RU2016108014A - Производные 25-он витамина d для определения метаболитов витамина d - Google Patents
Производные 25-он витамина d для определения метаболитов витамина d Download PDFInfo
- Publication number
- RU2016108014A RU2016108014A RU2016108014A RU2016108014A RU2016108014A RU 2016108014 A RU2016108014 A RU 2016108014A RU 2016108014 A RU2016108014 A RU 2016108014A RU 2016108014 A RU2016108014 A RU 2016108014A RU 2016108014 A RU2016108014 A RU 2016108014A
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- RU
- Russia
- Prior art keywords
- compound
- vitamin
- formula
- group
- paragraphs
- Prior art date
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- 150000003710 vitamin D derivatives Chemical class 0.000 title claims 12
- 239000002207 metabolite Substances 0.000 title 1
- 239000011782 vitamin Substances 0.000 title 1
- 229940088594 vitamin Drugs 0.000 title 1
- 229930003231 vitamin Natural products 0.000 title 1
- 235000013343 vitamin Nutrition 0.000 title 1
- 150000003722 vitamin derivatives Chemical class 0.000 title 1
- 150000001875 compounds Chemical class 0.000 claims 20
- QYSXJUFSXHHAJI-XFEUOLMDSA-N Vitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C/C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-XFEUOLMDSA-N 0.000 claims 15
- 229930003316 Vitamin D Natural products 0.000 claims 14
- 235000019166 vitamin D Nutrition 0.000 claims 14
- 239000011710 vitamin D Substances 0.000 claims 14
- 229940046008 vitamin d Drugs 0.000 claims 14
- 238000000034 method Methods 0.000 claims 10
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 8
- 239000003153 chemical reaction reagent Substances 0.000 claims 5
- 125000004429 atom Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000005647 linker group Chemical group 0.000 claims 3
- -1 vitamin D compound Chemical class 0.000 claims 3
- JWUBBDSIWDLEOM-UHFFFAOYSA-N 25-Hydroxycholecalciferol Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CCC1=C JWUBBDSIWDLEOM-UHFFFAOYSA-N 0.000 claims 2
- JWUBBDSIWDLEOM-DCHLRESJSA-N 25-Hydroxyvitamin D3 Natural products C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C/C=C1\C[C@@H](O)CCC1=C JWUBBDSIWDLEOM-DCHLRESJSA-N 0.000 claims 2
- JWUBBDSIWDLEOM-NQZHSCJISA-N 25-hydroxy-3 epi cholecalciferol Chemical compound C1([C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=CC=C1C[C@H](O)CCC1=C JWUBBDSIWDLEOM-NQZHSCJISA-N 0.000 claims 2
- KJKIIUAXZGLUND-ICCVIKJNSA-N 25-hydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)CCC1=C KJKIIUAXZGLUND-ICCVIKJNSA-N 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 230000001900 immune effect Effects 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- GMRQFYUYWCNGIN-UHFFFAOYSA-N 1,25-Dihydroxy-vitamin D3' Natural products C1CCC2(C)C(C(CCCC(C)(C)O)C)CCC2C1=CC=C1CC(O)CC(O)C1=C GMRQFYUYWCNGIN-UHFFFAOYSA-N 0.000 claims 1
- ZGLHBRQAEXKACO-XJRQOBMKSA-N 1alpha,25-dihydroxyvitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](\C=C\[C@H](C)C(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C ZGLHBRQAEXKACO-XJRQOBMKSA-N 0.000 claims 1
- MECHNRXZTMCUDQ-UHFFFAOYSA-N Vitamin D2 Natural products C1CCC2(C)C(C(C)C=CC(C)C(C)C)CCC2C1=CC=C1CC(O)CCC1=C MECHNRXZTMCUDQ-UHFFFAOYSA-N 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 239000013060 biological fluid Substances 0.000 claims 1
- 125000004057 biotinyl group Chemical group [H]N1C(=O)N([H])[C@]2([H])[C@@]([H])(SC([H])([H])[C@]12[H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C(*)=O 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 229960005084 calcitriol Drugs 0.000 claims 1
- GMRQFYUYWCNGIN-NKMMMXOESA-N calcitriol Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@@H](CCCC(C)(C)O)C)=C\C=C1\C[C@@H](O)C[C@H](O)C1=C GMRQFYUYWCNGIN-NKMMMXOESA-N 0.000 claims 1
- 125000004432 carbon atom Chemical group C* 0.000 claims 1
- 230000002860 competitive effect Effects 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000002270 dispersing agent Substances 0.000 claims 1
- 229960002061 ergocalciferol Drugs 0.000 claims 1
- 239000000945 filler Substances 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 210000004080 milk Anatomy 0.000 claims 1
- 239000008267 milk Substances 0.000 claims 1
