RU2014128297A - Комбинация факторов роста, цитокинов, антибактериальных/антивирусных факторов, факторов стволовых клеток, белков комплемента с3а/с4а, иммуноглобулинов и хемотоксических факторов - Google Patents

Комбинация факторов роста, цитокинов, антибактериальных/антивирусных факторов, факторов стволовых клеток, белков комплемента с3а/с4а, иммуноглобулинов и хемотоксических факторов Download PDF

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RU2014128297A
RU2014128297A RU2014128297A RU2014128297A RU2014128297A RU 2014128297 A RU2014128297 A RU 2014128297A RU 2014128297 A RU2014128297 A RU 2014128297A RU 2014128297 A RU2014128297 A RU 2014128297A RU 2014128297 A RU2014128297 A RU 2014128297A
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Prior art keywords
factors
combination
colitis
total
combination according
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RU2014128297A
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RU2642650C2 (ru
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Альберто Барторелли
Мария Роза Гобби
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Бионест Лтд.
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Priority claimed from IT002439A external-priority patent/ITMI20112439A1/it
Priority claimed from IT002435A external-priority patent/ITMI20112435A1/it
Priority claimed from IT002440A external-priority patent/ITMI20112440A1/it
Priority claimed from IT002443A external-priority patent/ITMI20112443A1/it
Priority claimed from IT002446A external-priority patent/ITMI20112446A1/it
Priority claimed from IT002433A external-priority patent/ITMI20112433A1/it
Priority claimed from IT002441A external-priority patent/ITMI20112441A1/it
Priority claimed from IT002432A external-priority patent/ITMI20112432A1/it
Priority claimed from IT002445A external-priority patent/ITMI20112445A1/it
Application filed by Бионест Лтд. filed Critical Бионест Лтд.
Publication of RU2014128297A publication Critical patent/RU2014128297A/ru
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Abstract

1. Комбинация цитокинов, факторов роста, хемотаксических факторов, факторов стволовых клеток, белков комплемента, иммуноглобулинов и антибактериальных/антивирусных факторов следующего состава:2. Комбинация по п. 1, получаемая путем экстрагирования молозива.3. Комбинация по п. 1, получаемая путем экстрагирования плаценты.4. Комбинация по п. 1, получаемая путем экстрагирования сыворотки, собранной за 5-15 дней до родов.5. Комбинация по пп. 1-4 для применения в лечении заболеваний, требующих восстановления тканей и регенерации и для замещения терапии/трансплантологии с применением стволовых клеток.6. Комбинация по п. 5, которую применяют для лечения заболеваний, являющихся аутоиммунными заболеваниями, невропатическими болями, остеопорозом, раневыми поражениями, ожогами, кожными язвами, повреждениями ротовой полости, некротическим острым колитом, болезнью Крона, гастро-эзофагальным рефлюксом, энтероколитом, вызванным СПИДом, синдромом раздраженной толстой кишки, инфекционным колитом, спастическим колитом, колитом, вызванным приемом антибиотиков, хиатальной грыжей, синдромом короткого пищевода.7. Фармацевтическая композиция, содержащая сочетания по пп. 1-4 в качестве активных ингредиентов в смеси с приемлемыми носителями и/или эксципиентами.8. Фармацевтическая композиция по п. 7 для перорального введения.9. Фармацевтическая композиция по п. 7 для местного введения.

Claims (9)

1. Комбинация цитокинов, факторов роста, хемотаксических факторов, факторов стволовых клеток, белков комплемента, иммуноглобулинов и антибактериальных/антивирусных факторов следующего состава:
Цитокины (пкг/мг)   Значение мин. Значение макс. IL-1a 0.80 2.90 IL-1b 0.02 0.09 IL-2 0.75 5.00 IL-4 0.04 0.17 IL-6 0.10 1.20 IL-8 0.50 2.50 IL-9 0.50 3.60 IL-10 0.50 2.80 IL-12 0.50 2.00 IL-15 1.10 4.30 IL-17 15.00 150.00 INF гамма 3.00 30.00 TNFα 15.00 30.00 IL-1 Ra 10.00 30.00 Итого 47.81 264.56 Факторы роста (пкг/мг)   Значение мин. Значение макс. TGF-β1 150.00 300.00 IGF-1 300.00 800.00 NGF 1.00 10.00 PDGF 5.00 100.00 EGF 4.80 9.40 ВМР2 15.00 50.00 b.FGF 100.00 200.00 FGF-2 5.00 20.00 HGF 40.00 80.00 VEGF 50.00 300.00 Итого 670.80 1869.40
Факторы стволовых клеток (пкг/мг)   Значение мин. Значение макс. G-CSF 10.00 20.00 GM-CSF 100.00 1000.00 LIF 15.00 50.00 SCF 1.00 10.00 SDF-1 10.00 40.00 Итого 136.00 1120.00 Хемотаксические факторы (пкг/мг)   Значение мин. Значение макс. EOTAXIN 1.00 15.00 MCP-1 1.00 5.00 Итого 2.00 20.00 Антибактериальные/антивирусные факторы (мкг/мг) Трансферрин 0.50 1.00 Лактоферрин 0.80 2.50 Лизоцим 10.00 40.00 Лактопероксидаза 10.00 30.00 Итого 21.30 73.5 Белки комплемента (пкг/мг)   Значение мин. Значение макс. C3A 0.20 0.70 C4A 0.90 2.00 Итого 1.10 2.70 Иммуноглобулины (мг/мг)   Значение мин. Значение макс. IgG 0.20 0.50 IgA 0.10 0.20 IgM 0.05 0.15 Итого 0.35 0.85
2. Комбинация по п. 1, получаемая путем экстрагирования молозива.
3. Комбинация по п. 1, получаемая путем экстрагирования плаценты.
4. Комбинация по п. 1, получаемая путем экстрагирования сыворотки, собранной за 5-15 дней до родов.
5. Комбинация по пп. 1-4 для применения в лечении заболеваний, требующих восстановления тканей и регенерации и для замещения терапии/трансплантологии с применением стволовых клеток.
6. Комбинация по п. 5, которую применяют для лечения заболеваний, являющихся аутоиммунными заболеваниями, невропатическими болями, остеопорозом, раневыми поражениями, ожогами, кожными язвами, повреждениями ротовой полости, некротическим острым колитом, болезнью Крона, гастро-эзофагальным рефлюксом, энтероколитом, вызванным СПИДом, синдромом раздраженной толстой кишки, инфекционным колитом, спастическим колитом, колитом, вызванным приемом антибиотиков, хиатальной грыжей, синдромом короткого пищевода.
7. Фармацевтическая композиция, содержащая сочетания по пп. 1-4 в качестве активных ингредиентов в смеси с приемлемыми носителями и/или эксципиентами.
8. Фармацевтическая композиция по п. 7 для перорального введения.
9. Фармацевтическая композиция по п. 7 для местного введения.
RU2014128297A 2011-12-30 2012-12-27 Комбинация факторов роста, цитокинов, антибактериальных/антивирусных факторов, факторов стволовых клеток, белков комплемента с3а/с4а, иммуноглобулинов и хемотаксических факторов RU2642650C2 (ru)

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