RU2013109380A - Способ сопутствующей терапии с применением теофиллина и фебуксостата - Google Patents
Способ сопутствующей терапии с применением теофиллина и фебуксостата Download PDFInfo
- Publication number
- RU2013109380A RU2013109380A RU2013109380/15A RU2013109380A RU2013109380A RU 2013109380 A RU2013109380 A RU 2013109380A RU 2013109380/15 A RU2013109380/15 A RU 2013109380/15A RU 2013109380 A RU2013109380 A RU 2013109380A RU 2013109380 A RU2013109380 A RU 2013109380A
- Authority
- RU
- Russia
- Prior art keywords
- theophylline
- cyano
- xanthine oxidoreductase
- oxidoreductase inhibitor
- phenyl
- Prior art date
Links
- ZFXYFBGIUFBOJW-UHFFFAOYSA-N theophylline Chemical compound O=C1N(C)C(=O)N(C)C2=C1NC=N2 ZFXYFBGIUFBOJW-UHFFFAOYSA-N 0.000 title claims abstract 92
- 238000000034 method Methods 0.000 title claims abstract 50
- 229960000278 theophylline Drugs 0.000 title claims abstract 46
- 238000002560 therapeutic procedure Methods 0.000 title 1
- 229940122272 Oxidoreductase inhibitor Drugs 0.000 claims abstract 47
- 108010091383 Xanthine dehydrogenase Proteins 0.000 claims abstract 47
- 102000005773 Xanthine dehydrogenase Human genes 0.000 claims abstract 47
- 108010093894 Xanthine oxidase Proteins 0.000 claims abstract 47
- 239000002457 oxidoreductase inhibitor Substances 0.000 claims abstract 47
- 201000005569 Gout Diseases 0.000 claims abstract 22
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims abstract 22
- 201000010099 disease Diseases 0.000 claims abstract 16
- 201000001431 Hyperuricemia Diseases 0.000 claims abstract 12
- 208000000913 Kidney Calculi Diseases 0.000 claims abstract 7
- 206010029148 Nephrolithiasis Diseases 0.000 claims abstract 7
- 208000001647 Renal Insufficiency Diseases 0.000 claims abstract 7
- 201000006370 kidney failure Diseases 0.000 claims abstract 7
- 206010006458 Bronchitis chronic Diseases 0.000 claims abstract 6
- 206010007027 Calculus urinary Diseases 0.000 claims abstract 6
- 208000006545 Chronic Obstructive Pulmonary Disease Diseases 0.000 claims abstract 6
- 206010014561 Emphysema Diseases 0.000 claims abstract 6
- 206010018634 Gouty Arthritis Diseases 0.000 claims abstract 6
- 208000012659 Joint disease Diseases 0.000 claims abstract 6
- 208000007718 Stable Angina Diseases 0.000 claims abstract 6
- 206010046337 Urate nephropathy Diseases 0.000 claims abstract 6
- LEHOTFFKMJEONL-UHFFFAOYSA-N Uric Acid Chemical compound N1C(=O)NC(=O)C2=C1NC(=O)N2 LEHOTFFKMJEONL-UHFFFAOYSA-N 0.000 claims abstract 6
- 230000001154 acute effect Effects 0.000 claims abstract 6
- 208000008784 apnea Diseases 0.000 claims abstract 6
- 208000037849 arterial hypertension Diseases 0.000 claims abstract 6
- 208000006673 asthma Diseases 0.000 claims abstract 6
- 230000036471 bradycardia Effects 0.000 claims abstract 6
- 208000006218 bradycardia Diseases 0.000 claims abstract 6
- 206010006451 bronchitis Diseases 0.000 claims abstract 6
- 208000007451 chronic bronchitis Diseases 0.000 claims abstract 6
- 230000001684 chronic effect Effects 0.000 claims abstract 6
- 208000030603 inherited susceptibility to asthma Diseases 0.000 claims abstract 6
