RU2011147201A - Регероматические и ароматические пиперазинил ацетидинил амиды как моноцилглицероловые ингибиторы липазы - Google Patents

Регероматические и ароматические пиперазинил ацетидинил амиды как моноцилглицероловые ингибиторы липазы Download PDF

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Publication number
RU2011147201A
RU2011147201A RU2011147201/15A RU2011147201A RU2011147201A RU 2011147201 A RU2011147201 A RU 2011147201A RU 2011147201/15 A RU2011147201/15 A RU 2011147201/15A RU 2011147201 A RU2011147201 A RU 2011147201A RU 2011147201 A RU2011147201 A RU 2011147201A
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RU
Russia
Prior art keywords
compound
xyz
isobutyl
cyclohexylmethyl
phenoxymethyl
Prior art date
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RU2011147201/15A
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English (en)
Russian (ru)
Inventor
Кристофер М. Флорес
Марина И. НЕЛЕН
Эрика Л. НАЛТОН
Стефен ПРАУТИ
Мэттью ТОДД
Суй-По ЧЖАН
Original Assignee
Янссен Фармацевтика Нв
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Application filed by Янссен Фармацевтика Нв filed Critical Янссен Фармацевтика Нв
Publication of RU2011147201A publication Critical patent/RU2011147201A/ru

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/496Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965Non-condensed pyrazines
    • A61K31/497Non-condensed pyrazines containing further heterocyclic rings
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0053Mouth and digestive tract, i.e. intraoral and peroral administration
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/02Drugs for disorders of the nervous system for peripheral neuropathies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/04Centrally acting analgesics, e.g. opioids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Biomedical Technology (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Inorganic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Plural Heterocyclic Compounds (AREA)
RU2011147201/15A 2009-04-22 2010-04-22 Регероматические и ароматические пиперазинил ацетидинил амиды как моноцилглицероловые ингибиторы липазы RU2011147201A (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US17166109P 2009-04-22 2009-04-22
US61/171,661 2009-04-22
PCT/US2010/032100 WO2010124122A1 (fr) 2009-04-22 2010-04-22 Pipérazinyl azétidinyl amides hétéroaromatiques et aromatiques en tant qu'inhibiteurs de la monoacylglycérol lipase

Publications (1)

Publication Number Publication Date
RU2011147201A true RU2011147201A (ru) 2013-05-27

Family

ID=42226535

Family Applications (1)

Application Number Title Priority Date Filing Date
RU2011147201/15A RU2011147201A (ru) 2009-04-22 2010-04-22 Регероматические и ароматические пиперазинил ацетидинил амиды как моноцилглицероловые ингибиторы липазы

Country Status (11)

Country Link
EP (1) EP2421535A1 (fr)
JP (1) JP2012524810A (fr)
KR (1) KR20120005517A (fr)
CN (1) CN102458407B (fr)
AU (1) AU2010238746B2 (fr)
BR (1) BRPI1014874A2 (fr)
CA (1) CA2759706A1 (fr)
IL (1) IL215797A0 (fr)
RU (1) RU2011147201A (fr)
TW (1) TW201103914A (fr)
WO (1) WO2010124122A1 (fr)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2760450A1 (fr) * 2011-09-30 2014-08-06 Janssen Pharmaceutica, N.V. Inhibiteurs de monoacylglycérol lipase pour le traitement de maladies métaboliques et de troubles apparentés
EP2935294A4 (fr) 2012-12-21 2016-08-31 Univ California Méthodes et compositions pour le traitement de la toxicité du cyanure et de sulfure d'hydrogène
JP6454349B2 (ja) * 2013-12-26 2019-01-16 武田薬品工業株式会社 モノアシルグリセロールリパーゼ(magl)阻害剤としての4−(ピペラジン−1−イル)−ピロリジン−2−オン化合物
WO2016158956A1 (fr) * 2015-03-30 2016-10-06 武田薬品工業株式会社 Composé hétérocyclique
US10463753B2 (en) 2016-02-19 2019-11-05 Lundbeck La Jolla Research Center, Inc. Radiolabeled monoacylglycerol lipase occupancy probe
BR112018068538B1 (pt) 2016-03-31 2023-12-12 Takeda Pharmaceutical Company Limited Composto, medicamento, e, uso de um composto
WO2017170830A1 (fr) 2016-03-31 2017-10-05 武田薬品工業株式会社 Composé hétérocyclique
MX2020007318A (es) 2017-09-29 2020-08-24 Takeda Pharmaceuticals Co Compuesto heterociclico.
EP3717477B1 (fr) 2017-11-28 2022-07-20 F. Hoffmann-La Roche AG Nouveaux composés hétérocycliques
TW201930300A (zh) * 2017-12-15 2019-08-01 瑞士商赫孚孟拉羅股份公司 新雜環化合物
EP3856178A1 (fr) * 2018-09-28 2021-08-04 Janssen Pharmaceutica NV Modulateurs de la monoacylglycérol lipase

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2915199B1 (fr) * 2007-04-18 2010-01-22 Sanofi Aventis Derives de triazolopyridine-carboxamides et triazolopyrimidine-carboxamides, leur preparation et leur application en therapeutique.
EP2180048B1 (fr) * 2008-10-09 2014-12-17 Janssen Pharmaceutica N.V. Forme cristalline alternative de la monoacylglycérol lipase (MGLL)

Also Published As

Publication number Publication date
CN102458407B (zh) 2014-03-05
KR20120005517A (ko) 2012-01-16
AU2010238746B2 (en) 2015-02-19
WO2010124122A1 (fr) 2010-10-28
CN102458407A (zh) 2012-05-16
IL215797A0 (en) 2012-01-31
JP2012524810A (ja) 2012-10-18
BRPI1014874A2 (pt) 2016-04-12
CA2759706A1 (fr) 2010-10-28
AU2010238746A1 (en) 2011-11-10
EP2421535A1 (fr) 2012-02-29
TW201103914A (en) 2011-02-01

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Effective date: 20150414