RU2012114770A - АЛЛОСТЕРИЧЕСКИЕ СРЕДСТВА ПОТЕНЦИРОВАНИЯ mGluR4, КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ ДИСФУНКЦИЙ - Google Patents
АЛЛОСТЕРИЧЕСКИЕ СРЕДСТВА ПОТЕНЦИРОВАНИЯ mGluR4, КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ ДИСФУНКЦИЙ Download PDFInfo
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- RU2012114770A RU2012114770A RU2012114770/13A RU2012114770A RU2012114770A RU 2012114770 A RU2012114770 A RU 2012114770A RU 2012114770/13 A RU2012114770/13 A RU 2012114770/13A RU 2012114770 A RU2012114770 A RU 2012114770A RU 2012114770 A RU2012114770 A RU 2012114770A
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- 238000000034 method Methods 0.000 title claims abstract 37
- 230000004064 dysfunction Effects 0.000 title claims abstract 25
- 102100038354 Metabotropic glutamate receptor 4 Human genes 0.000 title claims abstract 23
- 108010038422 metabotropic glutamate receptor 4 Proteins 0.000 title claims abstract 23
- 239000000203 mixture Substances 0.000 title claims 18
- 230000000926 neurological effect Effects 0.000 title claims 4
- 230000003281 allosteric effect Effects 0.000 title 1
- 229910052799 carbon Inorganic materials 0.000 claims abstract 87
- 150000001875 compounds Chemical class 0.000 claims abstract 86
- 125000004122 cyclic group Chemical group 0.000 claims abstract 75
- 229910052717 sulfur Inorganic materials 0.000 claims abstract 68
- 229910052760 oxygen Inorganic materials 0.000 claims abstract 67
- 125000001072 heteroaryl group Chemical group 0.000 claims abstract 55
- 125000003118 aryl group Chemical group 0.000 claims abstract 53
- 125000004430 oxygen atom Chemical group O* 0.000 claims abstract 53
- 125000004432 carbon atom Chemical group C* 0.000 claims abstract 52
- 125000004433 nitrogen atom Chemical group N* 0.000 claims abstract 52
- 125000004434 sulfur atom Chemical group 0.000 claims abstract 52
- 229910052736 halogen Inorganic materials 0.000 claims abstract 45
- 150000002367 halogens Chemical class 0.000 claims abstract 45
- 229910052739 hydrogen Inorganic materials 0.000 claims abstract 39
- 241000124008 Mammalia Species 0.000 claims abstract 30
- 230000000694 effects Effects 0.000 claims abstract 25
- 150000003839 salts Chemical class 0.000 claims abstract 19
- 229910052757 nitrogen Inorganic materials 0.000 claims abstract 13
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims abstract 11
- 125000002813 thiocarbonyl group Chemical group *C(*)=S 0.000 claims abstract 11
- 230000005062 synaptic transmission Effects 0.000 claims abstract 8
- 125000000217 alkyl group Chemical group 0.000 claims 83
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 67
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 28
- 208000035475 disorder Diseases 0.000 claims 21
- -1 ethylbenzyl Chemical group 0.000 claims 18
- 229910005965 SO 2 Inorganic materials 0.000 claims 13
- 239000003814 drug Substances 0.000 claims 11
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 9
- 230000003389 potentiating effect Effects 0.000 claims 9
- YLQBMQCUIZJEEH-UHFFFAOYSA-N Furan Chemical compound C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 claims 8
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 8
- 229940079593 drug Drugs 0.000 claims 8
- 201000000980 schizophrenia Diseases 0.000 claims 8
- XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 claims 7
- 208000028017 Psychotic disease Diseases 0.000 claims 7
- 201000010099 disease Diseases 0.000 claims 7
- 239000001257 hydrogen Substances 0.000 claims 7
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 7
- 208000019901 Anxiety disease Diseases 0.000 claims 6
- YNQLUTRBYVCPMQ-UHFFFAOYSA-N Ethylbenzene Chemical compound CCC1=CC=CC=C1 YNQLUTRBYVCPMQ-UHFFFAOYSA-N 0.000 claims 6
- 208000018737 Parkinson disease Diseases 0.000 claims 6
- 125000000218 acetic acid group Chemical group C(C)(=O)* 0.000 claims 6
- 229910052801 chlorine Inorganic materials 0.000 claims 6
- 125000001309 chloro group Chemical group Cl* 0.000 claims 6
- IUGYQRQAERSCNH-UHFFFAOYSA-N pivalic acid Chemical compound CC(C)(C)C(O)=O IUGYQRQAERSCNH-UHFFFAOYSA-N 0.000 claims 6
- 208000020925 Bipolar disease Diseases 0.000 claims 5
