RU2012103753A - Способ синтеза (2s, 3ar, 7as)-октагидро-1н-индол-карбоновой кислоты в качестве промежуточного соединения для получения трандолаприла - Google Patents
Способ синтеза (2s, 3ar, 7as)-октагидро-1н-индол-карбоновой кислоты в качестве промежуточного соединения для получения трандолаприла Download PDFInfo
- Publication number
- RU2012103753A RU2012103753A RU2012103753/04A RU2012103753A RU2012103753A RU 2012103753 A RU2012103753 A RU 2012103753A RU 2012103753/04 A RU2012103753/04 A RU 2012103753/04A RU 2012103753 A RU2012103753 A RU 2012103753A RU 2012103753 A RU2012103753 A RU 2012103753A
- Authority
- RU
- Russia
- Prior art keywords
- ethyl
- phenylethylamino
- compound
- formula
- indole
- Prior art date
Links
- 0 CC(*)C(C1[C@](C)CCCC1)C(c1ccccc1)=O Chemical compound CC(*)C(C1[C@](C)CCCC1)C(c1ccccc1)=O 0.000 description 1
- MTWILXWCYRQFOL-UHFFFAOYSA-N N#CCN(C1CCCCC1)C(c1ccccc1)=O Chemical compound N#CCN(C1CCCCC1)C(c1ccccc1)=O MTWILXWCYRQFOL-UHFFFAOYSA-N 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/42—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Heart & Thoracic Surgery (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Indole Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US22603009P | 2009-07-16 | 2009-07-16 | |
| US61/226,030 | 2009-07-16 | ||
| PCT/US2010/042219 WO2011009021A1 (en) | 2009-07-16 | 2010-07-16 | Processes for the synthesis of (2s, 3ar, 7as)-octahydro-1h-indole carboxylic acid as an intermediate for trandolapril |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| RU2012103753A true RU2012103753A (ru) | 2013-08-27 |
Family
ID=42585097
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU2012103753/04A RU2012103753A (ru) | 2009-07-16 | 2010-07-16 | Способ синтеза (2s, 3ar, 7as)-октагидро-1н-индол-карбоновой кислоты в качестве промежуточного соединения для получения трандолаприла |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8288565B2 (https=) |
| EP (1) | EP2454235A1 (https=) |
| JP (1) | JP2012533563A (https=) |
| CN (1) | CN102498098A (https=) |
| AU (1) | AU2010273259B2 (https=) |
| CA (1) | CA2768239A1 (https=) |
| CO (1) | CO6491043A2 (https=) |
| IN (1) | IN2012DN00453A (https=) |
| RU (1) | RU2012103753A (https=) |
| WO (1) | WO2011009021A1 (https=) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN111620788B (zh) * | 2020-04-20 | 2022-09-30 | 广东莱佛士制药技术有限公司 | 一种制备(2s,3s)-3-氨基-二环[2.2.2]辛烷-2-甲酸酯的方法 |
Family Cites Families (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US487932A (en) | 1892-12-13 | George b | ||
| US4350704A (en) | 1980-10-06 | 1982-09-21 | Warner-Lambert Company | Substituted acyl derivatives of octahydro-1H-indole-2-carboxylic acids |
| IE55867B1 (en) | 1981-12-29 | 1991-02-14 | Hoechst Ag | New derivatives of bicyclic aminoacids,processes for their preparation,agents containing these compounds and their use,and new bicyclic aminoacids as intermediates and processes for their preparation |
| US4490386A (en) | 1982-09-23 | 1984-12-25 | Warner-Lambert Company | Phosphate salts of 1-[2-[(1-alkoxycarbonyl-3-aralkyl)-amino]-1-oxoalkyl]octahydro-1H-indole-2-carboxylic acids, preparation of, and medical compositions thereof |
| US4556655A (en) | 1984-09-24 | 1985-12-03 | Schering Corporation | Antihypertensive compounds having both diuretic and angiotensin converting enzyme inhibitory activity |
