RU2016144176A3 - - Google Patents
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- RU2016144176A3 RU2016144176A3 RU2016144176A RU2016144176A RU2016144176A3 RU 2016144176 A3 RU2016144176 A3 RU 2016144176A3 RU 2016144176 A RU2016144176 A RU 2016144176A RU 2016144176 A RU2016144176 A RU 2016144176A RU 2016144176 A3 RU2016144176 A3 RU 2016144176A3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6801—Drug-antibody or immunoglobulin conjugates defined by the pharmacologically or therapeutically active agent
- A61K47/6803—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates
- A61K47/6811—Drugs conjugated to an antibody or immunoglobulin, e.g. cisplatin-antibody conjugates the drug being a protein or peptide, e.g. transferrin or bleomycin
- A61K47/6817—Toxins
- A61K47/6829—Bacterial toxins, e.g. diphteria toxins or Pseudomonas exotoxin A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/68—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment
- A61K47/6835—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site
- A61K47/6851—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell
- A61K47/6855—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an antibody, an immunoglobulin or a fragment thereof, e.g. an Fc-fragment the modifying agent being an antibody or an immunoglobulin bearing at least one antigen-binding site the antibody targeting a determinant of a tumour cell the tumour determinant being from breast cancer cell
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/40—Immunoglobulins specific features characterized by post-translational modification
- C07K2317/41—Glycosylation, sialylation, or fucosylation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/52—Constant or Fc region; Isotype
- C07K2317/522—CH1 domain
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/54—F(ab')2
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
- C07K2317/565—Complementarity determining region [CDR]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/622—Single chain antibody (scFv)
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
- C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
- C07K2317/626—Diabody or triabody
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/77—Internalization into the cell
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201461978516P | 2014-04-11 | 2014-04-11 | |
| US61/978,516 | 2014-04-11 | ||
| US201562107050P | 2015-01-23 | 2015-01-23 | |
| US62/107,050 | 2015-01-23 | ||
| PCT/US2015/025232 WO2015157592A1 (en) | 2014-04-11 | 2015-04-10 | Bispecific her2 antibodies |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU2016144176A RU2016144176A (ru) | 2018-05-14 |
| RU2016144176A3 true RU2016144176A3 (ru) | 2018-11-20 |
Family
ID=54288419
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016144176A RU2016144176A (ru) | 2014-04-11 | 2015-04-10 | Биспецифические антитела к her2 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10160812B2 (ru) |
| EP (1) | EP3129055B1 (ru) |
| JP (1) | JP2017512765A (ru) |
| KR (1) | KR20160143808A (ru) |
| CN (1) | CN106232139A (ru) |
| AU (1) | AU2015243377A1 (ru) |
