RU2014120179A - Терапевтическая комбинация для лечения рака - Google Patents
Терапевтическая комбинация для лечения рака Download PDFInfo
- Publication number
- RU2014120179A RU2014120179A RU2014120179/15A RU2014120179A RU2014120179A RU 2014120179 A RU2014120179 A RU 2014120179A RU 2014120179/15 A RU2014120179/15 A RU 2014120179/15A RU 2014120179 A RU2014120179 A RU 2014120179A RU 2014120179 A RU2014120179 A RU 2014120179A
- Authority
- RU
- Russia
- Prior art keywords
- therapeutic combination
- extract
- nerium
- species
- cisplatin
- Prior art date
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract 26
- 206010028980 Neoplasm Diseases 0.000 title claims abstract 4
- 201000011510 cancer Diseases 0.000 title claims abstract 4
- 244000187664 Nerium oleander Species 0.000 claims abstract 15
- 229960004316 cisplatin Drugs 0.000 claims abstract 9
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims abstract 9
- 230000000118 anti-neoplastic effect Effects 0.000 claims abstract 7
- 241000894007 species Species 0.000 claims abstract 5
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract 4
- 241001116389 Aloe Species 0.000 claims abstract 3
- 235000011399 aloe vera Nutrition 0.000 claims abstract 3
- 229960004562 carboplatin Drugs 0.000 claims abstract 3
- 190000008236 carboplatin Chemical compound 0.000 claims abstract 3
- 229950007221 nedaplatin Drugs 0.000 claims abstract 3
- 190000005734 nedaplatin Chemical compound 0.000 claims abstract 3
- 229960001756 oxaliplatin Drugs 0.000 claims abstract 3
- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims abstract 3
- 229950005566 picoplatin Drugs 0.000 claims abstract 3
- IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 claims abstract 3
- 229960005399 satraplatin Drugs 0.000 claims abstract 3
- 190014017285 satraplatin Chemical compound 0.000 claims abstract 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract 3
- 241000893864 Nerium Species 0.000 claims abstract 2
- 229940034982 antineoplastic agent Drugs 0.000 claims abstract 2
- 239000002246 antineoplastic agent Substances 0.000 claims abstract 2
- 229910052697 platinum Inorganic materials 0.000 claims abstract 2
- 206010006187 Breast cancer Diseases 0.000 claims 1
- 208000026310 Breast neoplasm Diseases 0.000 claims 1
- 206010009944 Colon cancer Diseases 0.000 claims 1
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 1
- 201000001441 melanoma Diseases 0.000 claims 1
- 201000002528 pancreatic cancer Diseases 0.000 claims 1
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549386P | 2011-10-20 | 2011-10-20 | |
| US61/549,386 | 2011-10-20 | ||
| PCT/US2012/061226 WO2013059753A1 (en) | 2011-10-20 | 2012-10-20 | Therapeutic combination for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017136415A Division RU2017136415A (ru) | 2011-10-20 | 2012-10-20 | Терапевтическая комбинация для лечения рака |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014120179A true RU2014120179A (ru) | 2015-11-27 |
Family
ID=48141445
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014120179/15A RU2014120179A (ru) | 2011-10-20 | 2012-10-20 | Терапевтическая комбинация для лечения рака |
| RU2017136415A RU2017136415A (ru) | 2011-10-20 | 2012-10-20 | Терапевтическая комбинация для лечения рака |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2017136415A RU2017136415A (ru) | 2011-10-20 | 2012-10-20 | Терапевтическая комбинация для лечения рака |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20130209579A1 (enExample) |
| EP (2) | EP3711754A1 (enExample) |
| JP (1) | JP6255346B2 (enExample) |
| CN (2) | CN104093405A (enExample) |
| AU (3) | AU2012325819B2 (enExample) |
| BR (1) | BR112014009421A2 (enExample) |
| CA (1) | CA2852274C (enExample) |
| GT (1) | GT201400071A (enExample) |
| IL (2) | IL231987B (enExample) |
| IN (1) | IN2014KN00796A (enExample) |
| MX (2) | MX365635B (enExample) |
| RU (2) | RU2014120179A (enExample) |
| WO (1) | WO2013059753A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5727934B2 (ja) * | 2008-10-14 | 2015-06-03 | ネリウム バイオテクノロジー、インク． | 強心配糖体抽出プロセスおよび組成物 |
