RU2018103234A - Гуманизированная мышца сердца - Google Patents
Гуманизированная мышца сердца Download PDFInfo
- Publication number
- RU2018103234A RU2018103234A RU2018103234A RU2018103234A RU2018103234A RU 2018103234 A RU2018103234 A RU 2018103234A RU 2018103234 A RU2018103234 A RU 2018103234A RU 2018103234 A RU2018103234 A RU 2018103234A RU 2018103234 A RU2018103234 A RU 2018103234A
- Authority
- RU
- Russia
- Prior art keywords
- nkx2
- handii
- tbx5
- human animal
- combination
- Prior art date
Links
- 210000004165 myocardium Anatomy 0.000 title 1
- 101000632197 Homo sapiens Homeobox protein Nkx-2.5 Proteins 0.000 claims 38
- 108010014480 T-box transcription factor 5 Proteins 0.000 claims 28
- 102100027875 Homeobox protein Nkx-2.5 Human genes 0.000 claims 27
- 210000002459 blastocyst Anatomy 0.000 claims 25
- -1 HANDII Proteins 0.000 claims 21
- 102100024755 T-box transcription factor TBX5 Human genes 0.000 claims 21
- 108090000623 proteins and genes Proteins 0.000 claims 19
- 241000282898 Sus scrofa Species 0.000 claims 17
- 210000004027 cell Anatomy 0.000 claims 16
- 210000000472 morula Anatomy 0.000 claims 16
- 101150115978 tbx5 gene Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 8
- 210000000287 oocyte Anatomy 0.000 claims 8
- 210000004940 nucleus Anatomy 0.000 claims 7
- 210000000130 stem cell Anatomy 0.000 claims 7
- 210000002064 heart cell Anatomy 0.000 claims 6
- 230000035772 mutation Effects 0.000 claims 6
- 102000004169 proteins and genes Human genes 0.000 claims 6
- 241001465754 Metazoa Species 0.000 claims 4
- 230000004927 fusion Effects 0.000 claims 4
- 210000005003 heart tissue Anatomy 0.000 claims 4
- 210000001082 somatic cell Anatomy 0.000 claims 4
- 108700028369 Alleles Proteins 0.000 claims 3
- 241000283690 Bos taurus Species 0.000 claims 3
- 241000283707 Capra Species 0.000 claims 3
- 241000283073 Equus caballus Species 0.000 claims 3
- 230000003213 activating effect Effects 0.000 claims 3
- 241000282887 Suidae Species 0.000 claims 2
- 230000037430 deletion Effects 0.000 claims 2
- 238000012217 deletion Methods 0.000 claims 2
- 210000001519 tissue Anatomy 0.000 claims 2
- 101100206168 Homo sapiens TBX5 gene Proteins 0.000 claims 1
- 230000004913 activation Effects 0.000 claims 1
- 210000004504 adult stem cell Anatomy 0.000 claims 1
- 210000004700 fetal blood Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 102000043416 human NKX2-5 Human genes 0.000 claims 1
- 210000004263 induced pluripotent stem cell Anatomy 0.000 claims 1
- 210000000056 organ Anatomy 0.000 claims 1
- 210000001778 pluripotent stem cell Anatomy 0.000 claims 1
- 235000015277 pork Nutrition 0.000 claims 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/108—Swine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Health & Medical Sciences (AREA)
- Environmental Sciences (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- Biotechnology (AREA)
- Animal Behavior & Ethology (AREA)
- Animal Husbandry (AREA)
- Biodiversity & Conservation Biology (AREA)
- General Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Wood Science & Technology (AREA)
- Organic Chemistry (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Cell Biology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Public Health (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Materials For Medical Uses (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562187040P | 2015-06-30 | 2015-06-30 | |
| US62/187,040 | 2015-06-30 | ||
| PCT/US2016/040431 WO2017004388A1 (en) | 2015-06-30 | 2016-06-30 | Humanized heart muscle |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2018103234A true RU2018103234A (ru) | 2019-07-31 |
Family
ID=57609529
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2018103234A RU2018103234A (ru) | 2015-06-30 | 2016-06-30 | Гуманизированная мышца сердца |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US10897880B2 (OSRAM) |
| EP (1) | EP3316899A4 (OSRAM) |
| JP (1) | JP2018523999A (OSRAM) |
| KR (1) | KR20180021135A (OSRAM) |
| CN (1) | CN108472318A (OSRAM) |
| AU (1) | AU2016288671A1 (OSRAM) |
| BR (1) | BR112017028608A2 (OSRAM) |
| CA (1) | CA2991056A1 (OSRAM) |
| CO (1) | CO2018000859A2 (OSRAM) |
| IL (1) | IL256544A (OSRAM) |
| MX (1) | MX2018000071A (OSRAM) |
| RU (1) | RU2018103234A (OSRAM) |
| WO (1) | WO2017004388A1 (OSRAM) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN108024522A (zh) | 2015-03-03 | 2018-05-11 | 明尼苏达大学董事会 | Etv2及其用途 |
| MX2018000273A (es) | 2015-06-30 | 2018-03-08 | Univ Minnesota | Musculo esqueletico humanizado. |
| BR112017028608A2 (pt) | 2015-06-30 | 2018-09-04 | Univ Minnesota | músculo cardíaco humanizado |
