RU2014131017A - Хиназолиноновые производные в качестве ингибиторов hcv - Google Patents
Хиназолиноновые производные в качестве ингибиторов hcv Download PDFInfo
- Publication number
- RU2014131017A RU2014131017A RU2014131017A RU2014131017A RU2014131017A RU 2014131017 A RU2014131017 A RU 2014131017A RU 2014131017 A RU2014131017 A RU 2014131017A RU 2014131017 A RU2014131017 A RU 2014131017A RU 2014131017 A RU2014131017 A RU 2014131017A
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- RU
- Russia
- Prior art keywords
- compound
- formula
- compound according
- paragraphs
- independently selected
- Prior art date
Links
- 239000003112 inhibitor Substances 0.000 title claims 2
- 150000001875 compounds Chemical class 0.000 claims abstract 19
- 125000000217 alkyl group Chemical group 0.000 claims abstract 6
- 229910052736 halogen Inorganic materials 0.000 claims abstract 6
- 150000002367 halogens Chemical class 0.000 claims abstract 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims abstract 6
- 239000008194 pharmaceutical composition Substances 0.000 claims abstract 6
- 125000001424 substituent group Chemical group 0.000 claims abstract 6
- 239000003814 drug Substances 0.000 claims abstract 4
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 4
- 239000001257 hydrogen Substances 0.000 claims abstract 4
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract 4
- 208000015181 infectious disease Diseases 0.000 claims abstract 4
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims abstract 4
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract 4
- 230000002265 prevention Effects 0.000 claims abstract 4
- 241000124008 Mammalia Species 0.000 claims abstract 3
- 125000003118 aryl group Chemical group 0.000 claims abstract 2
- 239000003937 drug carrier Substances 0.000 claims abstract 2
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims abstract 2
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 125000003830 C1- C4 alkylcarbonylamino group Chemical group 0.000 claims 2
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 2
- 125000004466 alkoxycarbonylamino group Chemical group 0.000 claims 2
- 125000003282 alkyl amino group Chemical group 0.000 claims 1
- 239000012453 solvate Substances 0.000 claims 1
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 2
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
- C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
- C07D491/10—Spiro-condensed systems
- C07D491/113—Spiro-condensed systems with two or more oxygen atoms as ring hetero atoms in the oxygen-containing ring
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D519/00—Heterocyclic compounds containing more than one system of two or more relevant hetero rings condensed among themselves or condensed with a common carbocyclic ring system not provided for in groups C07D453/00 or C07D455/00
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Virology (AREA)
- Epidemiology (AREA)
- Communicable Diseases (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Molecular Biology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Plural Heterocyclic Compounds (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11195841.9 | 2011-12-28 | ||
| EP11195841 | 2011-12-28 | ||
| EP12152267.6 | 2012-01-24 | ||
| EP12152267 | 2012-01-24 | ||
| PCT/EP2012/076942 WO2013098320A1 (en) | 2011-12-28 | 2012-12-27 | Quinazolinone derivatives as hcv inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014131017A true RU2014131017A (ru) | 2016-02-20 |
Family
ID=47505013
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014131017A RU2014131017A (ru) | 2011-12-28 | 2012-12-27 | Хиназолиноновые производные в качестве ингибиторов hcv |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9382261B2 (enExample) |
| EP (1) | EP2797913B1 (enExample) |
| JP (2) | JP6199891B2 (enExample) |
| CN (1) | CN104169271B (enExample) |
| AU (1) | AU2012360910B8 (enExample) |
| BR (1) | BR112014016007A8 (enExample) |
| CA (1) | CA2858646A1 (enExample) |
| ES (1) | ES2601461T3 (enExample) |
| IN (1) | IN2014MN01486A (enExample) |
| MX (1) | MX348127B (enExample) |
| RU (1) | RU2014131017A (enExample) |
