RU2016151761A - Очищенные композиции белков ivig и kh для модулирования лимфоцитов и лечения вируса гепатита b - Google Patents
Очищенные композиции белков ivig и kh для модулирования лимфоцитов и лечения вируса гепатита b Download PDFInfo
- Publication number
- RU2016151761A RU2016151761A RU2016151761A RU2016151761A RU2016151761A RU 2016151761 A RU2016151761 A RU 2016151761A RU 2016151761 A RU2016151761 A RU 2016151761A RU 2016151761 A RU2016151761 A RU 2016151761A RU 2016151761 A RU2016151761 A RU 2016151761A
- Authority
- RU
- Russia
- Prior art keywords
- seq
- amino acid
- acid sequence
- substantially pure
- protein
- Prior art date
Links
- 102000004169 proteins and genes Human genes 0.000 title claims 118
- 108090000623 proteins and genes Proteins 0.000 title claims 118
- 239000000203 mixture Substances 0.000 title claims 3
- 241000700721 Hepatitis B virus Species 0.000 title 1
- 210000004698 lymphocyte Anatomy 0.000 title 1
- 125000003275 alpha amino acid group Chemical group 0.000 claims 89
- 239000000047 product Substances 0.000 claims 25
- 238000000034 method Methods 0.000 claims 23
- 230000000694 effects Effects 0.000 claims 21
- 208000002672 hepatitis B Diseases 0.000 claims 20
- 210000002381 plasma Anatomy 0.000 claims 18
- 230000001105 regulatory effect Effects 0.000 claims 17
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 12
- 210000001744 T-lymphocyte Anatomy 0.000 claims 12
- 210000000952 spleen Anatomy 0.000 claims 9
- 210000005259 peripheral blood Anatomy 0.000 claims 8
- 239000011886 peripheral blood Substances 0.000 claims 8
- 108060003951 Immunoglobulin Proteins 0.000 claims 5
- 102000018358 immunoglobulin Human genes 0.000 claims 5
- 101001018097 Homo sapiens L-selectin Proteins 0.000 claims 4
- 102100033467 L-selectin Human genes 0.000 claims 4
- 239000000706 filtrate Substances 0.000 claims 4
- 238000001914 filtration Methods 0.000 claims 4
- 101000914514 Homo sapiens T-cell-specific surface glycoprotein CD28 Proteins 0.000 claims 3
- 102100027213 T-cell-specific surface glycoprotein CD28 Human genes 0.000 claims 3
- 239000012467 final product Substances 0.000 claims 3
- 210000003719 b-lymphocyte Anatomy 0.000 claims 2
- 238000010790 dilution Methods 0.000 claims 2
- 239000012895 dilution Substances 0.000 claims 2
- 210000003714 granulocyte Anatomy 0.000 claims 2
- 229940036107 hepatitis b immunoglobulin Drugs 0.000 claims 2
- 229940072221 immunoglobulins Drugs 0.000 claims 2
- 210000002540 macrophage Anatomy 0.000 claims 2
- 238000001728 nano-filtration Methods 0.000 claims 2
- 239000000725 suspension Substances 0.000 claims 2
- 238000000108 ultra-filtration Methods 0.000 claims 2
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000001954 sterilising effect Effects 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
- A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
- A61K35/14—Blood; Artificial blood
- A61K35/16—Blood plasma; Blood serum
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Virology (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Hematology (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Biotechnology (AREA)
- Cell Biology (AREA)
- Developmental Biology & Embryology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Oncology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Communicable Diseases (AREA)
- Gastroenterology & Hepatology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicinal Preparation (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201462003664P | 2014-05-28 | 2014-05-28 | |
| US62/003,664 | 2014-05-28 | ||
| PCT/US2015/032807 WO2015184050A1 (en) | 2014-05-28 | 2015-05-28 | Purified compositions of ivig and kh proteins for modulating lymphocytes and treating hepatitis b virus |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016151761A true RU2016151761A (ru) | 2018-07-03 |