- 235000013336 milk Nutrition 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- 238000010534 nucleophilic substitution reaction Methods 0.000 claims 1
- 210000002381 plasma Anatomy 0.000 claims 1
- 239000003755 preservative agent Substances 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 238000011002 quantification Methods 0.000 claims 1
- 125000000467 secondary amino group Chemical group [H]N([*:1])[*:2] 0.000 claims 1
- 210000002966 serum Anatomy 0.000 claims 1
- 239000002904 solvent Substances 0.000 claims 1
- 239000003381 stabilizer Substances 0.000 claims 1
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 1
- 235000001892 vitamin D2 Nutrition 0.000 claims 1
- 239000011653 vitamin D2 Substances 0.000 claims 1
- MECHNRXZTMCUDQ-RKHKHRCZSA-N vitamin D2 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)/C=C/[C@H](C)C(C)C)=C\C=C1\C[C@@H](O)CCC1=C MECHNRXZTMCUDQ-RKHKHRCZSA-N 0.000 claims 1
- 235000005282 vitamin D3 Nutrition 0.000 claims 1
- 239000011647 vitamin D3 Substances 0.000 claims 1
- QYSXJUFSXHHAJI-YRZJJWOYSA-N vitamin D3 Chemical compound C1(/[C@@H]2CC[C@@H]([C@]2(CCC1)C)[C@H](C)CCCC(C)C)=C\C=C1\C[C@@H](O)CCC1=C QYSXJUFSXHHAJI-YRZJJWOYSA-N 0.000 claims 1
- 229940021056 vitamin d3 Drugs 0.000 claims 1
Classifications
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
- G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
- G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
- G01N33/82—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving vitamins or their receptors
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C401/00—Irradiation products of cholesterol or its derivatives; Vitamin D derivatives, 9,10-seco cyclopenta[a]phenanthrene or analogues obtained by chemical preparation without irradiation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D495/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms
- C07D495/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having sulfur atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D495/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/12—Systems containing only non-condensed rings with a six-membered ring
- C07C2601/14—The ring being saturated
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2602/00—Systems containing two condensed rings
- C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
- C07C2602/14—All rings being cycloaliphatic
- C07C2602/24—All rings being cycloaliphatic the ring system containing nine carbon atoms, e.g. perhydroindane
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Immunology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Food Science & Technology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Analytical Chemistry (AREA)
- Microbiology (AREA)
- General Health & Medical Sciences (AREA)
- General Physics & Mathematics (AREA)
- Pathology (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102013215580.8 | 2013-08-07 | ||
| DE102013215580.8A DE102013215580A1 (de) | 2013-08-07 | 2013-08-07 | 25-OH Vitamin D Derivate zur Bestimmung von Vitamin D Metaboliten |
| PCT/EP2014/066620 WO2015018757A1 (de) | 2013-08-07 | 2014-08-01 | 25-oh vitamin d derivate zur bestimmung von vitamin d metaboliten |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2016108014A true RU2016108014A (ru) | 2017-09-08 |
Family
ID=51298740
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2016108014A RU2016108014A (ru) | 2013-08-07 | 2014-08-01 | Производные 25-он витамина d для определения метаболитов витамина d |
Country Status (10)
| Country | Link |
|---|---|
| US (2) | US10222388B2 (https=) |
| EP (1) | EP3030243B1 (https=) |
| JP (1) | JP6388941B2 (https=) |
| CN (1) | CN105636595B (https=) |
| AU (1) | AU2014304585A1 (https=) |
| DE (1) | DE102013215580A1 (https=) |
| IL (1) | IL243856A0 (https=) |
| MX (1) | MX2016001519A (https=) |
| RU (1) | RU2016108014A (https=) |
| WO (1) | WO2015018757A1 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9585934B2 (en) | 2014-10-22 | 2017-03-07 | Extend Biosciences, Inc. | Therapeutic vitamin D conjugates |
| WO2016065052A1 (en) | 2014-10-22 | 2016-04-28 | Extend Biosciences, Inc. | Insulin vitamin d conjugates |