Family Cites Families (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU721375B2 (en) * | 1996-01-09 | 2000-06-29 | Regents Of The University Of California, The | Porcine embryonic stem-like cells, methods of making and using the cells to produce transgenic pigs |
| US5994619A (en) * | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) * | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
| WO2003034818A1 (en) | 2001-10-24 | 2003-05-01 | Chugai Seiyaku Kabushiki Kaisha | Sgrf genetically modified nonhuman animal |
| US20040133931A1 (en) | 2003-01-08 | 2004-07-08 | Gavin William G. | Method and system for fusion and activation following nuclear transfer in reconstructed embryos |
| WO2003081990A2 (en) | 2002-03-22 | 2003-10-09 | St. Jude Children's Research Hospital | Improved method for generating genetically modified animals |
| WO2004004447A2 (en) | 2002-07-03 | 2004-01-15 | Merck & Co., Inc. | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| WO2006014551A2 (en) | 2004-07-06 | 2006-02-09 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| WO2008086040A1 (en) | 2007-01-11 | 2008-07-17 | University Of Pittsburgh | Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same |
| CA2675100A1 (en) | 2007-01-20 | 2008-07-24 | Boehringer Ingelheim International Gmbh | C-reactive protein (crp) knockout mouse |
| CN101679950A (zh) | 2007-02-22 | 2010-03-24 | 国立大学法人东京大学 | 利用胚泡互补的器官再生法 |
| EP2258166A4 (en) | 2008-02-22 | 2013-04-03 | Univ Tokyo | METHOD FOR PRODUCING GROUNDS FOR REPRODUCATIVE ANIMALS WITH LETAL PHENOTYPE CREATED BY GENODIMODIFICATION |
| US20110258715A1 (en) | 2008-08-22 | 2011-10-20 | The University Of Tokyo | ORGAN REGENERATION METHOD UTILIZING iPS CELL AND BLASTOCYST COMPLEMENTATION |
| US20120207744A1 (en) | 2009-03-19 | 2012-08-16 | Mendlein John D | Reprogramming compositions and methods of using the same |
| SG175880A1 (en) * | 2009-05-20 | 2011-12-29 | Cardio3 Biosciences Sa | Parmaceutical composition for the treatment of heart diseases. |
| WO2012149470A1 (en) | 2011-04-27 | 2012-11-01 | Amyris, Inc. | Methods for genomic modification |
| SG10201805199RA (en) | 2011-06-02 | 2018-07-30 | Harvard College | Methods and Uses for Ex Vivo Tissue Culture Systems |
| WO2013073246A1 (en) | 2011-11-18 | 2013-05-23 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| US20160029604A1 (en) | 2014-04-28 | 2016-02-04 | Recombinetics, Inc. | Multiplex gene editing |
| CN108024522A (zh) | 2015-03-03 | 2018-05-11 | 明尼苏达大学董事会 | Etv2及其用途 |
| BR112017028608A2 (pt) | 2015-06-30 | 2018-09-04 | Univ Minnesota | músculo cardíaco humanizado |
| MX2018000273A (es) | 2015-06-30 | 2018-03-08 | Univ Minnesota | Musculo esqueletico humanizado. |
| EP3367785A4 (en) | 2015-10-27 | 2019-08-14 | Regents of the University of Minnesota | COMPOSITIONS AND METHODS FOR CHIMERIC EMBRYO-ASSISTED ORGAN PRODUCTION |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
-
2016
- 2016-06-30 BR BR112017028608A patent/BR112017028608A2/pt not_active Application Discontinuation
- 2016-06-30 AU AU2016288671A patent/AU2016288671A1/en not_active Abandoned
- 2016-06-30 CN CN201680050242.9A patent/CN108472318A/zh active Pending
- 2016-06-30 WO PCT/US2016/040431 patent/WO2017004388A1/en not_active Ceased
- 2016-06-30 MX MX2018000071A patent/MX2018000071A/es unknown
- 2016-06-30 US US15/739,066 patent/US10897880B2/en active Active
- 2016-06-30 JP JP2017568252A patent/JP2018523999A/ja active Pending
- 2016-06-30 EP EP16818799.5A patent/EP3316899A4/en not_active Withdrawn
- 2016-06-30 RU RU2018103234A patent/RU2018103234A/ru not_active Application Discontinuation
- 2016-06-30 KR KR1020187002387A patent/KR20180021135A/ko not_active Ceased
- 2016-06-30 CA CA2991056A patent/CA2991056A1/en not_active Abandoned
-
2017
- 2017-12-25 IL IL256544A patent/IL256544A/en unknown
-
2018
- 2018-01-29 CO CONC2018/0000859A patent/CO2018000859A2/es unknown
-
2020
- 2020-12-11 US US17/118,981 patent/US20210169054A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| US20210169054A1 (en) | 2021-06-10 |
| AU2016288671A1 (en) | 2018-02-01 |
| BR112017028608A2 (pt) | 2018-09-04 |
| IL256544A (en) | 2018-02-28 |
| CO2018000859A2 (es) | 2018-07-10 |
| MX2018000071A (es) | 2018-03-16 |
| WO2017004388A1 (en) | 2017-01-05 |
| US10897880B2 (en) | 2021-01-26 |
| CA2991056A1 (en) | 2017-01-05 |
| CN108472318A (zh) | 2018-08-31 |
| KR20180021135A (ko) | 2018-02-28 |
| EP3316899A1 (en) | 2018-05-09 |
| EP3316899A4 (en) | 2019-04-03 |
| US20180177165A1 (en) | 2018-06-28 |
| JP2018523999A (ja) | 2018-08-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA93 | Acknowledgement of application withdrawn (no request for examination) |
Effective date: 20190701 |