| RU2016151761A3 RU2016151761A3 (https=) | 2018-12-26 |
Family
ID=54699755
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016151761A RU2016151761A (ru) | 2014-05-28 | 2015-05-28 | Очищенные композиции белков ivig и kh для модулирования лимфоцитов и лечения вируса гепатита b |
Country Status (10)
| Country | Link |
|---|---|
| EP (1) | EP3148574B1 (https=) |
| JP (1) | JP2017525752A (https=) |
| CN (1) | CN107106664A (https=) |
| AU (1) | AU2015266997A1 (https=) |
| BR (1) | BR112016027818A2 (https=) |
| CA (1) | CA2949994A1 (https=) |
| ES (1) | ES2878043T3 (https=) |
| MX (1) | MX2016015574A (https=) |
| RU (1) | RU2016151761A (https=) |
| WO (1) | WO2015184050A1 (https=) |
Families Citing this family (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2017525752A (ja) | 2014-05-28 | 2017-09-07 | レア アンチボディ アンチジェン サプライ インク | 静注用免疫グロブリンの精製組成物及びリンパ球を調整しｂ型肝炎を治療するためのｋｈタンパク質 |
| US10583179B2 (en) * | 2015-04-02 | 2020-03-10 | Kieu Hoang | Method of manufacturing and purifying prothrombin complex concentrate from Fraction III for intravenous injection and a method of curing and preventing Hemophilia A with inhibitors or Hemophilia B in patients infected with HIV-1 and HIV-2 |
| CN107921079A (zh) * | 2015-04-02 | 2018-04-17 | K·黄 | 由组分iii制造静脉注射免疫球蛋白的方法 |
| CN118903378A (zh) * | 2024-03-19 | 2024-11-08 | 北京达尔文细胞生物科技有限公司 | 一种蛋白聚合物在治疗渐冻症中的应用 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3825429C2 (de) * | 1988-07-27 | 1994-02-10 | Biotest Pharma Gmbh | Verfahren zur Herstellung eines intravenös verabreichbaren polyklonalen Immunglobulin-Präparates mit hohem IgM-Gehalt |
| US20040142325A1 (en) * | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| GB0315248D0 (en) * | 2003-06-30 | 2003-08-06 | Hoffmann La Roche | HCV regulated protein expression |
| TWI489994B (zh) * | 2008-03-17 | 2015-07-01 | Baxter Healthcare Sa | 供免疫球蛋白及玻尿酸酶之皮下投藥之用的組合及方法 |
| CA2639003A1 (en) | 2008-08-20 | 2010-02-20 | Canadian Blood Services | Inhibition of fc.gamma.r-mediated phagocytosis with reduced immunoglobulin preparations |
| EP2556087A1 (en) * | 2010-04-09 | 2013-02-13 | Novozymes Biopharma DK A/S | Albumin derivatives and variants |
| BR112012029067A2 (pt) * | 2010-05-14 | 2019-09-24 | Univ Colorado Regents | grupos-alvo de receptor do complemento 2 (cr2) melhorados. |
| TW201335181A (zh) * | 2012-01-31 | 2013-09-01 | Kieu Hoang | ５５種新發現的蛋白質之序列及其應用 |
| JP2017525752A (ja) | 2014-05-28 | 2017-09-07 | レア アンチボディ アンチジェン サプライ インク | 静注用免疫グロブリンの精製組成物及びリンパ球を調整しｂ型肝炎を治療するためのｋｈタンパク質 |
-
2015
- 2015-05-28 JP JP2017515008A patent/JP2017525752A/ja active Pending
- 2015-05-28 CA CA2949994A patent/CA2949994A1/en active Pending
- 2015-05-28 AU AU2015266997A patent/AU2015266997A1/en not_active Abandoned
- 2015-05-28 BR BR112016027818A patent/BR112016027818A2/pt not_active Application Discontinuation
- 2015-05-28 EP EP15799654.7A patent/EP3148574B1/en not_active Revoked
- 2015-05-28 MX MX2016015574A patent/MX2016015574A/es unknown
- 2015-05-28 RU RU2016151761A patent/RU2016151761A/ru not_active Application Discontinuation
- 2015-05-28 ES ES15799654T patent/ES2878043T3/es active Active
- 2015-05-28 WO PCT/US2015/032807 patent/WO2015184050A1/en not_active Ceased
- 2015-05-28 CN CN201580041532.2A patent/CN107106664A/zh active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| AU2015266997A1 (en) | 2016-12-08 |
| CA2949994A1 (en) | 2015-12-03 |
| EP3148574A1 (en) | 2017-04-05 |
| JP2017525752A (ja) | 2017-09-07 |
| EP3148574B1 (en) | 2021-04-14 |
| ES2878043T3 (es) | 2021-11-18 |
| BR112016027818A2 (pt) | 2017-10-24 |
| CN107106664A (zh) | 2017-08-29 |
| EP3148574A4 (en) | 2017-04-05 |
| WO2015184050A1 (en) | 2015-12-03 |
| RU2016151761A3 (https=) | 2018-12-26 |
| MX2016015574A (es) | 2018-05-28 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20200218 |