RU2012128509A - Способы лечения заболеваний желудочно-кишечного тракта - Google Patents
Способы лечения заболеваний желудочно-кишечного тракта Download PDFInfo
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- RU2012128509A RU2012128509A RU2012128509/04A RU2012128509A RU2012128509A RU 2012128509 A RU2012128509 A RU 2012128509A RU 2012128509/04 A RU2012128509/04 A RU 2012128509/04A RU 2012128509 A RU2012128509 A RU 2012128509A RU 2012128509 A RU2012128509 A RU 2012128509A
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Landscapes
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Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US26731609P | 2009-12-07 | 2009-12-07 | |
| US61/267,316 | 2009-12-07 | ||
| PCT/US2010/059294 WO2011071927A2 (en) | 2009-12-07 | 2010-12-07 | Treatments for gastrointestinal disorders |
Publications (1)
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| RU2012128509A true RU2012128509A (ru) | 2014-01-20 |
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| Application Number | Title | Priority Date | Filing Date |
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| RU2012128509/04A RU2012128509A (ru) | 2009-12-07 | 2010-12-07 | Способы лечения заболеваний желудочно-кишечного тракта |
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|---|---|
| US (3) | US8735360B2 (enExample) |
| EP (1) | EP2509992B1 (enExample) |
| JP (2) | JP5984675B2 (enExample) |
| KR (1) | KR20120103689A (enExample) |
| CN (1) | CN102822194B (enExample) |
| RU (1) | RU2012128509A (enExample) |
| WO (1) | WO2011071927A2 (enExample) |
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| MX2009013293A (es) | 2007-06-04 | 2010-02-15 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos. |
| EP2509992B1 (en) | 2009-12-07 | 2015-10-14 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| WO2012155114A1 (en) | 2011-05-11 | 2012-11-15 | Ironwood Pharmaceuticals, Inc. | Peptides derived from uroguanylin and their use in gastrointestinal disorders |
| US9527887B2 (en) * | 2011-06-08 | 2016-12-27 | Ironwood Pharmaceutical, Inc. | Treatments for gastrointestinal disorders |
| US9617305B2 (en) * | 2011-06-08 | 2017-04-11 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| HUE032237T2 (en) * | 2011-08-17 | 2017-09-28 | Ironwood Pharmaceuticals Inc | Treatments for gastrointestinal disorders |
| JP2016514671A (ja) * | 2013-03-15 | 2016-05-23 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼのアゴニストおよびその使用 |
| LT3003327T (lt) | 2013-06-05 | 2017-12-27 | Tricida Inc. | Protonus surišantys polimerai, skirti geriamajam vartojimui |
| CN113855703B (zh) | 2014-12-10 | 2025-11-25 | 特里赛达公司 | 用于口服施用的质子结合聚合物 |
| KR101714448B1 (ko) * | 2015-07-10 | 2017-03-09 | 가톨릭대학교 산학협력단 | 위 점막 손상의 예방 및 치료용 조성물 및 헬리코박터 파이로리 균의 우레아제 활성 저해능을 지닌 조성물 |
| WO2017193024A1 (en) | 2016-05-06 | 2017-11-09 | Tricida, Inc. | Hcl-binding compositions for and method of treating acid-base disorders |
| AU2018360867B2 (en) | 2017-11-03 | 2024-12-12 | Tricida, Inc. | Compositions for and method of treating acid-base disorders |
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| ES2216004T3 (es) | 1993-10-26 | 2004-10-16 | Thomas Jefferson University | Composiciones que se unen especificamente a celulas cancerosas colorectales y procedimientos de uso de las mismas. |
| US5518888A (en) | 1993-10-26 | 1996-05-21 | Thomas Jefferson University | ST receptor binding compounds and methods of using the same |
| US5962220A (en) | 1993-10-26 | 1999-10-05 | Thomas Jefferson University | Compositions that specifically bind to colorectal cells and methods of using the same |
| US5601990A (en) | 1994-09-13 | 1997-02-11 | Thomas Jefferson University | Methods of diagnosing colorectal tumors and metastasis thereof |
| US5879656A (en) | 1993-10-26 | 1999-03-09 | Thomas Jefferson University | Methods of treating metastatic colorectal cancer with ST receptor binding compounds |
| CH689139A5 (de) | 1995-04-03 | 1998-10-30 | Cerbios Pharma Sa | Verfahren zur Herstellung einer liposomalen, in Wasser dispergierbaren, oral zu verabreichenden, festen, trockenen therapeutischen Formulierung. |