| AU2016250616B2 (en) * | 2015-04-22 | 2021-01-21 | Syn-Nat Products Enterprise LLC | Co-crystal composition and its pharmaceutical use |
| EA037248B1 (ru) * | 2015-10-05 | 2021-02-26 | НУКАНА ПиЭлСи | Применение гемцитабин[фенил-бензокси-l-аланинил]фосфата в комбинации с карбоплатином |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1299100C (en) | 1986-05-13 | 1992-04-21 | Huseyin Ziya Ozel | Extracts of nerium species, methods of preparation and use therefor |
| US6565897B2 (en) | 1998-09-24 | 2003-05-20 | Ozelle Pharmaceuticals, Inc. | Extract of nerium species, pharmaceutical composition thereof and methods for preparation thereof |
| US7407675B2 (en) * | 2002-12-27 | 2008-08-05 | The Trustees Of Columbia University In The City Of New York | Anti-neoplastic compositions comprising extracts of black cohosh |
| US20060205679A1 (en) * | 2004-10-22 | 2006-09-14 | Azaya Therapeutics, Inc. | Topical and oral formulations of cardiac glycosides for treating skin diseases |
| US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| EP1803461A1 (en) * | 2005-12-27 | 2007-07-04 | Heinz-Herbert Fiebig | Therapeutic use of an extract from the leaves of Nerium oleander |
| PL2173337T3 (pl) | 2007-08-06 | 2014-11-28 | Univ Ohio | Fosfaplatyny i ich zastosowanie w leczeniu raków opornych na cisplatynę i karboplatynę |
| JP5727934B2 (ja) * | 2008-10-14 | 2015-06-03 | ネリウム バイオテクノロジー、インク． | 強心配糖体抽出プロセスおよび組成物 |
-
2012
- 2012-10-20 CA CA2852274A patent/CA2852274C/en not_active Expired - Fee Related
- 2012-10-20 EP EP20159407.4A patent/EP3711754A1/en not_active Withdrawn
- 2012-10-20 WO PCT/US2012/061226 patent/WO2013059753A1/en not_active Ceased
- 2012-10-20 RU RU2014120179/15A patent/RU2014120179A/ru unknown
- 2012-10-20 BR BR112014009421A patent/BR112014009421A2/pt not_active Application Discontinuation
- 2012-10-20 RU RU2017136415A patent/RU2017136415A/ru not_active Application Discontinuation
- 2012-10-20 CN CN201280051254.5A patent/CN104093405A/zh active Pending
- 2012-10-20 IN IN796KON2014 patent/IN2014KN00796A/en unknown
- 2012-10-20 AU AU2012325819A patent/AU2012325819B2/en not_active Ceased
- 2012-10-20 JP JP2014537346A patent/JP6255346B2/ja not_active Expired - Fee Related
- 2012-10-20 CN CN201910226194.XA patent/CN110269940A/zh active Pending
- 2012-10-20 MX MX2014004527A patent/MX365635B/es active IP Right Grant
- 2012-10-20 EP EP12841023.0A patent/EP2768498B1/en active Active
-
2013
- 2013-03-15 US US13/838,739 patent/US20130209579A1/en not_active Abandoned
-
2014
- 2014-04-07 IL IL231987A patent/IL231987B/en not_active IP Right Cessation
- 2014-04-14 MX MX2019006685A patent/MX2019006685A/es unknown
- 2014-04-15 GT GT201400071A patent/GT201400071A/es unknown
-
2017
- 2017-10-31 AU AU2017254875A patent/AU2017254875A1/en not_active Abandoned
-
2019
- 2019-05-21 AU AU2019203577A patent/AU2019203577A1/en not_active Abandoned
- 2019-05-22 US US16/419,226 patent/US20190343908A1/en not_active Abandoned
-
2020
- 2020-06-24 IL IL275636A patent/IL275636A/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| IL231987A0 (en) | 2014-05-28 |
| MX2014004527A (es) | 2014-09-15 |
| EP2768498A1 (en) | 2014-08-27 |
| MX365635B (es) | 2019-06-10 |
| NZ623550A (en) | 2016-06-24 |
| JP6255346B2 (ja) | 2017-12-27 |
| EP2768498A4 (en) | 2015-06-17 |
| IL231987B (en) | 2020-07-30 |
| IN2014KN00796A (enExample) | 2015-10-02 |
| AU2012325819B2 (en) | 2017-08-03 |
| AU2017254875A1 (en) | 2017-11-23 |
| EP2768498B1 (en) | 2020-03-04 |
| GT201400071A (es) | 2015-09-17 |
| CA2852274C (en) | 2019-08-06 |
| WO2013059753A1 (en) | 2013-04-25 |
| CN104093405A (zh) | 2014-10-08 |
| BR112014009421A2 (pt) | 2017-04-18 |
| RU2017136415A3 (enExample) | 2021-02-08 |
| US20190343908A1 (en) | 2019-11-14 |
| AU2012325819A1 (en) | 2014-04-24 |
| RU2017136415A (ru) | 2019-02-08 |
| CA2852274A1 (en) | 2013-04-25 |
| IL275636A (en) | 2020-08-31 |
| AU2019203577A1 (en) | 2019-06-13 |
| US20130209579A1 (en) | 2013-08-15 |
| EP3711754A1 (en) | 2020-09-23 |
| CN110269940A (zh) | 2019-09-24 |
| JP2014530878A (ja) | 2014-11-20 |
| MX2019006685A (es) | 2019-08-21 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA91 | Application withdrawn (on applicant's request) |
Effective date: 20171018 |