RU2014119787A - Антисмысловая регуляция экспрессии gccr - Google Patents
Антисмысловая регуляция экспрессии gccr Download PDFInfo
- Publication number
- RU2014119787A RU2014119787A RU2014119787/10A RU2014119787A RU2014119787A RU 2014119787 A RU2014119787 A RU 2014119787A RU 2014119787/10 A RU2014119787/10 A RU 2014119787/10A RU 2014119787 A RU2014119787 A RU 2014119787A RU 2014119787 A RU2014119787 A RU 2014119787A
- Authority
- RU
- Russia
- Prior art keywords
- modified oligonucleotide
- animal
- compound according
- seq
- compound
- Prior art date
Links
- 230000000692 anti-sense effect Effects 0.000 title claims 3
- 150000001875 compounds Chemical class 0.000 claims abstract 51
- 108091034117 Oligonucleotide Proteins 0.000 claims abstract 34
- 239000002777 nucleoside Substances 0.000 claims abstract 28
- 125000003835 nucleoside group Chemical group 0.000 claims abstract 21
- 230000000295 complement effect Effects 0.000 claims abstract 19
- 239000012634 fragment Substances 0.000 claims abstract 14
- 241001465754 Metazoa Species 0.000 claims 23
- 238000000034 method Methods 0.000 claims 20
- 239000000203 mixture Substances 0.000 claims 14
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims 13
- 239000008103 glucose Substances 0.000 claims 13
- 150000001720 carbohydrates Chemical class 0.000 claims 9
- 210000004369 blood Anatomy 0.000 claims 8
- 239000008280 blood Substances 0.000 claims 8
- 201000010099 disease Diseases 0.000 claims 8
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 8
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 7
- 239000003795 chemical substances by application Substances 0.000 claims 4
- 206010012601 diabetes mellitus Diseases 0.000 claims 4
- 208000016097 disease of metabolism Diseases 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000004519 manufacturing process Methods 0.000 claims 4
- 208000030159 metabolic disease Diseases 0.000 claims 4
- -1 bicyclic carbohydrate Chemical class 0.000 claims 3
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical group CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 claims 2
- OPTASPLRGRRNAP-UHFFFAOYSA-N cytosine Chemical compound NC=1C=CNC(=O)N=1 OPTASPLRGRRNAP-UHFFFAOYSA-N 0.000 claims 2
- 210000002966 serum Anatomy 0.000 claims 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 claims 2
- 229940104302 cytosine Drugs 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7115—Nucleic acids or oligonucleotides having modified bases, i.e. other than adenine, guanine, cytosine, uracil or thymine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
- C07H21/00—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
- C07H21/04—Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids with deoxyribosyl as saccharide radical
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/31—Chemical structure of the backbone
- C12N2310/315—Phosphorothioates
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/321—2'-O-R Modification
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/322—2'-R Modification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3231—Chemical structure of the sugar modified ring structure having an additional ring, e.g. LNA, ENA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/33—Chemical structure of the base
- C12N2310/334—Modified C
- C12N2310/3341—5-Methylcytosine
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/341—Gapmers, i.e. of the type ===---===
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/34—Spatial arrangement of the modifications
- C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/35—Nature of the modification
