RU2016106134A - Иммуногенные противовоспалительные композиции - Google Patents
Иммуногенные противовоспалительные композиции Download PDFInfo
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- RU2016106134A RU2016106134A RU2016106134A RU2016106134A RU2016106134A RU 2016106134 A RU2016106134 A RU 2016106134A RU 2016106134 A RU2016106134 A RU 2016106134A RU 2016106134 A RU2016106134 A RU 2016106134A RU 2016106134 A RU2016106134 A RU 2016106134A
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- 239000000203 mixture Substances 0.000 title claims 10
- 230000003110 anti-inflammatory effect Effects 0.000 title 1
- 241000588724 Escherichia coli Species 0.000 claims 14
- 238000000034 method Methods 0.000 claims 14
- 230000000890 antigenic effect Effects 0.000 claims 8
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 4
- 206010009887 colitis Diseases 0.000 claims 4
- 210000001072 colon Anatomy 0.000 claims 4
- 208000015181 infectious disease Diseases 0.000 claims 4
- 238000002347 injection Methods 0.000 claims 4
- 239000007924 injection Substances 0.000 claims 4
- 208000027496 Behcet disease Diseases 0.000 claims 2
- 208000009137 Behcet syndrome Diseases 0.000 claims 2
- 206010009895 Colitis ischaemic Diseases 0.000 claims 2
- 206010056979 Colitis microscopic Diseases 0.000 claims 2
- 206010009900 Colitis ulcerative Diseases 0.000 claims 2
- 206010061218 Inflammation Diseases 0.000 claims 2
- 201000006704 Ulcerative Colitis Diseases 0.000 claims 2
- 208000008609 collagenous colitis Diseases 0.000 claims 2
- 230000003203 everyday effect Effects 0.000 claims 2
- 230000028993 immune response Effects 0.000 claims 2
- 230000002757 inflammatory effect Effects 0.000 claims 2
- 230000004054 inflammatory process Effects 0.000 claims 2
- 210000000936 intestine Anatomy 0.000 claims 2
- 201000008222 ischemic colitis Diseases 0.000 claims 2
- 208000004341 lymphocytic colitis Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 238000007920 subcutaneous administration Methods 0.000 claims 1
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Claims (28)
1. Способ лечения индивидуума, страдающего воспалительным заболеванием кишечника, включающий введение внутрикожно или подкожно эффективного количества антигенной композиции, содержащей целые убитые клетки Е. coli, в виде последовательно вводимых доз с интервалом между дозами по меньшей мере один час.
2. Способ по п. 1, в котором две или более дозы вводятся в течение периода времени от 4 дней до 1 недели.
3. Способ по п. 1, в котором антигенная композиция вводится подкожно каждый день или через день.
4. Способ по п. 1, в котором дозы вводятся на протяжении периода дозирования, составляющего, по меньшей мере, одну неделю.
5. Способ по п. 2, в котором дозы вводятся на протяжении периода дозирования, составляющего, по меньшей мере, одну неделю.
6. Способ по п. 3, в котором дозы вводятся на протяжении периода дозирования, составляющего, по меньшей мере, одну неделю.
7. Способ по п. 4, в котором введение дозы по продолжительности составляет по меньшей мере две недели.
8. Способ по п. 5, в котором введение дозы по продолжительности составляет по меньшей мере две недели.
9. Способ по п. 6, в котором введение дозы по продолжительности составляет по меньшей мере две недели.
10. Способ по любому из пп. 1-9, в котором антигенная композиция вводится таким образом, что каждая доза является эффективной для того, чтобы вызвать видимую локализованную воспалительную иммунную реакцию в месте введения.
11. Способ по п. 10, в котором антигенная композиция вводится таким образом, что видимое локализованное воспаление в месте введения возникает в диапазоне от 1 до 48 ч.
12. Способ по любому из пп. 1-9, в котором целые убитые клетки Е. coli представляют собой клетки штамма Е. coli, отобранные у пациента, страдающего Е. coli инфекцией ободочной кишки.
13. Способ по п. 10, в котором целые убитые клетки Е. coli представляют собой клетки штамма Е. coli, отобранные у пациента, страдающего Е. coli инфекцией ободочной кишки.
14. Способ по любому из пп. 1-9, 11, 13, в котором воспалительное заболевание кишечника выбрано из группы, включающей: язвенный колит, коллагенозный колит, лимфоцитарный колит, ишемический колит, колит в отключенной кишке, синдром Бехчета и недифференцированный колит.
15. Применение эффективного количества антигенной композиции содержащей целые убитые клетки Е. coli для получения лекарственного средства для лечения индивидуума, страдающего воспалительным заболеванием кишечника, где композиция применяется внутрикожно или подкожно в виде последовательно вводимых доз с интервалом между дозами по меньшей мере один час.
16. Применение по п. 15, при котором две или более дозы вводятся в течение периода времени от 4 дней до 1 недели.
17. Применение по п. 15, при котором антигенная композиция вводится подкожно каждый день или через день.
18. Применение по п. 15, при котором дозы вводятся на протяжении периода дозирования, составляющего, по меньшей мере, одну неделю.
19. Применение по п. 16, при котором дозы вводятся на протяжении периода дозирования, составляющего, по меньшей мере, одну неделю.
20. Применение по п. 17, при котором дозы вводятся на протяжении периода дозирования, составляющего, по меньшей мере, одну неделю.
21. Применение по п. 18, при котором введение дозы по продолжительности составляет по меньшей мере две недели.
22. Применение по п. 19, при котором введение дозы по продолжительности составляет по меньшей мере две недели.
23. Применение по п. 20, при котором введение дозы по продолжительности составляет по меньшей мере две недели.
24. Применение по любому из пп. 15-23, при котором антигенная композиция вводится таким образом, что каждая доза является эффективной для того, чтобы вызвать видимую локализованную воспалительную иммунную реакцию в месте введения.
25. Применение по п. 24, при котором антигенная композиция вводится таким образом, что видимое локализованное воспаление в месте введения возникает в диапазоне от 1 до 48 ч.
26. Применение по любому из пп. 15-23, при котором целые убитые клетки Е. coli представляют собой клетки штамма Е. coli, отобранные у пациента, страдающего Е. coli инфекцией ободочной кишки.
27. Применение по п. 24, в котором целые убитые клетки Е. coli представляют собой клетки штамма Е. coli, отобранные у пациента, страдающего Е. coli инфекцией ободочной кишки.
28. Применение по любому из пп. 15-23, 25, 27, при котором воспалительное заболевание кишечника выбрано из группы, включающей: язвенный колит, коллагенозный колит, лимфоцитарный колит, ишемический колит, колит в отключенной кишке, синдром Бехчета и недифференцированный колит.
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