RU2017107273A - Антилимфоцитарные аутоантитела в качестве диагностических биомаркеров - Google Patents
Антилимфоцитарные аутоантитела в качестве диагностических биомаркеров Download PDFInfo
- Publication number
- RU2017107273A RU2017107273A RU2017107273A RU2017107273A RU2017107273A RU 2017107273 A RU2017107273 A RU 2017107273A RU 2017107273 A RU2017107273 A RU 2017107273A RU 2017107273 A RU2017107273 A RU 2017107273A RU 2017107273 A RU2017107273 A RU 2017107273A
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- Russia
- Prior art keywords
- lymphocyte
- individual
- level
- lymphocytes
- cells
- Prior art date
Links
- 230000000781 anti-lymphocytic effect Effects 0.000 title 1
- 239000000104 diagnostic biomarker Substances 0.000 title 1
- 210000001744 T-lymphocyte Anatomy 0.000 claims 25
- 210000004698 lymphocyte Anatomy 0.000 claims 15
- 210000004369 blood Anatomy 0.000 claims 14
- 239000008280 blood Substances 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 11
- 239000003153 chemical reaction reagent Substances 0.000 claims 9
- 239000000090 biomarker Substances 0.000 claims 8
- 210000004027 cell Anatomy 0.000 claims 6
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims 6
- 101100262440 Arabidopsis thaliana ECR1 gene Proteins 0.000 claims 5
- 231100000433 cytotoxic Toxicity 0.000 claims 5
- 230000001472 cytotoxic effect Effects 0.000 claims 5
- 208000027866 inflammatory disease Diseases 0.000 claims 4
- 210000000265 leukocyte Anatomy 0.000 claims 4
- 238000012544 monitoring process Methods 0.000 claims 4
- 230000002159 abnormal effect Effects 0.000 claims 2
- 238000003745 diagnosis Methods 0.000 claims 2
- 238000000684 flow cytometry Methods 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- 238000005259 measurement Methods 0.000 claims 2
- 102100037853 C-C chemokine receptor type 4 Human genes 0.000 claims 1
- 101710149863 C-C chemokine receptor type 4 Proteins 0.000 claims 1
- 102100025074 C-C chemokine receptor-like 2 Human genes 0.000 claims 1
- 102100028990 C-X-C chemokine receptor type 3 Human genes 0.000 claims 1
- 102100031658 C-X-C chemokine receptor type 5 Human genes 0.000 claims 1
- 102000017420 CD3 protein, epsilon/gamma/delta subunit Human genes 0.000 claims 1
- 108050005493 CD3 protein, epsilon/gamma/delta subunit Proteins 0.000 claims 1
- -1 Crth2 Proteins 0.000 claims 1
- 101000716068 Homo sapiens C-C chemokine receptor type 6 Proteins 0.000 claims 1
- 101000916050 Homo sapiens C-X-C chemokine receptor type 3 Proteins 0.000 claims 1
- 101000922405 Homo sapiens C-X-C chemokine receptor type 5 Proteins 0.000 claims 1
- 101001057504 Homo sapiens Interferon-stimulated gene 20 kDa protein Proteins 0.000 claims 1
- 101001055144 Homo sapiens Interleukin-2 receptor subunit alpha Proteins 0.000 claims 1
- 101000716102 Homo sapiens T-cell surface glycoprotein CD4 Proteins 0.000 claims 1
- 101000946843 Homo sapiens T-cell surface glycoprotein CD8 alpha chain Proteins 0.000 claims 1
- 102100027268 Interferon-stimulated gene 20 kDa protein Human genes 0.000 claims 1
- 102100036011 T-cell surface glycoprotein CD4 Human genes 0.000 claims 1
- 102100034922 T-cell surface glycoprotein CD8 alpha chain Human genes 0.000 claims 1
- 238000004458 analytical method Methods 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 230000004069 differentiation Effects 0.000 claims 1
- 239000003550 marker Substances 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/564—Immunoassay; Biospecific binding assay; Materials therefor for pre-existing immune complex or autoimmune disease, i.e. systemic lupus erythematosus, rheumatoid arthritis, multiple sclerosis, rheumatoid factors or complement components C1-C9
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/505—Cells of the immune system involving T-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5052—Cells of the immune system involving B-cells
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/5005—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells
- G01N33/5008—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics
- G01N33/5044—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving human or animal cells for testing or evaluating the effect of chemical or biological compounds, e.g. drugs, cosmetics involving specific cell types
- G01N33/5047—Cells of the immune system
- G01N33/5055—Cells of the immune system involving macrophages
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
- G01N33/536—Immunoassay; Biospecific binding assay; Materials therefor with immune complex formed in liquid phase
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
- G01N33/6854—Immunoglobulins
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/7051—T-cell receptor (TcR)-CD3 complex
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70514—CD4
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
- G01N2333/70503—Immunoglobulin superfamily, e.g. VCAMs, PECAM, LFA-3
- G01N2333/70517—CD8
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/10—Musculoskeletal or connective tissue disorders
- G01N2800/101—Diffuse connective tissue disease, e.g. Sjögren, Wegener's granulomatosis