- C12N2310/352—Nature of the modification linked to the nucleic acid via a carbon atom
- C12N2310/3525—MOE, methoxyethoxy
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Diabetes (AREA)
- Plant Pathology (AREA)
- Biophysics (AREA)
- Microbiology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Hematology (AREA)
- Obesity (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Endocrinology (AREA)
- Emergency Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161551378P | 2011-10-25 | 2011-10-25 | |
| US61/551,378 | 2011-10-25 | ||
| PCT/US2012/061984 WO2013063313A1 (en) | 2011-10-25 | 2012-10-25 | Antisense modulation of gccr expression |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2014119787A true RU2014119787A (ru) | 2015-12-10 |
Family
ID=48168513
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2014119787/10A RU2014119787A (ru) | 2011-10-25 | 2012-10-25 | Антисмысловая регуляция экспрессии gccr |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US8901098B2 (enExample) |
| EP (1) | EP2771463A4 (enExample) |
| JP (1) | JP2015501155A (enExample) |
| KR (1) | KR20140084232A (enExample) |
| CN (1) | CN103906838A (enExample) |
| AU (2) | AU2012328680A1 (enExample) |
| BR (1) | BR112014009790A2 (enExample) |
| CA (1) | CA2853373A1 (enExample) |
| HK (1) | HK1201555A1 (enExample) |
| IL (1) | IL232183A0 (enExample) |
| IN (1) | IN2014CN03749A (enExample) |
| MX (1) | MX350944B (enExample) |
| RU (1) | RU2014119787A (enExample) |
| WO (1) | WO2013063313A1 (enExample) |
Families Citing this family (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR102482890B1 (ko) | 2013-05-01 | 2022-12-30 | 아이오니스 파마수티컬즈, 인코포레이티드 | 아포지질단백질 (a) 발현을 조절하는 조성물 및 방법 |
| CN110903337A (zh) | 2014-05-01 | 2020-03-24 | Ionis制药公司 | 用于调节生长激素受体表达的组合物和方法 |
| WO2015179693A1 (en) | 2014-05-22 | 2015-11-26 | Isis Pharmaceuticals, Inc. | Conjugated antisense compounds and their use |
| JP6606557B2 (ja) * | 2015-04-16 | 2019-11-13 | アイオーニス ファーマシューティカルズ， インコーポレーテッド | Ｃ９ｏｒｆ７２発現を調節するための組成物 |
| CN108026529A (zh) * | 2015-09-30 | 2018-05-11 | Ionis制药公司 | 组合疗法 |
| US10083668B2 (en) | 2016-03-09 | 2018-09-25 | Semiconductor Energy Laboratory Co., Ltd. | Semiconductor device, display device, and electronic device |
| AU2017368050A1 (en) | 2016-11-29 | 2019-06-20 | Puretech Lyt, Inc. | Exosomes for delivery of therapeutic agents |
| SG11202003488WA (en) | 2017-10-20 | 2020-05-28 | Dicerna Pharmaceuticals Inc | Methods for treating hepatitis b infection |
| KR20200109311A (ko) | 2018-01-16 | 2020-09-22 | 다이서나 파마수이티컬, 인크. | Aldh2 발현을 억제하기 위한 조성물 및 방법 |
| MX2021009754A (es) | 2019-02-12 | 2021-09-08 | Dicerna Pharmaceuticals Inc | Metodos y composiciones para inhibir la expresion de cyp27a1. |
| CN109680095A (zh) * | 2019-02-25 | 2019-04-26 | 广西中医药大学 | 一种鉴定苦玄参品种的ssr引物组合物及其品种鉴定方法 |
| CA3135402A1 (en) | 2019-04-04 | 2020-10-08 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting gene expression in the central nervous system |
| MX2022011550A (es) | 2020-03-18 | 2023-01-04 | Dicerna Pharmaceuticals Inc | Composiciones y métodos para inhibir la expresión de angptl3. |
| AU2021321430A1 (en) | 2020-08-04 | 2023-03-02 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting PLP1 expression |
| MX2023001541A (es) | 2020-08-04 | 2023-03-08 | Dicerna Pharmaceuticals Inc | Administracion sistemica de oligonucleotidos. |
| TW202221120A (zh) | 2020-08-04 | 2022-06-01 | 美商黛瑟納製藥公司 | 用於治療代謝症候群之組成物及方法 |
| IL300338A (en) | 2020-08-05 | 2023-04-01 | Dicerna Pharmaceuticals Inc | Compounds and methods for inhibiting the expression of LPA |