| US20160161473A1 (en) | 2014-12-08 | 2016-06-09 | Calbiotech, Inc. | Biotin conjugates of analytes containing amino, hydroxyl, or thiol functional groups for use in immunodiagnostic assays |
| CN115850141B (zh) * | 2019-02-01 | 2024-09-20 | 科美博阳诊断技术(上海)有限公司 | 一种中间体化合物及其制备方法和应用 |
| CN116143692B (zh) * | 2019-02-01 | 2025-09-16 | 科美博阳诊断技术(上海)有限公司 | 用于测定维生素d的含量或存在的化合物、产品和方法 |
| CN112485418B (zh) * | 2020-10-26 | 2023-04-11 | 北京利德曼生化股份有限公司 | 一种用于人体维生素b12含量检测的释放剂及其应用 |
| EP4593867A2 (en) | 2022-09-30 | 2025-08-06 | Extend Biosciences, Inc. | Long-acting parathyroid hormone |
| CN119192387B (zh) * | 2023-06-25 | 2025-11-18 | 东莞市朋志生物科技有限公司 | 抗25-oh-vd及其抗体复合物的抗体、检测25-oh-vd的试剂和试剂盒 |
Family Cites Families (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4119647A (en) * | 1977-04-11 | 1978-10-10 | Hoffmann-La Roche Inc. | 25-Hydroxycholecalciferol-23,24-3 H and process for the preparation thereof |
| JPH075542B2 (ja) | 1988-09-14 | 1995-01-25 | 呉羽化学工業株式会社 | ビタミンｄ▲下３▼誘導体及びその製造方法 |
| CH681891A5 (https=) | 1992-10-09 | 1993-06-15 | Marigen Sa | |
| US5422127A (en) * | 1992-12-21 | 1995-06-06 | Bristol-Myers Squibb Company | Nutritional compositions containing vitamin D esters |
| US5478816A (en) * | 1993-07-02 | 1995-12-26 | Bristol-Myers Squibb Company | Liquid vitamin formulations containing vitamin D esters |
| DE873126T1 (de) * | 1995-12-29 | 2000-11-02 | A And D Assay, Inc. | Markierte vitamin d-verbindungen und deren verwendung |
| GB9623569D0 (en) | 1996-11-13 | 1997-01-08 | Immunodiagnostic Systems Ltd | Vitamin D immumoassay systems |
| DE69834109T2 (de) | 1997-05-16 | 2007-04-19 | Woman & Infants Hospital | 3-epi-vitamin d2 verbindungen und ihre anwendungen |
| WO1999067211A1 (de) | 1998-06-25 | 1999-12-29 | Immundiagnostik Gesellschaft Für Produktion Und Vertrieb Von Labordiagnostika Mbh | FUNKTIONELLE VITAMIN-D-DERIVATE UND VERFAHREN ZUR BESTIMMUNG VON 25-HYDROXY- UND 1α,25-DIHYDROXY-VITAMIN-D |
| JP2009509992A (ja) | 2005-09-29 | 2009-03-12 | エフ．ホフマン−ラ ロシュ アーゲー | ２５−ヒドロキシビタミンｄに対する抗体 |
| WO2007079394A2 (en) * | 2005-12-30 | 2007-07-12 | Revance Therapeutics, Inc. | Arginine heteromers for topical administration |
| EP2020026A4 (en) | 2006-05-16 | 2010-06-09 | Freescale Semiconductor Inc | INTEGRATED CIRCUIT WITH CONTACT POINTS AND INPUT / OUTPUT CELLS |
| CA2649338C (en) | 2006-06-06 | 2011-07-12 | F.Hoffman-La Roche Ag | Improved measurement of vitamin d |
| JP2010053118A (ja) * | 2008-07-28 | 2010-03-11 | Fujifilm Corp | ビオチン化チロキシン |
| CN102628872A (zh) * | 2012-03-31 | 2012-08-08 | 广州菲康生物技术有限公司 | 25羟基维生素d检测试剂盒及其制备方法 |
| DE102013205055A1 (de) | 2013-03-21 | 2014-09-25 | Orgentec Diagnostika Gmbh | Verfahren und Reagenz zur Bestimmung von Vitamin D Metaboliten |
-
2013
- 2013-08-07 DE DE102013215580.8A patent/DE102013215580A1/de not_active Withdrawn
-
2014
- 2014-08-01 RU RU2016108014A patent/RU2016108014A/ru unknown
- 2014-08-01 EP EP14748179.0A patent/EP3030243B1/de active Active
- 2014-08-01 US US14/910,881 patent/US10222388B2/en active Active
- 2014-08-01 CN CN201480044453.2A patent/CN105636595B/zh active Active
- 2014-08-01 AU AU2014304585A patent/AU2014304585A1/en not_active Abandoned
- 2014-08-01 JP JP2016532339A patent/JP6388941B2/ja active Active
- 2014-08-01 WO PCT/EP2014/066620 patent/WO2015018757A1/de not_active Ceased
- 2014-08-01 MX MX2016001519A patent/MX2016001519A/es unknown
-
2016
- 2016-01-31 IL IL243856A patent/IL243856A0/en unknown
-
2018
- 2018-10-04 US US16/151,812 patent/US11199553B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2015018757A1 (de) | 2015-02-12 |
| JP6388941B2 (ja) | 2018-09-12 |
| DE102013215580A1 (de) | 2015-02-12 |
| EP3030243A1 (de) | 2016-06-15 |
| US20170115313A9 (en) | 2017-04-27 |
| US10222388B2 (en) | 2019-03-05 |
| CN105636595A (zh) | 2016-06-01 |
| AU2014304585A1 (en) | 2016-02-18 |
| US11199553B2 (en) | 2021-12-14 |
| MX2016001519A (es) | 2016-06-23 |
| EP3030243B1 (de) | 2017-07-26 |
| US20190101548A1 (en) | 2019-04-04 |
| IL243856A0 (en) | 2016-04-21 |
| US20160195556A1 (en) | 2016-07-07 |
| JP2016532695A (ja) | 2016-10-20 |
| CN105636595B (zh) | 2019-08-27 |
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