AU2012325819B2 - Therapeutic combination for the treatment of cancer - Google Patents
Therapeutic combination for the treatment of cancer Download PDFInfo
- Publication number
- AU2012325819B2 AU2012325819B2 AU2012325819A AU2012325819A AU2012325819B2 AU 2012325819 B2 AU2012325819 B2 AU 2012325819B2 AU 2012325819 A AU2012325819 A AU 2012325819A AU 2012325819 A AU2012325819 A AU 2012325819A AU 2012325819 B2 AU2012325819 B2 AU 2012325819B2
- Authority
- AU
- Australia
- Prior art keywords
- cisplatin
- therapeutic combination
- cancer
- nerium
- extract
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 230000001225 therapeutic effect Effects 0.000 title claims abstract description 41
- 206010028980 Neoplasm Diseases 0.000 title claims description 22
- 201000011510 cancer Diseases 0.000 title claims description 19
- 238000011282 treatment Methods 0.000 title claims description 5
- 229960004316 cisplatin Drugs 0.000 claims abstract description 79
- DQLATGHUWYMOKM-UHFFFAOYSA-L cisplatin Chemical compound N[Pt](N)(Cl)Cl DQLATGHUWYMOKM-UHFFFAOYSA-L 0.000 claims abstract description 79
- 239000000284 extract Substances 0.000 claims abstract description 37
- BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 claims abstract description 34
- 239000002246 antineoplastic agent Substances 0.000 claims abstract description 19
- 229910052697 platinum Inorganic materials 0.000 claims abstract description 17
- 229940034982 antineoplastic agent Drugs 0.000 claims abstract description 16
- 238000000034 method Methods 0.000 claims description 34
- 244000187664 Nerium oleander Species 0.000 claims description 28
- 241000894007 species Species 0.000 claims description 15
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- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims description 12
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims description 11
- 230000000118 anti-neoplastic effect Effects 0.000 claims description 11
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims description 11
- 201000002528 pancreatic cancer Diseases 0.000 claims description 11
- 208000008443 pancreatic carcinoma Diseases 0.000 claims description 11
- 206010060862 Prostate cancer Diseases 0.000 claims description 7
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims description 7
- 201000001441 melanoma Diseases 0.000 claims description 7
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims description 6
- 229960004562 carboplatin Drugs 0.000 claims description 6
- 190000008236 carboplatin Chemical compound 0.000 claims description 6
- 229960005399 satraplatin Drugs 0.000 claims description 6
- 190014017285 satraplatin Chemical compound 0.000 claims description 6
- 201000005202 lung cancer Diseases 0.000 claims description 5
- 208000020816 lung neoplasm Diseases 0.000 claims description 5
- 229950007221 nedaplatin Drugs 0.000 claims description 5
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- DWAFYCQODLXJNR-BNTLRKBRSA-L oxaliplatin Chemical compound O1C(=O)C(=O)O[Pt]11N[C@@H]2CCCC[C@H]2N1 DWAFYCQODLXJNR-BNTLRKBRSA-L 0.000 claims description 5
- 229950005566 picoplatin Drugs 0.000 claims description 5
- IIMIOEBMYPRQGU-UHFFFAOYSA-L picoplatin Chemical compound N.[Cl-].[Cl-].[Pt+2].CC1=CC=CC=N1 IIMIOEBMYPRQGU-UHFFFAOYSA-L 0.000 claims description 5
- 206010006187 Breast cancer Diseases 0.000 claims description 4
- 208000026310 Breast neoplasm Diseases 0.000 claims description 4
- 206010009944 Colon cancer Diseases 0.000 claims description 4
- 208000001333 Colorectal Neoplasms Diseases 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 238000009472 formulation Methods 0.000 claims description 3
- 229940069521 aloe extract Drugs 0.000 claims 2
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- 235000011399 aloe vera Nutrition 0.000 description 3
- KLNFSAOEKUDMFA-UHFFFAOYSA-N azanide;2-hydroxyacetic acid;platinum(2+) Chemical compound [NH2-].[NH2-].[Pt+2].OCC(O)=O KLNFSAOEKUDMFA-UHFFFAOYSA-N 0.000 description 3
- 230000002401 inhibitory effect Effects 0.000 description 3
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- IWCNCUVTGOMGKG-UHFFFAOYSA-N 5alpha-oleandrigenin Natural products CC(=O)OC1CC2(O)C3CCC4CC(O)CCC4(C)C3CCC2(C)C1C1=CC(=O)OC1 IWCNCUVTGOMGKG-UHFFFAOYSA-N 0.000 description 2
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 description 2
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- 230000001093 anti-cancer Effects 0.000 description 2
- 229940041181 antineoplastic drug Drugs 0.000 description 2