- 208000028698 Cognitive impairment Diseases 0.000 claims 4
- 108010010914 Metabotropic glutamate receptors Proteins 0.000 claims 4
- 102000016193 Metabotropic glutamate receptors Human genes 0.000 claims 4
- KYQCOXFCLRTKLS-UHFFFAOYSA-N Pyrazine Chemical compound C1=CN=CC=N1 KYQCOXFCLRTKLS-UHFFFAOYSA-N 0.000 claims 4
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 4
- 208000010877 cognitive disease Diseases 0.000 claims 4
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 4
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- PCNDJXKNXGMECE-UHFFFAOYSA-N Phenazine Natural products C1=CC=CC2=NC3=CC=CC=C3N=C21 PCNDJXKNXGMECE-UHFFFAOYSA-N 0.000 claims 2
- CZPWVGJYEJSRLH-UHFFFAOYSA-N Pyrimidine Chemical compound C1=CN=CN=C1 CZPWVGJYEJSRLH-UHFFFAOYSA-N 0.000 claims 2
- 125000003545 alkoxy group Chemical group 0.000 claims 2
- 230000036506 anxiety Effects 0.000 claims 2
- 125000004429 atom Chemical group 0.000 claims 2
- 208000015802 attention deficit-hyperactivity disease Diseases 0.000 claims 2
- ARUKYTASOALXFG-UHFFFAOYSA-N cycloheptylcycloheptane Chemical class C1CCCCCC1C1CCCCCC1 ARUKYTASOALXFG-UHFFFAOYSA-N 0.000 claims 2
- 229910052731 fluorine Inorganic materials 0.000 claims 2
- 125000001153 fluoro group Chemical group F* 0.000 claims 2
- ZLTPDFXIESTBQG-UHFFFAOYSA-N isothiazole Chemical compound C=1C=NSC=1 ZLTPDFXIESTBQG-UHFFFAOYSA-N 0.000 claims 2
- 230000001071 malnutrition Effects 0.000 claims 2
- 235000000824 malnutrition Nutrition 0.000 claims 2
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims 2
- 208000015380 nutritional deficiency disease Diseases 0.000 claims 2
- 229930192474 thiophene Natural products 0.000 claims 2
- 206010000117 Abnormal behaviour Diseases 0.000 claims 1
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- 230000003542 behavioural effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
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- 230000004770 neurodegeneration Effects 0.000 claims 1
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- 208000011580 syndromic disease Diseases 0.000 claims 1
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- 0 *c1cc(NC(c2ccccn2)=O)ccc1N(C(C1(CC23CCCCC2)NC1)=O)C3=O Chemical compound *c1cc(NC(c2ccccn2)=O)ccc1N(C(C1(CC23CCCCC2)NC1)=O)C3=O 0.000 description 6
- YCEBADOUMKXYGH-UHFFFAOYSA-N CC(CCCC1)(C(N2c(c(Cl)c3)ccc3NC(c3c[s]cn3)=O)=O)N1C2=S Chemical compound CC(CCCC1)(C(N2c(c(Cl)c3)ccc3NC(c3c[s]cn3)=O)=O)N1C2=S YCEBADOUMKXYGH-UHFFFAOYSA-N 0.000 description 1
- YFUYTHHVQVPXIR-UHFFFAOYSA-N O=C(c([o]1)ccc1Cl)Nc(cc1)cc(Cl)c1N(C(C1N2CCOC1)=O)C2=S Chemical compound O=C(c([o]1)ccc1Cl)Nc(cc1)cc(Cl)c1N(C(C1N2CCOC1)=O)C2=S YFUYTHHVQVPXIR-UHFFFAOYSA-N 0.000 description 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
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- A—HUMAN NECESSITIES
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/22—Anxiolytics
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- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
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- A—HUMAN NECESSITIES
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- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- A—HUMAN NECESSITIES
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- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/10—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/04—Ortho-condensed systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D513/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00
- C07D513/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for in groups C07D463/00, C07D477/00 or C07D499/00 - C07D507/00 in which the condensed system contains two hetero rings
- C07D513/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hematology (AREA)
- Hospice & Palliative Care (AREA)
- Child & Adolescent Psychology (AREA)
- Diabetes (AREA)
- Psychology (AREA)
- Obesity (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US24003109P | 2009-09-04 | 2009-09-04 | |
| US61/240,031 | 2009-09-04 | ||
| PCT/US2010/048030 WO2011029104A1 (en) | 2009-09-04 | 2010-09-07 | Mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012114770A true RU2012114770A (ru) | 2013-10-10 |