| FR2605630B1 (fr) | 1986-10-22 | 1989-06-30 | Roussel Uclaf | Procede de preparation de derives de l'octahydroindole et intermediaires de preparation |
| DE19900205A1 (de) * | 1999-01-07 | 2000-07-13 | Basf Ag | Verfahren zur Herstellung von (2S,4R,9S)-Octahydro-1H-indol-2-carbonsäure und Zwischenprodukte dafür |
| JPWO2004065368A1 (ja) | 2003-01-21 | 2006-05-18 | 大原薬品工業株式会社 | トランドラプリル合成中間体の製造方法 |
| DE60300166T2 (de) * | 2003-04-15 | 2005-12-01 | Les Laboratoires Servier | Verfahren zur Synthese von (2S, 3aS, 7aS)-Perhydroindol-2-carbonsäure und seinen Estern, und Verwendung in der Synthese von Perindopril |
| SI21507A (sl) | 2003-05-16 | 2004-12-31 | LEK farmacevtska dru�ba d.d. | Postopek za pripravo spojin z ace inhibitornim delovanjem |
| US20070225505A1 (en) | 2003-11-25 | 2007-09-27 | Pau Cid | Method for the Preparation of (2S, 3AR, 7AS)-Octahydro-III-Indole-2-Carboxylic Acid as Key Intermediate in the Preparation of Trandolapril by Reacting a Cyclohexyl Aziridine with a Dialkyl Malonate |
| EP1689711A1 (de) | 2003-11-28 | 2006-08-16 | Azad Pharmaceutical Ingredients AG | Verfahren zur herstellung von n- 1-(s)-carbalkoxy-3-ph enylpropyl -s-alanyl-2s, 3ar, 7as-octahydroindol-2-carbonsäure;verbindungen |
| WO2006014916A2 (en) | 2004-07-26 | 2006-02-09 | Dr. Reddy's Laboratories Ltd. | Preparation of trandolapril |
| US20080171885A1 (en) | 2005-02-14 | 2008-07-17 | Lupin Limited | Process for Preparation of Highly Pure Trandolapril |
| DE602005004897D1 (de) | 2005-05-06 | 2008-04-03 | Sochinaz Sa | Verfahren zur Herstellung von i(2S, 3aR, 7aS)-octahydroindole-2-Carbonsäure und Umwandlung zum Trandolapril |
| JP2008545006A (ja) | 2005-07-05 | 2008-12-11 | シプラ・リミテッド | Ａｃｅ阻害剤の合成方法 |
| WO2009015166A1 (en) | 2007-07-24 | 2009-01-29 | Bristol-Myers Squibb Company | Piperidine derivatives as modulators of chemokine receptor activity |
| CN101423490B (zh) * | 2008-06-16 | 2012-07-18 | 重庆南松医药科技股份有限公司 | 群多普利关键中间体（2S,3aR,7as）-八氢－1H－吲哚－2－羧酸的合成方法 |
-
2010
- 2010-07-16 JP JP2012520807A patent/JP2012533563A/ja active Pending
- 2010-07-16 EP EP10737165A patent/EP2454235A1/en not_active Withdrawn
- 2010-07-16 RU RU2012103753/04A patent/RU2012103753A/ru not_active Application Discontinuation
- 2010-07-16 AU AU2010273259A patent/AU2010273259B2/en not_active Ceased
- 2010-07-16 CA CA2768239A patent/CA2768239A1/en not_active Abandoned
- 2010-07-16 IN IN453DEN2012 patent/IN2012DN00453A/en unknown
- 2010-07-16 WO PCT/US2010/042219 patent/WO2011009021A1/en not_active Ceased
- 2010-07-16 CN CN2010800413803A patent/CN102498098A/zh active Pending
- 2010-07-16 US US12/837,686 patent/US8288565B2/en not_active Expired - Fee Related
-
2012
- 2012-01-16 CO CO12005568A patent/CO6491043A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| EP2454235A1 (en) | 2012-05-23 |
| AU2010273259B2 (en) | 2013-03-07 |
| CO6491043A2 (es) | 2012-07-31 |
| AU2010273259A1 (en) | 2012-02-09 |
| US20110065930A1 (en) | 2011-03-17 |
| US8288565B2 (en) | 2012-10-16 |
| CA2768239A1 (en) | 2011-01-20 |
| IN2012DN00453A (https=) | 2015-05-15 |
| JP2012533563A (ja) | 2012-12-27 |
| WO2011009021A1 (en) | 2011-01-20 |
| CN102498098A (zh) | 2012-06-13 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FA92 | Acknowledgement of application withdrawn (lack of supplementary materials submitted) |
Effective date: 20140901 |