EA201890894A1 - Комбинированная терапия - Google Patents

Комбинированная терапия

Info

Publication number
EA201890894A1
EA201890894A1 EA201890894A EA201890894A EA201890894A1 EA 201890894 A1 EA201890894 A1 EA 201890894A1 EA 201890894 A EA201890894 A EA 201890894A EA 201890894 A EA201890894 A EA 201890894A EA 201890894 A1 EA201890894 A1 EA 201890894A1
Authority
EA
Eurasian Patent Office
Prior art keywords
alaninyl
phosphate
combined therapy
phenylbenzoxy
dicycloplatin
Prior art date
Application number
EA201890894A
Other languages
English (en)
Other versions
EA037248B1 (ru
Inventor
Хью Гриффит
Original Assignee
НУКАНА ПиЭлСи
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by НУКАНА ПиЭлСи filed Critical НУКАНА ПиЭлСи
Publication of EA201890894A1 publication Critical patent/EA201890894A1/ru
Publication of EA037248B1 publication Critical patent/EA037248B1/ru

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)

Abstract

Настоящее изобретение относится к комбинации гемцитабин[фенилбензокси-L-аланинил)]фосфата (химическое название: 2'-дезокси-2',2'-дифтор-D-цитидин-5'-O-[фенил(бензокси-L-аланинил)]фосфат) (NUC-1031) и противоракового средства на основе платины, выбранного из карбоплатина, дициклоплатина, оксалиплатина, сатраплатина и недаплатина. Комбинации могут использоваться для лечения злокачественного новообразования и, в частности, рака яичников.
EA201890894A 2015-10-05 2015-10-05 Применение гемцитабин[фенил-бензокси-l-аланинил]фосфата в комбинации с карбоплатином EA037248B1 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/GB2015/052902 WO2017060661A1 (en) 2015-10-05 2015-10-05 Combination therapy

Publications (2)

Publication Number Publication Date
EA201890894A1 true EA201890894A1 (ru) 2018-09-28
EA037248B1 EA037248B1 (ru) 2021-02-26

Family

ID=54330789

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201890894A EA037248B1 (ru) 2015-10-05 2015-10-05 Применение гемцитабин[фенил-бензокси-l-аланинил]фосфата в комбинации с карбоплатином

Country Status (12)

Country Link
US (3) US10660912B2 (ru)
EP (1) EP3359163B1 (ru)
JP (2) JP7038653B2 (ru)
KR (1) KR20180063075A (ru)
CN (1) CN108135920A (ru)
AU (1) AU2015411525B2 (ru)
CA (1) CA2994502C (ru)
EA (1) EA037248B1 (ru)
IL (1) IL257976A (ru)
MX (1) MX2018004137A (ru)
PH (1) PH12018500691A1 (ru)
WO (1) WO2017060661A1 (ru)

Families Citing this family (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0317009D0 (en) 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
NZ708177A (en) 2012-11-16 2017-08-25 Univ College Cardiff Consultants Ltd Process for preparing nucleoside prodrugs
KR102421929B1 (ko) 2014-06-25 2022-07-15 뉴카나 피엘씨 젬시타빈-전구 약물 함유 제제
SG11201608808TA (en) 2014-06-25 2016-11-29 Nucana Biomed Ltd Gemcitabine prodrugs
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
JP7038653B2 (ja) 2015-10-05 2022-03-18 ニューカナ パブリック リミテッド カンパニー 併用療法
BR112018011695A2 (pt) 2015-12-11 2018-11-27 Laurus Labs Private Ltd síntese diastereosseletiva de derivados fosfato e do pró-fármaco de gencitabina nuc-1031
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
SI3393478T1 (sl) * 2015-12-23 2020-07-31 NuCana plc Kombinacijska terapija
GB201709471D0 (en) 2017-06-14 2017-07-26 Nucana Biomed Ltd Diastereoselective synthesis of hosphate derivatives
GB201713914D0 (en) * 2017-08-30 2017-10-11 Nucana Biomed Ltd Combination therapy
KR20200090170A (ko) * 2017-11-21 2020-07-28 메돈케어 파마수티컬 씨오., 엘티디 디시클로플라틴을 함유하는 복합 산물, 이의 제조 및 용도