- G01N2800/104—Lupus erythematosus [SLE]
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/70—Mechanisms involved in disease identification
- G01N2800/7095—Inflammation
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Immunology (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Chemical & Material Sciences (AREA)
- Urology & Nephrology (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- General Health & Medical Sciences (AREA)
- Biotechnology (AREA)
- Pathology (AREA)
- General Physics & Mathematics (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Toxicology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Rehabilitation Therapy (AREA)
- Rheumatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462035073P | 2014-08-08 | 2014-08-08 | |
| US62/035,073 | 2014-08-08 | ||
| PCT/US2015/044372 WO2016023006A1 (en) | 2014-08-08 | 2015-08-07 | Anti-lymphocyte autoantibodies as diagnostic biomarkers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2017107273A true RU2017107273A (ru) | 2018-09-10 |
| RU2017107273A3 RU2017107273A3 (cg-RX-API-DMAC7.html) | 2019-01-18 |
Family
ID=55264686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017107273A RU2017107273A (ru) | 2014-08-08 | 2015-08-07 | Антилимфоцитарные аутоантитела в качестве диагностических биомаркеров |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US9709564B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP3177930A1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2017528734A (cg-RX-API-DMAC7.html) |
| CN (1) | CN107110861A (cg-RX-API-DMAC7.html) |
| BR (1) | BR112017002575B1 (cg-RX-API-DMAC7.html) |
| RU (1) | RU2017107273A (cg-RX-API-DMAC7.html) |
| WO (1) | WO2016023006A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6674543B2 (ja) | 2015-07-31 | 2020-04-01 | アレゲーニー・シンガー リサーチ インスティチュート | 抗体に基づく薬物のコンパニオン診断としての細胞結合補体活性化産物アッセイ |
| KR101674018B1 (ko) * | 2016-05-16 | 2016-11-08 | (주)글로리바이오텍 | Cd4, cd8 세포 정보를 이용한 hiv 진단 방법 |
| WO2017205532A1 (en) | 2016-05-24 | 2017-11-30 | Allegheny-Singer Research Institute | Methods and systems using c4 gene copy number and cell-bound complement activation products for identification of lupus and pre-lupus |
| WO2022067259A1 (en) * | 2020-09-28 | 2022-03-31 | Allegheny Singer Research Institute | Methods for determining a level of a cell fragment-bound complement activation product |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1756571B8 (en) * | 2004-04-09 | 2010-10-13 | University of Pittsburgh - Of the Commonwealth System of Higher Education | Real time method of detecting acute inflammatory conditions |
| ES2353311T3 (es) * | 2004-05-11 | 2011-03-01 | University Of Pittsburgh - Of The Commonwealth System Of Higher Education | Diagnóstico de enfermedades o afecciones inflamatorias para la medición de componentes del complemento sobre la superficie de glóbulos blancos. |
| WO2010045611A2 (en) * | 2008-10-16 | 2010-04-22 | Cypress Bioscience, Inc. | Method for diagnosis and monitoring of disease activity and response to treatment in systemic lupus erythematosus (sle) and other autoimmune diseases |
| ES2560809T3 (es) * | 2010-02-12 | 2016-02-22 | Yeda Research And Development Co. Ltd. | Diagnóstico de lupus eritematoso sistémico |
| EP2673644B1 (en) * | 2011-02-11 | 2016-02-10 | Exagen Diagnostics, Inc. | Methods for diagnosing systemic lupus erythematosus |
| CN102818890A (zh) * | 2011-06-10 | 2012-12-12 | 苏州卫生职业技术学院 | 一种检测系统性红斑狼疮患者自身抗体的方法 |
| HUE038441T2 (hu) * | 2011-12-13 | 2018-10-29 | Baxalta GmbH | Autoantitestek mérése alacsony vezetõképességû körülmények között |
| US20150204866A1 (en) * | 2012-08-02 | 2015-07-23 | Sense Proteomic Limited | Auto-antigen biomarkers for lupus |
| WO2014093268A1 (en) * | 2012-12-10 | 2014-06-19 | Allegheny-Singer Research Institute | Methods and systems for using complement-tagged molecules as biomarkers of disease |
| EP2954071B1 (en) | 2013-02-08 | 2020-08-12 | Allegheny-Singer Research Institute | Cell-bound complement activation products as diagnostic biomarkers for pre-lupus |
| CN103439517A (zh) * | 2013-09-11 | 2013-12-11 | 河北省健海生物芯片技术有限责任公司 | 一种系统性红斑狼疮自身抗体检测装置 |
-
2015
- 2015-08-07 EP EP15754066.7A patent/EP3177930A1/en not_active Withdrawn
- 2015-08-07 JP JP2017527543A patent/JP2017528734A/ja active Pending
- 2015-08-07 CN CN201580053913.2A patent/CN107110861A/zh active Pending
- 2015-08-07 BR BR112017002575-2A patent/BR112017002575B1/pt active IP Right Grant
- 2015-08-07 US US14/821,670 patent/US9709564B2/en active Active
- 2015-08-07 WO PCT/US2015/044372 patent/WO2016023006A1/en not_active Ceased
- 2015-08-07 RU RU2017107273A patent/RU2017107273A/ru not_active Application Discontinuation
Also Published As
| Publication number | Publication date |
|---|---|
| EP3177930A1 (en) | 2017-06-14 |
| BR112017002575A2 (pt) | 2018-01-30 |
| CN107110861A (zh) | 2017-08-29 |
| JP2017528734A (ja) | 2017-09-28 |
| US9709564B2 (en) | 2017-07-18 |
| RU2017107273A3 (cg-RX-API-DMAC7.html) | 2019-01-18 |
| US20160041164A1 (en) | 2016-02-11 |
| BR112017002575B1 (pt) | 2023-11-07 |
| WO2016023006A1 (en) | 2016-02-11 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20190610 |