- 208000017169 kidney disease Diseases 0.000 claims abstract 6
- 230000000750 progressive effect Effects 0.000 claims abstract 6
- 208000008281 urolithiasis Diseases 0.000 claims abstract 6
- 230000001988 toxicity Effects 0.000 claims abstract 5
- 231100000419 toxicity Toxicity 0.000 claims abstract 5
- 150000003839 salts Chemical class 0.000 claims 16
- -1 2-carboxypropoxy Chemical group 0.000 claims 9
- FFDDWBJYRJGZQH-UHFFFAOYSA-N 2-[3-cyano-4-(2-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound S1C(C(O)=O)=C(C)N=C1C1=CC=C(OCC(C)(C)O)C(C#N)=C1 FFDDWBJYRJGZQH-UHFFFAOYSA-N 0.000 claims 8
- FPODSLPQWIIKKI-UHFFFAOYSA-N 2-[3-cyano-4-(3-hydroxy-2-methylpropoxy)phenyl]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound C1=C(C#N)C(OCC(CO)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 FPODSLPQWIIKKI-UHFFFAOYSA-N 0.000 claims 8
- BQSJTQLCZDPROO-UHFFFAOYSA-N febuxostat Chemical compound C1=C(C#N)C(OCC(C)C)=CC=C1C1=NC(C)=C(C(O)=O)S1 BQSJTQLCZDPROO-UHFFFAOYSA-N 0.000 claims 8
- AETHRPHBGJAIBT-UHFFFAOYSA-N 1-[3-cyano-4-(2,2-dimethylpropoxy)phenyl]pyrazole-4-carboxylic acid Chemical compound C1=C(C#N)C(OCC(C)(C)C)=CC=C1N1N=CC(C(O)=O)=C1 AETHRPHBGJAIBT-UHFFFAOYSA-N 0.000 claims 4
- ZJDGVDDELZNDRA-UHFFFAOYSA-N 2-(3-cyano-4-hydroxyphenyl)-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound S1C(C(O)=O)=C(C)N=C1C1=CC=C(O)C(C#N)=C1 ZJDGVDDELZNDRA-UHFFFAOYSA-N 0.000 claims 4
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 4
- LCBACLAPKJRMIF-UHFFFAOYSA-N 2-[4-(2-carboxypropoxy)-3-cyanophenyl]-4-methyl-1,3-thiazole-5-carboxylic acid Chemical compound C1=C(C#N)C(OCC(C)C(O)=O)=CC=C1C1=NC(C)=C(C(O)=O)S1 LCBACLAPKJRMIF-UHFFFAOYSA-N 0.000 claims 3
- 206010007559 Cardiac failure congestive Diseases 0.000 claims 1
- 208000006029 Cardiomegaly Diseases 0.000 claims 1
- 208000007342 Diabetic Nephropathies Diseases 0.000 claims 1
- 206010019280 Heart failures Diseases 0.000 claims 1
- 206010020772 Hypertension Diseases 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000001145 Metabolic Syndrome Diseases 0.000 claims 1
- 201000000690 abdominal obesity-metabolic syndrome Diseases 0.000 claims 1
- 239000002253 acid Substances 0.000 claims 1
- 150000007513 acids Chemical class 0.000 claims 1
- 208000020832 chronic kidney disease Diseases 0.000 claims 1
- 206010012601 diabetes mellitus Diseases 0.000 claims 1
- 208000033679 diabetic kidney disease Diseases 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 201000007094 prostatitis Diseases 0.000 claims 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/425—Thiazoles
- A61K31/426—1,3-Thiazoles
-
- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/415—1,2-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
- A61K31/52—Purines, e.g. adenine
- A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
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- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P11/16—Central respiratory analeptics
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/08—Drugs for disorders of the urinary system of the prostate
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A—HUMAN NECESSITIES