Family
ID=43649686
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012114770/13A RU2012114770A (ru) | 2009-09-04 | 2010-09-07 | АЛЛОСТЕРИЧЕСКИЕ СРЕДСТВА ПОТЕНЦИРОВАНИЯ mGluR4, КОМПОЗИЦИИ И СПОСОБЫ ЛЕЧЕНИЯ НЕВРОЛОГИЧЕСКИХ ДИСФУНКЦИЙ |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US8779157B2 (enExample) |
| EP (1) | EP2473055A4 (enExample) |
| JP (1) | JP2013503909A (enExample) |
| CN (1) | CN102740699A (enExample) |
| AU (1) | AU2010289281A1 (enExample) |
| BR (1) | BR112012004919A2 (enExample) |
| CA (1) | CA2773038A1 (enExample) |
| IL (1) | IL218426A0 (enExample) |
| IN (1) | IN2012DN02580A (enExample) |
| RU (1) | RU2012114770A (enExample) |
| SG (1) | SG178999A1 (enExample) |
| WO (1) | WO2011029104A1 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2010208176A1 (en) | 2009-01-28 | 2011-09-15 | Vanderbilt University | Substituted 1,1,3,3-tetraoxidobenzo[d][1,3,2]dithiazoles as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US8759377B2 (en) | 2009-11-23 | 2014-06-24 | Vanderbilt University | Substituted dioxopiperidines and dioxopyrrolidines as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| SG11201602029VA (en) * | 2013-09-25 | 2016-04-28 | Hoffmann La Roche | Ethynyl derivatives |
| EP2853532B1 (en) | 2013-09-28 | 2020-12-09 | Instytut Farmakologii Polskiej Akademii Nauk | 1,2,4-oxadiazole derivatives as allosteric modulators of metabotropic glutamate receptors belonging to group III |
| TWI649310B (zh) * | 2014-01-10 | 2019-02-01 | 赫孚孟拉羅股份公司 | 乙炔基衍生物 |
| CR20160384A (es) * | 2014-02-25 | 2016-11-07 | Hoffmann La Roche | Derivados de etilino |
| WO2016115272A1 (en) | 2015-01-13 | 2016-07-21 | Vanderbilt University | Benzothiazole and benzisothiazole-substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10227343B2 (en) | 2015-01-30 | 2019-03-12 | Vanderbilt University | Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2016123629A1 (en) | 2015-01-30 | 2016-08-04 | Vanderbilt University | Indazole and azaindazole substituted compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| CN107207481B (zh) * | 2015-03-19 | 2020-03-03 | 豪夫迈·罗氏有限公司 | 作为mglur4的调节剂的3-(4-乙炔基苯基)六氢嘧啶-2,4-二酮衍生物 |
| US9987242B2 (en) | 2015-05-05 | 2018-06-05 | Northwestern University | Treatment of Levodopa-induced Dyskinesias |
| TR201909160T4 (tr) | 2015-07-15 | 2019-07-22 | Hoffmann La Roche | Metabotropik glutamat reseptörü modülatörleri olarak etinil türevleri. |
| WO2018015235A1 (en) | 2016-07-18 | 2018-01-25 | F. Hoffmann-La Roche Ag | Ethynyl derivatives |
| US10710997B2 (en) | 2016-09-01 | 2020-07-14 | Vanderbilt University | Isoquinoline amide and isoquinoline amide-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US10294222B2 (en) | 2016-09-01 | 2019-05-21 | Vanderbilt University | Benzomorpholine and benzomorpholine-substituted compounds as MGLUR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2018089546A1 (en) | 2016-11-08 | 2018-05-17 | Vanderbilt University | Isoquinoline ether compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| US11242342B2 (en) | 2016-11-08 | 2022-02-08 | Vanderbilt University | Isoquinoline amine compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| WO2019006157A1 (en) | 2017-06-28 | 2019-01-03 | Vanderbilt University | Pyridine quinoline compounds as mglur4 allosteric potentiators, compositions, and methods of treating neurological dysfunction |
| KR102687118B1 (ko) | 2017-08-16 | 2024-07-19 | 벤더르빌트 유니버시티 | Mglur4 알로스테릭 증강제로서의 인다졸 화합물, 조성물, 및 신경 기능장애 치료 방법 |
| CA3102326A1 (en) | 2018-07-26 | 2020-01-30 | Domain Therapeutics | Substituted quinazolinone derivatives and their use as positive allosteric modulators of mglur4 |
| CN119504747B (zh) * | 2024-11-26 | 2025-11-21 | 上海交通大学 | 一种含氮杂季碳双环海因类衍生物及其合成方法 |
Family Cites Families (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DK529378A (da) * | 1978-01-09 | 1979-07-10 | Shell Int Research | Anilidderivater |
| TW521073B (en) | 1994-01-05 | 2003-02-21 | Hoechst Marion Roussel Inc | New optionally substituted phenylimidazolidines, their preparation process, their use as anti-androgenic agent and the pharmaceutical compositions containing them |