| US5912014A (en) | 1996-03-15 | 1999-06-15 | Unigene Laboratories, Inc. | Oral salmon calcitonin pharmaceutical products |
| AU2530199A (en) * | 1998-02-06 | 1999-08-23 | Nycomed Imaging As | Targeting immunoreagents useful in therapeutic and diagnostic compositions and methods |
| AU2001256315A1 (en) | 2000-04-22 | 2001-11-07 | Ipf Pharmaceuticals Gmbh | Use of guanylate cyclase-c (gc-c) agonists as insulinotropic factors for treating diabetes type 2 |
| GB0105224D0 (en) * | 2001-03-02 | 2001-04-18 | Nycomed Amersham Plc | Improved peptide-chelate conjugates |
| US7304036B2 (en) | 2003-01-28 | 2007-12-04 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US7371727B2 (en) | 2003-01-28 | 2008-05-13 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| US20060281682A1 (en) * | 2003-01-28 | 2006-12-14 | Currie Mark G | Methods and compositions for the treatment of gastrointestinal disorders |
| ATE477268T1 (de) * | 2003-01-28 | 2010-08-15 | Ironwood Pharmaceuticals Inc | Zusammensetzungen zur behandlung von magen-darm- störungen |
| US7772188B2 (en) * | 2003-01-28 | 2010-08-10 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| WO2006138571A2 (en) * | 2005-06-16 | 2006-12-28 | Mohammed Saeed | Composition and methods for treating complications associated with ingestion of a medicinal, chemical or biological substance |
| WO2007022531A2 (en) | 2005-08-19 | 2007-02-22 | Microbia, Inc. | Methods and compositions for the treatment of gastrointestinal disorders |
| EP2650303A1 (en) * | 2007-02-26 | 2013-10-16 | Ironwood Pharmaceuticals, Inc. | Methods and compositions for the treatment of heart failure and other disorders |
| MX2009013293A (es) | 2007-06-04 | 2010-02-15 | Synergy Pharmaceuticals Inc | Agonistas de guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros trastornos. |
| US20120213846A1 (en) | 2008-08-15 | 2012-08-23 | Forest Laboratories Holdings Limited | Stable Solid Formulation of a GC-C Receptor Agonist Polypeptide Suitable for Oral Administration |
| US20120039949A1 (en) | 2008-09-04 | 2012-02-16 | Ironwood Pharmaceuticals, Inc. | Stable Solid Formulations of GC-C Receptor Agonist Polypeptides Suitable for Oral Administration |
| PH12012500916B1 (en) * | 2009-11-09 | 2018-03-23 | Ironwood Pharmaceuticals Inc | Treatments for gastrointestinal disorders |
| EP2509992B1 (en) | 2009-12-07 | 2015-10-14 | Ironwood Pharmaceuticals, Inc. | Treatments for gastrointestinal disorders |
| WO2011156453A2 (en) | 2010-06-09 | 2011-12-15 | Combimab, Inc. | Therapeutic peptides |
-
2010
- 2010-12-07 EP EP10795838.1A patent/EP2509992B1/en active Active
- 2010-12-07 WO PCT/US2010/059294 patent/WO2011071927A2/en not_active Ceased
- 2010-12-07 RU RU2012128509/04A patent/RU2012128509A/ru not_active Application Discontinuation
- 2010-12-07 US US13/514,158 patent/US8735360B2/en not_active Expired - Fee Related
- 2010-12-07 KR KR1020127017632A patent/KR20120103689A/ko not_active Withdrawn
- 2010-12-07 JP JP2012543205A patent/JP5984675B2/ja not_active Expired - Fee Related
- 2010-12-07 CN CN201080063196.9A patent/CN102822194B/zh not_active Expired - Fee Related
-
2014
- 2014-05-23 US US14/286,145 patent/US20140256634A1/en not_active Abandoned
-
2015
- 2015-01-05 US US14/589,213 patent/US20150119328A1/en not_active Abandoned
-
2016
- 2016-03-16 JP JP2016052695A patent/JP2016117764A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2011071927A3 (en) | 2011-10-13 |
| US20140256634A1 (en) | 2014-09-11 |
| CN102822194A (zh) | 2012-12-12 |
| EP2509992A2 (en) | 2012-10-17 |
| US20150119328A1 (en) | 2015-04-30 |
| US20130130995A1 (en) | 2013-05-23 |
| KR20120103689A (ko) | 2012-09-19 |
| JP2013512960A (ja) | 2013-04-18 |
| JP5984675B2 (ja) | 2016-09-06 |
| US8735360B2 (en) | 2014-05-27 |
| EP2509992B1 (en) | 2015-10-14 |
| CN102822194B (zh) | 2016-10-26 |
| WO2011071927A2 (en) | 2011-06-16 |
| JP2016117764A (ja) | 2016-06-30 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20150310 |