| US20240294907A1 (en) | 2020-10-08 | 2024-09-05 | Dicerna Pharmaceuticals, Inc. | Selective delivery of oligonucleotides to glial cells |
| CA3214439A1 (en) | 2021-04-12 | 2022-10-20 | Boehringer Ingelheim International Gmbh | Compositions and methods for inhibiting ketohexokinase (khk) |
| WO2022221430A1 (en) | 2021-04-14 | 2022-10-20 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for modulating pnpla3 expression |
| WO2022223515A2 (en) | 2021-04-19 | 2022-10-27 | Novo Nordisk A/S | Compositions and methods for inhibiting nuclear receptor subfamily 1 group h member 3 (nr1h3) expression |
| AR125992A1 (es) | 2021-05-28 | 2023-08-30 | Novo Nordisk As | Composiciones y métodos para inhibir la expresión del componente 1 de reducción de amidoxima mitocondrial (marc1) |
| US20230107967A1 (en) | 2021-08-25 | 2023-04-06 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting alpha-1 antitrypsin expression |
| TW202330920A (zh) | 2021-12-01 | 2023-08-01 | 美商戴瑟納製藥股份有限公司 | 用於調節ａｐｏｃ３表現之組合物及方法 |
| US20230374522A1 (en) | 2022-04-15 | 2023-11-23 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for modulating scap activity |
| AU2023269281A1 (en) | 2022-05-12 | 2024-10-10 | Dicerna Pharmaceuticals, Inc. | Compositions and methods for inhibiting mapt expression |
| IL316843A (en) | 2022-05-13 | 2025-01-01 | Dicerna Pharmaceuticals Inc | Compounds and methods for inhibiting SNCA deactivation |
| TWI868755B (zh) | 2022-06-24 | 2025-01-01 | 丹麥商諾佛 儂迪克股份有限公司 | 抑制跨膜絲胺酸蛋白酶６（ｔｍｐｒｓｓ６）表現的組成物及方法 |
| TW202430637A (zh) | 2022-11-16 | 2024-08-01 | 美商戴瑟納製藥股份有限公司 | Stat3靶向性寡核苷酸及其用途 |
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-
2012
- 2012-10-25 MX MX2014005067A patent/MX350944B/es active IP Right Grant
- 2012-10-25 BR BR112014009790A patent/BR112014009790A2/pt active Search and Examination
- 2012-10-25 AU AU2012328680A patent/AU2012328680A1/en not_active Abandoned
- 2012-10-25 EP EP12843053.5A patent/EP2771463A4/en not_active Withdrawn
- 2012-10-25 IN IN3749CHN2014 patent/IN2014CN03749A/en unknown
- 2012-10-25 US US13/660,885 patent/US8901098B2/en not_active Expired - Fee Related
- 2012-10-25 CN CN201280051744.5A patent/CN103906838A/zh active Pending
- 2012-10-25 JP JP2014539019A patent/JP2015501155A/ja active Pending
- 2012-10-25 RU RU2014119787/10A patent/RU2014119787A/ru not_active Application Discontinuation
- 2012-10-25 HK HK15101964.3A patent/HK1201555A1/xx unknown
- 2012-10-25 CA CA2853373A patent/CA2853373A1/en not_active Abandoned
- 2012-10-25 KR KR1020147013594A patent/KR20140084232A/ko not_active Withdrawn
- 2012-10-25 WO PCT/US2012/061984 patent/WO2013063313A1/en not_active Ceased
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2014
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- 2014-10-24 US US14/523,751 patent/US9567587B2/en not_active Expired - Fee Related
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|---|---|
| MX350944B (es) | 2017-09-26 |
| WO2013063313A1 (en) | 2013-05-02 |
| US20130150425A1 (en) | 2013-06-13 |
| MX2014005067A (es) | 2014-08-22 |
| US20150141493A1 (en) | 2015-05-21 |
| AU2018203564A1 (en) | 2018-06-07 |
| CN103906838A (zh) | 2014-07-02 |
| EP2771463A4 (en) | 2015-09-09 |
| KR20140084232A (ko) | 2014-07-04 |
| CA2853373A1 (en) | 2013-05-02 |
| US8901098B2 (en) | 2014-12-02 |
| HK1201555A1 (en) | 2015-09-04 |
| IL232183A0 (en) | 2014-06-30 |
| JP2015501155A (ja) | 2015-01-15 |
| US9567587B2 (en) | 2017-02-14 |
| IN2014CN03749A (enExample) | 2015-09-25 |
| EP2771463A1 (en) | 2014-09-03 |
| AU2012328680A1 (en) | 2014-05-01 |
| BR112014009790A2 (pt) | 2018-05-15 |
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