (en) * 1995-12-28 2000-06-27 Dendreon Corporation Immunostimulatory method
US7659119B2 (en) 1996-02-12 2010-02-09 Argos Therapeutics, Inc. Method and compositions for obtaining mature dendritic cells
US6558951B1 (en) 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
US20020094545A1 (en) 2000-11-30 2002-07-18 Harris Paul E. Growth of human dendritic cells for cancer immunotherapy in closed system using microcarrier beads
AU2002326463A1 (en) 2001-07-25 2003-02-17 Northwest Biotherapeutics, Inc. Methods and apparatus for enrichment and culture of monocytic dendritic cell precursors
CN1636229B (zh) * 2001-09-06 2012-12-19 西北生物治疗药物公司 引发单核树突细胞和t细胞th-1应答的组合物和方法
WO2004000444A1 (en) 2002-06-19 2003-12-31 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
ES2354944T3 (es) * 2002-12-06 2011-03-21 Northwest Biotherapeutics, Inc. Administración de células dendríticas maduradas parcialmente in vitro para el tratamiento de tumores.
KR100887560B1 (ko) 2007-04-24 2009-03-09 크레아젠 주식회사 준성숙 수지상 세포를 포함하는 류마티스 관절염 치료용약제학적 조성물
EP3375868A1 (en) 2007-11-08 2018-09-19 Dana Farber Cancer Institute, Inc. Stimulation of anti-tumor immunity using dendritic cell/tumor cell fusions and anti-cd3/cd28
EP2072617A1 (en) 2007-12-12 2009-06-24 Trimed Biotech GmbH Method for producing dendritic cells
AU2009237577B2 (en) 2008-04-18 2014-06-05 Baxter Healthcare Sa Microsphere-based composition for preventing and/or reversing new-onset autoimmune diabetes
EP2968406A4 (en) * 2013-03-14 2016-10-26 Icahn School Med Mount Sinai WITH AUTOLOGOUS TUMORLYSAT-LOADED DENDRITIC CELL VACCINE FOR THE TREATMENT OF LIVER CANCER

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20130273654A1 (en) * 2003-02-27 2013-10-17 Northwest Biotherapeutics, Inc. Generation of Dendritic Cells from Monocytic Dendritic Precursor Cells with GM-CSF in the Absence of Additional Cytokines

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR102919756B1 (ko) 2018-06-21 2026-01-28 유니버시테이트 젠트 치료용 수지상 세포의 시험관내 분화 및 성숙 방법

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CN114774356A (zh) 2022-07-22
MX2018000056A (es) 2018-05-28
BR112017028602A2 (pt) 2018-09-04
JP6985939B2 (ja) 2021-12-22
EP3317403A1 (en) 2018-05-09
RU2018103235A (ru) 2019-07-31
CN107849537A (zh) 2018-03-27
US20180187145A1 (en) 2018-07-05
CA2990640A1 (en) 2017-01-05
IL256522A (en) 2018-02-28
US11124768B2 (en) 2021-09-21
EP3317403A4 (en) 2019-07-03
JP2024101059A (ja) 2024-07-26
HK1255084A1 (en) 2019-08-02
AU2023202977A1 (en) 2023-06-01
US20220145246A1 (en) 2022-05-12
JP2018523996A (ja) 2018-08-30
AU2023202977B2 (en) 2026-03-05
WO2017004230A1 (en) 2017-01-05
AU2016286112A1 (en) 2018-02-15
KR20180022949A (ko) 2018-03-06
IL312668A (en) 2024-07-01
AU2016286112B2 (en) 2023-02-16
AR106496A1 (es) 2018-01-24
EP4574159A3 (en) 2025-09-17
IL256522B2 (en) 2024-10-01
EP3317403B1 (en) 2025-03-05
IL256522B1 (en) 2024-06-01
PL424035A1 (pl) 2019-01-02
ES3032055T3 (en) 2025-07-15
MX2023001622A (es) 2023-03-09
EP4574159A2 (en) 2025-06-25
RU2018103235A3 (https=) 2019-12-23

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