RU2017103675A - Способ размещения в цитоплазме антител в виде полного иммуноглобулина путем проникновения антител через клеточную мембрану и его применение - Google Patents
Способ размещения в цитоплазме антител в виде полного иммуноглобулина путем проникновения антител через клеточную мембрану и его применение Download PDFInfo
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Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| KR10-2014-0092673 | 2014-07-22 | ||
| KR20140092673 | 2014-07-22 | ||
| KR1020150103163A KR101602870B1 (ko) | 2014-07-22 | 2015-07-21 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| KR10-2015-0103163 | 2015-07-21 | ||
| PCT/KR2015/007626 WO2016013870A1 (ko) | 2014-07-22 | 2015-07-22 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
Publications (1)
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| RU2017103675A true RU2017103675A (ru) | 2018-08-06 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
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| RU2017103675A RU2017103675A (ru) | 2014-07-22 | 2015-07-22 | Способ размещения в цитоплазме антител в виде полного иммуноглобулина путем проникновения антител через клеточную мембрану и его применение |
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Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
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| US9701740B2 (en) | 2011-04-01 | 2017-07-11 | Yale University | Cell-penetrating anti-DNA antibodies and uses thereof inhibit DNA repair |
| KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| KR101602876B1 (ko) | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
| KR102000000B1 (ko) * | 2016-05-27 | 2019-07-12 | 오름테라퓨틱 주식회사 | 항체에 엔도좀 탈출능을 부여하는 엔도좀 탈출 구조 모티프 및 이의 활용 |
| BR112018074275A2 (pt) | 2016-05-27 | 2019-10-01 | Orum Therapeutics Inc | anticorpo de penetração no citosol e método de produção do mesmo |
| US12486318B2 (en) | 2016-06-15 | 2025-12-02 | Yale University | Anti-guanosine antibody as a molecular delivery vehicle |
| CA3027960C (en) | 2016-06-15 | 2022-06-14 | Yale University | Antibody-mediated autocatalytic, targeted delivery of nanocarriers to tumors |
| US20200339681A1 (en) | 2017-11-16 | 2020-10-29 | Orum Therapeutics Inc. | Antibody inhibiting activated ras in cell by internalizing into cytosol of cell, and use thereof |
| WO2019152806A1 (en) * | 2018-02-01 | 2019-08-08 | Yale University | Compositions and methods for enhancing nuclear translocation |
| JP7416433B2 (ja) * | 2018-04-10 | 2024-01-17 | ノースウェスタン ユニバーシティ | 標的指向性親和性ドメインに基づく膜タンパク質を含む細胞外小胞 |
| US10787487B2 (en) | 2018-06-21 | 2020-09-29 | Orum Therapeutics Inc. | Cell/tissue-specific cell-penetrating antibodies |
| JP2021532135A (ja) * | 2018-07-23 | 2021-11-25 | 中外製薬株式会社 | 標的細胞特異的な細胞質侵入抗原結合分子 |
| CN110759996B (zh) * | 2018-07-27 | 2022-09-06 | 深圳康体生命科技有限公司 | 一种gfp抗体 |
| CN108949565B (zh) * | 2018-09-26 | 2024-09-06 | 中国科学技术大学 | 用于红细胞负载冻干保护剂的装置及方法 |
| AU2020266770A1 (en) * | 2019-05-01 | 2021-10-14 | Universidade De Santiago De Compostela | Intracellular delivery of anti-KRAS antibodies formulated into nanocapsules |
| US20230076637A1 (en) | 2020-02-06 | 2023-03-09 | Ajou University Industry-Academic Cooperation Foundation | Fusion antibody for presenting antigen-derived t cell antigen epitope or peptide containing same on cell surface, and composition comprising same |
| CA3171833A1 (en) * | 2020-02-24 | 2021-09-02 | Oblique Therapeutics Ab | Kras epitopes and antibodies |
| AU2021263767A1 (en) * | 2020-04-30 | 2022-09-08 | Genentech, Inc. | KRas specific antibodies and uses thereof |
| CN117916258A (zh) | 2021-07-20 | 2024-04-19 | 亚洲大学校产学协力团 | 穿透进细胞以降解和去除靶蛋白的细胞穿透降解抗体及其用途 |
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| FR2706486B1 (fr) | 1993-06-16 | 1995-09-01 | Rhone Poulenc Rorer Sa | Séquences nucléiques, vecteurs les contenant, compositions pharmaceutiques et utilisations thérapeutiques. |
| CN1241574A (zh) | 1998-07-02 | 2000-01-19 | 中国人民解放军第四军医大学 | 抗肝癌单克隆抗体HAb25及其单链抗体和双功能抗体 |
| GB0226727D0 (en) | 2002-11-15 | 2002-12-24 | Medical Res Council | Intrabodies |