| BR (1) | BR112016022910A2 (ru) |
| CA (1) | CA2943299A1 (ru) |
| CL (1) | CL2016002547A1 (ru) |
| ES (1) | ES2819863T3 (ru) |
| HK (1) | HK1232127A1 (ru) |
| IL (1) | IL247478A0 (ru) |
| MX (1) | MX2016012830A (ru) |
| RU (1) | RU2016144176A (ru) |
| SG (1) | SG11201608192SA (ru) |
| TW (1) | TW201542594A (ru) |
| WO (1) | WO2015157592A1 (ru) |
Families Citing this family (36)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3733714A1 (en) * | 2019-04-30 | 2020-11-04 | Universität Zürich | Her2-binding tetrameric polypeptides |
| NZ725131A (en) * | 2014-04-11 | 2018-03-23 | Medimmune Llc | Tubulysin derivatives |
| RU2710194C9 (ru) | 2015-11-10 | 2020-09-14 | МЕДИММЬЮН, ЭлЭлСи | Связывающие молекулы, специфичные в отношении asct2, и их применения |
| TWI727380B (zh) | 2015-11-30 | 2021-05-11 | 美商輝瑞股份有限公司 | 位點專一性ｈｅｒ２抗體藥物共軛體 |
| CA3012960A1 (en) | 2016-02-01 | 2017-08-10 | Pfizer Inc. | Tubulysin analogs and methods for their preparation |
| JP2019506865A (ja) * | 2016-02-05 | 2019-03-14 | ゲンマブ エー／エス | 改善された内部移行特性を有する多重特異性抗原結合分子 |
| CN107446045A (zh) * | 2016-07-22 | 2017-12-08 | 北京天广实生物技术股份有限公司 | 一种抗her2的抗体、其药物组合物及用途 |
| EP3579848A4 (en) | 2017-02-08 | 2021-03-03 | Dragonfly Therapeutics, Inc. | MULTISPECIFIC BINDING PROTEINS FOR ACTIVATING NATURAL KILLER CELLS AND THEIR THERAPEUTIC USES FOR TREATING CANCER |
| AU2018220736A1 (en) | 2017-02-20 | 2019-09-05 | Dragonfly Therapeutics, Inc. | Proteins binding HER2, NKG2D and CD16 |
| CA3052837A1 (en) * | 2017-02-28 | 2018-09-07 | Seattle Genetics, Inc. | Cysteine mutated antibodies for conjugation |
| CR20200100A (es) | 2017-08-01 | 2020-05-09 | Medimmune Llc | Conjugado de anticuerpo monoclonal contra bcma -fármaco |
| CN107789631B (zh) * | 2017-11-03 | 2021-03-16 | 合肥瀚科迈博生物技术有限公司 | 抗人ErbB2双表位抗体-药物偶联物及其应用 |
| CN112368012A (zh) | 2018-02-08 | 2021-02-12 | 蜻蜓疗法股份有限公司 | 靶向nkg2d受体的抗体可变结构域 |
| SG10201801219VA (en) | 2018-02-13 | 2019-09-27 | Agency Science Tech & Res | Anti-HER2 Antibodies |
| SG11202008770QA (en) | 2018-03-13 | 2020-10-29 | Zymeworks Inc | Anti-her2 biparatopic antibody-drug conjugates and methods of use |
| US20210198370A1 (en) * | 2018-05-31 | 2021-07-01 | Board Of Regents, The University Of Texas System | Bi-specific antibodies and use thereof |
| EA202091888A1 (ru) * | 2018-08-08 | 2020-10-23 | Драгонфлай Терапьютикс, Инк. | Вариабельные домены антител, нацеленные на рецептор nkg2d |
| EP3864054A1 (en) * | 2018-10-08 | 2021-08-18 | Universität Zürich | Her2-binding tetrameric polypeptides |
| JP2024504880A (ja) * | 2018-12-24 | 2024-02-02 | サノフイ | 疑似ｆａｂベースの多重特異性結合タンパク質 |
| CN113226329A (zh) * | 2018-12-28 | 2021-08-06 | 国立大学法人东京大学 | 识别癌细胞的抗体与链霉亲和素突变体的融合蛋白 |
| JP2022529232A (ja) * | 2019-03-22 | 2022-06-20 | オリビア・ニュートン－ジョン・キャンサー・リサーチ・インスティテュート | 抗ｈｅｒ２結合分子 |
| JP7436520B2 (ja) * | 2019-05-31 | 2024-02-21 | ザイムワークス ビーシー インコーポレイテッド | 胆道癌の治療のための、ｈｅｒ２を標的とする二重特異性抗原結合構築物の使用方法 |
| US20220387618A1 (en) | 2019-11-15 | 2022-12-08 | Seagen Inc. | Methods of treating her2 positive breast cancer with tucatinib in combination with an anti-her2 antibody-drug conjugate |
| KR20210068264A (ko) | 2019-11-30 | 2021-06-09 | 김상엽 | 스트랩 부착형 헬스장갑 |