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- A61P19/00—Drugs for skeletal disorders
- A61P19/06—Antigout agents, e.g. antihyperuricemic or uricosuric agents
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
Landscapes
- Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Epidemiology (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Diabetes (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Rheumatology (AREA)
- Hematology (AREA)
- Emergency Medicine (AREA)
- Hospice & Palliative Care (AREA)
- Pain & Pain Management (AREA)
- Vascular Medicine (AREA)
- Endocrinology (AREA)
- Immunology (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US38148210P | 2010-09-10 | 2010-09-10 | |
| US61/381,482 | 2010-09-10 | ||
| PCT/US2011/050870 WO2012033941A1 (en) | 2010-09-10 | 2011-09-08 | Methods for concomitant treatment of theophylline and febuxostat |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2013109380A true RU2013109380A (ru) | 2014-10-20 |
Family
ID=44653592
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2013109380/15A RU2013109380A (ru) | 2010-09-10 | 2011-09-08 | Способ сопутствующей терапии с применением теофиллина и фебуксостата |
Country Status (11)
| Country | Link |
|---|---|
| US (3) | US9107912B2 (OSRAM) |
| EP (1) | EP2613780B1 (OSRAM) |
| JP (1) | JP5978216B2 (OSRAM) |
| KR (1) | KR101797936B1 (OSRAM) |
| CN (1) | CN103298466B (OSRAM) |
| AU (1) | AU2011299153B2 (OSRAM) |
| BR (1) | BR112013005792A8 (OSRAM) |
| CA (1) | CA2812034C (OSRAM) |
| ES (1) | ES2532210T3 (OSRAM) |
| RU (1) | RU2013109380A (OSRAM) |
| WO (1) | WO2012033941A1 (OSRAM) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1883405A4 (en) * | 2005-05-09 | 2010-01-27 | Takeda Pharmaceuticals North A | METHODS OF TREATING NEPHROLITHIASIS |
| JP5242393B2 (ja) * | 2005-08-03 | 2013-07-24 | タケダ ファーマシューティカルズ ユー．エス．エー． インコーポレイティド | 高血圧症の治療方法 |
| KR20150024919A (ko) * | 2006-11-13 | 2015-03-09 | 다케다 파마슈티칼스 유에스에이, 인코포레이티드 | 크산틴 옥시도리덕타아제 억제제를 사용하여 신장 기능을 보존하는 방법 |
| US20090124623A1 (en) * | 2006-11-13 | 2009-05-14 | Christopher Lademacher | Methods for preserving and/or increasing renal function using xanthine oxidoreductase inhibitors |
| MX2009007680A (es) * | 2007-01-19 | 2011-08-03 | Takeda Pharmaceuticals North America Inc | Metodos para prevenir o reducir el numero de expansiones graduales de gota utilizando inhibidores de oxidoreductasa de xantina y agentes anti-inflamatorios. |
| US20100311756A1 (en) * | 2009-01-22 | 2010-12-09 | Takeda Pharmaceuticals North America, Inc. | Methods for delaying the progression of at least one of cardiac hypertrophy, cardiac remodeling or left ventricular function or the onset of heart failure in subjects in need of treatment thereof |
| EP2613780B1 (en) | 2010-09-10 | 2014-11-12 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for concomitant treatment of theophylline and febuxostat |
| CN103862983B (zh) * | 2012-12-12 | 2016-12-21 | 石狮市冠鑫反光材料有限公司 | 3d立体画制作工艺 |
| ES2552706B1 (es) * | 2014-05-29 | 2016-09-13 | Universitat De Les Illes Balears | La teobromina y sus derivados para el tratamiento o prevenciónde la litiasis renal |