Family Cites Families (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US1011788A (en) 1909-09-01 1911-12-12 Colonial Trust Co Rotary motor.
US4526988A (en) * 1983-03-10 1985-07-02 Eli Lilly And Company Difluoro antivirals and intermediate therefor
US7462605B2 (en) 1998-01-23 2008-12-09 Celmed Oncology (Usa), Inc. Phosphoramidate compounds and methods of use
GB0011903D0 (en) * 2000-05-18 2000-07-05 Astrazeneca Ab Combination chemotherapy
MXPA04007876A (es) 2002-02-14 2005-06-20 Pharmasset Ltd Analogos de nucleosido fluorado modificados.
US7265096B2 (en) 2002-11-04 2007-09-04 Xenoport, Inc. Gemcitabine prodrugs, pharmaceutical compositions and uses thereof
GB0317009D0 (en) * 2003-07-21 2003-08-27 Univ Cardiff Chemical compounds
CA2558346A1 (en) * 2004-03-23 2005-10-06 Astrazeneca Ab Combination therapy
US9732055B2 (en) 2007-09-10 2017-08-15 Boston Biomedical, Inc. Compositions and methods for cancer treatment
FR2954310B1 (fr) 2009-12-18 2014-07-25 Univ Rouen Procede de dedoublement d'enantiomeres par evapocristallisation preferentielle
EP2609923B1 (en) 2010-03-31 2017-05-24 Gilead Pharmasset LLC Process for the crystallisation of (s)-isopropyl 2-(((s)-(perfluorophenoxy)(phenoxy)phosphoryl)amino)propanoate
CN104093405A (zh) * 2011-10-20 2014-10-08 奈瑞姆生物技术公司 用于治疗癌症的治疗组合
NZ708177A (en) * 2012-11-16 2017-08-25 Univ College Cardiff Consultants Ltd Process for preparing nucleoside prodrugs
AU2014354775A1 (en) 2013-11-27 2016-05-19 Idenix Pharmaceuticals Llc Nucleotides for the treatment of liver cancer
SG11201608808TA (en) 2014-06-25 2016-11-29 Nucana Biomed Ltd Gemcitabine prodrugs
KR102421929B1 (ko) 2014-06-25 2022-07-15 뉴카나 피엘씨 젬시타빈-전구 약물 함유 제제
ES2830784T3 (es) 2014-07-22 2021-06-04 NuCana plc Proceso para la preparación de gemcitabina-[fenil(benzoxi-L-alanil)]fosfato
GB201417644D0 (en) 2014-10-06 2014-11-19 Nucana Biomed Ltd Method of separating phosphate diastereoisomers
HUE038541T2 (hu) 2015-05-14 2018-10-29 NuCana plc Rák kezelési módszerek
JP7038653B2 (ja) 2015-10-05 2022-03-18 ニューカナ パブリック リミテッド カンパニー 併用療法
BR112018011695A2 (pt) 2015-12-11 2018-11-27 Laurus Labs Private Ltd síntese diastereosseletiva de derivados fosfato e do pró-fármaco de gencitabina nuc-1031
CA3008769A1 (en) 2015-12-23 2017-06-29 NuCana plc Combination therapy comprising nuc-1031 and cisplatin
GB201522771D0 (en) 2015-12-23 2016-02-03 Nucana Biomed Ltd Crystalline form of a phosphate derivative
SI3393478T1 (sl) 2015-12-23 2020-07-31 NuCana plc Kombinacijska terapija

Also Published As

Publication number Publication date
EP3359163B1 (en) 2023-12-20
EA037248B1 (ru) 2021-02-26
JP2018529740A (ja) 2018-10-11
IL257976A (en) 2018-05-31
US20220323475A1 (en) 2022-10-13
JP7038653B2 (ja) 2022-03-18
AU2015411525B2 (en) 2021-08-12
MX2018004137A (es) 2018-06-13
US20200268783A1 (en) 2020-08-27
CA2994502C (en) 2023-08-01
JP2022001599A (ja) 2022-01-06
WO2017060661A1 (en) 2017-04-13
KR20180063075A (ko) 2018-06-11
BR112018006880A2 (pt) 2018-10-16
US10660912B2 (en) 2020-05-26
PH12018500691A1 (en) 2018-10-15
EP3359163A1 (en) 2018-08-15
CA2994502A1 (en) 2017-04-13
US20180271889A1 (en) 2018-09-27
CN108135920A (zh) 2018-06-08
AU2015411525A1 (en) 2018-03-15

Similar Documents

Publication Publication Date Title
EA201890894A1 (ru) Комбинированная терапия
EA201891473A1 (ru) Комбинированная терапия
CY1118216T1 (el) Μεθοδοι αγωγης καρκινου
EA201892802A1 (ru) Производные аденозина для применения при лечении рака
EA201792169A1 (ru) 5'-замещенные нуклеозидные соединения
PH12018502535A1 (en) Substituted carbonucleoside derivatives useful as anticancer agents
EA201590987A1 (ru) Соединения и способы их применения
AU2016262079A8 (en) Combination of analogs or derivatives of dianhydrogalactitol with platinum-containing antineoplastic agents to treat cancer
MX2016006726A (es) Composiciones que comprenden anticuerpos anti-molecula de adhesion celular relacionada con antigeno carcinoembrionario 1 y anti-muerte celular programada para la terapia contra el cancer.
EA201590997A1 (ru) Соединения и способы их применения
CY1122074T1 (el) Νεα παραγωγα 3'-δεοξυαδενοσινης του φωσφοραμαδικου εστερα toy 2' και/η 5' aminoξεος ως αντικαρκινικες ενωσεις
CY1122243T1 (el) Παραγωγα ν-πυριδiνυλικoυ ακεταμιδιου ως αναστολεις της οδου σηματοδοτησης wnt
MX370662B (es) Composiciones que comprenden nanopartículas de paclitaxel y albúmina para usarse en el tratamiento de cáncer.
EA201892745A1 (ru) Фосфорамидатные производные нуклеозида в качестве противораковых агентов
EA201892769A3 (ru) Сложные диэфиры ациклических нуклеозидфосфонатов
TR201708567T4 (tr) Sigma ligandların kemik kanseri ağrısında kullanımı.
MX2018006953A (es) Compuestos de platino funcionalizados con monomaleimida para la terapia del cancer.
MX2019013808A (es) Compuestos desestabilizadores de microtubulina para usarse en el tratamiento del cancer.
EA201700286A1 (ru) Макромолекулярные комплексы переходного металла для лечения рака и способ их получения
EA202090270A1 (ru) Новые замещенные производные ксантина
RU2014145887A (ru) Комбинированная терапия с использованием антител против mif и химиотерапевтических средств
EA201992852A1 (ru) Схема дозирования тезетаксела и капецитабина
RU2014120179A (ru) Терапевтическая комбинация для лечения рака
EA202091218A1 (ru) Соли дифосфатфосфорамидата нуклеозидов в качестве противораковых соединений
EA201991336A1 (ru) Способы лечения рака с помощью антител к pd-1