- 229910002092 carbon dioxide Inorganic materials 0.000 description 2
- 230000000295 complement effect Effects 0.000 description 2
- 239000003085 diluting agent Substances 0.000 description 2
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 2
- 238000000605 extraction Methods 0.000 description 2
- 239000012091 fetal bovine serum Substances 0.000 description 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 description 2
- 210000003470 mitochondria Anatomy 0.000 description 2
- VMGAPWLDMVPYIA-HIDZBRGKSA-N n'-amino-n-iminomethanimidamide Chemical compound N\N=C\N=N VMGAPWLDMVPYIA-HIDZBRGKSA-N 0.000 description 2
- IWCNCUVTGOMGKG-YOVVEKLRSA-N oleandrigenin Chemical compound C1([C@@H]2[C@@]3(C)CC[C@@H]4[C@@]5(C)CC[C@H](O)C[C@H]5CC[C@H]4[C@@]3(O)C[C@@H]2OC(=O)C)=CC(=O)OC1 IWCNCUVTGOMGKG-YOVVEKLRSA-N 0.000 description 2
- 229950010050 oleandrin Drugs 0.000 description 2
- 239000000546 pharmaceutical excipient Substances 0.000 description 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 description 2
- BOLDJAUMGUJJKM-LSDHHAIUSA-N renifolin D Natural products CC(=C)[C@@H]1Cc2c(O)c(O)ccc2[C@H]1CC(=O)c3ccc(O)cc3O BOLDJAUMGUJJKM-LSDHHAIUSA-N 0.000 description 2
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- 108091003079 Bovine Serum Albumin Proteins 0.000 description 1
- 201000009030 Carcinoma Diseases 0.000 description 1
- FBPFZTCFMRRESA-KVTDHHQDSA-N D-Mannitol Chemical compound OC[C@@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-KVTDHHQDSA-N 0.000 description 1
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- GHASVSINZRGABV-UHFFFAOYSA-N Fluorouracil Chemical compound FC1=CNC(=O)NC1=O GHASVSINZRGABV-UHFFFAOYSA-N 0.000 description 1
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- 206010061535 Ovarian neoplasm Diseases 0.000 description 1
- 102220497176 Small vasohibin-binding protein_T47D_mutation Human genes 0.000 description 1
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- 239000007983 Tris buffer Substances 0.000 description 1
- 208000007097 Urinary Bladder Neoplasms Diseases 0.000 description 1
- 238000013459 approach Methods 0.000 description 1
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- 229960001760 dimethyl sulfoxide Drugs 0.000 description 1
- ZMXDDKWLCZADIW-UHFFFAOYSA-N dimethylformamide Substances CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 1
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- PPASLZSBLFJQEF-RKJRWTFHSA-M sodium ascorbate Substances [Na+].OC[C@@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RKJRWTFHSA-M 0.000 description 1
- 235000010378 sodium ascorbate Nutrition 0.000 description 1
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- PPASLZSBLFJQEF-RXSVEWSESA-M sodium-L-ascorbate Chemical compound [Na+].OC[C@H](O)[C@H]1OC(=O)C(O)=C1[O-] PPASLZSBLFJQEF-RXSVEWSESA-M 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/24—Apocynaceae (Dogbane family), e.g. plumeria or periwinkle
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/28—Compounds containing heavy metals
- A61K31/282—Platinum compounds
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/555—Heterocyclic compounds containing heavy metals, e.g. hemin, hematin, melarsoprol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/66—Phosphorus compounds
- A61K31/665—Phosphorus compounds having oxygen as a ring hetero atom, e.g. fosfomycin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
- A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/243—Platinum; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/88—Liliopsida (monocotyledons)
- A61K36/886—Aloeaceae (Aloe family), e.g. aloe vera
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Medical Informatics (AREA)
- Botany (AREA)
- Biotechnology (AREA)
- Alternative & Traditional Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Chemistry (AREA)
- Inorganic Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines Containing Plant Substances (AREA)
Priority Applications (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| AU2017254875A AU2017254875A1 (en) | 2011-10-20 | 2017-10-31 | Therapeutic combination for the treatment of cancer |
| AU2019203577A AU2019203577A1 (en) | 2011-10-20 | 2019-05-21 | Therapeutic combination for the treatment of cancer |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161549386P | 2011-10-20 | 2011-10-20 | |
| US61/549,386 | 2011-10-20 | ||
| PCT/US2012/061226 WO2013059753A1 (en) | 2011-10-20 | 2012-10-20 | Therapeutic combination for the treatment of cancer |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017254875A Division AU2017254875A1 (en) | 2011-10-20 | 2017-10-31 | Therapeutic combination for the treatment of cancer |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| AU2012325819A1 AU2012325819A1 (en) | 2014-04-24 |