| FR2725206B1 (fr) | 1994-09-29 | 1996-12-06 | Roussel Uclaf | Nouvelles imidazolidines substituees par un heterocycle, leur procede et des intermediaires de preparation, leur application comme medicaments et les compositions pharmaceutiques les renfermant |
| US6355664B1 (en) | 1997-03-03 | 2002-03-12 | Boehringer Ingelheim Pharmaceuticals, Inc. | Phenylpyrrolidines, phenylimidazolidines, 3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease |
| USRE38132E1 (en) | 1997-03-03 | 2003-06-03 | Boehringer Ingelheim Pharmaceuticals, Inc. | Phenylpyrrolidines, phenylimidazolidines,3-phenyl-1,3-oxizolidines and 3-phenyl-1,3-thiazolidines and their use in the treatment of inflammatory disease |
| US6809088B2 (en) | 1997-03-24 | 2004-10-26 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
| US6335445B1 (en) | 1997-03-24 | 2002-01-01 | Societe De Conseils De Recherches Et D'applications Scientifiques (S.C.R.A.S.) | Derivatives of 2-(iminomethyl)amino-phenyl, their preparation, their use as medicaments and the pharmaceutical compositions containing them |
| FR2764889B1 (fr) | 1997-06-20 | 2000-09-01 | Sod Conseils Rech Applic | Nouveaux derives du 2-(iminomethyl)amino-phenyle, leur preparation, leur application a titre de medicaments et les compositions pharmaceutiques les contenant |
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| US6353013B1 (en) | 1999-07-21 | 2002-03-05 | Boehringer Ingelheim Pharmaceuticals, Inc. | Small molecules useful in the treatment of inflammatory disease |
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| US7030141B2 (en) * | 2001-11-29 | 2006-04-18 | Christopher Franklin Bigge | Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade |
| AU2003259307A1 (en) | 2002-07-31 | 2004-02-16 | Euro-Celtique S.A. | Aryl substituted hydantoin compounds and their use as sodium channel blockers |
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| RU2354377C2 (ru) | 2003-07-11 | 2009-05-10 | Берингер Ингельхайм Ветмедика Гмбх | Способ лечения или предупреждения заболеваний центральной нервной системы с использованием соединений, обладающих селективностью в отношении альфа-3-субъединицы бензодиазепинового рецептора |
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| GB0713686D0 (en) * | 2007-07-13 | 2007-08-22 | Addex Pharmaceuticals Sa | New compounds 2 |
| US20090099243A1 (en) | 2007-10-16 | 2009-04-16 | Joachim Nozulak | Organic compounds |
-
2010
- 2010-09-07 CN CN2010800490890A patent/CN102740699A/zh active Pending
- 2010-09-07 AU AU2010289281A patent/AU2010289281A1/en not_active Abandoned
- 2010-09-07 SG SG2012015525A patent/SG178999A1/en unknown
- 2010-09-07 RU RU2012114770/13A patent/RU2012114770A/ru not_active Application Discontinuation
- 2010-09-07 WO PCT/US2010/048030 patent/WO2011029104A1/en not_active Ceased
- 2010-09-07 IN IN2580DEN2012 patent/IN2012DN02580A/en unknown
- 2010-09-07 CA CA2773038A patent/CA2773038A1/en not_active Abandoned
- 2010-09-07 JP JP2012528121A patent/JP2013503909A/ja not_active Withdrawn
- 2010-09-07 US US13/394,309 patent/US8779157B2/en not_active Expired - Fee Related
- 2010-09-07 BR BR112012004919A patent/BR112012004919A2/pt not_active IP Right Cessation
- 2010-09-07 EP EP10814634A patent/EP2473055A4/en not_active Withdrawn
-
2012
- 2012-03-01 IL IL218426A patent/IL218426A0/en unknown
Also Published As
| Publication number | Publication date |
|---|---|
| EP2473055A1 (en) | 2012-07-11 |
| CN102740699A (zh) | 2012-10-17 |
| IN2012DN02580A (enExample) | 2015-08-28 |
| SG178999A1 (en) | 2012-04-27 |
| IL218426A0 (en) | 2012-04-30 |
| AU2010289281A1 (en) | 2012-04-12 |
| BR112012004919A2 (pt) | 2019-09-24 |
| JP2013503909A (ja) | 2013-02-04 |
| EP2473055A4 (en) | 2013-02-13 |
| CA2773038A1 (en) | 2011-03-10 |
| WO2011029104A1 (en) | 2011-03-10 |
| US20120245153A1 (en) | 2012-09-27 |
| US8779157B2 (en) | 2014-07-15 |
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| Date | Code | Title | Description |
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| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
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