| AU2003219277A1 (en) | 2002-03-14 | 2003-09-29 | Medical Research Council | Intracellular antibodies |
| WO2004046188A2 (en) | 2002-11-15 | 2004-06-03 | Medical Research Council | Anti-activated ras antibodies |
| MX2008012392A (es) | 2006-03-27 | 2008-12-17 | Globeimmune Inc | Mutacion de ras, y composiciones y metodos relacionados con la misma. |
| US20110189206A1 (en) | 2008-01-03 | 2011-08-04 | Barbas Iii Carlos F | Antibody Targeting Through a Modular Recognition Domain |
| KR100849941B1 (ko) | 2008-04-29 | 2008-08-01 | 원우이에프엔지니어링주식회사 | 열 및 연기 화재감지장치 복합시험기 |
| EP2279002B1 (en) * | 2008-04-30 | 2013-08-14 | Ajou University Industry-Academic Cooperation Foundation | Anti-nucleic acid antibody inducing cell death of cancer cells and composition for preventing or treating cancers comprising the same |
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| CN101402675B (zh) | 2008-11-28 | 2012-05-30 | 中国人民解放军第三军医大学第三附属医院 | 一种靶向抑制ανβ3阳性细胞增殖的环肽 |
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| US9701740B2 (en) | 2011-04-01 | 2017-07-11 | Yale University | Cell-penetrating anti-DNA antibodies and uses thereof inhibit DNA repair |
| US9283272B2 (en) | 2012-03-30 | 2016-03-15 | The United States Of America As Represented By The Department Of Veterans Affairs | Targeting intracellular target-binding determinants with intracellular antibodies |
| US9815866B2 (en) | 2012-09-14 | 2017-11-14 | Japanese Foundation For Cancer Research | Peptides that bind to epithelial cell adhesion molecule |
| WO2015048477A1 (en) | 2013-09-27 | 2015-04-02 | H. Lee Moffitt Cancer Center And Research Institute, Inc. | Cyclic peptide conjugates and methods of use |
| KR101602876B1 (ko) | 2014-07-22 | 2016-03-11 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
| KR101602870B1 (ko) | 2014-07-22 | 2016-03-21 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 항체를 세포막을 투과하여 세포질에 위치시키는 방법 및 그의 이용 |
| WO2016013871A1 (ko) | 2014-07-22 | 2016-01-28 | 아주대학교산학협력단 | 완전한 이뮤노글로불린 형태의 세포질 침투능을 갖는 항체를 이용하여 세포내 활성화된 ras를 억제하는 방법 및 그의 이용 |
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| US20200339681A1 (en) | 2017-11-16 | 2020-10-29 | Orum Therapeutics Inc. | Antibody inhibiting activated ras in cell by internalizing into cytosol of cell, and use thereof |
| US10787487B2 (en) | 2018-06-21 | 2020-09-29 | Orum Therapeutics Inc. | Cell/tissue-specific cell-penetrating antibodies |
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2015
- 2015-07-21 KR KR1020150103163A patent/KR101602870B1/ko not_active Expired - Fee Related
- 2015-07-22 CA CA2955272A patent/CA2955272A1/en not_active Abandoned
- 2015-07-22 BR BR112017001304-5A patent/BR112017001304A2/pt not_active Application Discontinuation
- 2015-07-22 CN CN201580045139.0A patent/CN107001481A/zh active Pending
- 2015-07-22 US US15/327,369 patent/US10844136B2/en not_active Expired - Fee Related
- 2015-07-22 JP JP2017525495A patent/JP6595592B2/ja not_active Expired - Fee Related
- 2015-07-22 RU RU2017103675A patent/RU2017103675A/ru not_active Application Discontinuation
- 2015-07-22 AU AU2015292955A patent/AU2015292955B2/en not_active Ceased
- 2015-07-22 EP EP15825418.5A patent/EP3173428B1/en active Active
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2017
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- 2017-01-20 ZA ZA2017/00488A patent/ZA201700488B/en unknown
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|---|---|
| EP3173428A1 (en) | 2017-05-31 |
| JP6595592B2 (ja) | 2019-10-23 |
| AU2015292955B2 (en) | 2020-08-13 |
| CA2955272A1 (en) | 2016-01-28 |
| US20170218084A1 (en) | 2017-08-03 |
| CN107001481A (zh) | 2017-08-01 |
| KR20160011598A (ko) | 2016-02-01 |
| EP3173428B1 (en) | 2020-02-19 |
| KR101602870B1 (ko) | 2016-03-21 |
| AU2015292955A1 (en) | 2017-02-09 |
| US10844136B2 (en) | 2020-11-24 |
| ZA201700488B (en) | 2018-12-19 |
| IL250203B (en) | 2020-09-30 |
| EP3173428A4 (en) | 2018-01-24 |
| IL250203A0 (en) | 2017-03-30 |
| BR112017001304A2 (pt) | 2018-01-30 |
| JP2017529097A (ja) | 2017-10-05 |
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