| KR102133290B1 (ko) * | 2018-10-23 | 2020-07-13 | 연세대학교 산학협력단 | 결핵의 예방 또는 치료용 조성물 |
| CN120271528B (zh) * | 2025-04-08 | 2025-08-22 | 中国食品药品检定研究院 | 一种非布司他与苦豆碱共无定型物及其制备方法和应用 |
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| US4058614A (en) | 1973-12-04 | 1977-11-15 | Merck & Co., Inc. | Substituted imidazole compounds and therapeutic compositions therewith |
| US4296122A (en) | 1975-07-09 | 1981-10-20 | Merck & Co., Inc. | 2,3-Dihydro-6,7-disubstituted-5-(acyl)benzofuran-2-carboxylic acids |
| DE2707269A1 (de) | 1977-02-19 | 1978-08-24 | Hoechst Ag | Heterocyclische stickstoffverbindungen und verfahren zu ihrer herstellung |
| DE2707268A1 (de) | 1977-02-19 | 1978-08-31 | Hoechst Ag | Indol-3-carbaldehyd-oxime und verfahren zu ihrer herstellung |
| DE2707270A1 (de) | 1977-02-19 | 1978-08-24 | Hoechst Ag | Pyrazolo-diazepine und verfahren zu ihrer herstellung |
| DE2727802A1 (de) | 1977-06-21 | 1979-04-19 | Hoechst Ag | Sulfamoyl-arylketone und verfahren zu ihrer herstellung |
| JPS5936919B2 (ja) | 1978-10-14 | 1984-09-06 | 日本新薬株式会社 | インド−ル誘導体 |
| DE3112116A1 (de) * | 1981-03-27 | 1982-11-04 | Mundipharma GmbH, 6250 Limburg | "arzneimittel" |
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-
2011
- 2011-09-08 EP EP20110758053 patent/EP2613780B1/en not_active Revoked
- 2011-09-08 KR KR1020137009027A patent/KR101797936B1/ko not_active Expired - Fee Related
- 2011-09-08 AU AU2011299153A patent/AU2011299153B2/en not_active Ceased
- 2011-09-08 ES ES11758053.0T patent/ES2532210T3/es active Active
- 2011-09-08 US US13/227,828 patent/US9107912B2/en active Active
- 2011-09-08 BR BR112013005792A patent/BR112013005792A8/pt not_active Application Discontinuation
- 2011-09-08 CA CA2812034A patent/CA2812034C/en not_active Expired - Fee Related
- 2011-09-08 RU RU2013109380/15A patent/RU2013109380A/ru unknown
- 2011-09-08 JP JP2013528294A patent/JP5978216B2/ja active Active
- 2011-09-08 CN CN201180054390.5A patent/CN103298466B/zh not_active Expired - Fee Related
- 2011-09-08 WO PCT/US2011/050870 patent/WO2012033941A1/en not_active Ceased
- 2011-10-27 US US13/282,659 patent/US20120065207A1/en not_active Abandoned
- 2011-11-14 US US13/295,696 patent/US8372872B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| US9107912B2 (en) | 2015-08-18 |
| KR101797936B1 (ko) | 2017-11-15 |
| BR112013005792A8 (pt) | 2018-05-08 |
| EP2613780B1 (en) | 2014-11-12 |
| AU2011299153B2 (en) | 2014-10-30 |
| KR20130097775A (ko) | 2013-09-03 |
| WO2012033941A1 (en) | 2012-03-15 |
| US20120065236A1 (en) | 2012-03-15 |
| BR112013005792A2 (pt) | 2016-05-03 |
| US20120065215A1 (en) | 2012-03-15 |
| US20120065207A1 (en) | 2012-03-15 |
| CA2812034C (en) | 2018-10-23 |
| JP5978216B2 (ja) | 2016-08-24 |
| AU2011299153A1 (en) | 2013-03-07 |
| CN103298466B (zh) | 2015-11-25 |
| JP2013539747A (ja) | 2013-10-28 |
| CN103298466A (zh) | 2013-09-11 |
| ES2532210T3 (es) | 2015-03-25 |
| HK1189170A1 (zh) | 2014-05-30 |
| US8372872B2 (en) | 2013-02-12 |
| CA2812034A1 (en) | 2012-03-15 |
| EP2613780A1 (en) | 2013-07-17 |
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