AU2016288671A1 - Humanized heart muscle - Google Patents
Humanized heart muscle Download PDFInfo
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- AU2016288671A1 AU2016288671A1 AU2016288671A AU2016288671A AU2016288671A1 AU 2016288671 A1 AU2016288671 A1 AU 2016288671A1 AU 2016288671 A AU2016288671 A AU 2016288671A AU 2016288671 A AU2016288671 A AU 2016288671A AU 2016288671 A1 AU2016288671 A1 AU 2016288671A1
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- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0271—Chimeric vertebrates, e.g. comprising exogenous cells
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/15—Animals comprising multiple alterations of the genome, by transgenesis or homologous recombination, e.g. obtained by cross-breeding
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
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- A—HUMAN NECESSITIES
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- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/02—Animal zootechnically ameliorated
- A01K2267/025—Animal producing cells or organs for transplantation
Landscapes
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| PCT/US2016/040431 WO2017004388A1 (en) | 2015-06-30 | 2016-06-30 | Humanized heart muscle |
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| CN108024522A (zh) | 2015-03-03 | 2018-05-11 | 明尼苏达大学董事会 | Etv2及其用途 |
| MX2018000273A (es) | 2015-06-30 | 2018-03-08 | Univ Minnesota | Musculo esqueletico humanizado. |
| BR112017028608A2 (pt) | 2015-06-30 | 2018-09-04 | Univ Minnesota | músculo cardíaco humanizado |
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| AU721375B2 (en) * | 1996-01-09 | 2000-06-29 | Regents Of The University Of California, The | Porcine embryonic stem-like cells, methods of making and using the cells to produce transgenic pigs |
| US5994619A (en) * | 1996-04-01 | 1999-11-30 | University Of Massachusetts, A Public Institution Of Higher Education Of The Commonwealth Of Massachusetts, As Represented By Its Amherst Campus | Production of chimeric bovine or porcine animals using cultured inner cell mass cells |
| CN1241210A (zh) * | 1996-10-11 | 2000-01-12 | 得克萨斯农业及机械体系综合大学 | 产生原生殖细胞和转基因动物物种的方法 |
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| WO2004004447A2 (en) | 2002-07-03 | 2004-01-15 | Merck & Co., Inc. | Agouti-related protein deficient cells, non-human transgenic animals and methods of selecting compounds which regulate energy metabolism |
| GB2398784B (en) | 2003-02-26 | 2005-07-27 | Babraham Inst | Removal and modification of the immunoglobulin constant region gene cluster of a non-human mammal |
| WO2006014551A2 (en) | 2004-07-06 | 2006-02-09 | Michigan State University | In vivo methods for effecting tissue specific differentiation of embryonic stem cells |
| WO2008086040A1 (en) | 2007-01-11 | 2008-07-17 | University Of Pittsburgh | Muscle derived cells for the treatment of urinary tract pathologies and methods of making and using the same |
| CA2675100A1 (en) | 2007-01-20 | 2008-07-24 | Boehringer Ingelheim International Gmbh | C-reactive protein (crp) knockout mouse |
| CN101679950A (zh) | 2007-02-22 | 2010-03-24 | 国立大学法人东京大学 | 利用胚泡互补的器官再生法 |
| EP2258166A4 (en) | 2008-02-22 | 2013-04-03 | Univ Tokyo | METHOD FOR PRODUCING GROUNDS FOR REPRODUCATIVE ANIMALS WITH LETAL PHENOTYPE CREATED BY GENODIMODIFICATION |
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| WO2012149470A1 (en) | 2011-04-27 | 2012-11-01 | Amyris, Inc. | Methods for genomic modification |
| SG10201805199RA (en) | 2011-06-02 | 2018-07-30 | Harvard College | Methods and Uses for Ex Vivo Tissue Culture Systems |
| WO2013073246A1 (en) | 2011-11-18 | 2013-05-23 | Kyoto University | Method of inducing differentiation from pluripotent stem cells to skeletal muscle cells |
| IL221187A (en) | 2012-07-30 | 2017-01-31 | Adom Advanced Optical Tech Ltd | A system to perform optical tomography in two 2D beams |
| US20140115728A1 (en) | 2012-10-24 | 2014-04-24 | A. Joseph Tector | Double knockout (gt/cmah-ko) pigs, organs and tissues |
| US11377639B2 (en) * | 2013-11-15 | 2022-07-05 | Wisconsin Alumni Research Foundation | Lineage reprogramming to induced cardiac progenitor cells (iCPC) by defined factors |
| US20160029604A1 (en) | 2014-04-28 | 2016-02-04 | Recombinetics, Inc. | Multiplex gene editing |
| CN108024522A (zh) | 2015-03-03 | 2018-05-11 | 明尼苏达大学董事会 | Etv2及其用途 |
| BR112017028608A2 (pt) | 2015-06-30 | 2018-09-04 | Univ Minnesota | músculo cardíaco humanizado |
| MX2018000273A (es) | 2015-06-30 | 2018-03-08 | Univ Minnesota | Musculo esqueletico humanizado. |
| EP3367785A4 (en) | 2015-10-27 | 2019-08-14 | Regents of the University of Minnesota | COMPOSITIONS AND METHODS FOR CHIMERIC EMBRYO-ASSISTED ORGAN PRODUCTION |
| CN108125943A (zh) | 2018-01-17 | 2018-06-08 | 云南省第二人民医院 | 前胡醇当归脂作为制备抗动脉粥样硬化药物的应用 |
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| US20210169054A1 (en) | 2021-06-10 |
| BR112017028608A2 (pt) | 2018-09-04 |
| IL256544A (en) | 2018-02-28 |
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| MX2018000071A (es) | 2018-03-16 |
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| US10897880B2 (en) | 2021-01-26 |
| CA2991056A1 (en) | 2017-01-05 |
| CN108472318A (zh) | 2018-08-31 |
| RU2018103234A (ru) | 2019-07-31 |
| KR20180021135A (ko) | 2018-02-28 |
| EP3316899A1 (en) | 2018-05-09 |
| EP3316899A4 (en) | 2019-04-03 |
| US20180177165A1 (en) | 2018-06-28 |
| JP2018523999A (ja) | 2018-08-30 |
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| MK1 | Application lapsed section 142(2)(a) - no request for examination in relevant period |