| AU2012325819B2 true AU2012325819B2 (en) | 2017-08-03 |
Family
ID=48141445
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2012325819A Ceased AU2012325819B2 (en) | 2011-10-20 | 2012-10-20 | Therapeutic combination for the treatment of cancer |
| AU2017254875A Abandoned AU2017254875A1 (en) | 2011-10-20 | 2017-10-31 | Therapeutic combination for the treatment of cancer |
| AU2019203577A Abandoned AU2019203577A1 (en) | 2011-10-20 | 2019-05-21 | Therapeutic combination for the treatment of cancer |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AU2017254875A Abandoned AU2017254875A1 (en) | 2011-10-20 | 2017-10-31 | Therapeutic combination for the treatment of cancer |
| AU2019203577A Abandoned AU2019203577A1 (en) | 2011-10-20 | 2019-05-21 | Therapeutic combination for the treatment of cancer |
Country Status (13)
| Country | Link |
|---|---|
| US (2) | US20130209579A1 (enExample) |
| EP (2) | EP3711754A1 (enExample) |
| JP (1) | JP6255346B2 (enExample) |
| CN (2) | CN104093405A (enExample) |
| AU (3) | AU2012325819B2 (enExample) |
| BR (1) | BR112014009421A2 (enExample) |
| CA (1) | CA2852274C (enExample) |
| GT (1) | GT201400071A (enExample) |
| IL (2) | IL231987B (enExample) |
| IN (1) | IN2014KN00796A (enExample) |
| MX (2) | MX365635B (enExample) |
| RU (2) | RU2014120179A (enExample) |
| WO (1) | WO2013059753A1 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5727934B2 (ja) * | 2008-10-14 | 2015-06-03 | ネリウム バイオテクノロジー、インク． | 強心配糖体抽出プロセスおよび組成物 |
| AU2016250616B2 (en) * | 2015-04-22 | 2021-01-21 | Syn-Nat Products Enterprise LLC | Co-crystal composition and its pharmaceutical use |
| EA037248B1 (ru) * | 2015-10-05 | 2021-02-26 | НУКАНА ПиЭлСи | Применение гемцитабин[фенил-бензокси-l-аланинил]фосфата в комбинации с карбоплатином |
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| US20070154573A1 (en) * | 2005-12-27 | 2007-07-05 | Juay Jamil Rashan | Method of preparing and using a cold extract from the leaves of nerium oleander |
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| CA1299100C (en) | 1986-05-13 | 1992-04-21 | Huseyin Ziya Ozel | Extracts of nerium species, methods of preparation and use therefor |
| US6565897B2 (en) | 1998-09-24 | 2003-05-20 | Ozelle Pharmaceuticals, Inc. | Extract of nerium species, pharmaceutical composition thereof and methods for preparation thereof |
| US7407675B2 (en) * | 2002-12-27 | 2008-08-05 | The Trustees Of Columbia University In The City Of New York | Anti-neoplastic compositions comprising extracts of black cohosh |
| US20060205679A1 (en) * | 2004-10-22 | 2006-09-14 | Azaya Therapeutics, Inc. | Topical and oral formulations of cardiac glycosides for treating skin diseases |
| US7402325B2 (en) | 2005-07-28 | 2008-07-22 | Phoenix Biotechnology, Inc. | Supercritical carbon dioxide extract of pharmacologically active components from Nerium oleander |
| PL2173337T3 (pl) | 2007-08-06 | 2014-11-28 | Univ Ohio | Fosfaplatyny i ich zastosowanie w leczeniu raków opornych na cisplatynę i karboplatynę |
| JP5727934B2 (ja) * | 2008-10-14 | 2015-06-03 | ネリウム バイオテクノロジー、インク． | 強心配糖体抽出プロセスおよび組成物 |
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| US20070154573A1 (en) * | 2005-12-27 | 2007-07-05 | Juay Jamil Rashan | Method of preparing and using a cold extract from the leaves of nerium oleander |
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| MX2014004527A (es) | 2014-09-15 |
| EP2768498A1 (en) | 2014-08-27 |
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| NZ623550A (en) | 2016-06-24 |
| JP6255346B2 (ja) | 2017-12-27 |
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| EP2768498B1 (en) | 2020-03-04 |
| GT201400071A (es) | 2015-09-17 |
| CA2852274C (en) | 2019-08-06 |
| WO2013059753A1 (en) | 2013-04-25 |
| CN104093405A (zh) | 2014-10-08 |
| BR112014009421A2 (pt) | 2017-04-18 |
| RU2017136415A3 (enExample) | 2021-02-08 |
| US20190343908A1 (en) | 2019-11-14 |
| AU2012325819A1 (en) | 2014-04-24 |
| RU2017136415A (ru) | 2019-02-08 |
| CA2852274A1 (en) | 2013-04-25 |
| RU2014120179A (ru) | 2015-11-27 |
| IL275636A (en) | 2020-08-31 |
| AU2019203577A1 (en) | 2019-06-13 |
| US20130209579A1 (en) | 2013-08-15 |
| EP3711754A1 (en) | 2020-09-23 |
| CN110269940A (zh) | 2019-09-24 |
| JP2014530878A (ja) | 2014-11-20 |
| MX2019006685A (es) | 2019-08-21 |
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