| BR112022016232A2 (pt) * | 2020-02-19 | 2022-11-16 | Denali Therapeutics Inc | Proteínas biespecíficas anti-her2 manipuladas |
| IL295312A (en) | 2020-02-28 | 2022-10-01 | Regeneron Pharma | Bispecific antigen binding molecules that bind her2 and methods of using them |
| GB202004263D0 (en) | 2020-03-24 | 2020-05-06 | Autolus Ltd | Antibody conjugate |
| FR3112939B1 (fr) * | 2020-07-31 | 2024-01-05 | Univ Montpellier | Produit universel de thérapie cellulaire et son utilisation |
| BR112023004415A2 (pt) | 2020-09-11 | 2023-05-09 | Medimmune Ltd | Moléculas terapêuticas de ligação a b7-h4 |
| US11866502B2 (en) | 2020-10-22 | 2024-01-09 | Regeneron Pharmaceuticals, Inc. | Anti-FGFR2 antibodies and methods of use thereof |
| CN114539413A (zh) * | 2020-11-25 | 2022-05-27 | 三生国健药业（上海）股份有限公司 | 结合her2的多价双特异性抗体、其制备方法和用途 |
| CN117616052A (zh) * | 2021-07-05 | 2024-02-27 | 江苏康宁杰瑞生物制药有限公司 | 抗体药物偶联物及其应用 |
| TW202348252A (zh) | 2022-02-16 | 2023-12-16 | 英商梅迪繆思有限公司 | 用治療性結合分子治療癌症的組合療法 |
| WO2023169896A1 (en) | 2022-03-09 | 2023-09-14 | Astrazeneca Ab | BINDING MOLECULES AGAINST FRα |
| WO2023170216A1 (en) | 2022-03-11 | 2023-09-14 | Astrazeneca Ab | A SCORING METHOD FOR AN ANTI-FRα ANTIBODY-DRUG CONJUGATE THERAPY |
| CN116874606B (zh) * | 2023-09-08 | 2023-11-24 | 益科思特(北京)医药科技发展有限公司 | 一种靶向trop2和cd3的双特异性抗体及其制备方法与应用 |
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-
2015
- 2015-04-10 US US15/302,018 patent/US10160812B2/en active Active
- 2015-04-10 CA CA2943299A patent/CA2943299A1/en not_active Abandoned
- 2015-04-10 KR KR1020167031452A patent/KR20160143808A/ko unknown
- 2015-04-10 MX MX2016012830A patent/MX2016012830A/es unknown
- 2015-04-10 RU RU2016144176A patent/RU2016144176A/ru not_active Application Discontinuation
- 2015-04-10 BR BR112016022910A patent/BR112016022910A2/pt not_active Application Discontinuation
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- 2015-04-10 SG SG11201608192SA patent/SG11201608192SA/en unknown
- 2015-04-10 CN CN201580018988.7A patent/CN106232139A/zh not_active Withdrawn
- 2015-04-10 AU AU2015243377A patent/AU2015243377A1/en not_active Abandoned
- 2015-04-10 WO PCT/US2015/025232 patent/WO2015157592A1/en active Application Filing
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Also Published As
| Publication number | Publication date |
|---|---|
| CA2943299A1 (en) | 2015-10-15 |
| HK1232127A1 (zh) | 2018-01-05 |
| ES2819863T3 (es) | 2021-04-19 |
| IL247478A0 (en) | 2016-11-30 |
| RU2016144176A (ru) | 2018-05-14 |
| AU2015243377A1 (en) | 2016-09-15 |
| WO2015157592A1 (en) | 2015-10-15 |
| JP2017512765A (ja) | 2017-05-25 |
| SG11201608192SA (en) | 2016-10-28 |
| KR20160143808A (ko) | 2016-12-14 |
| US10160812B2 (en) | 2018-12-25 |
| TW201542594A (zh) | 2015-11-16 |
| EP3129055A4 (en) | 2017-11-22 |
| CL2016002547A1 (es) | 2017-06-23 |
| US20170291955A1 (en) | 2017-10-12 |
| EP3129055A1 (en) | 2017-02-15 |
| MX2016012830A (es) | 2017-01-05 |
| EP3129055B1 (en) | 2020-07-01 |
| CN106232139A (zh) | 2016-12-14 |
| BR112016022910A2 (pt) | 2017-10-17 |
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