| WO (1) | WO2013098320A1 (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9326973B2 (en) | 2012-01-13 | 2016-05-03 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US9717712B2 (en) | 2013-07-02 | 2017-08-01 | Bristol-Myers Squibb Company | Combinations comprising tricyclohexadecahexaene derivatives for use in the treatment of hepatitis C virus |
| US20150023913A1 (en) | 2013-07-02 | 2015-01-22 | Bristol-Myers Squibb Company | Hepatitis C Virus Inhibitors |
| US9775831B2 (en) | 2013-07-17 | 2017-10-03 | Bristol-Myers Squibb Company | Combinations comprising biphenyl derivatives for use in the treatment of HCV |
| US10617675B2 (en) | 2015-08-06 | 2020-04-14 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8143288B2 (en) | 2005-06-06 | 2012-03-27 | Bristol-Myers Squibb Company | Inhibitors of HCV replication |
| US7659270B2 (en) * | 2006-08-11 | 2010-02-09 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| US8329159B2 (en) | 2006-08-11 | 2012-12-11 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| JP2010506843A (ja) | 2006-10-13 | 2010-03-04 | エックスティーエル バイオファーマシューティカルズ リミテッド | Ｈｃｖを治療するための化合物および方法 |
| JP2010510245A (ja) | 2006-11-21 | 2010-04-02 | スミスクライン ビーチャム コーポレーション | 抗ウイルス化合物 |
| US7906655B2 (en) | 2008-08-07 | 2011-03-15 | Bristol-Myers Squibb Company | Hepatitis C virus inhibitors |
| PE20120124A1 (es) * | 2008-12-03 | 2012-03-17 | Presidio Pharmaceuticals Inc | Derivados 2-pirrolidin-3-il-1h-imidazol, como inhibidores de la proteina no estructural 5a del virus de la heptitis c |
| CA2750577A1 (en) | 2008-12-03 | 2010-06-10 | Presidio Pharmaceuticals, Inc. | Inhibitors of hcv ns5a |
| WO2011004276A1 (en) * | 2009-07-06 | 2011-01-13 | Pfizer Limited | Hepatitis c virus inhibitors |
| UA108211C2 (uk) * | 2009-11-04 | 2015-04-10 | Янссен Рід Айрленд | Бензімідазолімідазольні похідні |
| WO2011091446A1 (en) * | 2010-01-22 | 2011-07-28 | Glaxosmithkline Llc | Chemical compounds |
| BR112012022311A2 (pt) * | 2010-03-04 | 2016-08-23 | Enanta Pharm Inc | agentes farmacêuticos de combinação como inibidores da replicação de hcv. |
| MX2013001088A (es) * | 2010-07-26 | 2013-03-12 | Janssen R & D Ireland | Derivados heterobiciclicos como inhibidores del virus de la hepatitis c. |
| RU2621734C1 (ru) * | 2011-12-28 | 2017-06-07 | Янссен Сайенсиз Айрлэнд Юси | Гетеробициклические производные в качестве ингибиторов hcv |
-
2012
- 2012-12-27 AU AU2012360910A patent/AU2012360910B8/en not_active Ceased
- 2012-12-27 WO PCT/EP2012/076942 patent/WO2013098320A1/en not_active Ceased
- 2012-12-27 CN CN201280065174.5A patent/CN104169271B/zh not_active Expired - Fee Related
- 2012-12-27 RU RU2014131017A patent/RU2014131017A/ru not_active Application Discontinuation
- 2012-12-27 IN IN1486MUN2014 patent/IN2014MN01486A/en unknown
- 2012-12-27 CA CA2858646A patent/CA2858646A1/en not_active Abandoned
- 2012-12-27 US US14/368,511 patent/US9382261B2/en not_active Expired - Fee Related
- 2012-12-27 EP EP12810312.4A patent/EP2797913B1/en not_active Not-in-force
- 2012-12-27 MX MX2014008042A patent/MX348127B/es active IP Right Grant
- 2012-12-27 ES ES12810312.4T patent/ES2601461T3/es active Active
- 2012-12-27 JP JP2014549464A patent/JP6199891B2/ja not_active Expired - Fee Related
- 2012-12-27 BR BR112014016007A patent/BR112014016007A8/pt not_active IP Right Cessation
-
2017
- 2017-07-28 JP JP2017146186A patent/JP2018012699A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| AU2012360910B2 (en) | 2017-01-05 |
| JP2018012699A (ja) | 2018-01-25 |
| AU2012360910A1 (en) | 2014-06-26 |
| CN104169271A (zh) | 2014-11-26 |
| CA2858646A1 (en) | 2013-07-04 |
| US9382261B2 (en) | 2016-07-05 |
| IN2014MN01486A (enExample) | 2015-04-24 |
| WO2013098320A1 (en) | 2013-07-04 |
| AU2012360910B8 (en) | 2017-02-02 |
| BR112014016007A2 (pt) | 2017-06-13 |
| BR112014016007A8 (pt) | 2017-07-04 |
| EP2797913A1 (en) | 2014-11-05 |
| AU2012360910A8 (en) | 2017-02-02 |
| JP2015503537A (ja) | 2015-02-02 |
| MX2014008042A (es) | 2014-08-21 |
| EP2797913B1 (en) | 2016-08-17 |
| ES2601461T3 (es) | 2017-02-15 |
| JP6199891B2 (ja) | 2017-09-20 |
| MX348127B (es) | 2017-05-26 |
| CN104169271B (zh) | 2017-04-05 |
| US20140378485A1 (en) | 2014-12-25 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20180724 |