RU2016146581A - Макроциклические антибиотики широкого спектра действия - Google Patents

Макроциклические антибиотики широкого спектра действия Download PDF

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RU2016146581A
RU2016146581A RU2016146581A RU2016146581A RU2016146581A RU 2016146581 A RU2016146581 A RU 2016146581A RU 2016146581 A RU2016146581 A RU 2016146581A RU 2016146581 A RU2016146581 A RU 2016146581A RU 2016146581 A RU2016146581 A RU 2016146581A
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alkyl
optionally substituted
independently
aryl
cycloalkyl
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RU2016146581A
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RU2016146581A3 (OSRAM
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Такер Каррэн РОБЕРТС
Питер Эндрю Смит
Роберт И. ХАЙГУЧИ
Прасуна Параселли
Филиппе БЕРГЕРОН
Майкл Ф.Т. КЁЛЕР
Хуэйюн ХУ
Джейкоб Брэдли Шварц
Цуон ЛИ
Джеймс КРОФОРД
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АрКьюЭкс ФАРМАСЪЮТИКЛС, ИНК.
Дженентек, Инк.
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    • C07K5/10—Tetrapeptides
    • C07K5/1002—Tetrapeptides with the first amino acid being neutral
    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/101—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms, e.g. Val, Ile, Leu
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A61K31/407—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with other heterocyclic ring systems, e.g. ketorolac, physostigmine
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/4196—1,2,4-Triazoles
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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
    • A61K31/425—Thiazoles
    • A61K31/429—Thiazoles condensed with heterocyclic ring systems
    • A61K31/43—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems
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    • A61K31/425—Thiazoles
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    • A61K31/431—Compounds containing 4-thia-1-azabicyclo [3.2.0] heptane ring systems, i.e. compounds containing a ring system of the formula, e.g. penicillins, penems containing further heterocyclic rings, e.g. ticarcillin, azlocillin, oxacillin
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    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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    • A61K31/545—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine
    • A61K31/546—Compounds containing 5-thia-1-azabicyclo [4.2.0] octane ring systems, i.e. compounds containing a ring system of the formula:, e.g. cephalosporins, cefaclor, or cephalexine containing further heterocyclic rings, e.g. cephalothin
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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
RU2016146581A 2014-05-20 2015-05-19 Макроциклические антибиотики широкого спектра действия RU2016146581A (ru)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US201462000980P 2014-05-20 2014-05-20
US62/000,980 2014-05-20
US201562142404P 2015-04-02 2015-04-02
US62/142,404 2015-04-02
PCT/US2015/031631 WO2015179441A2 (en) 2014-05-20 2015-05-19 Macrocyclic broad spectrum antibiotics

Publications (2)

Publication Number Publication Date
RU2016146581A true RU2016146581A (ru) 2018-06-21
RU2016146581A3 RU2016146581A3 (OSRAM) 2018-12-20

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US (1) US10392422B2 (OSRAM)
EP (1) EP3145944B1 (OSRAM)
JP (2) JP6823588B2 (OSRAM)
KR (1) KR20170027721A (OSRAM)
CN (1) CN106661084B (OSRAM)
BR (1) BR112016027232A2 (OSRAM)
CA (1) CA2949681A1 (OSRAM)
MX (1) MX2016015218A (OSRAM)
RU (1) RU2016146581A (OSRAM)
WO (1) WO2015179441A2 (OSRAM)

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EP3377474B1 (en) * 2015-11-20 2023-08-16 RQX Pharmaceuticals, Inc. Macrocyclic broad spectrum antibiotics
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JP2020500207A (ja) 2016-09-28 2020-01-09 ブレード・セラピューティクス・インコーポレイテッド カルパインモジュレーター及びそれらの治療上の使用
EP3330260A1 (en) * 2016-12-01 2018-06-06 Enantia, S.L. Process for the preparation of an intermediate for the synthesis of i.a. carfilzomib
IL268483B2 (en) * 2017-02-15 2024-02-01 Rqx Pharmaceuticals Inc Macrocyclic broad spectrum antibiotics
CA3057443A1 (en) 2017-03-21 2018-09-27 The Scripps Research Institute Cu-and ni-catalyzed decarboxylative borylation reactions
CN106966947B (zh) * 2017-03-30 2019-09-03 河北医科大学 一种维格列汀的制备方法
JP7634988B2 (ja) * 2017-12-15 2025-02-25 メルク パテント ゲーエムベーハー 有機エレクトロルミネッセントデバイスに使用するための置換芳香族アミン
CN108806787B (zh) * 2018-07-06 2022-04-05 上海长海医院 面向临床手术的医用耗材智能监控系统
CN109355404B (zh) * 2018-08-30 2022-03-29 华南理工大学 基于聚合酶螺旋反应恒温检测单增李斯特菌的引物、试剂盒及检测方法
EP3852786A4 (en) * 2018-09-19 2022-09-28 Georgia Tech Research Corporation SELF-TITRATEING BACTERIAL PROTEASE-ACTIVATED PRODRUG
IL295889B2 (en) * 2019-05-28 2025-01-01 Hoffmann La Roche Broad-spectrum macrocyclic antibiotic
CN118063337B (zh) * 2024-02-19 2025-01-28 绵阳师范学院 一种(s)-3-氨基-2-戊酮盐酸盐的制备方法

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BR112016027232A2 (pt) 2018-06-26
JP6823588B2 (ja) 2021-02-03
CN106661084A (zh) 2017-05-10
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EP3145944A4 (en) 2018-01-03
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WO2015179441A2 (en) 2015-11-26
CA2949681A1 (en) 2015-11-26
JP2017517567A (ja) 2017-06-29
KR20170027721A (ko) 2017-03-10
US20170088582A1 (en) 2017-03-30
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