RU2016151761A - Очищенные композиции белков ivig и kh для модулирования лимфоцитов и лечения вируса гепатита b - Google Patents
Очищенные композиции белков ivig и kh для модулирования лимфоцитов и лечения вируса гепатита b Download PDFInfo
- Publication number
- RU2016151761A RU2016151761A RU2016151761A RU2016151761A RU2016151761A RU 2016151761 A RU2016151761 A RU 2016151761A RU 2016151761 A RU2016151761 A RU 2016151761A RU 2016151761 A RU2016151761 A RU 2016151761A RU 2016151761 A RU2016151761 A RU 2016151761A
- Authority
- RU
- Russia
- Prior art keywords
- seq
- amino acid
- acid sequence
- substantially pure
- protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title claims 118
- 108090000623 proteins and genes Proteins 0.000 title claims 118
- 239000000203 mixture Substances 0.000 title claims 3
- 241000700721 Hepatitis B virus Species 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 89
- 239000000047 product Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 23
- 230000000694 effects Effects 0.000 claims 21
- 208000002672 hepatitis B Diseases 0.000 claims 20
- 210000002381 plasma Anatomy 0.000 claims 18
- 230000001105 regulatory effect Effects 0.000 claims 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 12
- 210000000952 spleen Anatomy 0.000 claims 9
- 210000005259 peripheral blood Anatomy 0.000 claims 8
- 239000011886 peripheral blood Substances 0.000 claims 8
- 108060003951 Immunoglobulin Proteins 0.000 claims 5
- 102000018358 immunoglobulin Human genes 0.000 claims 5
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 4
- 102100033467 L-selectin Human genes 0.000 claims 4
- 239000000706 filtrate Substances 0.000 claims 4
- 238000001914 filtration Methods 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000012467 final product Substances 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 238000010790 dilution Methods 0.000 claims 2
- 239000012895 dilution Substances 0.000 claims 2
- 210000003714 granulocyte Anatomy 0.000 claims 2
- 229940036107 hepatitis b immunoglobulin Drugs 0.000 claims 2
- 229940072221 immunoglobulins Drugs 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 238000001728 nano-filtration Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 238000000108 ultra-filtration Methods 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462003664P | 2014-05-28 | 2014-05-28 | |
| US62/003,664 | 2014-05-28 | ||
| PCT/US2015/032807 WO2015184050A1 (en) | 2014-05-28 | 2015-05-28 | Purified compositions of ivig and kh proteins for modulating lymphocytes and treating hepatitis b virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016151761A true RU2016151761A (ru) | 2018-07-03 |
| RU2016151761A3 RU2016151761A3 (https=) | 2018-12-26 |
Family
ID=54699755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016151761A RU2016151761A (ru) | 2014-05-28 | 2015-05-28 | Очищенные композиции белков ivig и kh для модулирования лимфоцитов и лечения вируса гепатита b |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3148574B1 (https=) |
| JP (1) | JP2017525752A (https=) |
| CN (1) | CN107106664A (https=) |
| AU (1) | AU2015266997A1 (https=) |
| BR (1) | BR112016027818A2 (https=) |
| CA (1) | CA2949994A1 (https=) |
| ES (1) | ES2878043T3 (https=) |
| MX (1) | MX2016015574A (https=) |
| RU (1) | RU2016151761A (https=) |
| WO (1) | WO2015184050A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2015184050A1 (en) | 2014-05-28 | 2015-12-03 | Rare Antibody Antigen Supply, Inc. | Purified compositions of ivig and kh proteins for modulating lymphocytes and treating hepatitis b virus |
| US20160289300A1 (en) * | 2015-04-02 | 2016-10-06 | Kieu Hoang | Method of manufacturing intravenous immunoglobulin from fraction iii |
| CN107921080A (zh) * | 2015-04-02 | 2018-04-17 | K·黄 | 由组分iii制造并纯化出用于静脉注射的凝血酶原复合物浓缩剂的方法以及治疗和预防具有抑制剂的a型血友病或感染了hiv‑1和hiv‑2的b型血友病患者的方法 |
| CN118903378A (zh) * | 2024-03-19 | 2024-11-08 | 北京达尔文细胞生物科技有限公司 | 一种蛋白聚合物在治疗渐冻症中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3825429C2 (de) * | 1988-07-27 | 1994-02-10 | Biotest Pharma Gmbh | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| GB0315248D0 (en) * | 2003-06-30 | 2003-08-06 | Hoffmann La Roche | HCV regulated protein expression |
| TWI489994B (zh) | 2008-03-17 | 2015-07-01 | Baxter Healthcare Sa | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
| CA2639003A1 (en) | 2008-08-20 | 2010-02-20 | Canadian Blood Services | Inhibition of fc.gamma.r-mediated phagocytosis with reduced immunoglobulin preparations |
| US10233228B2 (en) * | 2010-04-09 | 2019-03-19 | Albumedix Ltd | Albumin derivatives and variants |
| WO2011143637A1 (en) * | 2010-05-14 | 2011-11-17 | The Regents Of The University Of Colorado, A Body Corporate | Improved complement receptor 2 (cr2) targeting groups |
| WO2015184050A1 (en) | 2014-05-28 | 2015-12-03 | Rare Antibody Antigen Supply, Inc. | Purified compositions of ivig and kh proteins for modulating lymphocytes and treating hepatitis b virus |
| TW201335181A (zh) | 2012-01-31 | 2013-09-01 | Kieu Hoang | ５５種新發現的蛋白質之序列及其應用 |
-
2015
- 2015-05-28 WO PCT/US2015/032807 patent/WO2015184050A1/en not_active Ceased
- 2015-05-28 JP JP2017515008A patent/JP2017525752A/ja active Pending
- 2015-05-28 RU RU2016151761A patent/RU2016151761A/ru not_active Application Discontinuation
- 2015-05-28 AU AU2015266997A patent/AU2015266997A1/en not_active Abandoned
- 2015-05-28 BR BR112016027818A patent/BR112016027818A2/pt not_active Application Discontinuation
- 2015-05-28 EP EP15799654.7A patent/EP3148574B1/en not_active Revoked
- 2015-05-28 ES ES15799654T patent/ES2878043T3/es active Active
- 2015-05-28 CN CN201580041532.2A patent/CN107106664A/zh active Pending
- 2015-05-28 MX MX2016015574A patent/MX2016015574A/es unknown
- 2015-05-28 CA CA2949994A patent/CA2949994A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| ES2878043T3 (es) | 2021-11-18 |
| EP3148574A4 (en) | 2017-04-05 |
| MX2016015574A (es) | 2018-05-28 |
| CN107106664A (zh) | 2017-08-29 |
| CA2949994A1 (en) | 2015-12-03 |
| WO2015184050A1 (en) | 2015-12-03 |
| EP3148574B1 (en) | 2021-04-14 |
| JP2017525752A (ja) | 2017-09-07 |
| AU2015266997A1 (en) | 2016-12-08 |
| BR112016027818A2 (pt) | 2017-10-24 |
| RU2016151761A3 (https=) | 2018-12-26 |
| EP3148574A1 (en) | 2017-04-05 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20200218 |